UniProtKB - P70579 (GRM8_RAT)
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Protein
Metabotropic glutamate receptor 8
Gene
Grm8
Organism
Rattus norvegicus (Rat)
Status
Functioni
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 156 | GlutamateBy similarity | 1 | |
Binding sitei | 227 | GlutamateBy similarity | 1 | |
Binding sitei | 309 | GlutamateBy similarity | 1 | |
Binding sitei | 401 | GlutamateBy similarity | 1 |
GO - Molecular functioni
- glutamate receptor activity Source: UniProtKB
- G-protein coupled receptor activity Source: UniProtKB
- group III metabotropic glutamate receptor activity Source: RGD
GO - Biological processi
- adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway Source: UniProtKB
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: RGD
- chemical synaptic transmission Source: UniProtKB
- detection of mechanical stimulus involved in sensory perception of pain Source: RGD
- negative regulation of cAMP biosynthetic process Source: RGD
- regulation of neuron death Source: UniProtKB
- regulation of neurotransmitter secretion Source: UniProtKB
- regulation of synaptic transmission, glutamatergic Source: GO_Central
- sensory perception of pain Source: UniProtKB
- synaptic transmission, glutamatergic Source: UniProtKB
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Sensory transduction |
Names & Taxonomyi
Protein namesi | Recommended name: Metabotropic glutamate receptor 8Short name: mGluR8 |
Gene namesi | Name:Grm8 Synonyms:Gprc1h, Mglur8 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 619858. Grm8. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 34 – 583 | ExtracellularSequence analysisAdd BLAST | 550 | |
Transmembranei | 584 – 608 | Helical; Name=1Sequence analysisAdd BLAST | 25 | |
Topological domaini | 609 – 620 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 621 – 641 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 642 – 647 | ExtracellularSequence analysis | 6 | |
Transmembranei | 648 – 668 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 669 – 695 | CytoplasmicSequence analysisAdd BLAST | 27 | |
Transmembranei | 696 – 716 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 717 – 746 | ExtracellularSequence analysisAdd BLAST | 30 | |
Transmembranei | 747 – 768 | Helical; Name=5Sequence analysisAdd BLAST | 22 | |
Topological domaini | 769 – 781 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 782 – 803 | Helical; Name=6Sequence analysisAdd BLAST | 22 | |
Topological domaini | 804 – 818 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 819 – 843 | Helical; Name=7Sequence analysisAdd BLAST | 25 | |
Topological domaini | 844 – 908 | CytoplasmicSequence analysisAdd BLAST | 65 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 33 | Sequence analysisAdd BLAST | 33 | |
ChainiPRO_0000012943 | 34 – 908 | Metabotropic glutamate receptor 8Add BLAST | 875 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 64 ↔ 106 | By similarity | ||
Glycosylationi | 95 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 246 ↔ 534 | By similarity | ||
Glycosylationi | 298 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 369 ↔ 384 | By similarity | ||
Disulfide bondi | 424 ↔ 431 | By similarity | ||
Glycosylationi | 452 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 480 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 516 ↔ 535 | By similarity | ||
Disulfide bondi | 520 ↔ 538 | By similarity | ||
Disulfide bondi | 541 ↔ 553 | By similarity | ||
Disulfide bondi | 556 ↔ 569 | By similarity | ||
Glycosylationi | 565 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Cross-linki | 882 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity |
Keywords - PTMi
Disulfide bond, Glycoprotein, Isopeptide bond, Ubl conjugationProteomic databases
PaxDbi | P70579. |
PRIDEi | P70579. |
PTM databases
PhosphoSitePlusi | P70579. |
Expressioni
Tissue specificityi
Prominent expression in olfactory bulb, pontine gray, lateral reticular nucleus of the thalamus, and piriform cortex. Less abundant expression incerebral cortex, hippocampus, cerebellum, and mammillary body.
Interactioni
Subunit structurei
Interacts with PICK1.1 Publication
Protein-protein interaction databases
BioGridi | 248875. 14 interactors. |
IntActi | P70579. 5 interactors. |
MINTi | P70579. |
STRINGi | 10116.ENSRNOP00000053829. |
Chemistry databases
BindingDBi | P70579. |
Structurei
3D structure databases
ProteinModelPortali | P70579. |
SMRi | P70579. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 177 – 179 | Glutamate bindingBy similarity | 3 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 3 family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
HOGENOMi | HOG000218635. |
HOVERGENi | HBG107965. |
InParanoidi | P70579. |
KOi | K04608. |
PhylomeDBi | P70579. |
Family and domain databases
Gene3Di | 2.10.50.30. 1 hit. |
InterProi | View protein in InterPro IPR001828. ANF_lig-bd_rcpt. IPR000337. GPCR_3. IPR011500. GPCR_3_9-Cys_dom. IPR038550. GPCR_3_9-Cys_sf. IPR017978. GPCR_3_C. IPR017979. GPCR_3_CS. IPR000162. GPCR_3_mtglu_rcpt. IPR000144. GPCR_3_mtglu_rcpt_8. IPR028082. Peripla_BP_I. |
Pfami | View protein in Pfam PF00003. 7tm_3. 1 hit. PF01094. ANF_receptor. 1 hit. PF07562. NCD3G. 1 hit. |
PRINTSi | PR00248. GPCRMGR. PR01058. MTABOTROPC8R. PR00593. MTABOTROPICR. |
SUPFAMi | SSF53822. SSF53822. 1 hit. |
PROSITEi | View protein in PROSITE PS00979. G_PROTEIN_RECEP_F3_1. 1 hit. PS00980. G_PROTEIN_RECEP_F3_2. 1 hit. PS00981. G_PROTEIN_RECEP_F3_3. 1 hit. PS50259. G_PROTEIN_RECEP_F3_4. 1 hit. |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P70579-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVCEGKRLAS CPCFFLLTAK FYWILTMMQR THSQEYAHSI RVDGDIILGG
60 70 80 90 100
LFPVHAKGER GVPCGELKKE KGIHRLEAML YAIDQINKDP DLLSNITLGV
110 120 130 140 150
RILDTCSRDT YALEQSLTFV QALIEKDASD VKCANGDPPI FTKPDKISGV
160 170 180 190 200
IGAAASSVSI MVANILRLFK IPQISYASTA PELSDNTRYD FFSRVVPPDS
210 220 230 240 250
YQAQAMVDIV TALGWNYVST LASEGNYGES GVEAFTQISR EIGGVCIAQS
260 270 280 290 300
QKIPREPRPG EFEKIIKRLL ETPNARAVIM FANEDDIRRI LEAAKKLNQS
310 320 330 340 350
GHFLWIGSDS WGSKIAPVYQ QEEIAEGAVT ILPKRASIDG FDRYFRSRTL
360 370 380 390 400
ANNRRNVWFA EFWEENFGCK LGSHGKRNSH IKKCTGLERI ARDSSYEQEG
410 420 430 440 450
KVQFVIDAVY SMAYALHNMH KERCPGYIGL CPRMVTIDGK ELLGYIRAVN
460 470 480 490 500
FNGSAGTPVT FNENGDAPGR YDIFQYQINN KSTEYKIIGH WTNQLHLKVE
510 520 530 540 550
DMQWANREHT HPASVCSLPC KPGERKKTVK GVPCCWHCER CEGYNYQVDE
560 570 580 590 600
LSCELCPLDQ RPNINRTGCQ RIPIIKLEWH SPWAVVPVFI AILGIIATTF
610 620 630 640 650
VIVTFVRYND TPIVRASGRE LSYVLLTGIF LCYSITFLMI AAPDTIICSF
660 670 680 690 700
RRIFLGLGMC FSYAALLTKT NRIHRIFEQG KKSVTAPKFI SPASQLVITF
710 720 730 740 750
SLISVQLLGV FVWFVVDPPH TIIDYGEQRT LDPENARGVL KCDISDLSLI
760 770 780 790 800
CSLGYSILLM VTCTVYAIKT RGVPETFNEA KPIGFTMYTT CIIWLAFIPI
810 820 830 840 850
FFGTAQSAEK MYIQTTTLTV SMSLSASVSL GMLYMPKVYI IIFHPEQNVQ
860 870 880 890 900
KRKRSFKAVV TAATMQSKLI QKGNDRPNGE VKSELCESLE TNTSSTKTTY
ISYSNHSI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U63288 mRNA. Translation: AAB09537.1. |
RefSeqi | NP_071538.1. NM_022202.1. |
UniGenei | Rn.44420. |
Genome annotation databases
GeneIDi | 60590. |
KEGGi | rno:60590. |
UCSCi | RGD:619858. rat. |
Similar proteinsi
Entry informationi
Entry namei | GRM8_RAT | |
Accessioni | P70579Primary (citable) accession number: P70579 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | February 1, 1997 | |
Last modified: | March 28, 2018 | |
This is version 137 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |