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Protein

Neurogenin-1

Gene

Neurog1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neurogenin-1
Short name:
NGN-1
Alternative name(s):
Neurogenic basic-helix-loop-helix protein
Neurogenic differentiation factor 3
Short name:
NeuroD3
Gene namesi
Name:Neurog1
Synonyms:Neurod3, Ngn, Ngn1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi3167. Neurog1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 244244Neurogenin-1PRO_0000127398Add
BLAST

Proteomic databases

PaxDbiP70595.

PTM databases

PhosphoSiteiP70595.

Expressioni

Tissue specificityi

Expression restricted to the embryonic nervous system.

Gene expression databases

GenevisibleiP70595. RN.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015916.

Structurei

3D structure databases

ProteinModelPortaliP70595.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini93 – 14553bHLHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3898. Eukaryota.
ENOG4111U26. LUCA.
GeneTreeiENSGT00680000099860.
HOGENOMiHOG000063655.
HOVERGENiHBG101129.
InParanoidiP70595.
KOiK09081.
OMAiYIWALAE.
OrthoDBiEOG7TTQB1.
PhylomeDBiP70595.
TreeFamiTF315153.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR032653. Ngn1.
[Graphical view]
PANTHERiPTHR19290:SF92. PTHR19290:SF92. 1 hit.
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70595-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAPLETCLS DLDCASSNSG SDLSSFLTDE EDCARLQPLA STSGLSVPAR
60 70 80 90 100
RSAPTLSGAS NVPGGQDEEQ ERRRRRGRAR VRSEALLHSL RRSRRVKAND
110 120 130 140 150
RERNRMHNLN AALDALRSVL PSFPDDTKLT KIETLRFAYN YIWALAETLR
160 170 180 190 200
LADQGLPGGG ARERLLPPQC VPCLPGPPSP ASDTESWGSG AAASPCATVA
210 220 230 240
SPLSDPSSPS ASEDFTYGPG GPLFSFPGLP KDLLHTTPCF IPYH
Length:244
Mass (Da):26,182
Last modified:February 1, 1997 - v1
Checksum:i47D0E91403143D61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67777 mRNA. Translation: AAC52857.1.
RefSeqiNP_062080.1. NM_019207.1.
UniGeneiRn.10606.

Genome annotation databases

EnsembliENSRNOT00000015916; ENSRNOP00000015916; ENSRNOG00000022405.
GeneIDi29410.
KEGGirno:29410.
UCSCiRGD:3167. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67777 mRNA. Translation: AAC52857.1.
RefSeqiNP_062080.1. NM_019207.1.
UniGeneiRn.10606.

3D structure databases

ProteinModelPortaliP70595.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015916.

PTM databases

PhosphoSiteiP70595.

Proteomic databases

PaxDbiP70595.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000015916; ENSRNOP00000015916; ENSRNOG00000022405.
GeneIDi29410.
KEGGirno:29410.
UCSCiRGD:3167. rat.

Organism-specific databases

CTDi4762.
RGDi3167. Neurog1.

Phylogenomic databases

eggNOGiKOG3898. Eukaryota.
ENOG4111U26. LUCA.
GeneTreeiENSGT00680000099860.
HOGENOMiHOG000063655.
HOVERGENiHBG101129.
InParanoidiP70595.
KOiK09081.
OMAiYIWALAE.
OrthoDBiEOG7TTQB1.
PhylomeDBiP70595.
TreeFamiTF315153.

Miscellaneous databases

NextBioi609072.
PROiP70595.

Gene expression databases

GenevisibleiP70595. RN.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR032653. Ngn1.
[Graphical view]
PANTHERiPTHR19290:SF92. PTHR19290:SF92. 1 hit.
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of neurogenin, a vertebrate neuronal determination gene."
    Ma Q., Kintner C., Anderson D.J.
    Cell 87:43-52(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Embryo.

Entry informationi

Entry nameiNGN1_RAT
AccessioniPrimary (citable) accession number: P70595
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 1, 1997
Last modified: November 11, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.