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P70555

- PTH2R_RAT

UniProt

P70555 - PTH2R_RAT

Protein

Parathyroid hormone 2 receptor

Gene

Pth2r

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor.

    GO - Molecular functioni

    1. parathyroid hormone receptor activity Source: RGD

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Parathyroid hormone 2 receptor
    Short name:
    PTH2 receptor
    Gene namesi
    Name:Pth2r
    Synonyms:Pthr2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi620612. Pth2r.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 546522Parathyroid hormone 2 receptorPRO_0000012851Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi51 – 511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi116 – 1161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiP70555.

    PTM databases

    PhosphoSiteiP70555.

    Expressioni

    Tissue specificityi

    Abundantly expressed in brain, arterial and cardiac endothelium. Found as well in sperm, in the head of the epididymis. Lower expression is found in vascular smooth muscle, exocrine pancreas, testis and placenta.

    Gene expression databases

    GenevestigatoriP70555.

    Interactioni

    Subunit structurei

    Binds to TIPF39/TIP39.By similarity

    Protein-protein interaction databases

    BioGridi249625. 1 interaction.
    STRINGi10116.ENSRNOP00000021099.

    Structurei

    3D structure databases

    ProteinModelPortaliP70555.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini27 – 143117ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini168 – 1747CytoplasmicSequence Analysis
    Topological domaini195 – 23541ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini259 – 27315CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini296 – 31318ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini335 – 36127CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini381 – 39111ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini415 – 546132CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei144 – 16724Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei175 – 19420Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei236 – 25823Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei274 – 29522Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei314 – 33421Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei362 – 38019Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei392 – 41423Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG293423.
    HOGENOMiHOG000008248.
    HOVERGENiHBG008318.
    InParanoidiP70555.
    KOiK04586.
    PhylomeDBiP70555.

    Family and domain databases

    InterProiIPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    [Graphical view]
    PfamiPF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view]
    PRINTSiPR00249. GPCRSECRETIN.
    SMARTiSM00008. HormR. 1 hit.
    [Graphical view]
    PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P70555-1 [UniParc]FASTAAdd to Basket

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    MPWLEALPYI CGWLILRSCL LVGAQLDSDG TITIEEQIVL VMKAKMQCEL    50
    NITAQFQEGE GNCFPEWDGL ICWPRGTAGK TSAMPCPSYV YDFNHKGVAF 100
    RHCTPNGTWD FIHGSNKTWA NYSDCFLQPD INIGKQEFFE NLYILYTVGY 150
    SISFGSLAVA ILIIGYFRRL HCTRNYIHLH LFVSFMLRAX SIFVKDRVAQ 200
    AHLGVEALQS LVMQGDLQNF IGGPSVDKSQ YVGCKIAVVM FIYFLATNYY 250
    WILVEGLYLH NLIFVSFFSD TKYLWGFILI GWGFPAVFVV AWAVARATLA 300
    DTRCWELSAG DRWIYXXPIL AAIGLNFILF LNTVRVLATK IWETNAVGHD 350
    MRKQYRKLAK STLVLVLVFG VHYIVFICQP HSFSGLWWEI RMHCELFFNS 400
    FQGFFVSIVY CYCNGEVQAE VKKTWTRWNL SIDWKKAPPC GGHRYGSVLT 450
    TVTHSTSSQS QMGPSTRLVL ISSKPAKTAC RQIDSHVTLP GYVWSSSEQD 500
    CQPQSTPEET KKGHGRQEDD SPVGESSRPV AFTIDTEGCK GESHPI 546
    Length:546
    Mass (Da):61,804
    Last modified:February 1, 1997 - v1
    Checksum:i2825AE4040313527
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U55836 mRNA. Translation: AAC52849.1.
    RefSeqiNP_112351.1. NM_031089.2.
    UniGeneiRn.10601.

    Genome annotation databases

    GeneIDi81753.
    KEGGirno:81753.
    UCSCiRGD:620612. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U55836 mRNA. Translation: AAC52849.1 .
    RefSeqi NP_112351.1. NM_031089.2.
    UniGenei Rn.10601.

    3D structure databases

    ProteinModelPortali P70555.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 249625. 1 interaction.
    STRINGi 10116.ENSRNOP00000021099.

    Chemistry

    GuidetoPHARMACOLOGYi 332.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P70555.

    Proteomic databases

    PRIDEi P70555.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 81753.
    KEGGi rno:81753.
    UCSCi RGD:620612. rat.

    Organism-specific databases

    CTDi 5746.
    RGDi 620612. Pth2r.

    Phylogenomic databases

    eggNOGi NOG293423.
    HOGENOMi HOG000008248.
    HOVERGENi HBG008318.
    InParanoidi P70555.
    KOi K04586.
    PhylomeDBi P70555.

    Miscellaneous databases

    NextBioi 615514.
    PROi P70555.

    Gene expression databases

    Genevestigatori P70555.

    Family and domain databases

    InterProi IPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    [Graphical view ]
    Pfami PF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view ]
    PRINTSi PR00249. GPCRSECRETIN.
    SMARTi SM00008. HormR. 1 hit.
    [Graphical view ]
    PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Distribution of parathyroid hormone-2 receptor messenger ribonucleic acid in rat."
      Usdin T.B., Bonner T.I., Harta G., Mezey E.
      Endocrinology 137:4285-4297(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiPTH2R_RAT
    AccessioniPrimary (citable) accession number: P70555
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3