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P70612

- CXCR1_RAT

UniProt

P70612 - CXCR1_RAT

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Protein
C-X-C chemokine receptor type 1
Gene
Cxcr1, Il8ra
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system By similarity.

GO - Molecular functioni

  1. interleukin-8 receptor activity Source: Ensembl

GO - Biological processi

  1. chemotaxis Source: UniProtKB-KW
  2. receptor internalization Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Chemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C chemokine receptor type 1
Short name:
CXC-R1
Short name:
CXCR-1
Alternative name(s):
High affinity interleukin-8 receptor A
Short name:
IL-8R A
CD_antigen: CD181
Gene namesi
Name:Cxcr1
Synonyms:Il8ra
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 9

Organism-specific databases

RGDi2905. Cxcr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4444Extracellular Reviewed prediction
Add
BLAST
Transmembranei45 – 7127Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini72 – 809Cytoplasmic Reviewed prediction
Transmembranei81 – 10121Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini102 – 11615Extracellular Reviewed prediction
Add
BLAST
Transmembranei117 – 13822Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini139 – 15921Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei160 – 17920Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini180 – 20425Extracellular Reviewed prediction
Add
BLAST
Transmembranei205 – 22521Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini226 – 24722Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei248 – 26922Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini270 – 29021Extracellular Reviewed prediction
Add
BLAST
Transmembranei291 – 31323Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini314 – 34936Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 349349C-X-C chemokine receptor type 1
PRO_0000069333Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi22 – 221N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi115 ↔ 192 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP70612.

PTM databases

PhosphoSiteiP70612.

Expressioni

Gene expression databases

GenevestigatoriP70612.

Structurei

3D structure databases

ProteinModelPortaliP70612.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00730000110292.
HOVERGENiHBG106917.
KOiK04175.
OMAiDTCERRN.
OrthoDBiEOG7ZPNK9.
PhylomeDBiP70612.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR001355. Chemokine_CXCR1.
IPR000174. Chemokine_CXCR_1/2.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF47. PTHR24227:SF47. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00427. INTRLEUKIN8R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70612-1 [UniParc]FASTAAdd to Basket

« Hide

MAEAEYFIWI APEGDFEEEF GNITRMLPTG EYFSPCKRVP MTNRQAVVVF    50
YALVFLLSLL GNSLVMLVIL YRRRTRSVTD VYVLNLAIAD LLFSLTLPFL 100
AVSKWKGWIF GTPLCKMVSL LKEVNFFSGI LLLACISVDR YLAIVHATRT 150
LTRKRYLVKF VCMGTWGLSL VLSLPFAIFR QAYKPYRSGT VCYEVLGEAT 200
ADLRITLRGL SHIFGFLLPL FIMLVCYGLT LRTLFKAHMR QKRRAMWVIF 250
AVVLVFLLCC LPYNLVLLSD TLLGAHLIQD TCERRNNIDQ ALYITEILGF 300
SHSCLNPVIY AFVGQSFRHE FLKILANLVH KEVLTHHSAS FRTSLTTIY 349
Length:349
Mass (Da):39,945
Last modified:February 1, 1997 - v1
Checksum:i9B1CDCE61568EABA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U71089 Genomic DNA. Translation: AAC52962.1.
RefSeqiNP_062183.1. NM_019310.1.
UniGeneiRn.138115.

Genome annotation databases

EnsembliENSRNOT00000070827; ENSRNOP00000066188; ENSRNOG00000048239.
GeneIDi54258.
KEGGirno:54258.
UCSCiRGD:2905. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U71089 Genomic DNA. Translation: AAC52962.1 .
RefSeqi NP_062183.1. NM_019310.1.
UniGenei Rn.138115.

3D structure databases

ProteinModelPortali P70612.
ModBasei Search...
MobiDBi Search...

Chemistry

GuidetoPHARMACOLOGYi 68.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P70612.

Proteomic databases

PRIDEi P70612.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000070827 ; ENSRNOP00000066188 ; ENSRNOG00000048239 .
GeneIDi 54258.
KEGGi rno:54258.
UCSCi RGD:2905. rat.

Organism-specific databases

CTDi 3577.
RGDi 2905. Cxcr1.

Phylogenomic databases

GeneTreei ENSGT00730000110292.
HOVERGENi HBG106917.
KOi K04175.
OMAi DTCERRN.
OrthoDBi EOG7ZPNK9.
PhylomeDBi P70612.

Miscellaneous databases

NextBioi 610774.

Gene expression databases

Genevestigatori P70612.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR001355. Chemokine_CXCR1.
IPR000174. Chemokine_CXCR_1/2.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24227. PTHR24227. 1 hit.
PTHR24227:SF47. PTHR24227:SF47. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00427. INTRLEUKIN8R.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of two rat genes orthologous to the human interleukin-8 receptors."
    Dunstan C.-A.N., Salafranca M.N., Adhikari S., Xia Y., Feng L., Harrison J.K.
    J. Biol. Chem. 271:32770-32776(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Wistar.
    Tissue: Lung.

Entry informationi

Entry nameiCXCR1_RAT
AccessioniPrimary (citable) accession number: P70612
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: April 16, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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