Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Solute carrier family 13 member 2

Gene

Slc13a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cotransport of sodium ions and dicarboxylates such as succinate and citrate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Sodium transport, Symport, Transport
LigandSodium

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 13 member 2
Alternative name(s):
Intestinal sodium/dicarboxylate cotransporter
Na(+)/dicarboxylate cotransporter 1
Short name:
NaDC-1
Gene namesi
Name:Slc13a2
Synonyms:Nadc1, Sdct1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi61920 Slc13a2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Transmembranei85 – 105HelicalSequence analysisAdd BLAST21
Transmembranei135 – 155HelicalSequence analysisAdd BLAST21
Transmembranei263 – 283HelicalSequence analysisAdd BLAST21
Transmembranei329 – 349HelicalSequence analysisAdd BLAST21
Transmembranei367 – 387HelicalSequence analysisAdd BLAST21
Transmembranei407 – 427HelicalSequence analysisAdd BLAST21
Transmembranei445 – 465HelicalSequence analysisAdd BLAST21
Transmembranei477 – 497HelicalSequence analysisAdd BLAST21
Transmembranei506 – 526HelicalSequence analysisAdd BLAST21
Transmembranei535 – 555HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001724911 – 587Solute carrier family 13 member 2Add BLAST587

Proteomic databases

PaxDbiP70545
PRIDEiP70545

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000038185

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1281 Eukaryota
COG0471 LUCA
HOGENOMiHOG000278432
HOVERGENiHBG055339
InParanoidiP70545
PhylomeDBiP70545

Family and domain databases

InterProiView protein in InterPro
IPR031312 Na/sul_symport_CS
IPR001898 SLC13A/DASS
PfamiView protein in Pfam
PF00939 Na_sulph_symp, 1 hit
PROSITEiView protein in PROSITE
PS01271 NA_SULFATE, 1 hit

Sequencei

Sequence statusi: Complete.

P70545-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATCWPALWA YRFYLIVLCL PIFLLPLPLI VQTKEAYCAY SIILMALLWC
60 70 80 90 100
TEALPLAVTV LFPIVLFLLM GIMDASEGLE YFKDTNILFV GGLMVAIAVE
110 120 130 140 150
HWNLHKRIAL QVLLIIGVRA ALLLLGFMLV TAFLSMWISN TATTAMMVPI
160 170 180 190 200
GHAVLEQLQA SKKDVEGGNN NPTFELQEEC PQKEVTKLDN GQPVSAPSEP
210 220 230 240 250
RTQKTQEHHR FSQGLSLCIC YSASIGGIDN LTGTTPNLVL QGQVNSLFPQ
260 270 280 290 300
NANVVNFASW FGFAFPTMII LLLLAWLWLQ VLFLGVNFRK NFGFGEGEEE
310 320 330 340 350
RKQAAFQVIK TQYRLLGPMS FAEKTCSTVL FVLLVVLWFT REPGFFPGWG
360 370 380 390 400
DTVFANEKGQ SMPSDGTVAI FISLVMFIIP SKIPGLMEDP KKPGKLKAPP
410 420 430 440 450
AILTWKTVND KMPWNIVILL GGGFALAKGS EQSGLSEWLG DKLTPLQHIP
460 470 480 490 500
PSATAVILCL LIAIFTECTS NVATTTLFLP ILASMAQAIC LHPLYVMLPC
510 520 530 540 550
TLAASLAFML PVATPPNAIV FSFGGLKVSD MARAGFLLNI IGVLATTLSI
560 570 580
NSWSIPIFKL DTFPSWAHSN TSQCLLNPSN STVPGGL
Length:587
Mass (Da):64,207
Last modified:September 19, 2002 - v2
Checksum:i964D80661F1EBE0A
GO

Sequence cautioni

The sequence AAB97095 differs from that shown. Reason: Frameshift at several positions.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51153 mRNA Translation: AAB97095.1 Frameshift.
UniGeneiRn.10821

Similar proteinsi

Entry informationi

Entry nameiS13A2_RAT
AccessioniPrimary (citable) accession number: P70545
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 19, 2002
Last modified: May 23, 2018
This is version 102 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health