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Protein

Natural resistance-associated macrophage protein 1

Gene

Slc11a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe2+ and Mn2+, cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Names & Taxonomyi

Protein namesi
Recommended name:
Natural resistance-associated macrophage protein 1
Short name:
NRAMP 1
Alternative name(s):
Solute carrier family 11 member 1
Gene namesi
Name:Slc11a1
Synonyms:Bcg, Nramp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1601463. Slc11a1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39CytoplasmicSequence analysisAdd BLAST39
Transmembranei40 – 60HelicalSequence analysisAdd BLAST21
Topological domaini61 – 123ExtracellularSequence analysisAdd BLAST63
Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Topological domaini145 – 152CytoplasmicSequence analysis8
Transmembranei153 – 173HelicalSequence analysisAdd BLAST21
Topological domaini174 – 199ExtracellularSequence analysisAdd BLAST26
Transmembranei200 – 220HelicalSequence analysisAdd BLAST21
Topological domaini221 – 245CytoplasmicSequence analysisAdd BLAST25
Transmembranei246 – 266HelicalSequence analysisAdd BLAST21
Topological domaini267 – 305ExtracellularSequence analysisAdd BLAST39
Transmembranei306 – 326HelicalSequence analysisAdd BLAST21
Topological domaini327 – 353CytoplasmicSequence analysisAdd BLAST27
Transmembranei354 – 374HelicalSequence analysisAdd BLAST21
Topological domaini375 – 391ExtracellularSequence analysisAdd BLAST17
Transmembranei392 – 412HelicalSequence analysisAdd BLAST21
Topological domaini413 – 422CytoplasmicSequence analysis10
Transmembranei423 – 443HelicalSequence analysisAdd BLAST21
Topological domaini444 – 451ExtracellularSequence analysis8
Transmembranei452 – 472HelicalSequence analysisAdd BLAST21
Topological domaini473 – 507CytoplasmicSequence analysisAdd BLAST35

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002125911 – 507Natural resistance-associated macrophage protein 1Add BLAST507

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi280N-linked (GlcNAc...)Sequence analysis1
Glycosylationi294N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP70553.
PRIDEiP70553.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054282.

Family & Domainsi

Sequence similaritiesi

Belongs to the NRAMP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1291. Eukaryota.
COG1914. LUCA.
HOGENOMiHOG000152203.
HOVERGENiHBG052665.
InParanoidiP70553.
KOiK12347.

Family and domain databases

HAMAPiMF_00221. NRAMP. 1 hit.
InterProiIPR001046. NRAMP_fam.
[Graphical view]
PANTHERiPTHR11706. PTHR11706. 1 hit.
PfamiPF01566. Nramp. 1 hit.
[Graphical view]
PRINTSiPR00447. NATRESASSCMP.
TIGRFAMsiTIGR01197. nramp. 1 hit.

Sequencei

Sequence statusi: Complete.

P70553-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRDKNPQRV NRPSYGSISS LPSPAPQPEP SRNTYLSEKI PIPSTEQLLW
60 70 80 90 100
VLLWATVLGL LCQRLAARLG VVTGKDLGEI CHLYYPKVPR ILLWLTIELA
110 120 130 140 150
IVGSDMQEVI GTAISFNLLS AGRIPLWGGV LITIVDTFFF LFLDNYGLRK
160 170 180 190 200
LEAFFGFLVT IMALTFGYEY VVARPSQGAL LKGLFLPSCP GCGQPELLQA
210 220 230 240 250
VGIVGAIIMP HNIYLHSALV KSREVDRTRR GDVREANMYF LTEATIALFV
260 270 280 290 300
SFIINLFVMA VFGQAFYQQT NEEAFNICAN SSLHNYAKIF PRDNNTVSVD
310 320 330 340 350
IYQGGVILGC LFGPAALYIW AVGLLAAGQS STMTGTYAGQ FVMEGFLKLR
360 370 380 390 400
WSRFARVLLT RSCAILPTVL VAVFRDLRDL SGLNDLLNVL QSLLLPFAVL
410 420 430 440 450
PILTFTSMPA VMQEFANGWL SKVITSCIMA LVCAINLYFV ISYLPSLPHP
460 470 480 490 500
AYFGLVALLA IGYLGLTAYL AWTCCIAHGA KFLTHSSHQR FLYGLPIEEQ

EGREGSG
Length:507
Mass (Da):55,922
Last modified:January 10, 2006 - v3
Checksum:i0A052B5EF53D1C64
GO

Sequence cautioni

The sequence AAB49833 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti404T → S in AAB49833 (PubMed:8875897).Curated1
Sequence conflicti409P → S in AAB49833 (PubMed:8875897).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC100653 mRNA. Translation: AAI00654.1.
U53822 Genomic DNA. Translation: AAB49833.1. Different initiation.
RefSeqiNP_001026828.1. NM_001031658.1.
UniGeneiRn.105919.

Genome annotation databases

GeneIDi316519.
KEGGirno:316519.
UCSCiRGD:1601463. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC100653 mRNA. Translation: AAI00654.1.
U53822 Genomic DNA. Translation: AAB49833.1. Different initiation.
RefSeqiNP_001026828.1. NM_001031658.1.
UniGeneiRn.105919.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054282.

Proteomic databases

PaxDbiP70553.
PRIDEiP70553.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi316519.
KEGGirno:316519.
UCSCiRGD:1601463. rat.

Organism-specific databases

CTDi6556.
RGDi1601463. Slc11a1.

Phylogenomic databases

eggNOGiKOG1291. Eukaryota.
COG1914. LUCA.
HOGENOMiHOG000152203.
HOVERGENiHBG052665.
InParanoidiP70553.
KOiK12347.

Miscellaneous databases

PROiP70553.

Family and domain databases

HAMAPiMF_00221. NRAMP. 1 hit.
InterProiIPR001046. NRAMP_fam.
[Graphical view]
PANTHERiPTHR11706. PTHR11706. 1 hit.
PfamiPF01566. Nramp. 1 hit.
[Graphical view]
PRINTSiPR00447. NATRESASSCMP.
TIGRFAMsiTIGR01197. nramp. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNRAM1_RAT
AccessioniPrimary (citable) accession number: P70553
Secondary accession number(s): Q496Z6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 10, 2006
Last modified: June 8, 2016
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.