UniProtKB - P70581 (NUP58_RAT)
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Nucleoporin p58/p45
Nup58
Functioni
GO - Molecular functioni
- nuclear localization sequence binding Source: RGD
- structural constituent of nuclear pore Source: UniProtKB
GO - Biological processi
- mRNA transport Source: UniProtKB-KW
- nucleocytoplasmic transport Source: UniProtKB
- protein heterooligomerization Source: RGD
- protein heterotetramerization Source: RGD
- protein heterotrimerization Source: RGD
- protein homooligomerization Source: RGD
- protein transport Source: UniProtKB-KW
- regulation of protein import into nucleus Source: RGD
Keywordsi
Biological process | mRNA transport, Protein transport, Translocation, Transport |
Enzyme and pathway databases
Reactomei | R-RNO-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript. R-RNO-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein. R-RNO-191859. snRNP Assembly. R-RNO-3108214. SUMOylation of DNA damage response and repair proteins. R-RNO-3301854. Nuclear Pore Complex (NPC) Disassembly. R-RNO-3371453. Regulation of HSF1-mediated heat shock response. R-RNO-4551638. SUMOylation of chromatin organization proteins. R-RNO-4570464. SUMOylation of RNA binding proteins. R-RNO-4615885. SUMOylation of DNA replication proteins. R-RNO-5578749. Transcriptional regulation by small RNAs. |
Names & Taxonomyi
Protein namesi | Recommended name: Nucleoporin p58/p45CuratedAlternative name(s): 58 kDa nucleoporinImported Nucleoporin-like protein 1 |
Gene namesi | |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 631334. Nup58. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000204894 | 1 – 585 | Nucleoporin p58/p45Add BLAST | 585 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 317 | PhosphothreonineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | P70581. |
PRIDEi | P70581. |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSRNOG00000012644. |
ExpressionAtlasi | P70581. baseline. |
Genevisiblei | P70581. RN. |
Interactioni
Subunit structurei
Protein-protein interaction databases
BioGridi | 251446. 1 interactor. |
CORUMi | P70581. |
STRINGi | 10116.ENSRNOP00000017204. |
Structurei
Secondary structure
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Helixi | 328 – 357 | Combined sources | 30 | |
Helixi | 360 – 363 | Combined sources | 4 | |
Helixi | 368 – 410 | Combined sources | 43 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2OSZ | X-ray | 2.85 | A/B/C/D | 327-415 | [»] | |
3T98 | X-ray | 2.50 | B | 327-415 | [»] | |
ProteinModelPortali | P70581. | |||||
SMRi | P70581. | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P70581. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 7 – 8 | 1 | 2 | |
Repeati | 30 – 31 | 2 | 2 | |
Repeati | 42 – 43 | 3 | 2 | |
Repeati | 61 – 62 | 4 | 2 | |
Repeati | 66 – 67 | 5 | 2 | |
Repeati | 474 – 475 | 6 | 2 | |
Repeati | 478 – 479 | 7 | 2 | |
Repeati | 499 – 500 | 8 | 2 | |
Repeati | 505 – 506 | 9 | 2 | |
Repeati | 515 – 516 | 10 | 2 | |
Repeati | 517 – 518 | 11 | 2 | |
Repeati | 531 – 532 | 12 | 2 | |
Repeati | 554 – 555 | 13 | 2 | |
Repeati | 564 – 565 | 14 | 2 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 7 – 565 | 14 X 2 AA repeats of F-GAdd BLAST | 559 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 242 – 262 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 300 – 367 | Sequence analysisAdd BLAST | 68 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coil, RepeatPhylogenomic databases
