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Protein
Submitted name:

Lost on transformation

Gene

Plagl1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. RNA polymerase II regulatory region sequence-specific DNA binding Source: Ensembl
  3. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
  4. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: GO_Central

GO - Biological processi

  1. cell differentiation Source: GO_Central
  2. skeletal muscle cell differentiation Source: Ensembl
  3. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Lost on transformationImported
Submitted name:
Protein Plagl1Imported
Gene namesi
Name:Plagl1Imported
Synonyms:Lot1Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi3014. Plagl1.

Subcellular locationi

GO - Cellular componenti

  1. Golgi apparatus Source: Ensembl
  2. nucleus Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiP70616.

Expressioni

Gene expression databases

GenevestigatoriP70616.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030918.

Structurei

3D structure databases

ProteinModelPortaliP70616.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

RepeatSAAS annotation, Zinc-fingerSAAS annotation

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00390000013640.
HOGENOMiHOG000294191.
HOVERGENiHBG053608.
InParanoidiP70616.
OMAiMLPMQPM.
OrthoDBiEOG71K62Q.
PhylomeDBiP70616.
TreeFamiTF332024.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR027770. PLAGL1.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 1 hit.
PTHR10032:SF125. PTHR10032:SF125. 1 hit.
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70616-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPFRCQKCG KSFLTLEKFT IHNYSHTRER PFKCSKTECG KAFVSKYKLM
60 70 80 90 100
RHMATHSPQK THQCTHCEKT FNRKDHLKNH LQTHDPNKMI YACEDCGKKY
110 120 130 140 150
HTMLGYKRHM ALHSASSGDL TCGVCTLELG STEVLLDHLK SHAEEKAHHA
160 170 180 190 200
PREKKHQCDH CERCFYTRKD VRRHLVVHTG CKDFLCQFCA QRFGRKDHLT
210 220 230 240 250
RHTKKTHSQE LMQESLQAGE YQGGYQPIAP PFQIKADPMP PFQLEMPPES
260 270 280 290 300
GLDGGLPPEI HGLVLASPEE VPQPMLSMPP MQPMPEQPFT LHPGVVPSSP
310 320 330 340 350
PPIILQEHKY SPVPTSFAPF VSMPMKADLK GFCNMGLFEE FPLQECQSPV
360 370 380 390 400
KFSQCFEMAK EGFGKVTLPK ELLVDAVNIA IPGSLEISSL LGFWQLPPPP
410 420 430 440 450
PQNGFMNGTI PVGAGEPLPH RITCLAQQQP PPLLPPPPPL PLPEPLPQPQ
460 470 480 490 500
LPPQFQLQLQ PQPQMQPQMQ LQPLQLQLPQ LLPQLQPEPE PEPEPEEEEE
510 520 530 540 550
EEEEIEEEEE IEEEEEAEPE AEEEEEAEDE EEAEEEEEEP QPEEAQIAMS
560 570 580
AVNMGQPPLP PTPHVFTAGT NTAILPHFHH AFR
Length:583
Mass (Da):65,960
Last modified:February 1, 1997 - v1
Checksum:i8501071AADFB3F4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06000387 Genomic DNA. No translation available.
AABR06000388 Genomic DNA. No translation available.
U72620 mRNA. Translation: AAB67042.1.
RefSeqiNP_036892.1. NM_012760.3.
UniGeneiRn.6977.

Genome annotation databases

EnsembliENSRNOT00000030329; ENSRNOP00000030918; ENSRNOG00000025587.
GeneIDi25157.
KEGGirno:25157.
UCSCiRGD:3014. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06000387 Genomic DNA. No translation available.
AABR06000388 Genomic DNA. No translation available.
U72620 mRNA. Translation: AAB67042.1.
RefSeqiNP_036892.1. NM_012760.3.
UniGeneiRn.6977.

3D structure databases

ProteinModelPortaliP70616.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030918.

Proteomic databases

PaxDbiP70616.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000030329; ENSRNOP00000030918; ENSRNOG00000025587.
GeneIDi25157.
KEGGirno:25157.
UCSCiRGD:3014. rat.

Organism-specific databases

CTDi5325.
RGDi3014. Plagl1.

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00390000013640.
HOGENOMiHOG000294191.
HOVERGENiHBG053608.
InParanoidiP70616.
OMAiMLPMQPM.
OrthoDBiEOG71K62Q.
PhylomeDBiP70616.
TreeFamiTF332024.

Miscellaneous databases

NextBioi605619.
PROiP70616.

Gene expression databases

GenevestigatoriP70616.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR027770. PLAGL1.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 1 hit.
PTHR10032:SF125. PTHR10032:SF125. 1 hit.
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a gene containing zinc-finger motifs based on lost expression in malignantly transformed rat ovarian surface epithelial cells."
    Abdollahi A., Godwin A.K., Miller P.D., Getts L.A., Schultz D.C., Taguchi T., Testa J.R., Hamilton T.C.
    Cancer Res. 57:2029-2034(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: OvaryImported.
  2. "Identification of a zinc-finger gene at 6q25: a chromosomal region implicated in development of many solid tumors."
    Abdollahi A., Roberts D., Godwin A.K., Schultz D.C., Sonoda G., Testa J.R., Hamilton T.C.
    Oncogene 14:1973-1979(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: OvaryImported.
  3. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  4. Ensembl
    Submitted (JAN-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiP70616_RAT
AccessioniPrimary (citable) accession number: P70616
Entry historyi
Integrated into UniProtKB/TrEMBL: February 1, 1997
Last sequence update: February 1, 1997
Last modified: April 1, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.