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UniProtKB - P70581 (NUP58_RAT)

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Protein

Nucleoporin p58/p45

Gene

Nup58

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane.1 Publication

GO - Molecular functioni

  • nuclear localization sequence binding Source: RGD
  • nucleocytoplasmic transporter activity Source: UniProtKB
  • structural constituent of nuclear pore Source: GO_Central
Complete GO annotation...

GO - Biological processi

  • mRNA transport Source: UniProtKB-KW
  • nucleocytoplasmic transport Source: UniProtKB
  • protein heterooligomerization Source: RGD
  • protein heterotetramerization Source: RGD
  • protein heterotrimerization Source: RGD
  • protein homooligomerization Source: RGD
  • protein transport Source: UniProtKB-KW
  • regulation of protein import into nucleus Source: RGD
Complete GO annotation...

Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-RNO-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-RNO-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-RNO-191859. snRNP Assembly.
R-RNO-3108214. SUMOylation of DNA damage response and repair proteins.
R-RNO-3301854. Nuclear Pore Complex (NPC) Disassembly.
R-RNO-3371453. Regulation of HSF1-mediated heat shock response.
R-RNO-4551638. SUMOylation of chromatin organization proteins.
R-RNO-4570464. SUMOylation of RNA binding proteins.
R-RNO-4615885. SUMOylation of DNA replication proteins.
R-RNO-5578749. Transcriptional regulation by small RNAs.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoporin p58/p45Curated
Alternative name(s):
58 kDa nucleoporinImported
Nucleoporin-like protein 1
Gene namesi
Name:Nup58Imported
Synonyms:Nupl1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi631334. Nup58.

Subcellular locationi

  • Nucleus › nuclear pore complex 1 Publication
  • Nucleus membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication
  • Nucleus membrane 1 Publication; Peripheral membrane protein 1 Publication; Nucleoplasmic side 1 Publication

    • Note: Biased towards cytoplasmic side. Central region of the nuclear pore complex, within the transporter.

GO - Cellular componenti

  • nuclear envelope Source: RGD
  • nuclear membrane Source: UniProtKB-SubCell
  • nuclear pore Source: UniProtKB
  • protein complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002048941 – 585Nucleoporin p58/p45Add BLAST585

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei317PhosphothreonineBy similarity1

Post-translational modificationi

O-glycosylated.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP70581.
PRIDEiP70581.

Expressioni

Tissue specificityi

Expressed in liver.1 Publication

Gene expression databases

BgeeiENSRNOG00000012644.
ExpressionAtlasiP70581. baseline.
GenevisibleiP70581. RN.

Interactioni

Subunit structurei

Component of the p62 complex, a complex composed of NUP62, NUP54, and isoform p58 and isoform p45 of NUP58. Isoform p58 interacts with NUTF2. Isoform p58 interacts with SRP1-alpha and Importin p97 proteins when they are together, but not with SRP1-alpha protein alone.1 Publication

Protein-protein interaction databases

BioGridi251446. 1 interactor.
STRINGi10116.ENSRNOP00000017204.

Structurei

Secondary structure

1585
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi328 – 357Combined sources30
Helixi360 – 363Combined sources4
Helixi368 – 410Combined sources43

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OSZX-ray2.85A/B/C/D327-415[»]
3T98X-ray2.50B327-415[»]
ProteinModelPortaliP70581.
SMRiP70581.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP70581.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati7 – 812
Repeati30 – 3122
Repeati42 – 4332
Repeati61 – 6242
Repeati66 – 6752
Repeati474 – 47562
Repeati478 – 47972
Repeati499 – 50082
Repeati505 – 50692
Repeati515 – 516102
Repeati517 – 518112
Repeati531 – 532122
Repeati554 – 555132
Repeati564 – 565142

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni7 – 56514 X 2 AA repeats of F-GAdd BLAST559

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili242 – 262Sequence analysisAdd BLAST21
Coiled coili300 – 367Sequence analysisAdd BLAST68

Domaini

Contains FG repeats.

Sequence similaritiesi

Belongs to the NUP58 family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IIR3. Eukaryota.
ENOG410ZJAM. LUCA.
GeneTreeiENSGT00730000111111.
HOGENOMiHOG000273874.
HOVERGENiHBG052703.
InParanoidiP70581.
KOiK14307.
OMAiIQGRVQI.
OrthoDBiEOG091G0KUR.
PhylomeDBiP70581.

