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Protein
Submitted name:

Protein tyrosine phosphatase 20

Gene

Ptpn18

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.SAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphataseSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Protein tyrosine phosphatase 20Imported
Gene namesi
Name:Ptpn18Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi1311586. Ptpn18.

PTM / Processingi

Proteomic databases

PaxDbiP70602.

PTM databases

iPTMnetiP70602.
PhosphoSitePlusiP70602.

Expressioni

Gene expression databases

GenevisibleiP70602. RN.

Interactioni

Protein-protein interaction databases

IntActiP70602. 2 interactors.
MINTiMINT-444795.
STRINGi10116.ENSRNOP00000061226.

Structurei

3D structure databases

ProteinModelPortaliP70602.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 291Tyrosine-protein phosphataseInterPro annotationAdd BLAST266
Domaini205 – 282TYR_PHOSPHATASE_2InterPro annotationAdd BLAST78

Phylogenomic databases

eggNOGiKOG0789. Eukaryota.
COG5599. LUCA.
HOGENOMiHOG000115776.
HOVERGENiHBG053419.
KOiK18024.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiView protein in InterPro
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
PfamiView protein in Pfam
PF00102. Y_phosphatase. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiView protein in SMART
SM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiView protein in PROSITE
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.

Sequencei

Sequence statusi: Complete.

P70602-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRQSDLVRS FLEQQEARDH RKGAILAREF SDIKARSVAW KTEGVCSTKA
60 70 80 90 100
GSQQGNSKKN RYKDVVPYDE TRVILSLLQE EGHGDYINAN FIRGTDGSQA
110 120 130 140 150
YIATQGPLPH TLLDFWRLVW EFGIKVILMA CQETENGRRK CERYWAQERE
160 170 180 190 200
PLQAGPFCIT LTKETALTSD ITLRTLQVTF QKESRPVHQL QYMSWPDHGV
210 220 230 240 250
PSSSDHILTM VEEARCLQGL GPGPLCVHCS AGCGRTGVLC AVDYVRQLLL
260 270 280 290 300
TQTIPPNFSL FEVVLEMRKQ RPAAVQTEEQ YRFLYHTVAQ LFSRTLQNNS
310 320 330 340 350
PLYQNLKENR APICKDSSSL RTSSALPATS RPLGGVLRSI SVPGPPTLPM
360 370 380 390 400
ADTYAVVQKR GASGSTGPGT RAPNSTDTPI YSQVAPRIQR PVSHTENAQG
410 420 430 440 450
TTALGRVPAD ENPSGPDAYE EVTDGAQTGG LGFNLRIGRP KGPRDPPAEW

TRV
Length:453
Mass (Da):50,107
Last modified:February 1, 1997 - v1
Checksum:i6CCC132206FB69AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69673 Genomic DNA. Translation: AAC52896.1.
RefSeqiNP_001013129.1. NM_001013111.1.
UniGeneiRn.228041.
Rn.9310.

Genome annotation databases

GeneIDi301333.
KEGGirno:301333.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69673 Genomic DNA. Translation: AAC52896.1.
RefSeqiNP_001013129.1. NM_001013111.1.
UniGeneiRn.228041.
Rn.9310.

3D structure databases

ProteinModelPortaliP70602.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP70602. 2 interactors.
MINTiMINT-444795.
STRINGi10116.ENSRNOP00000061226.

PTM databases

iPTMnetiP70602.
PhosphoSitePlusiP70602.

Proteomic databases

PaxDbiP70602.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi301333.
KEGGirno:301333.

Organism-specific databases

CTDi26469.
RGDi1311586. Ptpn18.

Phylogenomic databases

eggNOGiKOG0789. Eukaryota.
COG5599. LUCA.
HOGENOMiHOG000115776.
HOVERGENiHBG053419.
KOiK18024.

Gene expression databases

GenevisibleiP70602. RN.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiView protein in InterPro
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
PfamiView protein in Pfam
PF00102. Y_phosphatase. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiView protein in SMART
SM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiView protein in PROSITE
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiP70602_RAT
AccessioniPrimary (citable) accession number: P70602
Entry historyiIntegrated into UniProtKB/TrEMBL: February 1, 1997
Last sequence update: February 1, 1997
Last modified: March 15, 2017
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.