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Protein

Prostaglandin E2 receptor EP1 subtype

Gene

Ptger1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function (By similarity). Implicated the smooth muscle contractile response to PGE2 in various tissues. Isoform 1 and isoform 2 have identical ligand binding properties, but isoform 2 lacks coupling to calcium mobilization and may therefore attenuate the action of PGE2 on tissues.By similarity

GO - Molecular functioni

  • prostaglandin E receptor activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-391908. Prostanoid ligand receptors.
R-RNO-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin E2 receptor EP1 subtype
Short name:
PGE receptor EP1 subtype
Short name:
PGE2 receptor EP1 subtype
Alternative name(s):
Prostanoid EP1 receptor
Gene namesi
Name:Ptger1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi3434. Ptger1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39ExtracellularSequence analysisAdd BLAST39
Transmembranei40 – 62Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini63 – 80CytoplasmicSequence analysisAdd BLAST18
Transmembranei81 – 99Helical; Name=2Sequence analysisAdd BLAST19
Topological domaini100 – 113ExtracellularSequence analysisAdd BLAST14
Transmembranei114 – 135Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini136 – 157CytoplasmicSequence analysisAdd BLAST22
Transmembranei158 – 179Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini180 – 202ExtracellularSequence analysisAdd BLAST23
Transmembranei203 – 228Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini229 – 301CytoplasmicSequence analysisAdd BLAST73
Transmembranei302 – 323Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini324 – 337ExtracellularSequence analysisAdd BLAST14
Transmembranei338 – 357Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini358 – 405CytoplasmicSequence analysisAdd BLAST48

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5068.
GuidetoPHARMACOLOGYi340.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700521 – 405Prostaglandin E2 receptor EP1 subtypeAdd BLAST405

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...)Sequence analysis1
Glycosylationi24N-linked (GlcNAc...)Sequence analysis1
Glycosylationi34N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi112 ↔ 190PROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated.Curated

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP70597.
PRIDEiP70597.

PTM databases

PhosphoSitePlusiP70597.

Expressioni

Tissue specificityi

Highly abundant in kidney and lung. Found in a lesser extent in spleen, colon, and thymus. Also expressed in uterine myometrium and endometrium.

Gene expression databases

BgeeiENSRNOG00000004094.
GenevisibleiP70597. RN.

Interactioni

Protein-protein interaction databases

MINTiMINT-189620.
STRINGi10116.ENSRNOP00000005470.

Chemistry databases

BindingDBiP70597.

Structurei

3D structure databases

ProteinModelPortaliP70597.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119188.
HOGENOMiHOG000015238.
HOVERGENiHBG003621.
InParanoidiP70597.
KOiK04258.
OMAiTTCAAPW.
OrthoDBiEOG091G0NMF.
PhylomeDBiP70597.
TreeFamiTF324982.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001244. Prostglndn_DP_rcpt.
IPR000708. Prostglndn_EP1_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 2 hits.
PTHR11866:SF3. PTHR11866:SF3. 2 hits.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00428. PROSTAGLNDNR.
PR01788. PROSTANOIDR.
PR00580. PRSTNOIDEP1R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P70597-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSPYGLNLSL VDEATTCVTP RVPNTSVVLP TGGNGTSPAL PIFSMTLGAV
60 70 80 90 100
SNVLALALLA QVAGRLRRRR STATFLLFVA SLLAIDLAGH VIPGALVLRL
110 120 130 140 150
YTAGRAPAGG ACHFLGGCMV FFGLCPLLLG CGMAVERCVG VTQPLIHAAR
160 170 180 190 200
VSVARARLAL ALLAAMALAV ALLPLVHVGH YELQYPGTWC FISLGPPGGW
210 220 230 240 250
RQALLAGLFA GLGLAALLAA LVCNTLSGLA LLRARWRRRR SRRFRENAGP
260 270 280 290 300
DDRRRWGSRG LRLASASSAS SITSTTAALR SSRGGGSARR VHAHDVEMVG
310 320 330 340 350
QLVGIMVVSC ICWSPLLVLV VLAIGGWNSN SLQRPLFLAV RLASWNQILD
360 370 380 390 400
PWVYILLRQA MLRQLLRLLP LRVSAKGGPT ELSLTKSAWE ASSLRSSRHS

GFSHL
Length:405
Mass (Da):43,048
Last modified:February 1, 1997 - v1
Checksum:iE8312388B619F9EC
GO
Isoform 2 (identifier: P70597-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     319-366: LVVLAIGGWN...LRQAMLRQLL → RGAVAPQAKL...FFTLFGNLCK
     367-405: Missing.

Show »
Length:366
Mass (Da):38,498
Checksum:i82ADD2DCB12EB5C0
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001927319 – 366LVVLA…LRQLL → RGAVAPQAKLFSAPSWPLPA KDPACRQKPAPLLSRTLTFF TLFGNLCK in isoform 2. CuratedAdd BLAST48
Alternative sequenceiVSP_001928367 – 405Missing in isoform 2. CuratedAdd BLAST39

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U68037 mRNA. Translation: AAB07735.1.
D88751 mRNA. Translation: BAA13691.1.
D88752 mRNA. Translation: BAA13692.1.
RefSeqiNP_001265404.1. NM_001278475.1. [P70597-1]
UniGeneiRn.11423.

Genome annotation databases

EnsembliENSRNOT00000005470; ENSRNOP00000005470; ENSRNOG00000004094. [P70597-1]
GeneIDi25637.
KEGGirno:25637.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U68037 mRNA. Translation: AAB07735.1.
D88751 mRNA. Translation: BAA13691.1.
D88752 mRNA. Translation: BAA13692.1.
RefSeqiNP_001265404.1. NM_001278475.1. [P70597-1]
UniGeneiRn.11423.

3D structure databases

ProteinModelPortaliP70597.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-189620.
STRINGi10116.ENSRNOP00000005470.

Chemistry databases

BindingDBiP70597.
ChEMBLiCHEMBL5068.
GuidetoPHARMACOLOGYi340.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP70597.

Proteomic databases

PaxDbiP70597.
PRIDEiP70597.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000005470; ENSRNOP00000005470; ENSRNOG00000004094. [P70597-1]
GeneIDi25637.
KEGGirno:25637.

Organism-specific databases

CTDi5731.
RGDi3434. Ptger1.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119188.
HOGENOMiHOG000015238.
HOVERGENiHBG003621.
InParanoidiP70597.
KOiK04258.
OMAiTTCAAPW.
OrthoDBiEOG091G0NMF.
PhylomeDBiP70597.
TreeFamiTF324982.

Enzyme and pathway databases

ReactomeiR-RNO-391908. Prostanoid ligand receptors.
R-RNO-416476. G alpha (q) signalling events.

Miscellaneous databases

PROiP70597.

Gene expression databases

BgeeiENSRNOG00000004094.
GenevisibleiP70597. RN.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001244. Prostglndn_DP_rcpt.
IPR000708. Prostglndn_EP1_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 2 hits.
PTHR11866:SF3. PTHR11866:SF3. 2 hits.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00428. PROSTAGLNDNR.
PR01788. PROSTANOIDR.
PR00580. PRSTNOIDEP1R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPE2R1_RAT
AccessioniPrimary (citable) accession number: P70597
Secondary accession number(s): P97537
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 2, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.