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Protein

Small conductance calcium-activated potassium channel protein 2

Gene

Kcnn2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalmodulin-binding, Ion channel
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-1296052 Ca2+ activated K+ channels

Names & Taxonomyi

Protein namesi
Recommended name:
Small conductance calcium-activated potassium channel protein 2
Short name:
SK2
Short name:
SKCa 2
Short name:
SKCa2
Alternative name(s):
KCa2.2
Gene namesi
Name:Kcnn2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 18

Organism-specific databases

RGDi2963 Kcnn2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei140 – 160Helical; Name=Segment S1Sequence analysisAdd BLAST21
Transmembranei169 – 189Helical; Name=Segment S2Sequence analysisAdd BLAST21
Transmembranei215 – 235Helical; Name=Segment S3Sequence analysisAdd BLAST21
Transmembranei257 – 277Helical; Name=Segment S4Sequence analysisAdd BLAST21
Transmembranei306 – 326Helical; Name=Segment S5Sequence analysisAdd BLAST21
Intramembranei346 – 366Pore-forming; Name=Segment H5Sequence analysisAdd BLAST21
Transmembranei375 – 395Helical; Name=Segment S6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2547
GuidetoPHARMACOLOGYi382

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001550121 – 580Small conductance calcium-activated potassium channel protein 2Add BLAST580

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei161PhosphotyrosineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP70604
PRIDEiP70604

PTM databases

iPTMnetiP70604
PhosphoSitePlusiP70604

Expressioni

Tissue specificityi

Brain.

Gene expression databases

BgeeiENSRNOG00000016675
ExpressionAtlasiP70604 baseline and differential
GenevisibleiP70604 RN

Interactioni

Subunit structurei

Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Calm3P621616EBI-1031103,EBI-397530

GO - Molecular functioni

  • alpha-actinin binding Source: RGD
  • calmodulin binding Source: RGD
  • protein domain specific binding Source: RGD
  • protein homodimerization activity Source: RGD

Protein-protein interaction databases

DIPiDIP-35337N
IntActiP70604, 1 interactor
MINTiP70604
STRINGi10116.ENSRNOP00000060708

Chemistry databases

BindingDBiP70604

Structurei

Secondary structure

1580
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi398 – 401Combined sources4
Helixi414 – 439Combined sources26
Helixi446 – 485Combined sources40
Helixi489 – 523Combined sources35

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G4YX-ray1.60B396-487[»]
1KKDNMR-A396-487[»]
1QX7X-ray3.09D411-487[»]
2PNVX-ray2.10A/B488-526[»]
3SJQX-ray1.90C/D412-487[»]
4G27X-ray1.65B396-487[»]
4G28X-ray1.63B396-487[»]
4J9YX-ray1.51B396-487[»]
4J9ZX-ray1.66B396-487[»]
4QNHX-ray2.02B396-487[»]
ProteinModelPortaliP70604
SMRiP70604
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP70604

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni413 – 489Calmodulin-bindingAdd BLAST77

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi42 – 46Poly-Gly5
Compositional biasi52 – 56Poly-Ala5
Compositional biasi80 – 85Poly-Gly6
Compositional biasi88 – 103Poly-GlyAdd BLAST16
Compositional biasi564 – 567Poly-Arg4

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3684 Eukaryota
ENOG410XT9D LUCA
GeneTreeiENSGT00500000044784
HOGENOMiHOG000276908
HOVERGENiHBG052241
InParanoidiP70604
KOiK04943
PhylomeDBiP70604
TreeFamiTF315015

Family and domain databases

InterProiView protein in InterPro
IPR004178 CaM-bd_dom
IPR036122 CaM-bd_dom_sf
IPR015449 K_chnl_Ca-activ_SK
IPR013099 K_chnl_dom
PANTHERiPTHR10153 PTHR10153, 1 hit
PfamiView protein in Pfam
PF02888 CaMBD, 1 hit
PF07885 Ion_trans_2, 1 hit
PF03530 SK_channel, 1 hit
PRINTSiPR01451 SKCHANNEL
SMARTiView protein in SMART
SM01053 CaMBD, 1 hit
SUPFAMiSSF81327 SSF81327, 1 hit

Sequencei

Sequence statusi: Complete.

P70604-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSCRYNGGV MRPLSNLSSS RRNLHEMDSE AQPLQPPASV VGGGGGASSP
60 70 80 90 100
SAAAAASSSA PEIVVSKPEH NNSNNLALYG TGGGGSTGGG GGGGGGGGGS
110 120 130 140 150
GHGSSSGTKS SKKKNQNIGY KLGHRRALFE KRKRLSDYAL IFGMFGIVVM
160 170 180 190 200
VIETELSWGA YDKASLYSLA LKCLISLSTI ILLGLIIVYH AREIQLFMVD
210 220 230 240 250
NGADDWRIAM TYERIFFICL EILVCAIHPI PGNYTFTWTA RLAFSYAPST
260 270 280 290 300
TTADVDIILS IPMFLRLYLI ARVMLLHSKL FTDASSRSIG ALNKINFNTR
310 320 330 340 350
FVMKTLMTIC PGTVLLVFSI SLWIIAAWTV RACERYHDQQ DVTSNFLGAM
360 370 380 390 400
WLISITFLSI GYGDMVPNTY CGKGVCLLTG IMGAGCTALV VAVVARKLEL
410 420 430 440 450
TKAEKHVHNF MMDTQLTKRV KNAAANVLRE TWLIYKNTKL VKKIDHAKVR
460 470 480 490 500
KHQRKFLQAI HQLRSVKMEQ RKLNDQANTL VDLAKTQNIM YDMISDLNER
510 520 530 540 550
SEDFEKRIVT LETKLETLIG SIHALPGLIS QTIRQQQRDF IETQMENYDK
560 570 580
HVTYNAERSR SSSRRRRSSS TAPPTSSESS
Length:580
Mass (Da):63,848
Last modified:February 1, 1997 - v1
Checksum:iF71E0DAF7EEFA8D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69882 mRNA Translation: AAB09563.1
RefSeqiNP_062187.1, NM_019314.2
UniGeneiRn.44421

Genome annotation databases

EnsembliENSRNOT00000022530; ENSRNOP00000022530; ENSRNOG00000016675
GeneIDi54262
KEGGirno:54262
UCSCiRGD:2963 rat

Similar proteinsi

Entry informationi

Entry nameiKCNN2_RAT
AccessioniPrimary (citable) accession number: P70604
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health