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P70597

- PE2R1_RAT

UniProt

P70597 - PE2R1_RAT

Protein

Prostaglandin E2 receptor EP1 subtype

Gene

Ptger1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function By similarity. Implicated the smooth muscle contractile response to PGE2 in various tissues. Isoform 1 and isoform 2 have identical ligand binding properties, but isoform 2 lacks coupling to calcium mobilization and may therefore attenuate the action of PGE2 on tissues.By similarity

    GO - Molecular functioni

    1. prostaglandin E receptor activity Source: RGD

    GO - Biological processi

    1. response to lipopolysaccharide Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Prostaglandin E2 receptor EP1 subtype
    Short name:
    PGE receptor EP1 subtype
    Short name:
    PGE2 receptor EP1 subtype
    Alternative name(s):
    Prostanoid EP1 receptor
    Gene namesi
    Name:Ptger1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 19

    Organism-specific databases

    RGDi3434. Ptger1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 405405Prostaglandin E2 receptor EP1 subtypePRO_0000070052Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi7 – 71N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi24 – 241N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi34 – 341N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi112 ↔ 190PROSITE-ProRule annotation

    Post-translational modificationi

    Phosphorylated.Curated

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PRIDEiP70597.

    Expressioni

    Tissue specificityi

    Highly abundant in kidney and lung. Found in a lesser extent in spleen, colon, and thymus. Also expressed in uterine myometrium and endometrium.

    Gene expression databases

    GenevestigatoriP70597.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-189620.
    STRINGi10116.ENSRNOP00000005470.

    Structurei

    3D structure databases

    ProteinModelPortaliP70597.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3939ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini63 – 8018CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini100 – 11314ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini136 – 15722CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini180 – 20223ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini229 – 30173CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini324 – 33714ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini358 – 40548CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei40 – 6223Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei81 – 9919Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei114 – 13522Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei158 – 17922Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei203 – 22826Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei302 – 32322Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei338 – 35720Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG253446.
    GeneTreeiENSGT00690000102015.
    HOGENOMiHOG000015238.
    HOVERGENiHBG003621.
    InParanoidiP70597.
    KOiK04258.
    OMAiPAGGACH.
    OrthoDBiEOG7PP575.
    PhylomeDBiP70597.
    TreeFamiTF324982.

    Family and domain databases

    Gene3Di1.20.1070.10. 2 hits.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR008365. Prostanoid_rcpt.
    IPR001244. Prostglndn_DP_rcpt.
    IPR000708. Prostglndn_EP1_rcpt.
    [Graphical view]
    PANTHERiPTHR11866. PTHR11866. 1 hit.
    PTHR11866:SF3. PTHR11866:SF3. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00428. PROSTAGLNDNR.
    PR01788. PROSTANOIDR.
    PR00580. PRSTNOIDEP1R.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P70597-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSPYGLNLSL VDEATTCVTP RVPNTSVVLP TGGNGTSPAL PIFSMTLGAV    50
    SNVLALALLA QVAGRLRRRR STATFLLFVA SLLAIDLAGH VIPGALVLRL 100
    YTAGRAPAGG ACHFLGGCMV FFGLCPLLLG CGMAVERCVG VTQPLIHAAR 150
    VSVARARLAL ALLAAMALAV ALLPLVHVGH YELQYPGTWC FISLGPPGGW 200
    RQALLAGLFA GLGLAALLAA LVCNTLSGLA LLRARWRRRR SRRFRENAGP 250
    DDRRRWGSRG LRLASASSAS SITSTTAALR SSRGGGSARR VHAHDVEMVG 300
    QLVGIMVVSC ICWSPLLVLV VLAIGGWNSN SLQRPLFLAV RLASWNQILD 350
    PWVYILLRQA MLRQLLRLLP LRVSAKGGPT ELSLTKSAWE ASSLRSSRHS 400
    GFSHL 405
    Length:405
    Mass (Da):43,048
    Last modified:February 1, 1997 - v1
    Checksum:iE8312388B619F9EC
    GO
    Isoform 2 (identifier: P70597-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         319-366: LVVLAIGGWN...LRQAMLRQLL → RGAVAPQAKL...FFTLFGNLCK
         367-405: Missing.

