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P70566 (TMOD2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tropomodulin-2
Alternative name(s):
Neuronal tropomodulin
Short name=N-Tmod
Gene names
Name:Tmod2
Synonyms:Ntmod
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length351 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton By similarity.

Subunit structure

Binds to the N-terminus of tropomyosin and to actin. Binds to TMBr3 as well as to other low molecular mass tropomyosins (TM5a or TM5), but not to high molecular mass tropomyosins (TM2 or TMBr1).

Subcellular location

Cytoplasmcytoskeleton By similarity.

Tissue specificity

Neuronal-tissue specific.

Sequence similarities

Belongs to the tropomodulin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 351351Tropomodulin-2
PRO_0000186133

Sequences

Sequence LengthMass (Da)Tools
P70566 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 24F5C67EA897983E

FASTA35139,492
        10         20         30         40         50         60 
MALPFQKGLE KYKNIDEDEL LGKLSEEELK QLENVLDDLD PESATLPAGF RQKDQTQKAA 

        70         80         90        100        110        120 
TGPFDREHLL MYLEKEALEQ KDREDFVPFT GEKKGRVFIP KEKPVETRKE EKVTLDPELE 

       130        140        150        160        170        180 
EALASASDTE LYDLAAVLGV HNLLNNPKFD EETTNGQGRK GPVRNVVKGE KAKPVFEEPP 

       190        200        210        220        230        240 
NPTNVEASLQ QMKANDPSLQ EVNLNNIKNI PIPTLKEFAK ALETNTHVRK FSLAATRSND 

       250        260        270        280        290        300 
PVALAFAEML KVNKTLKSLN VESNFITGAG ILALVEALRE NDTLTEIKID NQRQQLGTAV 

       310        320        330        340        350 
EMEIAQMLEE NSRILKFGYQ FTKQGPRTRV AAAITKNNDL VRKKRVEGDR R 

« Hide

References

[1]"N-tropomodulin: a novel isoform of tropomodulin identified as the major binding protein to brain tropomyosin."
Watakabe A., Kobayashi R., Helfman D.M.
J. Cell Sci. 109:2299-2310(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Brain.
[2]Lubec G., Chen W.-Q.
Submitted (APR-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 82-93 AND 238-251, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: Sprague-Dawley.
Tissue: Hippocampus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U59240 mRNA. Translation: AAC52854.1.
RefSeqNP_113801.1. NM_031613.1.
XP_006243469.1. XM_006243407.1.
XP_006243470.1. XM_006243408.1.
UniGeneRn.74047.

3D structure databases

ProteinModelPortalP70566.
SMRP70566. Positions 181-346.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid248623. 1 interaction.
STRING10116.ENSRNOP00000014124.

2D gel databases

World-2DPAGE0004:P70566.

Proteomic databases

PaxDbP70566.
PRIDEP70566.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000014124; ENSRNOP00000014124; ENSRNOG00000010447.
GeneID58814.
KEGGrno:58814.
UCSCRGD:61948. rat.

Organism-specific databases

CTD29767.
RGD61948. Tmod2.

Phylogenomic databases

eggNOGNOG329422.
GeneTreeENSGT00740000115178.
HOGENOMHOG000261624.
HOVERGENHBG056172.
InParanoidP70566.
KOK10370.
OMAVNNPKFD.
OrthoDBEOG7D59Q1.
PhylomeDBP70566.
TreeFamTF315841.

Gene expression databases

GenevestigatorP70566.

Family and domain databases

InterProIPR004934. Tropomodulin.
[Graphical view]
PANTHERPTHR10901. PTHR10901. 1 hit.
PfamPF03250. Tropomodulin. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio611346.
PROP70566.

Entry information

Entry nameTMOD2_RAT
AccessionPrimary (citable) accession number: P70566
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: February 1, 1997
Last modified: May 14, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families