P70585 (GPR19_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable G-protein coupled receptor 19

Gene names

Name:

Gpr19

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	415 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Orphan receptor.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Abundant expression in the brain.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 415	415	Probable G-protein coupled receptor 19		PRO_0000069540
Regions
	Topological domain	1 – 69	69	Extracellular Potential
	Transmembrane	70 – 90	21	Helical; Name=1; Potential
	Topological domain	91 – 102	12	Cytoplasmic Potential
	Transmembrane	103 – 123	21	Helical; Name=2; Potential
	Topological domain	124 – 152	29	Extracellular Potential
	Transmembrane	153 – 173	21	Helical; Name=3; Potential
	Topological domain	174 – 182	9	Cytoplasmic Potential
	Transmembrane	183 – 203	21	Helical; Name=4; Potential
	Topological domain	204 – 221	18	Extracellular Potential
	Transmembrane	222 – 242	21	Helical; Name=5; Potential
	Topological domain	243 – 277	35	Cytoplasmic Potential
	Transmembrane	278 – 298	21	Helical; Name=6; Potential
	Topological domain	299 – 309	11	Extracellular Potential
	Transmembrane	310 – 332	23	Helical; Name=7; Potential
	Topological domain	333 – 415	83	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	25	1	N-linked (GlcNAc...) Potential
	Glycosylation	52	1	N-linked (GlcNAc...) Potential
	Disulfide bond	138 ↔ 210		By similarity
Experimental info
	Sequence conflict	44	1	H → S in AAB49752. Ref.2
	Sequence conflict	103	1	F → L in AAB49752. Ref.2
	Sequence conflict	281	1	L → F in AAB49752. Ref.2
	Sequence conflict	304	1	D → E in AAB49752. Ref.2
	Sequence conflict	393	1	F → L in AAB49752. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P70585 [UniParc]. Last modified December 6, 2005. Version 2. Checksum: 7C20B63FF1121FB9	FASTA	415	47,634
	10 20 30 40 50 60 MGFDHRMETD QPPVVTATLL VPLQNGSCVE AAEALLPHGL MELHEEHSWM SNRTDLQYEL 70 80 90 100 110 120 NPGEVATASI FFGALWLFSI FGNSLVCLVI HRSRRTQSTT NYFVVSMACA DLLISVASTP 130 140 150 160 170 180 FVVLQFTTGR WTLGSAMCKV VRYFQYLTPG VQIYVLLSIC IDRFYTIVYP LSFKVSREKA 190 200 210 220 230 240 KRMIAASWIL DAAFVTPVFF FYGSNWDSHC NYFLPPSWEG TAYTVIHFLV GFVIPSVLII 250 260 270 280 290 300 LFYQKVIKYI WRIGTDGRTL RRTMNIVPRT KVKTVKMFLL LNLVFLFSWL PFHVAQLWHP 310 320 330 340 350 360 HEQDYRKSSL VFTAVTWVSF SSSASKPTLY SIYNANFRRG MKETFCMSSM KCYRSNAYTI 370 380 390 400 410 TTSSRMAKRN YVGISEIPPV SRTITKDSIY DSFDREAREK KLAWPINSNP PNTFV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[2]	"A novel gene codes for a putative G protein-coupled receptor with an abundant expression in brain." O'Dowd B.F., Nguyen T., Lynch K.R., Kolakowski L.F. Jr., Thompson M., Cheng R., Marchese A., Ng G.Y.K., Heng H.H.Q., George S.R. FEBS Lett. 394:325-329(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 42-393.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC089971 mRNA. Translation: AAH89971.1. U65417 Genomic DNA. Translation: AAB49752.1.
IPI	IPI00366080.
PIR	S74238.
RefSeq	NP_542146.1. NM_080579.1.
UniGene	Rn.99370.
3D structure databases
ProteinModelPortal	P70585.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000009341.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P70585.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000009341; ENSRNOP00000009341; ENSRNOG00000007126.
GeneID	312787.
KEGG	rno:312787.
UCSC	RGD:71045. rat.
Organism-specific databases
CTD	2842.
RGD	71045. Gpr19.
Phylogenomic databases
eggNOG	NOG318116.
GeneTree	ENSGT00650000093368.
HOGENOM	HOG000112786.
HOVERGEN	HBG051799.
InParanoid	P70585.
KO	K04316.
OMA	QLWHPHE.
OrthoDB	EOG4SJ5F4.
Gene expression databases
Genevestigator	P70585.
GermOnline	ENSRNOG00000007126. Rattus norvegicus.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	665257.

Entry information

Entry name

GPR19_RAT

Accession

Primary (citable) accession number: P70585
Secondary accession number(s): Q5FVI1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	December 6, 2005
Last modified:	April 3, 2013
This is version 92 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program