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P70553

- NRAM1_RAT

UniProt

P70553 - NRAM1_RAT

Protein

Natural resistance-associated macrophage protein 1

Gene

Slc11a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 3 (10 Jan 2006)
      Previous versions | rss
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    Functioni

    Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe2+ and Mn2+, cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes By similarity.By similarity

    GO - Molecular functioni

    1. transporter activity Source: InterPro

    GO - Biological processi

    1. ion transport Source: UniProtKB-KW
    2. iron ion homeostasis Source: UniProtKB-KW

    Keywords - Biological processi

    Ion transport, Iron transport, Transport

    Keywords - Ligandi

    Iron

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Natural resistance-associated macrophage protein 1
    Short name:
    NRAMP 1
    Alternative name(s):
    Solute carrier family 11 member 1
    Gene namesi
    Name:Slc11a1
    Synonyms:Bcg, Nramp1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi1601463. Slc11a1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 507507Natural resistance-associated macrophage protein 1PRO_0000212591Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi280 – 2801N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi294 – 2941N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiP70553.

    Expressioni

    Gene expression databases

    GenevestigatoriP70553.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000020491.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3939CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini61 – 12363ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini145 – 1528CytoplasmicSequence Analysis
    Topological domaini174 – 19926ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini221 – 24525CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini267 – 30539ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini327 – 35327CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini375 – 39117ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini413 – 42210CytoplasmicSequence Analysis
    Topological domaini444 – 4518ExtracellularSequence Analysis
    Topological domaini473 – 50735CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei40 – 6021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei124 – 14421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei153 – 17321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei200 – 22021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei246 – 26621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei306 – 32621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei354 – 37421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei392 – 41221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei423 – 44321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei452 – 47221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NRAMP family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1914.
    HOGENOMiHOG000152203.
    HOVERGENiHBG052665.
    KOiK12347.

    Family and domain databases

    HAMAPiMF_00221. NRAMP.
    InterProiIPR001046. NRAMP_fam.
    [Graphical view]
    PANTHERiPTHR11706. PTHR11706. 1 hit.
    PfamiPF01566. Nramp. 1 hit.
    [Graphical view]
    PRINTSiPR00447. NATRESASSCMP.
    TIGRFAMsiTIGR01197. nramp. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P70553-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIRDKNPQRV NRPSYGSISS LPSPAPQPEP SRNTYLSEKI PIPSTEQLLW    50
    VLLWATVLGL LCQRLAARLG VVTGKDLGEI CHLYYPKVPR ILLWLTIELA 100
    IVGSDMQEVI GTAISFNLLS AGRIPLWGGV LITIVDTFFF LFLDNYGLRK 150
    LEAFFGFLVT IMALTFGYEY VVARPSQGAL LKGLFLPSCP GCGQPELLQA 200
    VGIVGAIIMP HNIYLHSALV KSREVDRTRR GDVREANMYF LTEATIALFV 250
    SFIINLFVMA VFGQAFYQQT NEEAFNICAN SSLHNYAKIF PRDNNTVSVD 300
    IYQGGVILGC LFGPAALYIW AVGLLAAGQS STMTGTYAGQ FVMEGFLKLR 350
    WSRFARVLLT RSCAILPTVL VAVFRDLRDL SGLNDLLNVL QSLLLPFAVL 400
    PILTFTSMPA VMQEFANGWL SKVITSCIMA LVCAINLYFV ISYLPSLPHP 450
    AYFGLVALLA IGYLGLTAYL AWTCCIAHGA KFLTHSSHQR FLYGLPIEEQ 500
    EGREGSG 507
    Length:507
    Mass (Da):55,922
    Last modified:January 10, 2006 - v3
    Checksum:i0A052B5EF53D1C64
    GO

    Sequence cautioni

    The sequence AAB49833.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti404 – 4041T → S in AAB49833. (PubMed:8875897)Curated
    Sequence conflicti409 – 4091P → S in AAB49833. (PubMed:8875897)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC100653 mRNA. Translation: AAI00654.1.
    U53822 Genomic DNA. Translation: AAB49833.1. Different initiation.
    RefSeqiNP_001026828.1. NM_001031658.1.
    UniGeneiRn.105919.

    Genome annotation databases

    GeneIDi316519.
    KEGGirno:316519.
    UCSCiRGD:1601463. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC100653 mRNA. Translation: AAI00654.1 .
    U53822 Genomic DNA. Translation: AAB49833.1 . Different initiation.
    RefSeqi NP_001026828.1. NM_001031658.1.
    UniGenei Rn.105919.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000020491.

    Proteomic databases

    PRIDEi P70553.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 316519.
    KEGGi rno:316519.
    UCSCi RGD:1601463. rat.

    Organism-specific databases

    CTDi 6556.
    RGDi 1601463. Slc11a1.

    Phylogenomic databases

    eggNOGi COG1914.
    HOGENOMi HOG000152203.
    HOVERGENi HBG052665.
    KOi K12347.

    Miscellaneous databases

    NextBioi 670947.
    PROi P70553.

    Gene expression databases

    Genevestigatori P70553.

    Family and domain databases

    HAMAPi MF_00221. NRAMP.
    InterProi IPR001046. NRAMP_fam.
    [Graphical view ]
    PANTHERi PTHR11706. PTHR11706. 1 hit.
    Pfami PF01566. Nramp. 1 hit.
    [Graphical view ]
    PRINTSi PR00447. NATRESASSCMP.
    TIGRFAMsi TIGR01197. nramp. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.
    2. "Genomic cloning and genetic mapping of the rat Nramp1 (Bcg) gene on chromosome 9."
      Ge L., Remmers E.F., Du Y., Wilder R.L.
      Mamm. Genome 7:856-857(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 336-507.
      Strain: Lewis.

    Entry informationi

    Entry nameiNRAM1_RAT
    AccessioniPrimary (citable) accession number: P70553
    Secondary accession number(s): Q496Z6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: January 10, 2006
    Last modified: October 1, 2014
    This is version 93 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3