ID   CXCR1_RAT               Reviewed;         349 AA.
AC   P70612;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   24-JAN-2024, entry version 152.
DE   RecName: Full=C-X-C chemokine receptor type 1;
DE            Short=CXC-R1;
DE            Short=CXCR-1;
DE   AltName: Full=High affinity interleukin-8 receptor A;
DE            Short=IL-8R A;
DE   AltName: CD_antigen=CD181;
GN   Name=Cxcr1; Synonyms=Il8ra;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Wistar; TISSUE=Lung;
RX   PubMed=8955112; DOI=10.1074/jbc.271.51.32770;
RA   Dunstan C.-A.N., Salafranca M.N., Adhikari S., Xia Y., Feng L.,
RA   Harrison J.K.;
RT   "Identification of two rat genes orthologous to the human interleukin-8
RT   receptors.";
RL   J. Biol. Chem. 271:32770-32776(1996).
CC   -!- FUNCTION: Receptor to interleukin-8, which is a powerful neutrophils
CC       chemotactic factor. Binding of IL-8 to the receptor causes activation
CC       of neutrophils. This response is mediated via a G-protein that
CC       activates a phosphatidylinositol-calcium second messenger system.
CC       {ECO:0000250|UniProtKB:P25024}.
CC   -!- SUBUNIT: Interacts with IL8. Interacts with GNAI2.
CC       {ECO:0000250|UniProtKB:P25024}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; U71089; AAC52962.1; -; Genomic_DNA.
DR   RefSeq; NP_062183.1; NM_019310.1.
DR   RefSeq; XP_006245335.2; XM_006245273.3.
DR   AlphaFoldDB; P70612; -.
DR   SMR; P70612; -.
DR   STRING; 10116.ENSRNOP00000070273; -.
DR   GlyCosmos; P70612; 1 site, No reported glycans.
DR   GlyGen; P70612; 1 site.
DR   PhosphoSitePlus; P70612; -.
DR   PaxDb; 10116-ENSRNOP00000066188; -.
DR   Ensembl; ENSRNOT00000090868.2; ENSRNOP00000070273.1; ENSRNOG00000048239.3.
DR   GeneID; 54258; -.
DR   KEGG; rno:54258; -.
DR   UCSC; RGD:2905; rat.
DR   AGR; RGD:2905; -.
DR   CTD; 3577; -.
DR   RGD; 2905; Cxcr1.
DR   eggNOG; KOG3656; Eukaryota.
DR   GeneTree; ENSGT01050000244848; -.
DR   InParanoid; P70612; -.
DR   OMA; SPVCYEV; -.
DR   OrthoDB; 5347598at2759; -.
DR   PhylomeDB; P70612; -.
DR   Reactome; R-RNO-380108; Chemokine receptors bind chemokines.
DR   Reactome; R-RNO-418594; G alpha (i) signalling events.
DR   Reactome; R-RNO-6798695; Neutrophil degranulation.
DR   PRO; PR:P70612; -.
DR   Proteomes; UP000002494; Chromosome 9.
DR   Bgee; ENSRNOG00000048239; Expressed in lung.
DR   GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0019957; F:C-C chemokine binding; IBA:GO_Central.
DR   GO; GO:0016493; F:C-C chemokine receptor activity; IBA:GO_Central.
DR   GO; GO:0019959; F:interleukin-8 binding; ISO:RGD.
DR   GO; GO:0004918; F:interleukin-8 receptor activity; ISO:RGD.
DR   GO; GO:0019722; P:calcium-mediated signaling; IBA:GO_Central.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; ISO:RGD.
DR   GO; GO:0006955; P:immune response; IBA:GO_Central.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR   GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR   GO; GO:0031623; P:receptor internalization; ISO:RGD.
DR   CDD; cd15178; 7tmA_CXCR1_2; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000174; Chemokine_CXCR_1/2.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   PANTHER; PTHR10489:SF916; C-X-C CHEMOKINE RECEPTOR TYPE 1; 1.
DR   PANTHER; PTHR10489; CELL ADHESION MOLECULE; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00427; INTRLEUKIN8R.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   Genevisible; P70612; RN.
PE   3: Inferred from homology;
KW   Cell membrane; Chemotaxis; Disulfide bond; G-protein coupled receptor;
KW   Glycoprotein; Membrane; Receptor; Reference proteome; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..349
FT                   /note="C-X-C chemokine receptor type 1"
FT                   /id="PRO_0000069333"
FT   TOPO_DOM        1..44
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        45..71
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        72..80
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        102..116
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        117..138
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        139..159
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        160..179
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        180..204
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        205..225
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        226..247
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        248..269
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        270..290
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        291..313
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        314..349
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        22
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        115..192
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   349 AA;  39945 MW;  9B1CDCE61568EABA CRC64;
     MAEAEYFIWI APEGDFEEEF GNITRMLPTG EYFSPCKRVP MTNRQAVVVF YALVFLLSLL
     GNSLVMLVIL YRRRTRSVTD VYVLNLAIAD LLFSLTLPFL AVSKWKGWIF GTPLCKMVSL
     LKEVNFFSGI LLLACISVDR YLAIVHATRT LTRKRYLVKF VCMGTWGLSL VLSLPFAIFR
     QAYKPYRSGT VCYEVLGEAT ADLRITLRGL SHIFGFLLPL FIMLVCYGLT LRTLFKAHMR
     QKRRAMWVIF AVVLVFLLCC LPYNLVLLSD TLLGAHLIQD TCERRNNIDQ ALYITEILGF
     SHSCLNPVIY AFVGQSFRHE FLKILANLVH KEVLTHHSAS FRTSLTTIY
//