    Show »
    Length:366
    Mass (Da):38,498
    Checksum:i82ADD2DCB12EB5C0
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei319 – 36648LVVLA…LRQLL → RGAVAPQAKLFSAPSWPLPA KDPACRQKPAPLLSRTLTFF TLFGNLCK in isoform 2. CuratedVSP_001927Add
    BLAST
    Alternative sequencei367 – 40539Missing in isoform 2. CuratedVSP_001928Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U68037 mRNA. Translation: AAB07735.1.
    D88751 mRNA. Translation: BAA13691.1.
    D88752 mRNA. Translation: BAA13692.1.
    RefSeqiNP_001265404.1. NM_001278475.1. [P70597-1]
    UniGeneiRn.11423.

    Genome annotation databases

    EnsembliENSRNOT00000005470; ENSRNOP00000005470; ENSRNOG00000004094. [P70597-1]
    GeneIDi25637.
    KEGGirno:25637.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U68037 mRNA. Translation: AAB07735.1 .
    D88751 mRNA. Translation: BAA13691.1 .
    D88752 mRNA. Translation: BAA13692.1 .
    RefSeqi NP_001265404.1. NM_001278475.1. [P70597-1 ]
    UniGenei Rn.11423.

    3D structure databases

    ProteinModelPortali P70597.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-189620.
    STRINGi 10116.ENSRNOP00000005470.

    Chemistry

    BindingDBi P70597.
    ChEMBLi CHEMBL5068.
    GuidetoPHARMACOLOGYi 340.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PRIDEi P70597.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000005470 ; ENSRNOP00000005470 ; ENSRNOG00000004094 . [P70597-1 ]
    GeneIDi 25637.
    KEGGi rno:25637.

    Organism-specific databases

    CTDi 5731.
    RGDi 3434. Ptger1.

    Phylogenomic databases

    eggNOGi NOG253446.
    GeneTreei ENSGT00690000102015.
    HOGENOMi HOG000015238.
    HOVERGENi HBG003621.
    InParanoidi P70597.
    KOi K04258.
    OMAi PAGGACH.
    OrthoDBi EOG7PP575.
    PhylomeDBi P70597.
    TreeFami TF324982.

    Miscellaneous databases

    NextBioi 607463.
    PROi P70597.

    Gene expression databases

    Genevestigatori P70597.

    Family and domain databases

    Gene3Di 1.20.1070.10. 2 hits.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR008365. Prostanoid_rcpt.
    IPR001244. Prostglndn_DP_rcpt.
    IPR000708. Prostglndn_EP1_rcpt.
    [Graphical view ]
    PANTHERi PTHR11866. PTHR11866. 1 hit.
    PTHR11866:SF3. PTHR11866:SF3. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00428. PROSTAGLNDNR.
    PR01788. PROSTANOIDR.
    PR00580. PRSTNOIDEP1R.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes."
      Boie Y., Stocco R., Sawyer N., Slipetz D.M., Ungrin M.D., Neuschafer-Rube F., Puschel G.P., Metters K.M., Abramovitz M.
      Eur. J. Pharmacol. 340:227-241(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
    2. "Suppression of prostaglandin E receptor signaling by the variant form of EP1 subtype."
      Okuda-Ashitaka E., Sakamoto K., Ezashi T., Miwa K., Ito S., Hayaishi O.
      J. Biol. Chem. 271:31255-31261(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING.
      Strain: Wistar.
      Tissue: Uterus.

    Entry informationi

    Entry nameiPE2R1_RAT
    AccessioniPrimary (citable) accession number: P70597
    Secondary accession number(s): P97537
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3