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Protein

Ninjurin-1

Gene

Ninj1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues. Cell adhesion requires divalent cations (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Ninjurin-1
Alternative name(s):
Nerve injury-induced protein 1
Gene namesi
Name:Ninj1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi3179 Ninj1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 79ExtracellularSequence analysisAdd BLAST79
Transmembranei80 – 100HelicalSequence analysisAdd BLAST21
Topological domaini101 – 120CytoplasmicSequence analysisAdd BLAST20
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Topological domaini142 – 152ExtracellularSequence analysisAdd BLAST11

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001596451 – 152Ninjurin-1Add BLAST152

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei18PhosphoserineCombined sources1
Modified residuei21PhosphoserineCombined sources1
Modified residuei25PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP70617
PRIDEiP70617

PTM databases

iPTMnetiP70617
PhosphoSitePlusiP70617

Expressioni

Inductioni

By nerve injury.

Gene expression databases

BgeeiENSRNOG00000016587
GenevisibleiP70617 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022341

Family & Domainsi

Sequence similaritiesi

Belongs to the ninjurin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWIJ Eukaryota
ENOG4111RPK LUCA
GeneTreeiENSGT00390000012754
HOGENOMiHOG000037625
HOVERGENiHBG052622
InParanoidiP70617
OMAiNINHYAN
OrthoDBiEOG091G0W0Q
PhylomeDBiP70617
TreeFamiTF323538

Family and domain databases

InterProiView protein in InterPro
IPR007007 Ninjurin
IPR015639 Ninjurin1
PANTHERiPTHR12316 PTHR12316, 1 hit
PTHR12316:SF19 PTHR12316:SF19, 1 hit
PfamiView protein in Pfam
PF04923 Ninjurin, 1 hit

Sequencei

Sequence statusi: Complete.

P70617-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPGTEEYEL NGDLRPGSPG SPDASPPRWG LRNRPINVNH YANKKSAAES
60 70 80 90 100
MLDIALLMAN ASQLKAVVEQ GNEFAFFVPL VVLISISLVL QIGVGVLLIF
110 120 130 140 150
LVKYDLNNPA KHAKLDFLNN LATGLVFIIV VVNIFITAFG VQKPVMDVAP

RQ
Length:152
Mass (Da):16,539
Last modified:February 1, 1997 - v1
Checksum:i414B3B9DE1807E80
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72660 mRNA Translation: AAB17559.1
RefSeqiNP_036999.1, NM_012867.1
UniGeneiRn.11245

Genome annotation databases

EnsembliENSRNOT00000022341; ENSRNOP00000022341; ENSRNOG00000016587
GeneIDi25338
KEGGirno:25338

Similar proteinsi

Entry informationi

Entry nameiNINJ1_RAT
AccessioniPrimary (citable) accession number: P70617
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 1, 1997
Last modified: May 23, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health