P70566 (TMOD2_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tropomodulin-2

Alternative name(s):
Neuronal tropomodulin
Short name=N-Tmod

Gene names

Name:	Tmod2
Synonyms:	Ntmod

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	351 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton By similarity.
Subunit structure	Binds to the N-terminus of tropomyosin and to actin. Binds to TMBr3 as well as to other low molecular mass tropomyosins (TM5a or TM5), but not to high molecular mass tropomyosins (TM2 or TMBr1).
Subcellular location	Cytoplasm › cytoskeleton By similarity.
Tissue specificity	Neuronal-tissue specific.
Sequence similarities	Belongs to the tropomodulin family.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Ligand	Actin-binding
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	actin filament organization Traceable author statement Ref.1. Source: RGD learning or memory Inferred from electronic annotation. Source: Compara neuron-neuron synaptic transmission Inferred from electronic annotation. Source: Compara positive regulation of G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell growth cone Inferred from direct assay Ref.1. Source: RGD
Molecular_function	actin binding Inferred from direct assay Ref.1. Source: RGD tropomyosin binding Inferred from direct assay Ref.1. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 351	351	Tropomodulin-2		PRO_0000186133

Sequences

	Sequence		Length	Mass (Da)
	P70566 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 24F5C67EA897983E	FASTA	351	39,492
	10 20 30 40 50 60 MALPFQKGLE KYKNIDEDEL LGKLSEEELK QLENVLDDLD PESATLPAGF RQKDQTQKAA 70 80 90 100 110 120 TGPFDREHLL MYLEKEALEQ KDREDFVPFT GEKKGRVFIP KEKPVETRKE EKVTLDPELE 130 140 150 160 170 180 EALASASDTE LYDLAAVLGV HNLLNNPKFD EETTNGQGRK GPVRNVVKGE KAKPVFEEPP 190 200 210 220 230 240 NPTNVEASLQ QMKANDPSLQ EVNLNNIKNI PIPTLKEFAK ALETNTHVRK FSLAATRSND 250 260 270 280 290 300 PVALAFAEML KVNKTLKSLN VESNFITGAG ILALVEALRE NDTLTEIKID NQRQQLGTAV 310 320 330 340 350 EMEIAQMLEE NSRILKFGYQ FTKQGPRTRV AAAITKNNDL VRKKRVEGDR R

References

[1]	"N-tropomodulin: a novel isoform of tropomodulin identified as the major binding protein to brain tropomyosin." Watakabe A., Kobayashi R., Helfman D.M. J. Cell Sci. 109:2299-2310(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Brain.
[2]	Lubec G., Chen W.-Q. Submitted (APR-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 82-93 AND 238-251, MASS SPECTROMETRY. Strain: Sprague-Dawley. Tissue: Hippocampus.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U59240 mRNA. Translation: AAC52854.1.
IPI	IPI00189722.
RefSeq	NP_113801.1. NM_031613.1.
UniGene	Rn.74047.
3D structure databases
ProteinModelPortal	P70566.
SMR	P70566. Positions 181-346.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000014124.
2D gel databases
World-2DPAGE	0004:P70566.
Proteomic databases
PaxDb	P70566.
PRIDE	P70566.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000014124; ENSRNOP00000014124; ENSRNOG00000010447.
GeneID	58814.
KEGG	rno:58814.
UCSC	RGD:61948. rat.
Organism-specific databases
CTD	29767.
RGD	61948. Tmod2.
Phylogenomic databases
eggNOG	NOG329422.
GeneTree	ENSGT00550000074341.
HOGENOM	HOG000261624.
HOVERGEN	HBG056172.
InParanoid	P70566.
KO	K10370.
OMA	KFDEETA.
OrthoDB	EOG4X97HG.
Gene expression databases
Genevestigator	P70566.
GermOnline	ENSRNOG00000010447. Rattus norvegicus.
Family and domain databases
InterPro	IPR004934. Tropomodulin. [Graphical view]
PANTHER	PTHR10901. PTHR10901. 1 hit.
Pfam	PF03250. Tropomodulin. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	611346.

Entry information

Entry name

TMOD2_RAT

Accession

Primary (citable) accession number: P70566

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2002
Last sequence update:	February 1, 1997
Last modified:	April 3, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program