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P70555 (PTH2R_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Parathyroid hormone 2 receptor

Short name=PTH2 receptor
Gene names
Name:Pth2r
Synonyms:Pthr2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length546 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor.

Subunit structure

Binds to TIPF39/TIP39 By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Abundantly expressed in brain, arterial and cardiac endothelium. Found as well in sperm, in the head of the epididymis. Lower expression is found in vascular smooth muscle, exocrine pancreas, testis and placenta.

Sequence similarities

Belongs to the G-protein coupled receptor 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 546522Parathyroid hormone 2 receptor
PRO_0000012851

Regions

Topological domain27 – 143117Extracellular Potential
Transmembrane144 – 16724Helical; Name=1; Potential
Topological domain168 – 1747Cytoplasmic Potential
Transmembrane175 – 19420Helical; Name=2; Potential
Topological domain195 – 23541Extracellular Potential
Transmembrane236 – 25823Helical; Name=3; Potential
Topological domain259 – 27315Cytoplasmic Potential
Transmembrane274 – 29522Helical; Name=4; Potential
Topological domain296 – 31318Extracellular Potential
Transmembrane314 – 33421Helical; Name=5; Potential
Topological domain335 – 36127Cytoplasmic Potential
Transmembrane362 – 38019Helical; Name=6; Potential
Topological domain381 – 39111Extracellular Potential
Transmembrane392 – 41423Helical; Name=7; Potential
Topological domain415 – 546132Cytoplasmic Potential

Amino acid modifications

Glycosylation511N-linked (GlcNAc...) Potential
Glycosylation1061N-linked (GlcNAc...) Potential
Glycosylation1161N-linked (GlcNAc...) Potential
Glycosylation1211N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P70555 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 2825AE4040313527

FASTA54661,804
        10         20         30         40         50         60 
MPWLEALPYI CGWLILRSCL LVGAQLDSDG TITIEEQIVL VMKAKMQCEL NITAQFQEGE 

        70         80         90        100        110        120 
GNCFPEWDGL ICWPRGTAGK TSAMPCPSYV YDFNHKGVAF RHCTPNGTWD FIHGSNKTWA 

       130        140        150        160        170        180 
NYSDCFLQPD INIGKQEFFE NLYILYTVGY SISFGSLAVA ILIIGYFRRL HCTRNYIHLH 

       190        200        210        220        230        240 
LFVSFMLRAX SIFVKDRVAQ AHLGVEALQS LVMQGDLQNF IGGPSVDKSQ YVGCKIAVVM 

       250        260        270        280        290        300 
FIYFLATNYY WILVEGLYLH NLIFVSFFSD TKYLWGFILI GWGFPAVFVV AWAVARATLA 

       310        320        330        340        350        360 
DTRCWELSAG DRWIYXXPIL AAIGLNFILF LNTVRVLATK IWETNAVGHD MRKQYRKLAK 

       370        380        390        400        410        420 
STLVLVLVFG VHYIVFICQP HSFSGLWWEI RMHCELFFNS FQGFFVSIVY CYCNGEVQAE 

       430        440        450        460        470        480 
VKKTWTRWNL SIDWKKAPPC GGHRYGSVLT TVTHSTSSQS QMGPSTRLVL ISSKPAKTAC 

       490        500        510        520        530        540 
RQIDSHVTLP GYVWSSSEQD CQPQSTPEET KKGHGRQEDD SPVGESSRPV AFTIDTEGCK 


GESHPI 

« Hide

References

[1]"Distribution of parathyroid hormone-2 receptor messenger ribonucleic acid in rat."
Usdin T.B., Bonner T.I., Harta G., Mezey E.
Endocrinology 137:4285-4297(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U55836 mRNA. Translation: AAC52849.1.
RefSeqNP_112351.1. NM_031089.2.
UniGeneRn.10601.

3D structure databases

ProteinModelPortalP70555.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid249625. 1 interaction.
STRING10116.ENSRNOP00000021099.

Chemistry

GuidetoPHARMACOLOGY332.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP70555.

Proteomic databases

PRIDEP70555.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID81753.
KEGGrno:81753.
UCSCRGD:620612. rat.

Organism-specific databases

CTD5746.
RGD620612. Pth2r.

Phylogenomic databases

eggNOGNOG293423.
HOGENOMHOG000008248.
HOVERGENHBG008318.
InParanoidP70555.
KOK04586.
PhylomeDBP70555.

Gene expression databases

GenevestigatorP70555.

Family and domain databases

InterProIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSPR00249. GPCRSECRETIN.
SMARTSM00008. HormR. 1 hit.
[Graphical view]
PROSITEPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio615514.
PROP70555.

Entry information

Entry namePTH2R_RAT
AccessionPrimary (citable) accession number: P70555
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: April 16, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries