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P70616

- P70616_RAT

UniProt

P70616 - P70616_RAT

Protein
Submitted name:

Lost on transformation

Gene

Plagl1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. DNA binding Source: Ensembl
    2. metal ion binding Source: UniProtKB-KW
    3. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome

    GO - Biological processi

    1. apoptotic process Source: InterPro
    2. cell differentiation Source: RefGenome
    3. positive regulation of transcription from RNA polymerase II promoter Source: InterPro
    4. skeletal muscle cell differentiation Source: Ensembl
    5. transcription from RNA polymerase II promoter Source: GOC

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Lost on transformationImported
    Submitted name:
    Protein Plagl1Imported
    Gene namesi
    Name:Plagl1Imported
    Synonyms:Lot1Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi3014. Plagl1.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: RefGenome

    Keywords - Cellular componenti

    NucleusSAAS annotation

    Expressioni

    Gene expression databases

    GenevestigatoriP70616.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000030918.

    Family & Domainsi

    Keywords - Domaini

    RepeatSAAS annotation, Zinc-fingerSAAS annotation

    Phylogenomic databases

    eggNOGiCOG5048.
    GeneTreeiENSGT00390000013640.
    HOGENOMiHOG000294191.
    HOVERGENiHBG053608.
    InParanoidiP70616.
    OMAiMLPMQPM.
    OrthoDBiEOG71K62Q.
    TreeFamiTF332024.

    Family and domain databases

    Gene3Di3.30.160.60. 5 hits.
    InterProiIPR027775. C2H2_Znf_fam.
    IPR027770. PLAGL1.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PANTHERiPTHR10032. PTHR10032. 1 hit.
    PTHR10032:SF125. PTHR10032:SF125. 1 hit.
    PfamiPF00096. zf-C2H2. 1 hit.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 7 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 7 hits.
    PS50157. ZINC_FINGER_C2H2_2. 6 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P70616-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPFRCQKCG KSFLTLEKFT IHNYSHTRER PFKCSKTECG KAFVSKYKLM    50
    RHMATHSPQK THQCTHCEKT FNRKDHLKNH LQTHDPNKMI YACEDCGKKY 100
    HTMLGYKRHM ALHSASSGDL TCGVCTLELG STEVLLDHLK SHAEEKAHHA 150
    PREKKHQCDH CERCFYTRKD VRRHLVVHTG CKDFLCQFCA QRFGRKDHLT 200
    RHTKKTHSQE LMQESLQAGE YQGGYQPIAP PFQIKADPMP PFQLEMPPES 250
    GLDGGLPPEI HGLVLASPEE VPQPMLSMPP MQPMPEQPFT LHPGVVPSSP 300
    PPIILQEHKY SPVPTSFAPF VSMPMKADLK GFCNMGLFEE FPLQECQSPV 350
    KFSQCFEMAK EGFGKVTLPK ELLVDAVNIA IPGSLEISSL LGFWQLPPPP 400
    PQNGFMNGTI PVGAGEPLPH RITCLAQQQP PPLLPPPPPL PLPEPLPQPQ 450
    LPPQFQLQLQ PQPQMQPQMQ LQPLQLQLPQ LLPQLQPEPE PEPEPEEEEE 500
    EEEEIEEEEE IEEEEEAEPE AEEEEEAEDE EEAEEEEEEP QPEEAQIAMS 550
    AVNMGQPPLP PTPHVFTAGT NTAILPHFHH AFR 583
    Length:583
    Mass (Da):65,960
    Last modified:February 1, 1997 - v1
    Checksum:i8501071AADFB3F4B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06000387 Genomic DNA. No translation available.
    AABR06000388 Genomic DNA. No translation available.
    U72620 mRNA. Translation: AAB67042.1.
    RefSeqiNP_036892.1. NM_012760.3.
    UniGeneiRn.6977.

    Genome annotation databases

    EnsembliENSRNOT00000030329; ENSRNOP00000030918; ENSRNOG00000025587.
    GeneIDi25157.
    KEGGirno:25157.
    UCSCiRGD:3014. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06000387 Genomic DNA. No translation available.
    AABR06000388 Genomic DNA. No translation available.
    U72620 mRNA. Translation: AAB67042.1 .
    RefSeqi NP_036892.1. NM_012760.3.
    UniGenei Rn.6977.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000030918.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000030329 ; ENSRNOP00000030918 ; ENSRNOG00000025587 .
    GeneIDi 25157.
    KEGGi rno:25157.
    UCSCi RGD:3014. rat.

    Organism-specific databases

    CTDi 5325.
    RGDi 3014. Plagl1.

    Phylogenomic databases

    eggNOGi COG5048.
    GeneTreei ENSGT00390000013640.
    HOGENOMi HOG000294191.
    HOVERGENi HBG053608.
    InParanoidi P70616.
    OMAi MLPMQPM.
    OrthoDBi EOG71K62Q.
    TreeFami TF332024.

    Miscellaneous databases

    NextBioi 605619.
    PROi P70616.

    Gene expression databases

    Genevestigatori P70616.

    Family and domain databases

    Gene3Di 3.30.160.60. 5 hits.
    InterProi IPR027775. C2H2_Znf_fam.
    IPR027770. PLAGL1.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    PANTHERi PTHR10032. PTHR10032. 1 hit.
    PTHR10032:SF125. PTHR10032:SF125. 1 hit.
    Pfami PF00096. zf-C2H2. 1 hit.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 7 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 7 hits.
    PS50157. ZINC_FINGER_C2H2_2. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a gene containing zinc-finger motifs based on lost expression in malignantly transformed rat ovarian surface epithelial cells."
      Abdollahi A., Godwin A.K., Miller P.D., Getts L.A., Schultz D.C., Taguchi T., Testa J.R., Hamilton T.C.
      Cancer Res. 57:2029-2034(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: OvaryImported.
    2. "Identification of a zinc-finger gene at 6q25: a chromosomal region implicated in development of many solid tumors."
      Abdollahi A., Roberts D., Godwin A.K., Schultz D.C., Sonoda G., Testa J.R., Hamilton T.C.
      Oncogene 14:1973-1979(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: OvaryImported.
    3. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    4. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiP70616_RAT
    AccessioniPrimary (citable) accession number: P70616
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3