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Protein

Neurogenin-1

Gene

Neurog1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Neurogenin-1
Short name:
NGN-1
Alternative name(s):
Neurogenic basic-helix-loop-helix protein
Neurogenic differentiation factor 3
Short name:
NeuroD3
Gene namesi
Name:Neurog1
Synonyms:Neurod3, Ngn, Ngn1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi3167 Neurog1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001273981 – 244Neurogenin-1Add BLAST244

Proteomic databases

PaxDbiP70595

PTM databases

iPTMnetiP70595
PhosphoSitePlusiP70595

Expressioni

Tissue specificityi

Expression restricted to the embryonic nervous system.

Gene expression databases

BgeeiENSRNOG00000022405
GenevisibleiP70595 RN

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015916

Structurei

3D structure databases

ProteinModelPortaliP70595
SMRiP70595
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini93 – 145bHLHPROSITE-ProRule annotationAdd BLAST53

Phylogenomic databases

eggNOGiKOG3898 Eukaryota
ENOG4111U26 LUCA
GeneTreeiENSGT00680000099860
HOGENOMiHOG000063655
HOVERGENiHBG101129
InParanoidiP70595
KOiK09081
OMAiYIWALAE
OrthoDBiEOG091G0PNH
PhylomeDBiP70595
TreeFamiTF315153

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR032653 Ngn1
PANTHERiPTHR19290:SF130 PTHR19290:SF130, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

P70595-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAPLETCLS DLDCASSNSG SDLSSFLTDE EDCARLQPLA STSGLSVPAR
60 70 80 90 100
RSAPTLSGAS NVPGGQDEEQ ERRRRRGRAR VRSEALLHSL RRSRRVKAND
110 120 130 140 150
RERNRMHNLN AALDALRSVL PSFPDDTKLT KIETLRFAYN YIWALAETLR
160 170 180 190 200
LADQGLPGGG ARERLLPPQC VPCLPGPPSP ASDTESWGSG AAASPCATVA
210 220 230 240
SPLSDPSSPS ASEDFTYGPG GPLFSFPGLP KDLLHTTPCF IPYH
Length:244
Mass (Da):26,182
Last modified:February 1, 1997 - v1
Checksum:i47D0E91403143D61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67777 mRNA Translation: AAC52857.1
RefSeqiNP_062080.1, NM_019207.1
UniGeneiRn.10606

Genome annotation databases

EnsembliENSRNOT00000015916; ENSRNOP00000015916; ENSRNOG00000022405
GeneIDi29410
KEGGirno:29410
UCSCiRGD:3167 rat

Similar proteinsi

Entry informationi

Entry nameiNGN1_RAT
AccessioniPrimary (citable) accession number: P70595
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 1, 1997
Last modified: May 23, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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