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P70616

- P70616_RAT

UniProt

P70616 - P70616_RAT

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Protein
Submitted name: Lost on transformation
Gene
Plagl1, Lot1
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. DNA binding Source: Ensembl
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome

GO - Biological processi

  1. apoptotic process Source: InterPro
  2. cell differentiation Source: RefGenome
  3. positive regulation of transcription from RNA polymerase II promoter Source: InterPro
  4. skeletal muscle cell differentiation Source: Ensembl
  5. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Lost on transformationImported
Submitted name:
Protein Plagl1Imported
Gene namesi
Name:Plagl1Imported
Synonyms:Lot1Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi3014. Plagl1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotations

Expressioni

Gene expression databases

GenevestigatoriP70616.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030918.

Family & Domainsi

Keywords - Domaini

RepeatSAAS annotations, Zinc-fingerSAAS annotations

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00390000013640.
HOGENOMiHOG000294191.
HOVERGENiHBG053608.
InParanoidiP70616.
OMAiMLPMQPM.
OrthoDBiEOG71K62Q.
TreeFamiTF332024.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR027770. PLAGL1.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 1 hit.
PTHR10032:SF125. PTHR10032:SF125. 1 hit.
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70616-1 [UniParc]FASTAAdd to Basket

« Hide

MAPFRCQKCG KSFLTLEKFT IHNYSHTRER PFKCSKTECG KAFVSKYKLM    50
RHMATHSPQK THQCTHCEKT FNRKDHLKNH LQTHDPNKMI YACEDCGKKY 100
HTMLGYKRHM ALHSASSGDL TCGVCTLELG STEVLLDHLK SHAEEKAHHA 150
PREKKHQCDH CERCFYTRKD VRRHLVVHTG CKDFLCQFCA QRFGRKDHLT 200
RHTKKTHSQE LMQESLQAGE YQGGYQPIAP PFQIKADPMP PFQLEMPPES 250
GLDGGLPPEI HGLVLASPEE VPQPMLSMPP MQPMPEQPFT LHPGVVPSSP 300
PPIILQEHKY SPVPTSFAPF VSMPMKADLK GFCNMGLFEE FPLQECQSPV 350
KFSQCFEMAK EGFGKVTLPK ELLVDAVNIA IPGSLEISSL LGFWQLPPPP 400
PQNGFMNGTI PVGAGEPLPH RITCLAQQQP PPLLPPPPPL PLPEPLPQPQ 450
LPPQFQLQLQ PQPQMQPQMQ LQPLQLQLPQ LLPQLQPEPE PEPEPEEEEE 500
EEEEIEEEEE IEEEEEAEPE AEEEEEAEDE EEAEEEEEEP QPEEAQIAMS 550
AVNMGQPPLP PTPHVFTAGT NTAILPHFHH AFR 583
Length:583
Mass (Da):65,960
Last modified:February 1, 1997 - v1
Checksum:i8501071AADFB3F4B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06000387 Genomic DNA. No translation available.
AABR06000388 Genomic DNA. No translation available.
U72620 mRNA. Translation: AAB67042.1.
RefSeqiNP_036892.1. NM_012760.3.
UniGeneiRn.6977.

Genome annotation databases

EnsembliENSRNOT00000030329; ENSRNOP00000030918; ENSRNOG00000025587.
GeneIDi25157.
KEGGirno:25157.
UCSCiRGD:3014. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06000387 Genomic DNA. No translation available.
AABR06000388 Genomic DNA. No translation available.
U72620 mRNA. Translation: AAB67042.1 .
RefSeqi NP_036892.1. NM_012760.3.
UniGenei Rn.6977.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000030918.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000030329 ; ENSRNOP00000030918 ; ENSRNOG00000025587 .
GeneIDi 25157.
KEGGi rno:25157.
UCSCi RGD:3014. rat.

Organism-specific databases

CTDi 5325.
RGDi 3014. Plagl1.

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00390000013640.
HOGENOMi HOG000294191.
HOVERGENi HBG053608.
InParanoidi P70616.
OMAi MLPMQPM.
OrthoDBi EOG71K62Q.
TreeFami TF332024.

Miscellaneous databases

NextBioi 605619.
PROi P70616.

Gene expression databases

Genevestigatori P70616.

Family and domain databases

Gene3Di 3.30.160.60. 5 hits.
InterProi IPR027775. C2H2_Znf_fam.
IPR027770. PLAGL1.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
PANTHERi PTHR10032. PTHR10032. 1 hit.
PTHR10032:SF125. PTHR10032:SF125. 1 hit.
Pfami PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 7 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a gene containing zinc-finger motifs based on lost expression in malignantly transformed rat ovarian surface epithelial cells."
    Abdollahi A., Godwin A.K., Miller P.D., Getts L.A., Schultz D.C., Taguchi T., Testa J.R., Hamilton T.C.
    Cancer Res. 57:2029-2034(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: OvaryImported.
  2. "Identification of a zinc-finger gene at 6q25: a chromosomal region implicated in development of many solid tumors."
    Abdollahi A., Roberts D., Godwin A.K., Schultz D.C., Sonoda G., Testa J.R., Hamilton T.C.
    Oncogene 14:1973-1979(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: OvaryImported.
  3. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  4. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiP70616_RAT
AccessioniPrimary (citable) accession number: P70616
Entry historyi
Integrated into UniProtKB/TrEMBL: February 1, 1997
Last sequence update: February 1, 1997
Last modified: September 3, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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