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P70612 (CXCR1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-X-C chemokine receptor type 1

Short name=CXC-R1
Short name=CXCR-1
Alternative name(s):
High affinity interleukin-8 receptor A
Short name=IL-8R A
CD_antigen=CD181
Gene names
Name:Cxcr1
Synonyms:Il8ra
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length349 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 349349C-X-C chemokine receptor type 1
PRO_0000069333

Regions

Topological domain1 – 4444Extracellular Potential
Transmembrane45 – 7127Helical; Name=1; Potential
Topological domain72 – 809Cytoplasmic Potential
Transmembrane81 – 10121Helical; Name=2; Potential
Topological domain102 – 11615Extracellular Potential
Transmembrane117 – 13822Helical; Name=3; Potential
Topological domain139 – 15921Cytoplasmic Potential
Transmembrane160 – 17920Helical; Name=4; Potential
Topological domain180 – 20425Extracellular Potential
Transmembrane205 – 22521Helical; Name=5; Potential
Topological domain226 – 24722Cytoplasmic Potential
Transmembrane248 – 26922Helical; Name=6; Potential
Topological domain270 – 29021Extracellular Potential
Transmembrane291 – 31323Helical; Name=7; Potential
Topological domain314 – 34936Cytoplasmic Potential

Amino acid modifications

Glycosylation221N-linked (GlcNAc...) Potential
Disulfide bond115 ↔ 192 By similarity

Sequences

Sequence LengthMass (Da)Tools
P70612 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 9B1CDCE61568EABA

FASTA34939,945
        10         20         30         40         50         60 
MAEAEYFIWI APEGDFEEEF GNITRMLPTG EYFSPCKRVP MTNRQAVVVF YALVFLLSLL 

        70         80         90        100        110        120 
GNSLVMLVIL YRRRTRSVTD VYVLNLAIAD LLFSLTLPFL AVSKWKGWIF GTPLCKMVSL 

       130        140        150        160        170        180 
LKEVNFFSGI LLLACISVDR YLAIVHATRT LTRKRYLVKF VCMGTWGLSL VLSLPFAIFR 

       190        200        210        220        230        240 
QAYKPYRSGT VCYEVLGEAT ADLRITLRGL SHIFGFLLPL FIMLVCYGLT LRTLFKAHMR 

       250        260        270        280        290        300 
QKRRAMWVIF AVVLVFLLCC LPYNLVLLSD TLLGAHLIQD TCERRNNIDQ ALYITEILGF 

       310        320        330        340 
SHSCLNPVIY AFVGQSFRHE FLKILANLVH KEVLTHHSAS FRTSLTTIY 

« Hide

References

[1]"Identification of two rat genes orthologous to the human interleukin-8 receptors."
Dunstan C.-A.N., Salafranca M.N., Adhikari S., Xia Y., Feng L., Harrison J.K.
J. Biol. Chem. 271:32770-32776(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Wistar.
Tissue: Lung.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U71089 Genomic DNA. Translation: AAC52962.1.
RefSeqNP_062183.1. NM_019310.1.
UniGeneRn.138115.

3D structure databases

ProteinModelPortalP70612.
ModBaseSearch...
MobiDBSearch...

Chemistry

GuidetoPHARMACOLOGY68.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP70612.

Proteomic databases

PRIDEP70612.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000070827; ENSRNOP00000066188; ENSRNOG00000048239.
GeneID54258.
KEGGrno:54258.
UCSCRGD:2905. rat.

Organism-specific databases

CTD3577.
RGD2905. Cxcr1.

Phylogenomic databases

GeneTreeENSGT00730000110292.
HOVERGENHBG106917.
KOK04175.
OMADTCERRN.
OrthoDBEOG7ZPNK9.
PhylomeDBP70612.

Gene expression databases

GenevestigatorP70612.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR001355. Chemokine_CXCR1.
IPR000174. Chemokine_CXCR_1/2.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF47. PTHR24227:SF47. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00427. INTRLEUKIN8R.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio610774.

Entry information

Entry nameCXCR1_RAT
AccessionPrimary (citable) accession number: P70612
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: April 16, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries