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Protein

Small conductance calcium-activated potassium channel protein 1

Gene

Kcnn1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity).By similarity

GO - Molecular functioni

  • calmodulin binding Source: GO_Central
  • protein heterodimerization activity Source: RGD
  • small conductance calcium-activated potassium channel activity Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Calmodulin-binding

Enzyme and pathway databases

ReactomeiR-RNO-1296052. Ca2+ activated K+ channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Small conductance calcium-activated potassium channel protein 1
Short name:
SK1
Short name:
SKCa 1
Short name:
SKCa1
Alternative name(s):
KCa2.1
Gene namesi
Name:Kcnn1
Synonyms:Sk1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi2962. Kcnn1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei107 – 12721Helical; Name=Segment S1Sequence analysisAdd
BLAST
Transmembranei136 – 15621Helical; Name=Segment S2Sequence analysisAdd
BLAST
Transmembranei224 – 24421Helical; Name=Segment S3Sequence analysisAdd
BLAST
Transmembranei273 – 29321Helical; Name=Segment S4Sequence analysisAdd
BLAST
Transmembranei313 – 33321Helical; Name=Segment S5Sequence analysisAdd
BLAST
Intramembranei342 – 36221Pore-forming; Name=Segment H5Sequence analysisAdd
BLAST
Transmembranei487 – 50721Helical; Name=Segment S6Sequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • neuronal cell body Source: RGD
  • plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2096673.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 536536Small conductance calcium-activated potassium channel protein 1PRO_0000155009Add
BLAST

Proteomic databases

PaxDbiP70606.
PRIDEiP70606.

PTM databases

iPTMnetiP70606.
PhosphoSiteiP70606.

Expressioni

Tissue specificityi

Widely expressed including brain.

Gene expression databases

BgeeiENSRNOG00000029264.
ExpressionAtlasiP70606. baseline.
GenevisibleiP70606. RN.

Interactioni

Subunit structurei

Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding (By similarity).By similarity

GO - Molecular functioni

  • calmodulin binding Source: GO_Central
  • protein heterodimerization activity Source: RGD

Protein-protein interaction databases

IntActiP70606. 1 interaction.
MINTiMINT-7138580.
STRINGi10116.ENSRNOP00000042517.

Chemistry

BindingDBiP70606.

Structurei

3D structure databases

ProteinModelPortaliP70606.
SMRiP70606. Positions 363-457.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni380 – 45980Calmodulin-bindingBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi66 – 749Poly-Glu

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3684. Eukaryota.
ENOG410XT9D. LUCA.
GeneTreeiENSGT00500000044784.
HOVERGENiHBG052241.
InParanoidiP70606.
KOiK04942.
OMAiIAMNTCK.
OrthoDBiEOG091G03YH.
PhylomeDBiP70606.

Family and domain databases

InterProiIPR004178. CaM-bd_dom.
IPR015449. K_chnl_Ca-activ_SK.
IPR013099. K_chnl_dom.
[Graphical view]
PANTHERiPTHR10153. PTHR10153. 1 hit.
PfamiPF02888. CaMBD. 1 hit.
PF07885. Ion_trans_2. 1 hit.
PF03530. SK_channel. 1 hit.
[Graphical view]
PRINTSiPR01451. SKCHANNEL.
SMARTiSM01053. CaMBD. 1 hit.
[Graphical view]
SUPFAMiSSF81327. SSF81327. 1 hit.

Sequencei

Sequence statusi: Complete.

P70606-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSRSHNGSV GRPLGSGPGF LGWEPVDPEA GRPRQPTQGP GLQMMAKGQP
60 70 80 90 100
AGLSPSGPRG HSQAQEEEEE EEDEDRPGSG KPPTVSHRLG HRRALFEKRK
110 120 130 140 150
RLSDYALIFG MFGIVVMVTE TELSWGVYTK ESLCSFALKC LISLSTVILL
160 170 180 190 200
GLVILYHARE IQLFLVDNGA DDWRIAMTWE RVSLISLELA VCAIHPVPGH
210 220 230 240 250
YRFTWTARLA FSLVPSAAEA DVDVLLSIPM FLRLYLLARV MLLHSRIFTD
260 270 280 290 300
ASSRSIGALN RVTFNTRFVT KTLMTICPGT VLLVFSISSW IVAAWTVRVC
310 320 330 340 350
ERYHDKQEVT SNFLGAMWLI SITFLSIGYG DMVPHTYCGK GVCLLTGIMG
360 370 380 390 400
AGCTALVVAV VARKLELTKA EKHVHNFMMD TQLTKRVKNA AANVLRETWL
410 420 430 440 450
IYKHTRLVKK PDQSRVRKHQ RKFLQAIHQA QKLRTVKIEQ GKVNDQANTL
460 470 480 490 500
ADLAKAQSIA YEVVSELQAQ QEELEARLAA LESRLDVLGA SLQALPSLIA
510 520 530
QAICPLPPPW PGPSHLTTAA QSPQSHWLPT TASDCG
Length:536
Mass (Da):59,215
Last modified:November 1, 1998 - v2
Checksum:i97FF82071B0BE36A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000973 mRNA. Translation: AAB82740.1.
U69885 mRNA. Translation: AAB09564.1.
RefSeqiNP_062186.1. NM_019313.1.
UniGeneiRn.44422.

Genome annotation databases

EnsembliENSRNOT00000044291; ENSRNOP00000042517; ENSRNOG00000029264.
GeneIDi54261.
KEGGirno:54261.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000973 mRNA. Translation: AAB82740.1.
U69885 mRNA. Translation: AAB09564.1.
RefSeqiNP_062186.1. NM_019313.1.
UniGeneiRn.44422.

3D structure databases

ProteinModelPortaliP70606.
SMRiP70606. Positions 363-457.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP70606. 1 interaction.
MINTiMINT-7138580.
STRINGi10116.ENSRNOP00000042517.

Chemistry

BindingDBiP70606.
ChEMBLiCHEMBL2096673.

PTM databases

iPTMnetiP70606.
PhosphoSiteiP70606.

Proteomic databases

PaxDbiP70606.
PRIDEiP70606.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000044291; ENSRNOP00000042517; ENSRNOG00000029264.
GeneIDi54261.
KEGGirno:54261.

Organism-specific databases

CTDi3780.
RGDi2962. Kcnn1.

Phylogenomic databases

eggNOGiKOG3684. Eukaryota.
ENOG410XT9D. LUCA.
GeneTreeiENSGT00500000044784.
HOVERGENiHBG052241.
InParanoidiP70606.
KOiK04942.
OMAiIAMNTCK.
OrthoDBiEOG091G03YH.
PhylomeDBiP70606.

Enzyme and pathway databases

ReactomeiR-RNO-1296052. Ca2+ activated K+ channels.

Miscellaneous databases

PROiP70606.

Gene expression databases

BgeeiENSRNOG00000029264.
ExpressionAtlasiP70606. baseline.
GenevisibleiP70606. RN.

Family and domain databases

InterProiIPR004178. CaM-bd_dom.
IPR015449. K_chnl_Ca-activ_SK.
IPR013099. K_chnl_dom.
[Graphical view]
PANTHERiPTHR10153. PTHR10153. 1 hit.
PfamiPF02888. CaMBD. 1 hit.
PF07885. Ion_trans_2. 1 hit.
PF03530. SK_channel. 1 hit.
[Graphical view]
PRINTSiPR01451. SKCHANNEL.
SMARTiSM01053. CaMBD. 1 hit.
[Graphical view]
SUPFAMiSSF81327. SSF81327. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKCNN1_RAT
AccessioniPrimary (citable) accession number: P70606
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.