eggNOGi | ENOG410IIR3. Eukaryota. ENOG410ZJAM. LUCA. |
GeneTreei | ENSGT00730000111111. |
HOGENOMi | HOG000273874. |
HOVERGENi | HBG052703. |
InParanoidi | P70581. |
KOi | K14307. |
OMAi | HIQGRVQ. |
OrthoDBi | EOG091G0KUR. |
PhylomeDBi | P70581. |
Family and domain databases
InterProi | View protein in InterPro IPR024882. Nucleoporin_p58/p45. |
PANTHERi | PTHR13437. PTHR13437. 1 hit. |
s (4)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MATGFSFGSG TLGSTTVAPG GTGTGSGFSF GASSTPSVGL NFGTLGSSAT
60 70 80 90 100
PASTSTSASG FGTGLFGSKP GTGFTLGGTS AGTTATTSAS TTGFSLGFSK
110 120 130 140 150
PAASATPFAL PVTSTTASGL TLSSALTSAP AASTGFTLNN LGATPATTTA
160 170 180 190 200
ASTGLSLGGA LAGLGGSLFQ SGNTATSGLG QNALSLSLGT ATPTSAASSE
210 220 230 240 250
GLGGIDFSTS SDKKSDKTGT RPEDSKALKD ENLPPVICQD VENLQKFVKE
260 270 280 290 300
QKQVQEEISR MSSKAMLKVQ EDIKALKQLL SLAASGLQRN TLNIDKLKLE
310 320 330 340 350
TAQELKNAEI ALRTQKTPPG LQHENTAPAD YFRVLVQQFE VQLQQYRQQI
360 370 380 390 400
EELENHLATQ ANNSHITPQD LSMAMQKIYQ TFVALAAQLQ SIHENVKVLK
410 420 430 440 450
EQYLSYRKMF LGDAGDVFEA RRTEAKKWQN APRVTTGPTP FSTMPNAAAV
460 470 480 490 500
AMAATLTQQQ QPATGPQPSL GVSFGTPFGS GIGTGLQSSG LGSSNLGGFG
510 520 530 540 550
TSSGFGCGTT GASTFGFGTT DKPSGSLSAG FGSSSTSGFN FSNPGITASA
560 570 580
GLTFGVSNPA SAGFGTGGQL LQLKRPPAGN KRGKR
The sequence of this isoform differs from the canonical sequence as follows:
224-245: Missing.
531-535: FGSSS → LCASA
536-585: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-260: Missing.
328-337: PADYFRVLVQ → SPDDERLQVH
466-468: PQP → DGW
469-585: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
466-471: PQPSLG → LNAFKL
472-585: Missing.
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_008582 | 1 – 260 | Missing in isoform p23. 1 PublicationAdd BLAST | 260 | |
Alternative sequenceiVSP_008579 | 224 – 245 | Missing in isoform p45. 1 PublicationAdd BLAST | 22 | |
Alternative sequenceiVSP_008576 | 328 – 337 | PADYFRVLVQ → SPDDERLQVH in isoform p23. 1 Publication | 10 | |
Alternative sequenceiVSP_008583 | 466 – 471 | PQPSLG → LNAFKL in isoform H6. Curated | 6 | |
Alternative sequenceiVSP_008577 | 466 – 468 | PQP → DGW in isoform p23. 1 Publication | 3 | |
Alternative sequenceiVSP_008578 | 469 – 585 | Missing in isoform p23. 1 PublicationAdd BLAST | 117 | |
Alternative sequenceiVSP_008584 | 472 – 585 | Missing in isoform H6. CuratedAdd BLAST | 114 | |
Alternative sequenceiVSP_008580 | 531 – 535 | FGSSS → LCASA in isoform p45. 1 Publication | 5 | |
Alternative sequenceiVSP_008581 | 536 – 585 | Missing in isoform p45. 1 PublicationAdd BLAST | 50 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U63839 mRNA. Translation: AAC52789.1. AH007036 mRNA. Translation: AAC82539.1. AF000900 mRNA. Translation: AAC82318.1. BC085690 mRNA. Translation: AAH85690.1. AF000901 mRNA. Translation: AAC82319.1. |
RefSeqi | NP_620791.1. NM_139091.2. [P70581-1] |
UniGenei | Rn.11099. |
Genome annotation databases
Ensembli | ENSRNOT00000017204; ENSRNOP00000017204; ENSRNOG00000012644. [P70581-1] |
GeneIDi | 245922. |
KEGGi | rno:245922. |
UCSCi | RGD:631334. rat. [P70581-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Entry informationi
Entry namei | NUP58_RAT | |
Accessioni | P70581Primary (citable) accession number: P70581 Secondary accession number(s): Q9JHE1, Q9QWK7, Q9Z2W7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 10, 2003 |
Last sequence update: | February 1, 1997 | |
Last modified: | March 28, 2018 | |
This is version 128 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |