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P70585

- GPR19_RAT

UniProt

P70585 - GPR19_RAT

Protein

Probable G-protein coupled receptor 19

Gene

Gpr19

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 2 (06 Dec 2005)
      Previous versions | rss
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    Functioni

    Orphan receptor.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable G-protein coupled receptor 19
    Gene namesi
    Name:Gpr19
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 4

    Organism-specific databases

    RGDi71045. Gpr19.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 415415Probable G-protein coupled receptor 19PRO_0000069540Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi25 – 251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi52 – 521N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi138 ↔ 210PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    PTM databases

    PhosphoSiteiP70585.

    Expressioni

    Tissue specificityi

    Abundant expression in the brain.

    Gene expression databases

    GenevestigatoriP70585.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000009341.

    Structurei

    3D structure databases

    ProteinModelPortaliP70585.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6969ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini91 – 10212CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini124 – 15229ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini174 – 1829CytoplasmicSequence Analysis
    Topological domaini204 – 22118ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini243 – 27735CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini299 – 30911ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini333 – 41583CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei70 – 9021Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei103 – 12321Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei153 – 17321Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei183 – 20321Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei222 – 24221Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei278 – 29821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei310 – 33223Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG318116.
    GeneTreeiENSGT00730000110635.
    HOGENOMiHOG000112786.
    HOVERGENiHBG051799.
    InParanoidiP70585.
    KOiK04316.
    OMAiQLWHPHE.
    OrthoDBiEOG7SXW36.
    PhylomeDBiP70585.
    TreeFamiTF331630.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P70585-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGFDHRMETD QPPVVTATLL VPLQNGSCVE AAEALLPHGL MELHEEHSWM    50
    SNRTDLQYEL NPGEVATASI FFGALWLFSI FGNSLVCLVI HRSRRTQSTT 100
    NYFVVSMACA DLLISVASTP FVVLQFTTGR WTLGSAMCKV VRYFQYLTPG 150
    VQIYVLLSIC IDRFYTIVYP LSFKVSREKA KRMIAASWIL DAAFVTPVFF 200
    FYGSNWDSHC NYFLPPSWEG TAYTVIHFLV GFVIPSVLII LFYQKVIKYI 250
    WRIGTDGRTL RRTMNIVPRT KVKTVKMFLL LNLVFLFSWL PFHVAQLWHP 300
    HEQDYRKSSL VFTAVTWVSF SSSASKPTLY SIYNANFRRG MKETFCMSSM 350
    KCYRSNAYTI TTSSRMAKRN YVGISEIPPV SRTITKDSIY DSFDREAREK 400
    KLAWPINSNP PNTFV 415
    Length:415
    Mass (Da):47,634
    Last modified:December 6, 2005 - v2
    Checksum:i7C20B63FF1121FB9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti44 – 441H → S in AAB49752. (PubMed:8830667)Curated
    Sequence conflicti103 – 1031F → L in AAB49752. (PubMed:8830667)Curated
    Sequence conflicti281 – 2811L → F in AAB49752. (PubMed:8830667)Curated
    Sequence conflicti304 – 3041D → E in AAB49752. (PubMed:8830667)Curated
    Sequence conflicti393 – 3931F → L in AAB49752. (PubMed:8830667)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC089971 mRNA. Translation: AAH89971.1.
    U65417 Genomic DNA. Translation: AAB49752.1.
    PIRiS74238.
    RefSeqiNP_542146.1. NM_080579.1.
    XP_006237585.1. XM_006237523.1.
    XP_006237586.1. XM_006237524.1.
    UniGeneiRn.99370.

    Genome annotation databases

    EnsembliENSRNOT00000009341; ENSRNOP00000009341; ENSRNOG00000007126.
    GeneIDi312787.
    KEGGirno:312787.
    UCSCiRGD:71045. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC089971 mRNA. Translation: AAH89971.1 .
    U65417 Genomic DNA. Translation: AAB49752.1 .
    PIRi S74238.
    RefSeqi NP_542146.1. NM_080579.1.
    XP_006237585.1. XM_006237523.1.
    XP_006237586.1. XM_006237524.1.
    UniGenei Rn.99370.

    3D structure databases

    ProteinModelPortali P70585.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000009341.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P70585.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000009341 ; ENSRNOP00000009341 ; ENSRNOG00000007126 .
    GeneIDi 312787.
    KEGGi rno:312787.
    UCSCi RGD:71045. rat.

    Organism-specific databases

    CTDi 2842.
    RGDi 71045. Gpr19.

    Phylogenomic databases

    eggNOGi NOG318116.
    GeneTreei ENSGT00730000110635.
    HOGENOMi HOG000112786.
    HOVERGENi HBG051799.
    InParanoidi P70585.
    KOi K04316.
    OMAi QLWHPHE.
    OrthoDBi EOG7SXW36.
    PhylomeDBi P70585.
    TreeFami TF331630.

    Miscellaneous databases

    NextBioi 665257.
    PROi P70585.

    Gene expression databases

    Genevestigatori P70585.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    2. "A novel gene codes for a putative G protein-coupled receptor with an abundant expression in brain."
      O'Dowd B.F., Nguyen T., Lynch K.R., Kolakowski L.F. Jr., Thompson M., Cheng R., Marchese A., Ng G.Y.K., Heng H.H.Q., George S.R.
      FEBS Lett. 394:325-329(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 42-393.

    Entry informationi

    Entry nameiGPR19_RAT
    AccessioniPrimary (citable) accession number: P70585
    Secondary accession number(s): Q5FVI1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3