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P70566

- TMOD2_RAT

UniProt

P70566 - TMOD2_RAT

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Protein

Tropomodulin-2

Gene
Tmod2, Ntmod
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton By similarity.

GO - Molecular functioni

  1. actin binding Source: RGD
  2. tropomyosin binding Source: RGD

GO - Biological processi

  1. actin filament organization Source: RGD
  2. learning or memory Source: Ensembl
  3. neuron-neuron synaptic transmission Source: Ensembl
  4. positive regulation of G-protein coupled receptor protein signaling pathway Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tropomodulin-2
Alternative name(s):
Neuronal tropomodulin
Short name:
N-Tmod
Gene namesi
Name:Tmod2
Synonyms:Ntmod
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 8

Organism-specific databases

RGDi61948. Tmod2.

Subcellular locationi

Cytoplasmcytoskeleton By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. cytoskeleton Source: UniProtKB-SubCell
  3. growth cone Source: RGD
  4. neuron projection Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351Tropomodulin-2PRO_0000186133Add
BLAST

Proteomic databases

PaxDbiP70566.
PRIDEiP70566.

2D gel databases

World-2DPAGE0004:P70566.

Expressioni

Tissue specificityi

Neuronal-tissue specific.

Gene expression databases

GenevestigatoriP70566.

Interactioni

Subunit structurei

Binds to the N-terminus of tropomyosin and to actin. Binds to TMBr3 as well as to other low molecular mass tropomyosins (TM5a or TM5), but not to high molecular mass tropomyosins (TM2 or TMBr1).

Protein-protein interaction databases

BioGridi248623. 1 interaction.
STRINGi10116.ENSRNOP00000014124.

Structurei

3D structure databases

ProteinModelPortaliP70566.
SMRiP70566. Positions 181-346.

Family & Domainsi

Sequence similaritiesi

Belongs to the tropomodulin family.

Phylogenomic databases

eggNOGiNOG329422.
GeneTreeiENSGT00740000115178.
HOGENOMiHOG000261624.
HOVERGENiHBG056172.
InParanoidiP70566.
KOiK10370.
OMAiVNNPKFD.
OrthoDBiEOG7D59Q1.
PhylomeDBiP70566.
TreeFamiTF315841.

Family and domain databases

InterProiIPR004934. Tropomodulin.
[Graphical view]
PANTHERiPTHR10901. PTHR10901. 1 hit.
PfamiPF03250. Tropomodulin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70566-1 [UniParc]FASTAAdd to Basket

« Hide

MALPFQKGLE KYKNIDEDEL LGKLSEEELK QLENVLDDLD PESATLPAGF    50
RQKDQTQKAA TGPFDREHLL MYLEKEALEQ KDREDFVPFT GEKKGRVFIP 100
KEKPVETRKE EKVTLDPELE EALASASDTE LYDLAAVLGV HNLLNNPKFD 150
EETTNGQGRK GPVRNVVKGE KAKPVFEEPP NPTNVEASLQ QMKANDPSLQ 200
EVNLNNIKNI PIPTLKEFAK ALETNTHVRK FSLAATRSND PVALAFAEML 250
KVNKTLKSLN VESNFITGAG ILALVEALRE NDTLTEIKID NQRQQLGTAV 300
EMEIAQMLEE NSRILKFGYQ FTKQGPRTRV AAAITKNNDL VRKKRVEGDR 350
R 351
Length:351
Mass (Da):39,492
Last modified:February 1, 1997 - v1
Checksum:i24F5C67EA897983E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U59240 mRNA. Translation: AAC52854.1.
RefSeqiNP_113801.1. NM_031613.1.
XP_006243469.1. XM_006243407.1.
XP_006243470.1. XM_006243408.1.
UniGeneiRn.74047.

Genome annotation databases

EnsembliENSRNOT00000014124; ENSRNOP00000014124; ENSRNOG00000010447.
GeneIDi58814.
KEGGirno:58814.
UCSCiRGD:61948. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U59240 mRNA. Translation: AAC52854.1 .
RefSeqi NP_113801.1. NM_031613.1.
XP_006243469.1. XM_006243407.1.
XP_006243470.1. XM_006243408.1.
UniGenei Rn.74047.

3D structure databases

ProteinModelPortali P70566.
SMRi P70566. Positions 181-346.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 248623. 1 interaction.
STRINGi 10116.ENSRNOP00000014124.

2D gel databases

World-2DPAGE 0004:P70566.

Proteomic databases

PaxDbi P70566.
PRIDEi P70566.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000014124 ; ENSRNOP00000014124 ; ENSRNOG00000010447 .
GeneIDi 58814.
KEGGi rno:58814.
UCSCi RGD:61948. rat.

Organism-specific databases

CTDi 29767.
RGDi 61948. Tmod2.

Phylogenomic databases

eggNOGi NOG329422.
GeneTreei ENSGT00740000115178.
HOGENOMi HOG000261624.
HOVERGENi HBG056172.
InParanoidi P70566.
KOi K10370.
OMAi VNNPKFD.
OrthoDBi EOG7D59Q1.
PhylomeDBi P70566.
TreeFami TF315841.

Miscellaneous databases

NextBioi 611346.
PROi P70566.

Gene expression databases

Genevestigatori P70566.

Family and domain databases

InterProi IPR004934. Tropomodulin.
[Graphical view ]
PANTHERi PTHR10901. PTHR10901. 1 hit.
Pfami PF03250. Tropomodulin. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "N-tropomodulin: a novel isoform of tropomodulin identified as the major binding protein to brain tropomyosin."
    Watakabe A., Kobayashi R., Helfman D.M.
    J. Cell Sci. 109:2299-2310(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.
  2. Lubec G., Chen W.-Q.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 82-93 AND 238-251, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Hippocampus.

Entry informationi

Entry nameiTMOD2_RAT
AccessioniPrimary (citable) accession number: P70566
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: February 1, 1997
Last modified: May 14, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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