ID   P70616_RAT              Unreviewed;       583 AA.
AC   P70616;
DT   01-FEB-1997, integrated into UniProtKB/TrEMBL.
DT   01-FEB-1997, sequence version 1.
DT   27-MAR-2024, entry version 159.
DE   SubName: Full=Lost on transformation {ECO:0000313|EMBL:AAB67042.1};
DE   SubName: Full=PLAG1 like zinc finger 1 {ECO:0000313|Ensembl:ENSRNOP00000030918.2};
GN   Name=Plagl1 {ECO:0000313|Ensembl:ENSRNOP00000030918.2,
GN   ECO:0000313|RGD:3014}; Synonyms=Lot1 {ECO:0000313|EMBL:AAB67042.1};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|EMBL:AAB67042.1};
RN   [1] {ECO:0000313|EMBL:AAB67042.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Ovary {ECO:0000313|EMBL:AAB67042.1};
RX   PubMed=9158001;
RA   Abdollahi A., Godwin A.K., Miller P.D., Getts L.A., Schultz D.C.,
RA   Taguchi T., Testa J.R., Hamilton T.C.;
RT   "Identification of a gene containing zinc-finger motifs based on lost
RT   expression in malignantly transformed rat ovarian surface epithelial
RT   cells.";
RL   Cancer Res. 57:2029-2034(1997).
RN   [2] {ECO:0000313|EMBL:AAB67042.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Ovary {ECO:0000313|EMBL:AAB67042.1};
RX   PubMed=9150364; DOI=10.1038/sj.onc.1201034;
RA   Abdollahi A., Roberts D., Godwin A.K., Schultz D.C., Sonoda G., Testa J.R.,
RA   Hamilton T.C.;
RT   "Identification of a zinc-finger gene at 6q25: a chromosomal region
RT   implicated in development of many solid tumors.";
RL   Oncogene 14:1973-1979(1997).
RN   [3] {ECO:0000313|Ensembl:ENSRNOP00000030918.2, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000030918.2,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [4] {ECO:0000313|Ensembl:ENSRNOP00000030918.2}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000030918.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; U72620; AAB67042.1; -; mRNA.
DR   RefSeq; NP_036892.1; NM_012760.3.
DR   STRING; 10116.ENSRNOP00000030918; -.
DR   PaxDb; 10116-ENSRNOP00000030918; -.
DR   Ensembl; ENSRNOT00000030329.4; ENSRNOP00000030918.2; ENSRNOG00000025587.5.
DR   GeneID; 25157; -.
DR   KEGG; rno:25157; -.
DR   UCSC; RGD:3014; rat.
DR   AGR; RGD:3014; -.
DR   CTD; 5325; -.
DR   RGD; 3014; Plagl1.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000162004; -.
DR   HOGENOM; CLU_405410_0_0_1; -.
DR   OMA; HHAPREK; -.
DR   OrthoDB; 2971215at2759; -.
DR   TreeFam; TF332024; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000025587; Expressed in esophagus and 19 other cell types or tissues.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR   GO; GO:0003677; F:DNA binding; ISO:RGD.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:RGD.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; ISO:RGD.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR   GO; GO:0010468; P:regulation of gene expression; ISO:RGD.
DR   GO; GO:0035914; P:skeletal muscle cell differentiation; ISO:RGD.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 5.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR24408; ZINC FINGER PROTEIN; 1.
DR   PANTHER; PTHR24408:SF20; ZINC FINGER PROTEIN PLAGL2; 1.
DR   Pfam; PF00096; zf-C2H2; 2.
DR   SMART; SM00355; ZnF_C2H2; 7.
DR   SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 3.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6.
PE   2: Evidence at transcript level;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transcription {ECO:0000256|ARBA:ARBA00023015};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00042}.
FT   DOMAIN          4..31
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   DOMAIN          32..61
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   DOMAIN          62..89
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   DOMAIN          91..118
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   DOMAIN          156..183
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   DOMAIN          184..212
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   REGION          427..454
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          484..568
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        429..454
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        490..543
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   583 AA;  65960 MW;  8501071AADFB3F4B CRC64;
     MAPFRCQKCG KSFLTLEKFT IHNYSHTRER PFKCSKTECG KAFVSKYKLM RHMATHSPQK
     THQCTHCEKT FNRKDHLKNH LQTHDPNKMI YACEDCGKKY HTMLGYKRHM ALHSASSGDL
     TCGVCTLELG STEVLLDHLK SHAEEKAHHA PREKKHQCDH CERCFYTRKD VRRHLVVHTG
     CKDFLCQFCA QRFGRKDHLT RHTKKTHSQE LMQESLQAGE YQGGYQPIAP PFQIKADPMP
     PFQLEMPPES GLDGGLPPEI HGLVLASPEE VPQPMLSMPP MQPMPEQPFT LHPGVVPSSP
     PPIILQEHKY SPVPTSFAPF VSMPMKADLK GFCNMGLFEE FPLQECQSPV KFSQCFEMAK
     EGFGKVTLPK ELLVDAVNIA IPGSLEISSL LGFWQLPPPP PQNGFMNGTI PVGAGEPLPH
     RITCLAQQQP PPLLPPPPPL PLPEPLPQPQ LPPQFQLQLQ PQPQMQPQMQ LQPLQLQLPQ
     LLPQLQPEPE PEPEPEEEEE EEEEIEEEEE IEEEEEAEPE AEEEEEAEDE EEAEEEEEEP
     QPEEAQIAMS AVNMGQPPLP PTPHVFTAGT NTAILPHFHH AFR
//