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P70612

- CXCR1_RAT

UniProt

P70612 - CXCR1_RAT

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Protein

C-X-C chemokine receptor type 1

Gene

Cxcr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system (By similarity).By similarity

GO - Molecular functioni

  1. interleukin-8 receptor activity Source: Ensembl

GO - Biological processi

  1. cellular defense response Source: Ensembl
  2. chemotaxis Source: UniProtKB-KW
  3. neutrophil activation Source: Ensembl
  4. phospholipase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
  5. positive regulation of cell proliferation Source: Ensembl
  6. receptor internalization Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Chemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C chemokine receptor type 1
Short name:
CXC-R1
Short name:
CXCR-1
Alternative name(s):
High affinity interleukin-8 receptor A
Short name:
IL-8R A
CD_antigen: CD181
Gene namesi
Name:Cxcr1
Synonyms:Il8ra
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 9

Organism-specific databases

RGDi2905. Cxcr1.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. mast cell granule Source: Ensembl
  4. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 349349C-X-C chemokine receptor type 1PRO_0000069333Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi22 – 221N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi115 ↔ 192PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP70612.

PTM databases

PhosphoSiteiP70612.

Expressioni

Gene expression databases

GenevestigatoriP70612.

Structurei

3D structure databases

ProteinModelPortaliP70612.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4444ExtracellularSequence AnalysisAdd
BLAST
Topological domaini72 – 809CytoplasmicSequence Analysis
Topological domaini102 – 11615ExtracellularSequence AnalysisAdd
BLAST
Topological domaini139 – 15921CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini180 – 20425ExtracellularSequence AnalysisAdd
BLAST
Topological domaini226 – 24722CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini270 – 29021ExtracellularSequence AnalysisAdd
BLAST
Topological domaini314 – 34936CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei45 – 7127Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei81 – 10121Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei117 – 13822Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei160 – 17920Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei205 – 22521Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei248 – 26922Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei291 – 31323Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000118785.
HOVERGENiHBG106917.
InParanoidiP70612.
KOiK04175.
OMAiDTCERRN.
OrthoDBiEOG7ZPNK9.
PhylomeDBiP70612.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR001355. Chemokine_CXCR1.
IPR000174. Chemokine_CXCR_1/2.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF47. PTHR24227:SF47. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00427. INTRLEUKIN8R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70612-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEAEYFIWI APEGDFEEEF GNITRMLPTG EYFSPCKRVP MTNRQAVVVF
60 70 80 90 100
YALVFLLSLL GNSLVMLVIL YRRRTRSVTD VYVLNLAIAD LLFSLTLPFL
110 120 130 140 150
AVSKWKGWIF GTPLCKMVSL LKEVNFFSGI LLLACISVDR YLAIVHATRT
160 170 180 190 200
LTRKRYLVKF VCMGTWGLSL VLSLPFAIFR QAYKPYRSGT VCYEVLGEAT
210 220 230 240 250
ADLRITLRGL SHIFGFLLPL FIMLVCYGLT LRTLFKAHMR QKRRAMWVIF
260 270 280 290 300
AVVLVFLLCC LPYNLVLLSD TLLGAHLIQD TCERRNNIDQ ALYITEILGF
310 320 330 340
SHSCLNPVIY AFVGQSFRHE FLKILANLVH KEVLTHHSAS FRTSLTTIY
Length:349
Mass (Da):39,945
Last modified:February 1, 1997 - v1
Checksum:i9B1CDCE61568EABA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U71089 Genomic DNA. Translation: AAC52962.1.
RefSeqiNP_062183.1. NM_019310.1.
XP_006245335.2. XM_006245273.2.
UniGeneiRn.138115.

Genome annotation databases

EnsembliENSRNOT00000070827; ENSRNOP00000066188; ENSRNOG00000048239.
GeneIDi54258.
KEGGirno:54258.
UCSCiRGD:2905. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U71089 Genomic DNA. Translation: AAC52962.1 .
RefSeqi NP_062183.1. NM_019310.1.
XP_006245335.2. XM_006245273.2.
UniGenei Rn.138115.

3D structure databases

ProteinModelPortali P70612.
ModBasei Search...
MobiDBi Search...

Chemistry

GuidetoPHARMACOLOGYi 68.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P70612.

Proteomic databases

PRIDEi P70612.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000070827 ; ENSRNOP00000066188 ; ENSRNOG00000048239 .
GeneIDi 54258.
KEGGi rno:54258.
UCSCi RGD:2905. rat.

Organism-specific databases

CTDi 3577.
RGDi 2905. Cxcr1.

Phylogenomic databases

GeneTreei ENSGT00760000118785.
HOVERGENi HBG106917.
InParanoidi P70612.
KOi K04175.
OMAi DTCERRN.
OrthoDBi EOG7ZPNK9.
PhylomeDBi P70612.

Miscellaneous databases

NextBioi 610774.

Gene expression databases

Genevestigatori P70612.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR001355. Chemokine_CXCR1.
IPR000174. Chemokine_CXCR_1/2.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24227. PTHR24227. 1 hit.
PTHR24227:SF47. PTHR24227:SF47. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00427. INTRLEUKIN8R.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of two rat genes orthologous to the human interleukin-8 receptors."
    Dunstan C.-A.N., Salafranca M.N., Adhikari S., Xia Y., Feng L., Harrison J.K.
    J. Biol. Chem. 271:32770-32776(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Wistar.
    Tissue: Lung.

Entry informationi

Entry nameiCXCR1_RAT
AccessioniPrimary (citable) accession number: P70612
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: October 29, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3