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P70564

- SPB5_RAT

UniProt

P70564 - SPB5_RAT

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Protein

Serpin B5

Gene

Serpinb5

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei340 – 3412Reactive bond homologBy similarity

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: RefGenome

GO - Biological processi

  1. negative regulation of endopeptidase activity Source: RefGenome
  2. regulation of proteolysis Source: RefGenome
Complete GO annotation...

Protein family/group databases

MEROPSiI04.980.

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin B5
Alternative name(s):
Maspin
Peptidase inhibitor 5
Short name:
PI-5
Gene namesi
Name:Serpinb5
Synonyms:Pi5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi69342. Serpinb5.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. extracellular space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375Serpin B5PRO_0000032488Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi133 – 1331N-linked (GlcNAc...)Sequence Analysis
Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis
Glycosylationi298 – 2981N-linked (GlcNAc...)Sequence Analysis
Glycosylationi361 – 3611N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP70564.

Expressioni

Gene expression databases

GenevestigatoriP70564.

Interactioni

Subunit structurei

Interacts with IRF6.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003625.

Structurei

3D structure databases

ProteinModelPortaliP70564.
SMRiP70564. Positions 1-375.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family. Ov-serpin subfamily.Curated

Phylogenomic databases

eggNOGiCOG4826.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiP70564.
KOiK10139.
PhylomeDBiP70564.

Family and domain databases

InterProiIPR000240. Serpin_B9/Maspin.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
PRINTSiPR00676. MASPIN.
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70564-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDALRLANSA FAVELFKQLC EKEPAGNILF SPICLSTSLS LAQVGAKGDT
60 70 80 90 100
ANEIGQVLHF ENVKDVPFGF KPITSDVNKL SSFYSLKLIK RLYIDKSLNL
110 120 130 140 150
STEFISSTKR PYANELETVD FKDKLEETKG QINSSIKELT DGHFEDILPE
160 170 180 190 200
NSISDQTKIL VVNAAYFVGK WMKKFPESET KECPFRINKT DTKPVQMMNL
210 220 230 240 250
EATFCLGNID DINCKIIELP FQNKHLSMLI VLPKDVEDES TGLEKIEKQL
260 270 280 290 300
NPETLLQWTN PSTMANAKVK LSLPKFKVEK MIDPKASLES LGLKSLFNES
310 320 330 340 350
TSDFSGMSET KGVSVSNVIH RVCLEITEDG GDSIEVPGSR ILQHKDEFKA
360 370
DHPFLFIVRH NKTRNIVFLG KFSSP
Length:375
Mass (Da):42,063
Last modified:February 1, 1997 - v1
Checksum:iE82C4EC6A0F2E482
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58857 mRNA. Translation: AAB06043.1.
RefSeqiNP_476449.1. NM_057108.2.
UniGeneiRn.25752.

Genome annotation databases

GeneIDi116589.
KEGGirno:116589.
UCSCiRGD:69342. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58857 mRNA. Translation: AAB06043.1 .
RefSeqi NP_476449.1. NM_057108.2.
UniGenei Rn.25752.

3D structure databases

ProteinModelPortali P70564.
SMRi P70564. Positions 1-375.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000003625.

Protein family/group databases

MEROPSi I04.980.

Proteomic databases

PaxDbi P70564.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 116589.
KEGGi rno:116589.
UCSCi RGD:69342. rat.

Organism-specific databases

CTDi 5268.
RGDi 69342. Serpinb5.

Phylogenomic databases

eggNOGi COG4826.
HOGENOMi HOG000238519.
HOVERGENi HBG005957.
InParanoidi P70564.
KOi K10139.
PhylomeDBi P70564.

Miscellaneous databases

NextBioi 619265.
PROi P70564.

Gene expression databases

Genevestigatori P70564.

Family and domain databases

InterProi IPR000240. Serpin_B9/Maspin.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view ]
PANTHERi PTHR11461. PTHR11461. 1 hit.
Pfami PF00079. Serpin. 1 hit.
[Graphical view ]
PRINTSi PR00676. MASPIN.
SMARTi SM00093. SERPIN. 1 hit.
[Graphical view ]
SUPFAMi SSF56574. SSF56574. 1 hit.
PROSITEi PS00284. SERPIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Rat and human maspins: structures, metastatic suppressor activity and mutation in prostate cancer cells."
    Umekita Y., Hiipakka R.A., Liao S.
    Cancer Lett. 113:87-93(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Vagina.

Entry informationi

Entry nameiSPB5_RAT
AccessioniPrimary (citable) accession number: P70564
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: October 29, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3