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Protein

Nuclear pore complex protein Nup54

Gene

Nup54

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane.1 Publication

GO - Molecular functioni

  • nucleocytoplasmic transporter activity Source: UniProtKB
  • structural constituent of nuclear pore Source: GO_Central

GO - Biological processi

  • mRNA transport Source: UniProtKB-KW
  • NLS-bearing protein import into nucleus Source: GO_Central
  • nuclear pore organization Source: GO_Central
  • nucleocytoplasmic transport Source: UniProtKB
  • protein heterooligomerization Source: RGD
  • protein heterotetramerization Source: RGD
  • protein heterotrimerization Source: RGD
  • protein homooligomerization Source: RGD
  • protein localization to nuclear inner membrane Source: GO_Central
  • protein targeting Source: UniProtKB
  • regulation of protein import into nucleus Source: RGD

Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-RNO-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-RNO-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-RNO-191859. snRNP Assembly.
R-RNO-3108214. SUMOylation of DNA damage response and repair proteins.
R-RNO-3301854. Nuclear Pore Complex (NPC) Disassembly.
R-RNO-3371453. Regulation of HSF1-mediated heat shock response.
R-RNO-4551638. SUMOylation of chromatin organization proteins.
R-RNO-4570464. SUMOylation of RNA binding proteins.
R-RNO-4615885. SUMOylation of DNA replication proteins.
R-RNO-5578749. Transcriptional regulation by small RNAs.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear pore complex protein Nup54
Alternative name(s):
54 kDa nucleoporin
Nucleoporin Nup54
Gene namesi
Name:Nup54
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi619926. Nup54.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002048761 – 510Nuclear pore complex protein Nup54Add BLAST510

Post-translational modificationi

O-glycosylated.

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP70582.
PRIDEiP70582.

Expressioni

Gene expression databases

BgeeiENSRNOG00000002247.
GenevisibleiP70582. RN.

Interactioni

Subunit structurei

Component of the p62 complex, a complex composed of NUP62, NUP54, and the isoform p58 and isoform p45 of NUP58. Interacts with NUTF2.1 Publication

Protein-protein interaction databases

BioGridi248440. 2 interactors.
CORUMiP70582.
STRINGi10116.ENSRNOP00000003070.

Structurei

Secondary structure

1510
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi347 – 401Combined sources55
Helixi460 – 488Combined sources29

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3T97X-ray2.80B346-407[»]
3T98X-ray2.50A/C445-494[»]
4J3HX-ray1.50A/B453-494[»]
SMRiP70582.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati5 – 612
Repeati25 – 2622
Repeati28 – 2932
Repeati61 – 6242
Repeati63 – 6452
Repeati67 – 6862
Repeati87 – 8872
Repeati447 – 44882

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni5 – 4488 X 2 AA repeats of F-GAdd BLAST444

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi6 – 89Gly-richAdd BLAST84
Compositional biasi30 – 34Poly-Thr5
Compositional biasi93 – 100Poly-Gln8
Compositional biasi208 – 211Poly-Gln4

Domaini

Contains FG repeats.

Sequence similaritiesi

Belongs to the NUP54 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3091. Eukaryota.
ENOG410XPU5. LUCA.
GeneTreeiENSGT00390000013620.
HOGENOMiHOG000046583.
HOVERGENiHBG052698.
InParanoidiP70582.
KOiK14308.
OMAiWNQLQAY.
OrthoDBiEOG091G0BAH.
PhylomeDBiP70582.
TreeFamiTF320237.

Family and domain databases

InterProiView protein in InterPro
IPR024864. Nup54/Nup57/Nup44.
IPR025712. Nup54_alpha-helical_dom.
PANTHERiPTHR13000. PTHR13000. 1 hit.
PfamiView protein in Pfam
PF13874. Nup54. 1 hit.

Sequencei

Sequence statusi: Complete.

P70582-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFNFGAPSG TSGTSTATAA PAGGFGGFGT TTTTAGSAFS FSAPTNTGST
60 70 80 90 100
GLLGGTQNKG FGFGTGFGTS TGTGTGLGTG LGTGLGFGGF NTQQQQQQQQ
110 120 130 140 150
TSLGGLFSQP AQAPAQSNQL INTASALSAP TLLGDERDAI LAKWNQLQAF
160 170 180 190 200
WGTGKGYFNN NIPPVEFTQE NPFCRFKAVG YSCMPNNKDE DGLVVLIFNK
210 220 230 240 250
KETDIRSQQQ QLVESLHKVL GGNQTLTVNV EGIKTLPDDQ TEVVIYIVER
260 270 280 290 300
SPNGTSRRVP ATTLYAHFEQ ANIKTQLQQL GVTLSMTRTE LSPAQIKQLL
310 320 330 340 350
QNPPAGVDPI IWEQAKVDNP DSEKLIPVPM VGFKELLRRL KVQDQMTKQH
360 370 380 390 400
QTRLDIISED ISELQKNQTT TMAKIAQYKR KLMDLSHRTL QVLIKQEIQR
410 420 430 440 450
KSGYAIQAEE EQLRVQLDTI QGELNAPTQF KGRLNELMSQ IRMQNHFGAV
460 470 480 490 500
KSEEKYYIDA DLLREIKQHL KQQQEGLSHL ISIIKDDLED IKLVEHGLNE
510
TIHSRGGVFS
Length:510
Mass (Da):55,745
Last modified:February 1, 1997 - v1
Checksum:i10454CFED967B910
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63840 mRNA. Translation: AAC52790.1.
BC078858 mRNA. Translation: AAH78858.1.
RefSeqiNP_059057.1. NM_017361.1.
UniGeneiRn.11160.

Genome annotation databases

EnsembliENSRNOT00000003070; ENSRNOP00000003070; ENSRNOG00000002247.
GeneIDi53372.
KEGGirno:53372.
UCSCiRGD:619926. rat.

Similar proteinsi

Entry informationi

Entry nameiNUP54_RAT
AccessioniPrimary (citable) accession number: P70582
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: February 1, 1997
Last modified: September 27, 2017
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families