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Protein

Probable G-protein coupled receptor 19

Gene

Gpr19

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 19
Gene namesi
Name:Gpr19
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi71045. Gpr19.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6969ExtracellularSequence AnalysisAdd
BLAST
Transmembranei70 – 9021Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini91 – 10212CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei103 – 12321Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini124 – 15229ExtracellularSequence AnalysisAdd
BLAST
Transmembranei153 – 17321Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini174 – 1829CytoplasmicSequence Analysis
Transmembranei183 – 20321Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini204 – 22118ExtracellularSequence AnalysisAdd
BLAST
Transmembranei222 – 24221Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini243 – 27735CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei278 – 29821Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini299 – 30911ExtracellularSequence AnalysisAdd
BLAST
Transmembranei310 – 33223Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini333 – 41583CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 415415Probable G-protein coupled receptor 19PRO_0000069540Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi25 – 251N-linked (GlcNAc...)Sequence Analysis
Glycosylationi52 – 521N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi138 ↔ 210PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

PTM databases

PhosphoSiteiP70585.

Expressioni

Tissue specificityi

Abundant expression in the brain.

Gene expression databases

GenevestigatoriP70585.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009341.

Structurei

3D structure databases

ProteinModelPortaliP70585.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG318116.
GeneTreeiENSGT00780000121924.
HOGENOMiHOG000112786.
HOVERGENiHBG051799.
InParanoidiP70585.
KOiK04316.
OMAiQLWHPHE.
OrthoDBiEOG7SXW36.
PhylomeDBiP70585.
TreeFamiTF331630.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70585-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFDHRMETD QPPVVTATLL VPLQNGSCVE AAEALLPHGL MELHEEHSWM
60 70 80 90 100
SNRTDLQYEL NPGEVATASI FFGALWLFSI FGNSLVCLVI HRSRRTQSTT
110 120 130 140 150
NYFVVSMACA DLLISVASTP FVVLQFTTGR WTLGSAMCKV VRYFQYLTPG
160 170 180 190 200
VQIYVLLSIC IDRFYTIVYP LSFKVSREKA KRMIAASWIL DAAFVTPVFF
210 220 230 240 250
FYGSNWDSHC NYFLPPSWEG TAYTVIHFLV GFVIPSVLII LFYQKVIKYI
260 270 280 290 300
WRIGTDGRTL RRTMNIVPRT KVKTVKMFLL LNLVFLFSWL PFHVAQLWHP
310 320 330 340 350
HEQDYRKSSL VFTAVTWVSF SSSASKPTLY SIYNANFRRG MKETFCMSSM
360 370 380 390 400
KCYRSNAYTI TTSSRMAKRN YVGISEIPPV SRTITKDSIY DSFDREAREK
410
KLAWPINSNP PNTFV
Length:415
Mass (Da):47,634
Last modified:December 6, 2005 - v2
Checksum:i7C20B63FF1121FB9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti44 – 441H → S in AAB49752 (PubMed:8830667).Curated
Sequence conflicti103 – 1031F → L in AAB49752 (PubMed:8830667).Curated
Sequence conflicti281 – 2811L → F in AAB49752 (PubMed:8830667).Curated
Sequence conflicti304 – 3041D → E in AAB49752 (PubMed:8830667).Curated
Sequence conflicti393 – 3931F → L in AAB49752 (PubMed:8830667).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089971 mRNA. Translation: AAH89971.1.
U65417 Genomic DNA. Translation: AAB49752.1.
PIRiS74238.
RefSeqiNP_542146.1. NM_080579.1.
XP_006237585.1. XM_006237523.2.
XP_006237586.1. XM_006237524.1.
XP_008761601.1. XM_008763379.1.
UniGeneiRn.99370.

Genome annotation databases

EnsembliENSRNOT00000009341; ENSRNOP00000009341; ENSRNOG00000007126.
GeneIDi312787.
KEGGirno:312787.
UCSCiRGD:71045. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089971 mRNA. Translation: AAH89971.1.
U65417 Genomic DNA. Translation: AAB49752.1.
PIRiS74238.
RefSeqiNP_542146.1. NM_080579.1.
XP_006237585.1. XM_006237523.2.
XP_006237586.1. XM_006237524.1.
XP_008761601.1. XM_008763379.1.
UniGeneiRn.99370.

3D structure databases

ProteinModelPortaliP70585.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009341.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP70585.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000009341; ENSRNOP00000009341; ENSRNOG00000007126.
GeneIDi312787.
KEGGirno:312787.
UCSCiRGD:71045. rat.

Organism-specific databases

CTDi2842.
RGDi71045. Gpr19.

Phylogenomic databases

eggNOGiNOG318116.
GeneTreeiENSGT00780000121924.
HOGENOMiHOG000112786.
HOVERGENiHBG051799.
InParanoidiP70585.
KOiK04316.
OMAiQLWHPHE.
OrthoDBiEOG7SXW36.
PhylomeDBiP70585.
TreeFamiTF331630.

Miscellaneous databases

NextBioi665257.
PROiP70585.

Gene expression databases

GenevestigatoriP70585.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "A novel gene codes for a putative G protein-coupled receptor with an abundant expression in brain."
    O'Dowd B.F., Nguyen T., Lynch K.R., Kolakowski L.F. Jr., Thompson M., Cheng R., Marchese A., Ng G.Y.K., Heng H.H.Q., George S.R.
    FEBS Lett. 394:325-329(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 42-393.

Entry informationi

Entry nameiGPR19_RAT
AccessioniPrimary (citable) accession number: P70585
Secondary accession number(s): Q5FVI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 6, 2005
Last modified: February 4, 2015
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.