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Protein

Translation initiation factor eIF-2B subunit gamma

Gene

Eif2b3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.

GO - Molecular functioni

GO - Biological processi

  • cellular response to stimulus Source: UniProtKB
  • hippocampus development Source: RGD
  • oligodendrocyte development Source: UniProtKB
  • response to glucose Source: UniProtKB
  • response to heat Source: UniProtKB
  • response to peptide hormone Source: UniProtKB
  • translation Source: RGD
  • translational initiation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

ReactomeiR-RNO-72731. Recycling of eIF2:GDP.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor eIF-2B subunit gamma
Alternative name(s):
eIF-2B GDP-GTP exchange factor subunit gamma
Gene namesi
Name:Eif2b3
Synonyms:Eif2bg
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi620821. Eif2b3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001560801 – 452Translation initiation factor eIF-2B subunit gammaAdd BLAST452

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei260PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP70541.
PRIDEiP70541.

Expressioni

Tissue specificityi

Brain, heart, liver, muscle and testis.

Gene expression databases

BgeeiENSRNOG00000018375.
GenevisibleiP70541. RN.

Interactioni

Subunit structurei

Complex of five different subunits; alpha, beta, gamma, delta and epsilon.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024841.

Structurei

3D structure databases

ProteinModelPortaliP70541.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1462. Eukaryota.
COG1208. LUCA.
GeneTreeiENSGT00510000047486.
HOVERGENiHBG051461.
InParanoidiP70541.
KOiK03241.
OMAiEEGCNIQ.
OrthoDBiEOG091G0BQX.
PhylomeDBiP70541.

Family and domain databases

Gene3Di3.90.550.10. 2 hits.
InterProiIPR005835. NTP_transferase_dom.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 4 hits.

Sequencei

Sequence statusi: Complete.

P70541-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFQAVVMAV GGGSRMTDLT SSIPKPLLPV GNKPLIWYPL NLLERVGFEE
60 70 80 90 100
VIVVTTKDVQ KALCAEFKMK LKPDIVCIPD EADMGTADSL RHIYPKLKTD
110 120 130 140 150
VLVLGCDLIT DVALHEVVDL FRAYDASLAM LMRKGQESTE PVPGQKGKKK
160 170 180 190 200
TVEQRDFIGV DSTGKRLLFM ANEADLDEEL VIKGSILQKH PRIHFQTGLV
210 220 230 240 250
DAHLYCLKKY VVDFLMENKS ITSIRSELIP YLVRKQFSSA SSQQRQEDKE
260 270 280 290 300
EDLKKKEPKS LDIYSFIKKD NTLTLAPYDA CWNAFRRDKW EDLSRSQVRC
310 320 330 340 350
YVHIMKEGLC SRVSTLGLYM EANRQVPKLL SVLCPEESMI HPSAQIANKH
360 370 380 390 400
LIGADSLIGS DTQVGEKSSI KRSVIGSSCV IRDRVTVTNC LLMNSVTVEE
410 420 430 440 450
GSSIHGSVIC NNAVVEAGAE IRDCLIGSGQ RIEAKAKRMN EVIVGNDQLM

EI
Length:452
Mass (Da):50,435
Last modified:June 13, 2006 - v2
Checksum:iBA33492D1700BE4F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti399E → G in AAC52788 (PubMed:8809057).Curated1
Sequence conflicti410C → F in AAC52788 (PubMed:8809057).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38253 mRNA. Translation: AAC52788.1.
BC072507 mRNA. Translation: AAH72507.1.
PIRiS72266.
RefSeqiNP_598293.2. NM_133609.2.
XP_006238692.1. XM_006238630.3.
UniGeneiRn.10577.

Genome annotation databases

EnsembliENSRNOT00000024841; ENSRNOP00000024841; ENSRNOG00000018375.
GeneIDi171145.
KEGGirno:171145.
UCSCiRGD:620821. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38253 mRNA. Translation: AAC52788.1.
BC072507 mRNA. Translation: AAH72507.1.
PIRiS72266.
RefSeqiNP_598293.2. NM_133609.2.
XP_006238692.1. XM_006238630.3.
UniGeneiRn.10577.

3D structure databases

ProteinModelPortaliP70541.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024841.

Proteomic databases

PaxDbiP70541.
PRIDEiP70541.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000024841; ENSRNOP00000024841; ENSRNOG00000018375.
GeneIDi171145.
KEGGirno:171145.
UCSCiRGD:620821. rat.

Organism-specific databases

CTDi8891.
RGDi620821. Eif2b3.

Phylogenomic databases

eggNOGiKOG1462. Eukaryota.
COG1208. LUCA.
GeneTreeiENSGT00510000047486.
HOVERGENiHBG051461.
InParanoidiP70541.
KOiK03241.
OMAiEEGCNIQ.
OrthoDBiEOG091G0BQX.
PhylomeDBiP70541.

Enzyme and pathway databases

ReactomeiR-RNO-72731. Recycling of eIF2:GDP.

Miscellaneous databases

PROiP70541.

Gene expression databases

BgeeiENSRNOG00000018375.
GenevisibleiP70541. RN.

Family and domain databases

Gene3Di3.90.550.10. 2 hits.
InterProiIPR005835. NTP_transferase_dom.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 4 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiEI2BG_RAT
AccessioniPrimary (citable) accession number: P70541
Secondary accession number(s): Q6IN08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 13, 2006
Last modified: November 2, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.