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P70553 (NRAM1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Natural resistance-associated macrophage protein 1

Short name=NRAMP 1
Alternative name(s):
Solute carrier family 11 member 1
Gene names
Name:Slc11a1
Synonyms:Bcg, Nramp1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length507 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe2+ and Mn2+, cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes By similarity. HAMAP-Rule MF_00221

Subcellular location

Membrane; Multi-pass membrane protein Probable HAMAP-Rule MF_00221.

Sequence similarities

Belongs to the NRAMP family.

Sequence caution

The sequence AAB49833.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processIon transport
Iron transport
Transport
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   LigandIron
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_procession transport

Inferred from electronic annotation. Source: UniProtKB-KW

iron ion homeostasis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functiontransporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 507507Natural resistance-associated macrophage protein 1 HAMAP-Rule MF_00221
PRO_0000212591

Regions

Topological domain1 – 3939Cytoplasmic Potential
Transmembrane40 – 6021Helical; Potential
Topological domain61 – 12363Extracellular Potential
Transmembrane124 – 14421Helical; Potential
Topological domain145 – 1528Cytoplasmic Potential
Transmembrane153 – 17321Helical; Potential
Topological domain174 – 19926Extracellular Potential
Transmembrane200 – 22021Helical; Potential
Topological domain221 – 24525Cytoplasmic Potential
Transmembrane246 – 26621Helical; Potential
Topological domain267 – 30539Extracellular Potential
Transmembrane306 – 32621Helical; Potential
Topological domain327 – 35327Cytoplasmic Potential
Transmembrane354 – 37421Helical; Potential
Topological domain375 – 39117Extracellular Potential
Transmembrane392 – 41221Helical; Potential
Topological domain413 – 42210Cytoplasmic Potential
Transmembrane423 – 44321Helical; Potential
Topological domain444 – 4518Extracellular Potential
Transmembrane452 – 47221Helical; Potential
Topological domain473 – 50735Cytoplasmic Potential

Amino acid modifications

Glycosylation2801N-linked (GlcNAc...) Potential
Glycosylation2941N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict4041T → S in AAB49833. Ref.2
Sequence conflict4091P → S in AAB49833. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P70553 [UniParc].

Last modified January 10, 2006. Version 3.
Checksum: 0A052B5EF53D1C64

FASTA50755,922
        10         20         30         40         50         60 
MIRDKNPQRV NRPSYGSISS LPSPAPQPEP SRNTYLSEKI PIPSTEQLLW VLLWATVLGL 

        70         80         90        100        110        120 
LCQRLAARLG VVTGKDLGEI CHLYYPKVPR ILLWLTIELA IVGSDMQEVI GTAISFNLLS 

       130        140        150        160        170        180 
AGRIPLWGGV LITIVDTFFF LFLDNYGLRK LEAFFGFLVT IMALTFGYEY VVARPSQGAL 

       190        200        210        220        230        240 
LKGLFLPSCP GCGQPELLQA VGIVGAIIMP HNIYLHSALV KSREVDRTRR GDVREANMYF 

       250        260        270        280        290        300 
LTEATIALFV SFIINLFVMA VFGQAFYQQT NEEAFNICAN SSLHNYAKIF PRDNNTVSVD 

       310        320        330        340        350        360 
IYQGGVILGC LFGPAALYIW AVGLLAAGQS STMTGTYAGQ FVMEGFLKLR WSRFARVLLT 

       370        380        390        400        410        420 
RSCAILPTVL VAVFRDLRDL SGLNDLLNVL QSLLLPFAVL PILTFTSMPA VMQEFANGWL 

       430        440        450        460        470        480 
SKVITSCIMA LVCAINLYFV ISYLPSLPHP AYFGLVALLA IGYLGLTAYL AWTCCIAHGA 

       490        500 
KFLTHSSHQR FLYGLPIEEQ EGREGSG 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Prostate.
[2]"Genomic cloning and genetic mapping of the rat Nramp1 (Bcg) gene on chromosome 9."
Ge L., Remmers E.F., Du Y., Wilder R.L.
Mamm. Genome 7:856-857(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 336-507.
Strain: Lewis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC100653 mRNA. Translation: AAI00654.1.
U53822 Genomic DNA. Translation: AAB49833.1. Different initiation.
RefSeqNP_001026828.1. NM_001031658.1.
UniGeneRn.105919.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000020491.

Proteomic databases

PRIDEP70553.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID316519.
KEGGrno:316519.
UCSCRGD:1601463. rat.

Organism-specific databases

CTD6556.
RGD1601463. Slc11a1.

Phylogenomic databases

eggNOGCOG1914.
HOGENOMHOG000152203.
HOVERGENHBG052665.
KOK12347.

Gene expression databases

GenevestigatorP70553.

Family and domain databases

HAMAPMF_00221. NRAMP.
InterProIPR001046. NRAMP-like.
[Graphical view]
PANTHERPTHR11706. PTHR11706. 1 hit.
PfamPF01566. Nramp. 1 hit.
[Graphical view]
PRINTSPR00447. NATRESASSCMP.
TIGRFAMsTIGR01197. nramp. 1 hit.
ProtoNetSearch...

Other

NextBio670947.
PROP70553.

Entry information

Entry nameNRAM1_RAT
AccessionPrimary (citable) accession number: P70553
Secondary accession number(s): Q496Z6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 10, 2006
Last modified: February 19, 2014
This is version 91 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families