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Protein

Solute carrier family 13 member 2

Gene

Slc13a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cotransport of sodium ions and dicarboxylates such as succinate and citrate.

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 13 member 2
Alternative name(s):
Intestinal sodium/dicarboxylate cotransporter
Na(+)/dicarboxylate cotransporter 1
Short name:
NaDC-1
Gene namesi
Name:Slc13a2
Synonyms:Nadc1, Sdct1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi61920. Slc13a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei13 – 3321HelicalSequence analysisAdd
BLAST
Transmembranei53 – 7321HelicalSequence analysisAdd
BLAST
Transmembranei85 – 10521HelicalSequence analysisAdd
BLAST
Transmembranei135 – 15521HelicalSequence analysisAdd
BLAST
Transmembranei263 – 28321HelicalSequence analysisAdd
BLAST
Transmembranei329 – 34921HelicalSequence analysisAdd
BLAST
Transmembranei367 – 38721HelicalSequence analysisAdd
BLAST
Transmembranei407 – 42721HelicalSequence analysisAdd
BLAST
Transmembranei445 – 46521HelicalSequence analysisAdd
BLAST
Transmembranei477 – 49721HelicalSequence analysisAdd
BLAST
Transmembranei506 – 52621HelicalSequence analysisAdd
BLAST
Transmembranei535 – 55521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 587587Solute carrier family 13 member 2PRO_0000172491Add
BLAST

Proteomic databases

PaxDbiP70545.
PRIDEiP70545.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000038185.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1281. Eukaryota.
COG0471. LUCA.
HOGENOMiHOG000278432.
HOVERGENiHBG055339.
InParanoidiP70545.
PhylomeDBiP70545.

Family and domain databases

InterProiIPR001898. Na/sul_symport.
IPR031312. Na/sul_symport_CS.
[Graphical view]
PfamiPF00939. Na_sulph_symp. 1 hit.
[Graphical view]
PROSITEiPS01271. NA_SULFATE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70545-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATCWPALWA YRFYLIVLCL PIFLLPLPLI VQTKEAYCAY SIILMALLWC
60 70 80 90 100
TEALPLAVTV LFPIVLFLLM GIMDASEGLE YFKDTNILFV GGLMVAIAVE
110 120 130 140 150
HWNLHKRIAL QVLLIIGVRA ALLLLGFMLV TAFLSMWISN TATTAMMVPI
160 170 180 190 200
GHAVLEQLQA SKKDVEGGNN NPTFELQEEC PQKEVTKLDN GQPVSAPSEP
210 220 230 240 250
RTQKTQEHHR FSQGLSLCIC YSASIGGIDN LTGTTPNLVL QGQVNSLFPQ
260 270 280 290 300
NANVVNFASW FGFAFPTMII LLLLAWLWLQ VLFLGVNFRK NFGFGEGEEE
310 320 330 340 350
RKQAAFQVIK TQYRLLGPMS FAEKTCSTVL FVLLVVLWFT REPGFFPGWG
360 370 380 390 400
DTVFANEKGQ SMPSDGTVAI FISLVMFIIP SKIPGLMEDP KKPGKLKAPP
410 420 430 440 450
AILTWKTVND KMPWNIVILL GGGFALAKGS EQSGLSEWLG DKLTPLQHIP
460 470 480 490 500
PSATAVILCL LIAIFTECTS NVATTTLFLP ILASMAQAIC LHPLYVMLPC
510 520 530 540 550
TLAASLAFML PVATPPNAIV FSFGGLKVSD MARAGFLLNI IGVLATTLSI
560 570 580
NSWSIPIFKL DTFPSWAHSN TSQCLLNPSN STVPGGL
Length:587
Mass (Da):64,207
Last modified:September 19, 2002 - v2
Checksum:i964D80661F1EBE0A
GO

Sequence cautioni

The sequence AAB97095.1 differs from that shown. Reason: Frameshift at several positions. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51153 mRNA. Translation: AAB97095.1. Frameshift.
UniGeneiRn.10821.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51153 mRNA. Translation: AAB97095.1. Frameshift.
UniGeneiRn.10821.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000038185.

Proteomic databases

PaxDbiP70545.
PRIDEiP70545.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi61920. Slc13a2.

Phylogenomic databases

eggNOGiKOG1281. Eukaryota.
COG0471. LUCA.
HOGENOMiHOG000278432.
HOVERGENiHBG055339.
InParanoidiP70545.
PhylomeDBiP70545.

Miscellaneous databases

PROiP70545.

Family and domain databases

InterProiIPR001898. Na/sul_symport.
IPR031312. Na/sul_symport_CS.
[Graphical view]
PfamiPF00939. Na_sulph_symp. 1 hit.
[Graphical view]
PROSITEiPS01271. NA_SULFATE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of the cDNA for a rat intestinal Na+/dicarboxylate cotransporter reveals partial sequence homology with a rat intestinal mucin."
    Khatri I.A., Kovacs S.V.B., Forstner J.F.
    Biochim. Biophys. Acta 1309:58-62(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.

Entry informationi

Entry nameiS13A2_RAT
AccessioniPrimary (citable) accession number: P70545
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 19, 2002
Last modified: July 6, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.