Family and domain databases

InterProiView protein in InterPro
IPR024882. Nucleoporin_p58/p45.
PANTHERiPTHR13437. PTHR13437. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform p58 (identifier: P70581-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATGFSFGSG TLGSTTVAPG GTGTGSGFSF GASSTPSVGL NFGTLGSSAT 
        60         70         80         90        100
PASTSTSASG FGTGLFGSKP GTGFTLGGTS AGTTATTSAS TTGFSLGFSK 
       110        120        130        140        150
PAASATPFAL PVTSTTASGL TLSSALTSAP AASTGFTLNN LGATPATTTA 
       160        170        180        190        200
ASTGLSLGGA LAGLGGSLFQ SGNTATSGLG QNALSLSLGT ATPTSAASSE 
       210        220        230        240        250
GLGGIDFSTS SDKKSDKTGT RPEDSKALKD ENLPPVICQD VENLQKFVKE 
       260        270        280        290        300
QKQVQEEISR MSSKAMLKVQ EDIKALKQLL SLAASGLQRN TLNIDKLKLE 
       310        320        330        340        350
TAQELKNAEI ALRTQKTPPG LQHENTAPAD YFRVLVQQFE VQLQQYRQQI 
       360        370        380        390        400
EELENHLATQ ANNSHITPQD LSMAMQKIYQ TFVALAAQLQ SIHENVKVLK 
       410        420        430        440        450
EQYLSYRKMF LGDAGDVFEA RRTEAKKWQN APRVTTGPTP FSTMPNAAAV 
       460        470        480        490        500
AMAATLTQQQ QPATGPQPSL GVSFGTPFGS GIGTGLQSSG LGSSNLGGFG 
       510        520        530        540        550
TSSGFGCGTT GASTFGFGTT DKPSGSLSAG FGSSSTSGFN FSNPGITASA 
       560        570        580 
GLTFGVSNPA SAGFGTGGQL LQLKRPPAGN KRGKR
Length:585
Mass (Da):59,265
Last modified:February 1, 1997 - v1
Checksum:i4D5F5C2744A75C3C
GO
Isoform p45 (identifier: P70581-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     224-245: Missing.
     531-535: FGSSS → LCASA
     536-585: Missing.

Show »
Length:513
Mass (Da):51,821
Checksum:iC70EC7465F5AAD0B
GO
Isoform p23 (identifier: P70581-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-260: Missing.
     328-337: PADYFRVLVQ → SPDDERLQVH
     466-468: PQP → DGW
     469-585: Missing.

Note: No experimental confirmation available.
Show »
Length:208
Mass (Da):23,325
Checksum:i372EE982D097DBCD
GO
Isoform H6 (identifier: P70581-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     466-471: PQPSLG → LNAFKL
     472-585: Missing.

Note: No experimental confirmation available.
Show »
Length:471
Mass (Da):48,579
Checksum:i689BE7709B203C17
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0085821 – 260Missing in isoform p23. 1 PublicationAdd BLAST260
Alternative sequenceiVSP_008579224 – 245Missing in isoform p45. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_008576328 – 337PADYFRVLVQ → SPDDERLQVH in isoform p23. 1 Publication10
Alternative sequenceiVSP_008583466 – 471PQPSLG → LNAFKL in isoform H6. Curated6
Alternative sequenceiVSP_008577466 – 468PQP → DGW in isoform p23. 1 Publication3
Alternative sequenceiVSP_008578469 – 585Missing in isoform p23. 1 PublicationAdd BLAST117
Alternative sequenceiVSP_008584472 – 585Missing in isoform H6. CuratedAdd BLAST114
Alternative sequenceiVSP_008580531 – 535FGSSS → LCASA in isoform p45. 1 Publication5
Alternative sequenceiVSP_008581536 – 585Missing in isoform p45. 1 PublicationAdd BLAST50

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63839 mRNA. Translation: AAC52789.1.
AH007036 mRNA. Translation: AAC82539.1.
AF000900 mRNA. Translation: AAC82318.1.
BC085690 mRNA. Translation: AAH85690.1.
AF000901 mRNA. Translation: AAC82319.1.
RefSeqiNP_620791.1. NM_139091.2. [P70581-1]
UniGeneiRn.11099.

Genome annotation databases

EnsembliENSRNOT00000017204; ENSRNOP00000017204; ENSRNOG00000012644. [P70581-1]
GeneIDi245922.
KEGGirno:245922.
UCSCiRGD:631334. rat. [P70581-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiNUP58_RAT
AccessioniPrimary (citable) accession number: P70581
Secondary accession number(s): Q9JHE1, Q9QWK7, Q9Z2W7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: February 1, 1997
Last modified: July 5, 2017
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families