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Protein

Probable G-protein coupled receptor 19

Gene

Gpr19

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 19
Gene namesi
Name:Gpr19
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi71045. Gpr19.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 69ExtracellularSequence analysisAdd BLAST69
Transmembranei70 – 90Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini91 – 102CytoplasmicSequence analysisAdd BLAST12
Transmembranei103 – 123Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini124 – 152ExtracellularSequence analysisAdd BLAST29
Transmembranei153 – 173Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini174 – 182CytoplasmicSequence analysis9
Transmembranei183 – 203Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini204 – 221ExtracellularSequence analysisAdd BLAST18
Transmembranei222 – 242Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini243 – 277CytoplasmicSequence analysisAdd BLAST35
Transmembranei278 – 298Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini299 – 309ExtracellularSequence analysisAdd BLAST11
Transmembranei310 – 332Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini333 – 415CytoplasmicSequence analysisAdd BLAST83

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695401 – 415Probable G-protein coupled receptor 19Add BLAST415

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi25N-linked (GlcNAc...)Sequence analysis1
Glycosylationi52N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi138 ↔ 210PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP70585.

PTM databases

iPTMnetiP70585.
PhosphoSitePlusiP70585.

Expressioni

Tissue specificityi

Abundant expression in the brain.

Gene expression databases

BgeeiENSRNOG00000007126.
GenevisibleiP70585. RN.

Structurei

3D structure databases

ProteinModelPortaliP70585.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00860000133695.
HOGENOMiHOG000112786.
HOVERGENiHBG051799.
InParanoidiP70585.
KOiK04316.
OMAiQLWHPHE.
OrthoDBiEOG091G0ZDG.
PhylomeDBiP70585.
TreeFamiTF331630.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70585-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFDHRMETD QPPVVTATLL VPLQNGSCVE AAEALLPHGL MELHEEHSWM
60 70 80 90 100
SNRTDLQYEL NPGEVATASI FFGALWLFSI FGNSLVCLVI HRSRRTQSTT
110 120 130 140 150
NYFVVSMACA DLLISVASTP FVVLQFTTGR WTLGSAMCKV VRYFQYLTPG
160 170 180 190 200
VQIYVLLSIC IDRFYTIVYP LSFKVSREKA KRMIAASWIL DAAFVTPVFF
210 220 230 240 250
FYGSNWDSHC NYFLPPSWEG TAYTVIHFLV GFVIPSVLII LFYQKVIKYI
260 270 280 290 300
WRIGTDGRTL RRTMNIVPRT KVKTVKMFLL LNLVFLFSWL PFHVAQLWHP
310 320 330 340 350
HEQDYRKSSL VFTAVTWVSF SSSASKPTLY SIYNANFRRG MKETFCMSSM
360 370 380 390 400
KCYRSNAYTI TTSSRMAKRN YVGISEIPPV SRTITKDSIY DSFDREAREK
410
KLAWPINSNP PNTFV
Length:415
Mass (Da):47,634
Last modified:December 6, 2005 - v2
Checksum:i7C20B63FF1121FB9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti44H → S in AAB49752 (PubMed:8830667).Curated1
Sequence conflicti103F → L in AAB49752 (PubMed:8830667).Curated1
Sequence conflicti281L → F in AAB49752 (PubMed:8830667).Curated1
Sequence conflicti304D → E in AAB49752 (PubMed:8830667).Curated1
Sequence conflicti393F → L in AAB49752 (PubMed:8830667).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089971 mRNA. Translation: AAH89971.1.
U65417 Genomic DNA. Translation: AAB49752.1.
PIRiS74238.
RefSeqiNP_542146.1. NM_080579.1.
XP_006237586.1. XM_006237524.2.
XP_017448148.1. XM_017592659.1.
XP_017448149.1. XM_017592660.1.
XP_017448150.1. XM_017592661.1.
XP_017448151.1. XM_017592662.1.
UniGeneiRn.99370.

Genome annotation databases

EnsembliENSRNOT00000009341; ENSRNOP00000009341; ENSRNOG00000007126.
GeneIDi312787.
KEGGirno:312787.
UCSCiRGD:71045. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089971 mRNA. Translation: AAH89971.1.
U65417 Genomic DNA. Translation: AAB49752.1.
PIRiS74238.
RefSeqiNP_542146.1. NM_080579.1.
XP_006237586.1. XM_006237524.2.
XP_017448148.1. XM_017592659.1.
XP_017448149.1. XM_017592660.1.
XP_017448150.1. XM_017592661.1.
XP_017448151.1. XM_017592662.1.
UniGeneiRn.99370.

3D structure databases

ProteinModelPortaliP70585.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP70585.
PhosphoSitePlusiP70585.

Proteomic databases

PaxDbiP70585.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000009341; ENSRNOP00000009341; ENSRNOG00000007126.
GeneIDi312787.
KEGGirno:312787.
UCSCiRGD:71045. rat.

Organism-specific databases

CTDi2842.
RGDi71045. Gpr19.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00860000133695.
HOGENOMiHOG000112786.
HOVERGENiHBG051799.
InParanoidiP70585.
KOiK04316.
OMAiQLWHPHE.
OrthoDBiEOG091G0ZDG.
PhylomeDBiP70585.
TreeFamiTF331630.

Miscellaneous databases

PROiP70585.

Gene expression databases

BgeeiENSRNOG00000007126.
GenevisibleiP70585. RN.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPR19_RAT
AccessioniPrimary (citable) accession number: P70585
Secondary accession number(s): Q5FVI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 6, 2005
Last modified: November 30, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.