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P70564 (SPB5_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serpin B5
Alternative name(s):
Maspin
Peptidase inhibitor 5
Short name=PI-5
Gene names
Name:Serpinb5
Synonyms:Pi5
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length375 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity By similarity.

Subunit structure

Interacts with IRF6 By similarity.

Subcellular location

Secretedextracellular space.

Sequence similarities

Belongs to the serpin family. Ov-serpin subfamily.

Ontologies

Keywords
   Cellular componentSecreted
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of proteolysis

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Cellular_componentcytoplasm

Inferred from Biological aspect of Ancestor. Source: RefGenome

extracellular space

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine-type endopeptidase inhibitor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 375375Serpin B5
PRO_0000032488

Sites

Site340 – 3412Reactive bond homolog By similarity

Amino acid modifications

Glycosylation991N-linked (GlcNAc...) Potential
Glycosylation1331N-linked (GlcNAc...) Potential
Glycosylation1881N-linked (GlcNAc...) Potential
Glycosylation2981N-linked (GlcNAc...) Potential
Glycosylation3611N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P70564 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: E82C4EC6A0F2E482

FASTA37542,063
        10         20         30         40         50         60 
MDALRLANSA FAVELFKQLC EKEPAGNILF SPICLSTSLS LAQVGAKGDT ANEIGQVLHF 

        70         80         90        100        110        120 
ENVKDVPFGF KPITSDVNKL SSFYSLKLIK RLYIDKSLNL STEFISSTKR PYANELETVD 

       130        140        150        160        170        180 
FKDKLEETKG QINSSIKELT DGHFEDILPE NSISDQTKIL VVNAAYFVGK WMKKFPESET 

       190        200        210        220        230        240 
KECPFRINKT DTKPVQMMNL EATFCLGNID DINCKIIELP FQNKHLSMLI VLPKDVEDES 

       250        260        270        280        290        300 
TGLEKIEKQL NPETLLQWTN PSTMANAKVK LSLPKFKVEK MIDPKASLES LGLKSLFNES 

       310        320        330        340        350        360 
TSDFSGMSET KGVSVSNVIH RVCLEITEDG GDSIEVPGSR ILQHKDEFKA DHPFLFIVRH 

       370 
NKTRNIVFLG KFSSP 

« Hide

References

[1]"Rat and human maspins: structures, metastatic suppressor activity and mutation in prostate cancer cells."
Umekita Y., Hiipakka R.A., Liao S.
Cancer Lett. 113:87-93(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Vagina.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U58857 mRNA. Translation: AAB06043.1.
RefSeqNP_476449.1. NM_057108.2.
UniGeneRn.25752.

3D structure databases

ProteinModelPortalP70564.
SMRP70564. Positions 1-375.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000003625.

Protein family/group databases

MEROPSI04.980.

Proteomic databases

PaxDbP70564.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID116589.
KEGGrno:116589.
UCSCRGD:69342. rat.

Organism-specific databases

CTD5268.
RGD69342. Serpinb5.

Phylogenomic databases

eggNOGCOG4826.
HOGENOMHOG000238519.
HOVERGENHBG005957.
InParanoidP70564.
KOK10139.

Gene expression databases

GenevestigatorP70564.

Family and domain databases

InterProIPR000240. Serpin_B9/Maspin.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERPTHR11461. PTHR11461. 1 hit.
PfamPF00079. Serpin. 1 hit.
[Graphical view]
PRINTSPR00676. MASPIN.
SMARTSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMSSF56574. SSF56574. 1 hit.
PROSITEPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio619265.
PROP70564.

Entry information

Entry nameSPB5_RAT
AccessionPrimary (citable) accession number: P70564
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: March 19, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families