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Protein

Small conductance calcium-activated potassium channel protein 1

Gene

Kcnn1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity).By similarity

GO - Molecular functioni

  • calmodulin binding Source: GO_Central
  • protein heterodimerization activity Source: RGD
  • small conductance calcium-activated potassium channel activity Source: RGD

Keywordsi

Molecular functionCalmodulin-binding, Ion channel
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-1296052 Ca2+ activated K+ channels

Names & Taxonomyi

Protein namesi
Recommended name:
Small conductance calcium-activated potassium channel protein 1
Short name:
SK1
Short name:
SKCa 1
Short name:
SKCa1
Alternative name(s):
KCa2.1
Gene namesi
Name:Kcnn1
Synonyms:Sk1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi2962 Kcnn1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei107 – 127Helical; Name=Segment S1Sequence analysisAdd BLAST21
Transmembranei136 – 156Helical; Name=Segment S2Sequence analysisAdd BLAST21
Transmembranei224 – 244Helical; Name=Segment S3Sequence analysisAdd BLAST21
Transmembranei273 – 293Helical; Name=Segment S4Sequence analysisAdd BLAST21
Transmembranei313 – 333Helical; Name=Segment S5Sequence analysisAdd BLAST21
Intramembranei342 – 362Pore-forming; Name=Segment H5Sequence analysisAdd BLAST21
Transmembranei487 – 507Helical; Name=Segment S6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3743

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001550091 – 536Small conductance calcium-activated potassium channel protein 1Add BLAST536

Proteomic databases

PaxDbiP70606
PRIDEiP70606

PTM databases

iPTMnetiP70606
PhosphoSitePlusiP70606

Expressioni

Tissue specificityi

Widely expressed including brain.

Gene expression databases

BgeeiENSRNOG00000029264
ExpressionAtlasiP70606 baseline and differential
GenevisibleiP70606 RN

Interactioni

Subunit structurei

Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding (By similarity).By similarity

GO - Molecular functioni

  • calmodulin binding Source: GO_Central
  • protein heterodimerization activity Source: RGD

Protein-protein interaction databases

IntActiP70606, 1 interactor
MINTiP70606
STRINGi10116.ENSRNOP00000042517

Chemistry databases

BindingDBiP70606

Structurei

3D structure databases

ProteinModelPortaliP70606
SMRiP70606
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni380 – 459Calmodulin-bindingBy similarityAdd BLAST80

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi66 – 74Poly-Glu9

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3684 Eukaryota
ENOG410XT9D LUCA
GeneTreeiENSGT00500000044784
HOVERGENiHBG052241
InParanoidiP70606
KOiK04942
OMAiAMTWQRM
OrthoDBiEOG091G03YH
PhylomeDBiP70606

Family and domain databases

InterProiView protein in InterPro
IPR004178 CaM-bd_dom
IPR036122 CaM-bd_dom_sf
IPR015449 K_chnl_Ca-activ_SK
IPR013099 K_chnl_dom
PANTHERiPTHR10153 PTHR10153, 1 hit
PfamiView protein in Pfam
PF02888 CaMBD, 1 hit
PF07885 Ion_trans_2, 1 hit
PF03530 SK_channel, 1 hit
PRINTSiPR01451 SKCHANNEL
SMARTiView protein in SMART
SM01053 CaMBD, 1 hit
SUPFAMiSSF81327 SSF81327, 1 hit

Sequencei

Sequence statusi: Complete.

P70606-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSRSHNGSV GRPLGSGPGF LGWEPVDPEA GRPRQPTQGP GLQMMAKGQP
60 70 80 90 100
AGLSPSGPRG HSQAQEEEEE EEDEDRPGSG KPPTVSHRLG HRRALFEKRK
110 120 130 140 150
RLSDYALIFG MFGIVVMVTE TELSWGVYTK ESLCSFALKC LISLSTVILL
160 170 180 190 200
GLVILYHARE IQLFLVDNGA DDWRIAMTWE RVSLISLELA VCAIHPVPGH
210 220 230 240 250
YRFTWTARLA FSLVPSAAEA DVDVLLSIPM FLRLYLLARV MLLHSRIFTD
260 270 280 290 300
ASSRSIGALN RVTFNTRFVT KTLMTICPGT VLLVFSISSW IVAAWTVRVC
310 320 330 340 350
ERYHDKQEVT SNFLGAMWLI SITFLSIGYG DMVPHTYCGK GVCLLTGIMG
360 370 380 390 400
AGCTALVVAV VARKLELTKA EKHVHNFMMD TQLTKRVKNA AANVLRETWL
410 420 430 440 450
IYKHTRLVKK PDQSRVRKHQ RKFLQAIHQA QKLRTVKIEQ GKVNDQANTL
460 470 480 490 500
ADLAKAQSIA YEVVSELQAQ QEELEARLAA LESRLDVLGA SLQALPSLIA
510 520 530
QAICPLPPPW PGPSHLTTAA QSPQSHWLPT TASDCG
Length:536
Mass (Da):59,215
Last modified:November 1, 1998 - v2
Checksum:i97FF82071B0BE36A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000973 mRNA Translation: AAB82740.1
U69885 mRNA Translation: AAB09564.1
RefSeqiNP_062186.1, NM_019313.1
XP_017455721.1, XM_017600232.1
UniGeneiRn.44422

Genome annotation databases

EnsembliENSRNOT00000044291; ENSRNOP00000042517; ENSRNOG00000029264
GeneIDi54261
KEGGirno:54261

Similar proteinsi

Entry informationi

Entry nameiKCNN1_RAT
AccessioniPrimary (citable) accession number: P70606
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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