P70612 (CXCR1_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
C-X-C chemokine receptor type 1
Short name=CXC-R1
Short name=CXCR-1

Alternative name(s):
High affinity interleukin-8 receptor A
Short name=IL-8R A
CD_antigen=CD181

Gene names

Name:	Cxcr1
Synonyms:	Il8ra

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	349 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Chemotaxis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chemotaxis Inferred from electronic annotation. Source: UniProtKB-KW elevation of cytosolic calcium ion concentration Inferred from electronic annotation. Source: InterPro negative regulation of cAMP biosynthetic process Inferred from electronic annotation. Source: InterPro receptor internalization Inferred from electronic annotation. Source: Compara
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	interleukin-8 receptor activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 349	349	C-X-C chemokine receptor type 1		PRO_0000069333
Regions
	Topological domain	1 – 44	44	Extracellular Potential
	Transmembrane	45 – 71	27	Helical; Name=1; Potential
	Topological domain	72 – 80	9	Cytoplasmic Potential
	Transmembrane	81 – 101	21	Helical; Name=2; Potential
	Topological domain	102 – 116	15	Extracellular Potential
	Transmembrane	117 – 138	22	Helical; Name=3; Potential
	Topological domain	139 – 159	21	Cytoplasmic Potential
	Transmembrane	160 – 179	20	Helical; Name=4; Potential
	Topological domain	180 – 204	25	Extracellular Potential
	Transmembrane	205 – 225	21	Helical; Name=5; Potential
	Topological domain	226 – 247	22	Cytoplasmic Potential
	Transmembrane	248 – 269	22	Helical; Name=6; Potential
	Topological domain	270 – 290	21	Extracellular Potential
	Transmembrane	291 – 313	23	Helical; Name=7; Potential
	Topological domain	314 – 349	36	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	22	1	N-linked (GlcNAc...) Potential
	Disulfide bond	115 ↔ 192		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P70612 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 9B1CDCE61568EABA	FASTA	349	39,945
	10 20 30 40 50 60 MAEAEYFIWI APEGDFEEEF GNITRMLPTG EYFSPCKRVP MTNRQAVVVF YALVFLLSLL 70 80 90 100 110 120 GNSLVMLVIL YRRRTRSVTD VYVLNLAIAD LLFSLTLPFL AVSKWKGWIF GTPLCKMVSL 130 140 150 160 170 180 LKEVNFFSGI LLLACISVDR YLAIVHATRT LTRKRYLVKF VCMGTWGLSL VLSLPFAIFR 190 200 210 220 230 240 QAYKPYRSGT VCYEVLGEAT ADLRITLRGL SHIFGFLLPL FIMLVCYGLT LRTLFKAHMR 250 260 270 280 290 300 QKRRAMWVIF AVVLVFLLCC LPYNLVLLSD TLLGAHLIQD TCERRNNIDQ ALYITEILGF 310 320 330 340 SHSCLNPVIY AFVGQSFRHE FLKILANLVH KEVLTHHSAS FRTSLTTIY

References

[1]	"Identification of two rat genes orthologous to the human interleukin-8 receptors." Dunstan C.-A.N., Salafranca M.N., Adhikari S., Xia Y., Feng L., Harrison J.K. J. Biol. Chem. 271:32770-32776(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Wistar. Tissue: Lung.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U71089 Genomic DNA. Translation: AAC52962.1.
IPI	IPI00190524.
RefSeq	NP_062183.1. NM_019310.1.
UniGene	Rn.138115.
3D structure databases
ProteinModelPortal	P70612.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P70612.
Proteomic databases
PRIDE	P70612.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000070827; ENSRNOP00000066188; ENSRNOG00000048239.
GeneID	54258.
KEGG	rno:54258.
UCSC	RGD:2905. rat.
Organism-specific databases
CTD	3577.
RGD	2905. Cxcr1.
Phylogenomic databases
GeneTree	ENSGT00640000091250.
HOVERGEN	HBG106917.
KO	K04175.
Gene expression databases
Genevestigator	P70612.
Family and domain databases
InterPro	IPR000174. Chemokine_CXCR. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00427. INTRLEUKIN8R.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	610774.

Entry information

Entry name

CXCR1_RAT

Accession

Primary (citable) accession number: P70612

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	May 1, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program