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P70612

- CXCR1_RAT

UniProt

P70612 - CXCR1_RAT

Protein

C-X-C chemokine receptor type 1

Gene

Cxcr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system By similarity.By similarity

    GO - Molecular functioni

    1. interleukin-8 receptor activity Source: Ensembl

    GO - Biological processi

    1. chemotaxis Source: UniProtKB-KW
    2. receptor internalization Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Chemotaxis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-X-C chemokine receptor type 1
    Short name:
    CXC-R1
    Short name:
    CXCR-1
    Alternative name(s):
    High affinity interleukin-8 receptor A
    Short name:
    IL-8R A
    CD_antigen: CD181
    Gene namesi
    Name:Cxcr1
    Synonyms:Il8ra
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 9

    Organism-specific databases

    RGDi2905. Cxcr1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 349349C-X-C chemokine receptor type 1PRO_0000069333Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi22 – 221N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi115 ↔ 192PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP70612.

    PTM databases

    PhosphoSiteiP70612.

    Expressioni

    Gene expression databases

    GenevestigatoriP70612.

    Structurei

    3D structure databases

    ProteinModelPortaliP70612.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4444ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini72 – 809CytoplasmicSequence Analysis
    Topological domaini102 – 11615ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini139 – 15921CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini180 – 20425ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini226 – 24722CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini270 – 29021ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini314 – 34936CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei45 – 7127Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei81 – 10121Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei117 – 13822Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei160 – 17920Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei205 – 22521Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei248 – 26922Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei291 – 31323Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    GeneTreeiENSGT00730000110292.
    HOVERGENiHBG106917.
    KOiK04175.
    OMAiDTCERRN.
    OrthoDBiEOG7ZPNK9.
    PhylomeDBiP70612.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR001355. Chemokine_CXCR1.
    IPR000174. Chemokine_CXCR_1/2.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24227. PTHR24227. 1 hit.
    PTHR24227:SF47. PTHR24227:SF47. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00427. INTRLEUKIN8R.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P70612-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEAEYFIWI APEGDFEEEF GNITRMLPTG EYFSPCKRVP MTNRQAVVVF    50
    YALVFLLSLL GNSLVMLVIL YRRRTRSVTD VYVLNLAIAD LLFSLTLPFL 100
    AVSKWKGWIF GTPLCKMVSL LKEVNFFSGI LLLACISVDR YLAIVHATRT 150
    LTRKRYLVKF VCMGTWGLSL VLSLPFAIFR QAYKPYRSGT VCYEVLGEAT 200
    ADLRITLRGL SHIFGFLLPL FIMLVCYGLT LRTLFKAHMR QKRRAMWVIF 250
    AVVLVFLLCC LPYNLVLLSD TLLGAHLIQD TCERRNNIDQ ALYITEILGF 300
    SHSCLNPVIY AFVGQSFRHE FLKILANLVH KEVLTHHSAS FRTSLTTIY 349
    Length:349
    Mass (Da):39,945
    Last modified:February 1, 1997 - v1
    Checksum:i9B1CDCE61568EABA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U71089 Genomic DNA. Translation: AAC52962.1.
    RefSeqiNP_062183.1. NM_019310.1.
    UniGeneiRn.138115.

    Genome annotation databases

    EnsembliENSRNOT00000070827; ENSRNOP00000066188; ENSRNOG00000048239.
    GeneIDi54258.
    KEGGirno:54258.
    UCSCiRGD:2905. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U71089 Genomic DNA. Translation: AAC52962.1 .
    RefSeqi NP_062183.1. NM_019310.1.
    UniGenei Rn.138115.

    3D structure databases

    ProteinModelPortali P70612.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    GuidetoPHARMACOLOGYi 68.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P70612.

    Proteomic databases

    PRIDEi P70612.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000070827 ; ENSRNOP00000066188 ; ENSRNOG00000048239 .
    GeneIDi 54258.
    KEGGi rno:54258.
    UCSCi RGD:2905. rat.

    Organism-specific databases

    CTDi 3577.
    RGDi 2905. Cxcr1.

    Phylogenomic databases

    GeneTreei ENSGT00730000110292.
    HOVERGENi HBG106917.
    KOi K04175.
    OMAi DTCERRN.
    OrthoDBi EOG7ZPNK9.
    PhylomeDBi P70612.

    Miscellaneous databases

    NextBioi 610774.

    Gene expression databases

    Genevestigatori P70612.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR001355. Chemokine_CXCR1.
    IPR000174. Chemokine_CXCR_1/2.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24227. PTHR24227. 1 hit.
    PTHR24227:SF47. PTHR24227:SF47. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00427. INTRLEUKIN8R.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of two rat genes orthologous to the human interleukin-8 receptors."
      Dunstan C.-A.N., Salafranca M.N., Adhikari S., Xia Y., Feng L., Harrison J.K.
      J. Biol. Chem. 271:32770-32776(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Wistar.
      Tissue: Lung.

    Entry informationi

    Entry nameiCXCR1_RAT
    AccessioniPrimary (citable) accession number: P70612
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3