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P70585 (GPR19_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable G-protein coupled receptor 19
Gene names
Name:Gpr19
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length415 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Orphan receptor.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Abundant expression in the brain.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 415415Probable G-protein coupled receptor 19
PRO_0000069540

Regions

Topological domain1 – 6969Extracellular Potential
Transmembrane70 – 9021Helical; Name=1; Potential
Topological domain91 – 10212Cytoplasmic Potential
Transmembrane103 – 12321Helical; Name=2; Potential
Topological domain124 – 15229Extracellular Potential
Transmembrane153 – 17321Helical; Name=3; Potential
Topological domain174 – 1829Cytoplasmic Potential
Transmembrane183 – 20321Helical; Name=4; Potential
Topological domain204 – 22118Extracellular Potential
Transmembrane222 – 24221Helical; Name=5; Potential
Topological domain243 – 27735Cytoplasmic Potential
Transmembrane278 – 29821Helical; Name=6; Potential
Topological domain299 – 30911Extracellular Potential
Transmembrane310 – 33223Helical; Name=7; Potential
Topological domain333 – 41583Cytoplasmic Potential

Amino acid modifications

Glycosylation251N-linked (GlcNAc...) Potential
Glycosylation521N-linked (GlcNAc...) Potential
Disulfide bond138 ↔ 210 By similarity

Experimental info

Sequence conflict441H → S in AAB49752. Ref.2
Sequence conflict1031F → L in AAB49752. Ref.2
Sequence conflict2811L → F in AAB49752. Ref.2
Sequence conflict3041D → E in AAB49752. Ref.2
Sequence conflict3931F → L in AAB49752. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P70585 [UniParc].

Last modified December 6, 2005. Version 2.
Checksum: 7C20B63FF1121FB9

FASTA41547,634
        10         20         30         40         50         60 
MGFDHRMETD QPPVVTATLL VPLQNGSCVE AAEALLPHGL MELHEEHSWM SNRTDLQYEL 

        70         80         90        100        110        120 
NPGEVATASI FFGALWLFSI FGNSLVCLVI HRSRRTQSTT NYFVVSMACA DLLISVASTP 

       130        140        150        160        170        180 
FVVLQFTTGR WTLGSAMCKV VRYFQYLTPG VQIYVLLSIC IDRFYTIVYP LSFKVSREKA 

       190        200        210        220        230        240 
KRMIAASWIL DAAFVTPVFF FYGSNWDSHC NYFLPPSWEG TAYTVIHFLV GFVIPSVLII 

       250        260        270        280        290        300 
LFYQKVIKYI WRIGTDGRTL RRTMNIVPRT KVKTVKMFLL LNLVFLFSWL PFHVAQLWHP 

       310        320        330        340        350        360 
HEQDYRKSSL VFTAVTWVSF SSSASKPTLY SIYNANFRRG MKETFCMSSM KCYRSNAYTI 

       370        380        390        400        410 
TTSSRMAKRN YVGISEIPPV SRTITKDSIY DSFDREAREK KLAWPINSNP PNTFV 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[2]"A novel gene codes for a putative G protein-coupled receptor with an abundant expression in brain."
O'Dowd B.F., Nguyen T., Lynch K.R., Kolakowski L.F. Jr., Thompson M., Cheng R., Marchese A., Ng G.Y.K., Heng H.H.Q., George S.R.
FEBS Lett. 394:325-329(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 42-393.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC089971 mRNA. Translation: AAH89971.1.
U65417 Genomic DNA. Translation: AAB49752.1.
PIRS74238.
RefSeqNP_542146.1. NM_080579.1.
XP_006237585.1. XM_006237523.1.
XP_006237586.1. XM_006237524.1.
UniGeneRn.99370.

3D structure databases

ProteinModelPortalP70585.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000009341.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP70585.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000009341; ENSRNOP00000009341; ENSRNOG00000007126.
GeneID312787.
KEGGrno:312787.
UCSCRGD:71045. rat.

Organism-specific databases

CTD2842.
RGD71045. Gpr19.

Phylogenomic databases

eggNOGNOG318116.
GeneTreeENSGT00730000110635.
HOGENOMHOG000112786.
HOVERGENHBG051799.
InParanoidP70585.
KOK04316.
OMAQLWHPHE.
OrthoDBEOG7SXW36.
PhylomeDBP70585.
TreeFamTF331630.

Gene expression databases

GenevestigatorP70585.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio665257.
PROP70585.

Entry information

Entry nameGPR19_RAT
AccessionPrimary (citable) accession number: P70585
Secondary accession number(s): Q5FVI1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 6, 2005
Last modified: April 16, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries