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P70555

- PTH2R_RAT

UniProt

P70555 - PTH2R_RAT

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Protein

Parathyroid hormone 2 receptor

Gene

Pth2r

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor.

GO - Molecular functioni

  1. parathyroid hormone receptor activity Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Parathyroid hormone 2 receptor
Short name:
PTH2 receptor
Gene namesi
Name:Pth2r
Synonyms:Pthr2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi620612. Pth2r.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 143117ExtracellularSequence AnalysisAdd
BLAST
Transmembranei144 – 16724Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini168 – 1747CytoplasmicSequence Analysis
Transmembranei175 – 19420Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini195 – 23541ExtracellularSequence AnalysisAdd
BLAST
Transmembranei236 – 25823Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini259 – 27315CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei274 – 29522Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini296 – 31318ExtracellularSequence AnalysisAdd
BLAST
Transmembranei314 – 33421Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini335 – 36127CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei362 – 38019Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini381 – 39111ExtracellularSequence AnalysisAdd
BLAST
Transmembranei392 – 41423Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini415 – 546132CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 546522Parathyroid hormone 2 receptorPRO_0000012851Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi51 – 511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence Analysis
Glycosylationi116 – 1161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP70555.

PTM databases

PhosphoSiteiP70555.

Expressioni

Tissue specificityi

Abundantly expressed in brain, arterial and cardiac endothelium. Found as well in sperm, in the head of the epididymis. Lower expression is found in vascular smooth muscle, exocrine pancreas, testis and placenta.

Gene expression databases

GenevestigatoriP70555.

Interactioni

Subunit structurei

Binds to TIPF39/TIP39.By similarity

Protein-protein interaction databases

BioGridi249625. 1 interaction.
STRINGi10116.ENSRNOP00000021099.

Structurei

3D structure databases

ProteinModelPortaliP70555.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG293423.
HOGENOMiHOG000008248.
HOVERGENiHBG008318.
InParanoidiP70555.
KOiK04586.
PhylomeDBiP70555.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70555-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPWLEALPYI CGWLILRSCL LVGAQLDSDG TITIEEQIVL VMKAKMQCEL
60 70 80 90 100
NITAQFQEGE GNCFPEWDGL ICWPRGTAGK TSAMPCPSYV YDFNHKGVAF
110 120 130 140 150
RHCTPNGTWD FIHGSNKTWA NYSDCFLQPD INIGKQEFFE NLYILYTVGY
160 170 180 190 200
SISFGSLAVA ILIIGYFRRL HCTRNYIHLH LFVSFMLRAX SIFVKDRVAQ
210 220 230 240 250
AHLGVEALQS LVMQGDLQNF IGGPSVDKSQ YVGCKIAVVM FIYFLATNYY
260 270 280 290 300
WILVEGLYLH NLIFVSFFSD TKYLWGFILI GWGFPAVFVV AWAVARATLA
310 320 330 340 350
DTRCWELSAG DRWIYXXPIL AAIGLNFILF LNTVRVLATK IWETNAVGHD
360 370 380 390 400
MRKQYRKLAK STLVLVLVFG VHYIVFICQP HSFSGLWWEI RMHCELFFNS
410 420 430 440 450
FQGFFVSIVY CYCNGEVQAE VKKTWTRWNL SIDWKKAPPC GGHRYGSVLT
460 470 480 490 500
TVTHSTSSQS QMGPSTRLVL ISSKPAKTAC RQIDSHVTLP GYVWSSSEQD
510 520 530 540
CQPQSTPEET KKGHGRQEDD SPVGESSRPV AFTIDTEGCK GESHPI
Length:546
Mass (Da):61,804
Last modified:February 1, 1997 - v1
Checksum:i2825AE4040313527
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U55836 mRNA. Translation: AAC52849.1.
RefSeqiNP_112351.1. NM_031089.2.
UniGeneiRn.10601.

Genome annotation databases

GeneIDi81753.
KEGGirno:81753.
UCSCiRGD:620612. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U55836 mRNA. Translation: AAC52849.1 .
RefSeqi NP_112351.1. NM_031089.2.
UniGenei Rn.10601.

3D structure databases

ProteinModelPortali P70555.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 249625. 1 interaction.
STRINGi 10116.ENSRNOP00000021099.

Chemistry

GuidetoPHARMACOLOGYi 332.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P70555.

Proteomic databases

PRIDEi P70555.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 81753.
KEGGi rno:81753.
UCSCi RGD:620612. rat.

Organism-specific databases

CTDi 5746.
RGDi 620612. Pth2r.

Phylogenomic databases

eggNOGi NOG293423.
HOGENOMi HOG000008248.
HOVERGENi HBG008318.
InParanoidi P70555.
KOi K04586.
PhylomeDBi P70555.

Miscellaneous databases

NextBioi 615514.
PROi P70555.

Gene expression databases

Genevestigatori P70555.

Family and domain databases

InterProi IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view ]
PRINTSi PR00249. GPCRSECRETIN.
SMARTi SM00008. HormR. 1 hit.
[Graphical view ]
PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Distribution of parathyroid hormone-2 receptor messenger ribonucleic acid in rat."
    Usdin T.B., Bonner T.I., Harta G., Mezey E.
    Endocrinology 137:4285-4297(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiPTH2R_RAT
AccessioniPrimary (citable) accession number: P70555
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: October 29, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3