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P70564

- SPB5_RAT

UniProt

P70564 - SPB5_RAT

Protein

Serpin B5

Gene

Serpinb5

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei340 – 3412Reactive bond homologBy similarity

    GO - Molecular functioni

    1. serine-type endopeptidase inhibitor activity Source: RefGenome

    GO - Biological processi

    1. negative regulation of endopeptidase activity Source: RefGenome
    2. regulation of proteolysis Source: RefGenome

    Protein family/group databases

    MEROPSiI04.980.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serpin B5
    Alternative name(s):
    Maspin
    Peptidase inhibitor 5
    Short name:
    PI-5
    Gene namesi
    Name:Serpinb5
    Synonyms:Pi5
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi69342. Serpinb5.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. extracellular space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 375375Serpin B5PRO_0000032488Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi133 – 1331N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi298 – 2981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi361 – 3611N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP70564.

    Expressioni

    Gene expression databases

    GenevestigatoriP70564.

    Interactioni

    Subunit structurei

    Interacts with IRF6.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000003625.

    Structurei

    3D structure databases

    ProteinModelPortaliP70564.
    SMRiP70564. Positions 1-375.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the serpin family. Ov-serpin subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG4826.
    HOGENOMiHOG000238519.
    HOVERGENiHBG005957.
    InParanoidiP70564.
    KOiK10139.
    PhylomeDBiP70564.

    Family and domain databases

    InterProiIPR000240. Serpin_B9/Maspin.
    IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    PRINTSiPR00676. MASPIN.
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.
    PROSITEiPS00284. SERPIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P70564-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDALRLANSA FAVELFKQLC EKEPAGNILF SPICLSTSLS LAQVGAKGDT    50
    ANEIGQVLHF ENVKDVPFGF KPITSDVNKL SSFYSLKLIK RLYIDKSLNL 100
    STEFISSTKR PYANELETVD FKDKLEETKG QINSSIKELT DGHFEDILPE 150
    NSISDQTKIL VVNAAYFVGK WMKKFPESET KECPFRINKT DTKPVQMMNL 200
    EATFCLGNID DINCKIIELP FQNKHLSMLI VLPKDVEDES TGLEKIEKQL 250
    NPETLLQWTN PSTMANAKVK LSLPKFKVEK MIDPKASLES LGLKSLFNES 300
    TSDFSGMSET KGVSVSNVIH RVCLEITEDG GDSIEVPGSR ILQHKDEFKA 350
    DHPFLFIVRH NKTRNIVFLG KFSSP 375
    Length:375
    Mass (Da):42,063
    Last modified:February 1, 1997 - v1
    Checksum:iE82C4EC6A0F2E482
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U58857 mRNA. Translation: AAB06043.1.
    RefSeqiNP_476449.1. NM_057108.2.
    UniGeneiRn.25752.

    Genome annotation databases

    GeneIDi116589.
    KEGGirno:116589.
    UCSCiRGD:69342. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U58857 mRNA. Translation: AAB06043.1 .
    RefSeqi NP_476449.1. NM_057108.2.
    UniGenei Rn.25752.

    3D structure databases

    ProteinModelPortali P70564.
    SMRi P70564. Positions 1-375.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000003625.

    Protein family/group databases

    MEROPSi I04.980.

    Proteomic databases

    PaxDbi P70564.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 116589.
    KEGGi rno:116589.
    UCSCi RGD:69342. rat.

    Organism-specific databases

    CTDi 5268.
    RGDi 69342. Serpinb5.

    Phylogenomic databases

    eggNOGi COG4826.
    HOGENOMi HOG000238519.
    HOVERGENi HBG005957.
    InParanoidi P70564.
    KOi K10139.
    PhylomeDBi P70564.

    Miscellaneous databases

    NextBioi 619265.
    PROi P70564.

    Gene expression databases

    Genevestigatori P70564.

    Family and domain databases

    InterProi IPR000240. Serpin_B9/Maspin.
    IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    PRINTSi PR00676. MASPIN.
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    PROSITEi PS00284. SERPIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Rat and human maspins: structures, metastatic suppressor activity and mutation in prostate cancer cells."
      Umekita Y., Hiipakka R.A., Liao S.
      Cancer Lett. 113:87-93(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Vagina.

    Entry informationi

    Entry nameiSPB5_RAT
    AccessioniPrimary (citable) accession number: P70564
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3