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Protein

Membrane-associated progesterone receptor component 1

Gene

Pgrmc1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for progesterone (By similarity). May be implicated in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) immunotoxicity.By similarity

GO - Molecular functioni

GO - Biological processi

  • axon guidance Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

Lipid-binding, Steroid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-associated progesterone receptor component 1
Alternative name(s):
25-DX
Acidic 25 kDa protein
Ventral midline antigen
Short name:
VEMA
Gene namesi
Name:Pgrmc1
Synonyms:25dx, Lewi, Pgrmc
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi70890. Pgrmc1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 2423LumenalSequence analysisAdd
BLAST
Transmembranei25 – 4319HelicalSequence analysisAdd
BLAST
Topological domaini44 – 195152CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 195194Membrane-associated progesterone receptor component 1PRO_0000121742Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei54 – 541PhosphoserineBy similarity
Modified residuei74 – 741PhosphothreonineBy similarity
Modified residuei181 – 1811PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP70580.
PRIDEiP70580.

PTM databases

iPTMnetiP70580.
PhosphoSiteiP70580.

Expressioni

Tissue specificityi

Expressed at high levels in lung, liver, kidney and brain, low in testis and spleen. Not expressed in heart and skeletal muscle.

Inductioni

By dioxin.

Gene expression databases

ExpressionAtlasiP70580. baseline and differential.
GenevisibleiP70580. RN.

Interactioni

Protein-protein interaction databases

BioGridi253702. 1 interaction.
MINTiMINT-4567455.
STRINGi10116.ENSRNOP00000017101.

Chemistry

BindingDBiP70580.

Structurei

3D structure databases

ProteinModelPortaliP70580.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini72 – 171100Cytochrome b5 heme-bindingAdd
BLAST

Domaini

The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 107 and 131.By similarity

Sequence similaritiesi

Belongs to the cytochrome b5 family. MAPR subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1110. Eukaryota.
ENOG4111UG0. LUCA.
GeneTreeiENSGT00730000110959.
HOGENOMiHOG000187840.
HOVERGENiHBG059971.
InParanoidiP70580.
KOiK17278.
OMAiAYDKEIG.
OrthoDBiEOG7KWSKJ.
PhylomeDBiP70580.

Family and domain databases

Gene3Di3.10.120.10. 1 hit.
InterProiIPR001199. Cyt_B5-like_heme/steroid-bd.
[Graphical view]
PfamiPF00173. Cyt-b5. 1 hit.
[Graphical view]
SMARTiSM01117. Cyt-b5. 1 hit.
[Graphical view]
SUPFAMiSSF55856. SSF55856. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70580-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAEDVVATG ADPSELEGGG LLQEIFTSPL NLLLLGLCIF LLYKIVRGDQ
60 70 80 90 100
PGASGDNDDD EPPPLPRLKP RDFTPAELRR YDGVQDPRIL MAINGKVFDV
110 120 130 140 150
TKGRKFYGPE GPYGVFAGRD ASRGLATFCL DKEALKDEYD DLSDLTPAQQ
160 170 180 190
ETLNDWDSQF TFKYHHVGKL LKEGEEPTVY SDDEEPKDEA ARKSD
Length:195
Mass (Da):21,598
Last modified:January 23, 2007 - v3
Checksum:i1E8F8605AA3098A2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti161 – 1677TFKYHHV → SSPSSTITW in AAB07125 (PubMed:9006096).Curated
Sequence conflicti172 – 1743KEG → EGA in AAB07125 (PubMed:9006096).Curated
Sequence conflicti178 – 1781T → I in AAB07125 (PubMed:9006096).Curated
Sequence conflicti186 – 19510PKDEAARKSD → QKMRLLGRVTEAVSGAYLFL YFAKSFVTFQSVFTTW in AAB07125 (PubMed:9006096).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63315 mRNA. Translation: AAB07125.1.
AJ005837 mRNA. Translation: CAA06732.1.
AF163321 mRNA. Translation: AAF17359.1.
BC062073 mRNA. Translation: AAH62073.1.
RefSeqiNP_068534.1. NM_021766.1.
UniGeneiRn.102356.

Genome annotation databases

EnsembliENSRNOT00000079231; ENSRNOP00000071066; ENSRNOG00000012786.
GeneIDi291948.
KEGGirno:291948.
UCSCiRGD:70890. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63315 mRNA. Translation: AAB07125.1.
AJ005837 mRNA. Translation: CAA06732.1.
AF163321 mRNA. Translation: AAF17359.1.
BC062073 mRNA. Translation: AAH62073.1.
RefSeqiNP_068534.1. NM_021766.1.
UniGeneiRn.102356.

3D structure databases

ProteinModelPortaliP70580.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi253702. 1 interaction.
MINTiMINT-4567455.
STRINGi10116.ENSRNOP00000017101.

Chemistry

BindingDBiP70580.

PTM databases

iPTMnetiP70580.
PhosphoSiteiP70580.

Proteomic databases

PaxDbiP70580.
PRIDEiP70580.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000079231; ENSRNOP00000071066; ENSRNOG00000012786.
GeneIDi291948.
KEGGirno:291948.
UCSCiRGD:70890. rat.

Organism-specific databases

CTDi10857.
RGDi70890. Pgrmc1.

Phylogenomic databases

eggNOGiKOG1110. Eukaryota.
ENOG4111UG0. LUCA.
GeneTreeiENSGT00730000110959.
HOGENOMiHOG000187840.
HOVERGENiHBG059971.
InParanoidiP70580.
KOiK17278.
OMAiAYDKEIG.
OrthoDBiEOG7KWSKJ.
PhylomeDBiP70580.

Miscellaneous databases

PROiP70580.

Gene expression databases

ExpressionAtlasiP70580. baseline and differential.
GenevisibleiP70580. RN.

Family and domain databases

Gene3Di3.10.120.10. 1 hit.
InterProiIPR001199. Cyt_B5-like_heme/steroid-bd.
[Graphical view]
PfamiPF00173. Cyt-b5. 1 hit.
[Graphical view]
SMARTiSM01117. Cyt-b5. 1 hit.
[Graphical view]
SUPFAMiSSF55856. SSF55856. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of a novel gene induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat liver."
    Selmin O., Lucier G.W., Clark G.C., Tritscher A.M., Vanden Heuvel J.P., Gastel J.A., Walker N.J., Sutter T.R., Bell D.A.
    Carcinogenesis 17:2609-2615(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Liver.
  2. "Rat homologue to a putative progesterone binding protein: molecular characterization and localization."
    Noelte I., Sohn K., Wegehingl S., Wieland F.
    Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Fischer 344.
    Tissue: Liver.
  3. "Cloning and expression of VEMA: a novel ventral midline antigen in the rat CNS."
    Runko E., Wideman C., Kaprielian Z.
    Mol. Cell. Neurosci. 14:428-443(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Spinal cord.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  5. "Acidic 25-kDa protein in rat liver microsomes."
    Hubbard M.J., McHugh N.J.
    Submitted (JUL-1999) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-15.
    Strain: Wistar.
    Tissue: Liver.
  6. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
    Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.
    Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-181, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-181, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPGRC1_RAT
AccessioniPrimary (citable) accession number: P70580
Secondary accession number(s): O70606, Q549C4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.