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Protein

Membrane-associated progesterone receptor component 1

Gene

Pgrmc1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs). May be implicated in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) immunotoxicity (PubMed:9006096).By similarity1 Publication

Miscellaneous

Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2).By similarity

GO - Molecular functioni

GO - Biological processi

  • associative learning Source: ARUK-UCL
  • axon guidance Source: RGD
  • memory Source: ARUK-UCL
  • modification of synaptic structure Source: ARUK-UCL
  • negative regulation of synapse organization Source: ARUK-UCL
  • positive regulation of protein localization to plasma membrane Source: ARUK-UCL

Keywordsi

Molecular functionReceptor
LigandLipid-binding, Steroid-binding

Enzyme and pathway databases

ReactomeiR-RNO-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-associated progesterone receptor component 1
Short name:
mPRBy similarity
Alternative name(s):
25-DX1 Publication
Acidic 25 kDa protein1 Publication
Ventral midline antigen1 Publication
Short name:
VEMA1 Publication
Gene namesi
Name:Pgrmc1Imported
Synonyms:25dx, Lewi, Pgrmc
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi70890. Pgrmc1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 24LumenalSequence analysisAdd BLAST23
Transmembranei25 – 43HelicalSequence analysisAdd BLAST19
Topological domaini44 – 195CytoplasmicSequence analysisAdd BLAST152

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001217422 – 195Membrane-associated progesterone receptor component 1Add BLAST194

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei54PhosphoserineBy similarity1
Modified residuei74PhosphothreonineBy similarity1
Modified residuei181PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP70580.
PRIDEiP70580.

PTM databases

iPTMnetiP70580.
PhosphoSitePlusiP70580.

Expressioni

Tissue specificityi

Expressed at high levels in lung, liver, kidney and brain, low in testis and spleen. Not expressed in heart and skeletal muscle.

Inductioni

By dioxin.

Gene expression databases

BgeeiENSRNOG00000012786.
ExpressionAtlasiP70580. baseline.
GenevisibleiP70580. RN.

Interactioni

Subunit structurei

Homodimer. Forms stable homodimer through hydrophobic heme-heme stacking interactions.By similarity

Protein-protein interaction databases

BioGridi253702. 1 interactor.
MINTiMINT-4567455.
STRINGi10116.ENSRNOP00000017101.

Chemistry databases

BindingDBiP70580.

Structurei

3D structure databases

ProteinModelPortaliP70580.
SMRiP70580.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 171Cytochrome b5 heme-bindingAdd BLAST100

Domaini

The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 107 and 131.By similarity

Sequence similaritiesi

Belongs to the cytochrome b5 family. MAPR subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1110. Eukaryota.
ENOG4111UG0. LUCA.
GeneTreeiENSGT00730000110959.
HOGENOMiHOG000187840.
HOVERGENiHBG059971.
InParanoidiP70580.
KOiK17278.
OrthoDBiEOG091G0PXT.
PhylomeDBiP70580.

Family and domain databases

Gene3Di3.10.120.10. 1 hit.
InterProiView protein in InterPro
IPR001199. Cyt_B5-like_heme/steroid-bd.
IPR036400. Cyt_B5-like_heme/steroid_sf.
PfamiView protein in Pfam
PF00173. Cyt-b5. 1 hit.
SMARTiView protein in SMART
SM01117. Cyt-b5. 1 hit.
SUPFAMiSSF55856. SSF55856. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70580-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAEDVVATG ADPSELEGGG LLQEIFTSPL NLLLLGLCIF LLYKIVRGDQ
60 70 80 90 100
PGASGDNDDD EPPPLPRLKP RDFTPAELRR YDGVQDPRIL MAINGKVFDV
110 120 130 140 150
TKGRKFYGPE GPYGVFAGRD ASRGLATFCL DKEALKDEYD DLSDLTPAQQ
160 170 180 190
ETLNDWDSQF TFKYHHVGKL LKEGEEPTVY SDDEEPKDEA ARKSD
Length:195
Mass (Da):21,598
Last modified:January 23, 2007 - v3
Checksum:i1E8F8605AA3098A2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti161 – 167TFKYHHV → SSPSSTITW in AAB07125 (PubMed:9006096).Curated7
Sequence conflicti172 – 174KEG → EGA in AAB07125 (PubMed:9006096).Curated3
Sequence conflicti178T → I in AAB07125 (PubMed:9006096).Curated1
Sequence conflicti186 – 195PKDEAARKSD → QKMRLLGRVTEAVSGAYLFL YFAKSFVTFQSVFTTW in AAB07125 (PubMed:9006096).Curated10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63315 mRNA. Translation: AAB07125.1.
AJ005837 mRNA. Translation: CAA06732.1.
AF163321 mRNA. Translation: AAF17359.1.
BC062073 mRNA. Translation: AAH62073.1.
RefSeqiNP_068534.1. NM_021766.1.
UniGeneiRn.102356.

Genome annotation databases

EnsembliENSRNOT00000079231; ENSRNOP00000071066; ENSRNOG00000012786.
GeneIDi291948.
KEGGirno:291948.
UCSCiRGD:70890. rat.

Similar proteinsi

Entry informationi

Entry nameiPGRC1_RAT
AccessioniPrimary (citable) accession number: P70580
Secondary accession number(s): O70606, Q549C4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: November 22, 2017
This is version 134 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families