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Protein

Ninjurin-1

Gene

Ninj1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues. Cell adhesion requires divalent cations (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Ninjurin-1
Alternative name(s):
Nerve injury-induced protein 1
Gene namesi
Name:Ninj1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi3179. Ninj1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7979ExtracellularSequence analysisAdd
BLAST
Transmembranei80 – 10021HelicalSequence analysisAdd
BLAST
Topological domaini101 – 12020CytoplasmicSequence analysisAdd
BLAST
Transmembranei121 – 14121HelicalSequence analysisAdd
BLAST
Topological domaini142 – 15211ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 152152Ninjurin-1PRO_0000159645Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei18 – 181PhosphoserineCombined sources
Modified residuei21 – 211PhosphoserineCombined sources
Modified residuei25 – 251PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP70617.
PRIDEiP70617.

PTM databases

iPTMnetiP70617.

Expressioni

Inductioni

By nerve injury.

Gene expression databases

GenevisibleiP70617. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022341.

Family & Domainsi

Sequence similaritiesi

Belongs to the ninjurin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWIJ. Eukaryota.
ENOG4111RPK. LUCA.
GeneTreeiENSGT00390000012754.
HOGENOMiHOG000037625.
HOVERGENiHBG052622.
InParanoidiP70617.
OMAiIFIVKWN.
OrthoDBiEOG7QK0F5.
PhylomeDBiP70617.
TreeFamiTF323538.

Family and domain databases

InterProiIPR007007. Ninjurin.
IPR015639. Ninjurin1.
[Graphical view]
PANTHERiPTHR12316. PTHR12316. 1 hit.
PTHR12316:SF19. PTHR12316:SF19. 1 hit.
PfamiPF04923. Ninjurin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70617-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPGTEEYEL NGDLRPGSPG SPDASPPRWG LRNRPINVNH YANKKSAAES
60 70 80 90 100
MLDIALLMAN ASQLKAVVEQ GNEFAFFVPL VVLISISLVL QIGVGVLLIF
110 120 130 140 150
LVKYDLNNPA KHAKLDFLNN LATGLVFIIV VVNIFITAFG VQKPVMDVAP

RQ
Length:152
Mass (Da):16,539
Last modified:February 1, 1997 - v1
Checksum:i414B3B9DE1807E80
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72660 mRNA. Translation: AAB17559.1.
RefSeqiNP_036999.1. NM_012867.1.
UniGeneiRn.11245.

Genome annotation databases

EnsembliENSRNOT00000022341; ENSRNOP00000022341; ENSRNOG00000016587.
GeneIDi25338.
KEGGirno:25338.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72660 mRNA. Translation: AAB17559.1.
RefSeqiNP_036999.1. NM_012867.1.
UniGeneiRn.11245.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022341.

PTM databases

iPTMnetiP70617.

Proteomic databases

PaxDbiP70617.
PRIDEiP70617.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000022341; ENSRNOP00000022341; ENSRNOG00000016587.
GeneIDi25338.
KEGGirno:25338.

Organism-specific databases

CTDi4814.
RGDi3179. Ninj1.

Phylogenomic databases

eggNOGiENOG410IWIJ. Eukaryota.
ENOG4111RPK. LUCA.
GeneTreeiENSGT00390000012754.
HOGENOMiHOG000037625.
HOVERGENiHBG052622.
InParanoidiP70617.
OMAiIFIVKWN.
OrthoDBiEOG7QK0F5.
PhylomeDBiP70617.
TreeFamiTF323538.

Miscellaneous databases

PROiP70617.

Gene expression databases

GenevisibleiP70617. RN.

Family and domain databases

InterProiIPR007007. Ninjurin.
IPR015639. Ninjurin1.
[Graphical view]
PANTHERiPTHR12316. PTHR12316. 1 hit.
PTHR12316:SF19. PTHR12316:SF19. 1 hit.
PfamiPF04923. Ninjurin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Ninjurin, a novel adhesion molecule, is induced by nerve injury and promotes axonal growth."
    Araki T., Milbrandt J.
    Neuron 17:353-361(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18; SER-21 AND SER-25, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNINJ1_RAT
AccessioniPrimary (citable) accession number: P70617
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 1, 1997
Last modified: June 8, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.