Reviewed, UniProtKB/Swiss-Prot P70555 (PTH2R_RAT)

Names and origin

Protein names

Recommended name:
    Parathyroid hormone 2 receptor
      Short name=PTH2 receptor

Gene names

Name:	Pth2r
Synonyms:	Pthr2

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	546 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor.
Subunit structure	Binds to TIPF39/TIP39 By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Abundantly expressed in brain, arterial and cardiac endothelium. Found as well in sperm, in the head of the epididymis. Lower expression is found in vascular smooth muscle, exocrine pancreas, testis and placenta.
Sequence similarities	Belongs to the G-protein coupled receptor 2 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Signal Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	parathyroid hormone receptor activity Inferred from direct assay. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 546	522	Parathyroid hormone 2 receptor		PRO_0000012851
Regions
	Topological domain	27 – 143	117	Extracellular Potential
	Transmembrane	144 – 167	24	1 Potential
	Topological domain	168 – 174	7	Cytoplasmic Potential
	Transmembrane	175 – 194	20	2 Potential
	Topological domain	195 – 235	41	Extracellular Potential
	Transmembrane	236 – 258	23	3 Potential
	Topological domain	259 – 273	15	Cytoplasmic Potential
	Transmembrane	274 – 295	22	4 Potential
	Topological domain	296 – 313	18	Extracellular Potential
	Transmembrane	314 – 334	21	5 Potential
	Topological domain	335 – 361	27	Cytoplasmic Potential
	Transmembrane	362 – 380	19	6 Potential
	Topological domain	381 – 391	11	Extracellular Potential
	Transmembrane	392 – 414	23	7 Potential
	Topological domain	415 – 546	132	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	51	1	N-linked (GlcNAc...) Potential
	Glycosylation	106	1	N-linked (GlcNAc...) Potential
	Glycosylation	116	1	N-linked (GlcNAc...) Potential
	Glycosylation	121	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P70555-1 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 2825AE4040313527	FASTA	546	61,804
	10 20 30 40 50 60 MPWLEALPYI CGWLILRSCL LVGAQLDSDG TITIEEQIVL VMKAKMQCEL NITAQFQEGE 70 80 90 100 110 120 GNCFPEWDGL ICWPRGTAGK TSAMPCPSYV YDFNHKGVAF RHCTPNGTWD FIHGSNKTWA 130 140 150 160 170 180 NYSDCFLQPD INIGKQEFFE NLYILYTVGY SISFGSLAVA ILIIGYFRRL HCTRNYIHLH 190 200 210 220 230 240 LFVSFMLRAX SIFVKDRVAQ AHLGVEALQS LVMQGDLQNF IGGPSVDKSQ YVGCKIAVVM 250 260 270 280 290 300 FIYFLATNYY WILVEGLYLH NLIFVSFFSD TKYLWGFILI GWGFPAVFVV AWAVARATLA 310 320 330 340 350 360 DTRCWELSAG DRWIYXXPIL AAIGLNFILF LNTVRVLATK IWETNAVGHD MRKQYRKLAK 370 380 390 400 410 420 STLVLVLVFG VHYIVFICQP HSFSGLWWEI RMHCELFFNS FQGFFVSIVY CYCNGEVQAE 430 440 450 460 470 480 VKKTWTRWNL SIDWKKAPPC GGHRYGSVLT TVTHSTSSQS QMGPSTRLVL ISSKPAKTAC 490 500 510 520 530 540 RQIDSHVTLP GYVWSSSEQD CQPQSTPEET KKGHGRQEDD SPVGESSRPV AFTIDTEGCK GESHPI

References

[1]	"Distribution of parathyroid hormone-2 receptor messenger ribonucleic acid in rat." Usdin T.B., Bonner T.I., Harta G., Mezey E. Endocrinology 137:4285-4297(1996) [PubMed: 8828488] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	U55836 mRNA. Translation: AAC52849.1.
IPI	IPI00189698.
RefSeq	NP_112351.1.
UniGene	Rn.10601
3D structure databases
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Genome annotation databases
Ensembl	ENSRNOG00000015259. Rattus norvegicus. [Contig view]
GeneID	81753.
KEGG	rno:81753.
Organism-specific databases
RGD	620612. Pth2r.
Phylogenomic databases
HOVERGEN	P70555.
Gene expression databases
ArrayExpress	P70555.
GermOnline	ENSRNOG00000015259. Rattus norvegicus.
Family and domain databases
InterPro	IPR017981. GPCR_2-like. IPR001879. GPCR_2_extracellular. IPR000832. GPCR_2_secretin-like. IPR017983. GPCR_2_secretin-like_CS. [Graphical view]
Pfam	PF00002. 7tm_2. 1 hit. PF02793. HRM. 1 hit. [Graphical view]
PRINTS	PR00249. GPCRSECRETIN.
SMART	SM00008. HormR. 1 hit. [Graphical view]
PROSITE	PS00649. G_PROTEIN_RECEP_F2_1. 1 hit. PS00650. G_PROTEIN_RECEP_F2_2. 1 hit. PS50227. G_PROTEIN_RECEP_F2_3. 1 hit. PS50261. G_PROTEIN_RECEP_F2_4. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	615514.

Entry information

Entry name

PTH2R_RAT

Accession

Primary (citable) accession number: P70555

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	June 16, 2009
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)