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P70539

- ACV1C_RAT

UniProt

P70539 - ACV1C_RAT

Protein

Activin receptor type-1C

Gene

Acvr1c

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.4 Publications

    Catalytic activityi

    ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

    Cofactori

    Magnesium or manganese.Curated

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei222 – 2221ATPBy similarityPROSITE-ProRule annotation
    Active sitei323 – 3231Proton acceptorBy similarityPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi201 – 2099ATPBy similarityPROSITE-ProRule annotation

    GO - Molecular functioni

    1. activin binding Source: MGI
    2. activin receptor activity, type I Source: UniProtKB
    3. ATP binding Source: HGNC
    4. BMP receptor binding Source: RGD
    5. growth factor binding Source: UniProt
    6. metal ion binding Source: UniProtKB
    7. protein serine/threonine kinase activity Source: HGNC
    8. receptor signaling protein serine/threonine kinase activity Source: InterPro
    9. SMAD binding Source: HGNC
    10. transforming growth factor beta-activated receptor activity Source: InterPro

    GO - Biological processi

    1. activin receptor signaling pathway Source: GOC
    2. apoptotic process Source: UniProtKB-KW
    3. cell differentiation Source: UniProtKB
    4. cerebellum development Source: RGD
    5. hippocampus development Source: RGD
    6. midbrain development Source: RGD
    7. ovarian follicle development Source: RGD
    8. protein phosphorylation Source: UniProtKB
    9. regulation of apoptotic process Source: UniProtKB
    10. response to drug Source: RGD
    11. response to glucose Source: RGD
    12. response to lipid Source: RGD
    13. response to organic cyclic compound Source: RGD
    14. transforming growth factor beta receptor complex assembly Source: RGD

    Keywords - Molecular functioni

    Kinase, Receptor, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Apoptosis

    Keywords - Ligandi

    ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Activin receptor type-1C (EC:2.7.11.30)
    Alternative name(s):
    Activin receptor type IC
    Short name:
    ACTR-IC
    Activin receptor-like kinase 7
    Short name:
    ALK-7
    Gene namesi
    Name:Acvr1cImported
    Synonyms:Alk7
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi621789. Acvr1c.

    Subcellular locationi

    Membrane 1 Publication; Single-pass type I membrane protein 1 Publication

    GO - Cellular componenti

    1. activin receptor complex Source: UniProtKB
    2. cell surface Source: RGD
    3. cytoplasm Source: RGD
    4. plasma membrane Source: RGD

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi194 – 1941T → D: Constitutively activates downstream transcription factor function. 2 Publications
    Mutagenesisi222 – 2221K → R: Fails to activate downstream transcription factor function. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 493468Activin receptor type-1CPRO_0000042630Add
    BLAST

    Proteomic databases

    PaxDbiP70539.

    Expressioni

    Tissue specificityi

    Expressed in brain, kidney, lung, liver, testis, ovary, adrenal gland, heart, prostate, gastrointestinal tract, and spleen. Distributed throughout both adult and embryonic central nervous system and pancreatic islet cells.5 Publications

    Gene expression databases

    GenevestigatoriP70539.

    Interactioni

    Subunit structurei

    Binds the type 2 receptor protein ACVR2A.

    Structurei

    3D structure databases

    ProteinModelPortaliP70539.
    SMRiP70539. Positions 161-489.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini26 – 11388ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini135 – 493359CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei114 – 13421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini165 – 19430GSPROSITE-ProRule annotationAdd
    BLAST
    Domaini195 – 485291Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 GS domain.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000230587.
    HOVERGENiHBG054502.
    InParanoidiP70539.
    KOiK13568.
    PhylomeDBiP70539.

    Family and domain databases

    InterProiIPR000472. Activin_rcpt.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    IPR003605. TGF_beta_rcpt_GS.
    IPR000333. TGFB_receptor.
    [Graphical view]
    PANTHERiPTHR23255. PTHR23255. 1 hit.
    PfamiPF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    PF08515. TGF_beta_GS. 1 hit.
    [Graphical view]
    SMARTiSM00467. GS. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS51256. GS. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P70539-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTPARRSALS LALLLVALAS DLAAGLKCVC LLCDSSNFTC QTEGACWASV    50
    MLTNGKEQVS KSCVSLPELN AQVFCHSSNN VTKTECCFTD FCNNITQHLP 100
    TASPDAPRLG PTELTVVITV PVCLLSIAAM LTIWACQDRQ CTYRKTKRHN 150
    VEEPLAEYSL VNAGKTLKDL IYDATASGSG SGPPLLVQRT IARTIVLQEI 200
    VGKGRFGEVW HGRWCGEDVA VKIFSSRDER SWFREAEIYQ TVMLRHENIL 250
    GFIAADNKDN GTWTQLWLVS EYHEQGSLYD YLNRNIVTVA GMVKLALSIA 300
    SGLAHLHMEI VGTQGKPAIA HRDIKSKNIL VKKCDTCAIA DLGLAVKHDS 350
    IMNTIDIPQN PKVGTKRYMA PEMLDDTMNV NIFESFKRAD IYSVGLVYWE 400
    IARRCSVGGL VEEYQLPYYD MVPSDPSIEE MRKVVCDQKL RPNLPNQWQS 450
    CEALRVMGRI MRECWYANGA ARLTALRVKK TISQLCVKED CKA 493
    Length:493
    Mass (Da):54,842
    Last modified:February 1, 1997 - v1
    Checksum:iFB2BB3C2A026BCC3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti5 – 51R → S in AAC52919. (PubMed:8940033)Curated
    Sequence conflicti60 – 601S → I in AAC52919. (PubMed:8940033)Curated
    Sequence conflicti97 – 971Q → L in AAC52919. (PubMed:8940033)Curated
    Sequence conflicti183 – 1831P → L in AAC52919. (PubMed:8940033)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U35025 mRNA. Translation: AAC52803.1.
    U69702 mRNA. Translation: AAC52919.1.
    RefSeqiNP_620790.1. NM_139090.1.
    UniGeneiRn.10580.

    Genome annotation databases

    GeneIDi245921.
    KEGGirno:245921.
    UCSCiRGD:621789. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U35025 mRNA. Translation: AAC52803.1 .
    U69702 mRNA. Translation: AAC52919.1 .
    RefSeqi NP_620790.1. NM_139090.1.
    UniGenei Rn.10580.

    3D structure databases

    ProteinModelPortali P70539.
    SMRi P70539. Positions 161-489.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi P70539.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 245921.
    KEGGi rno:245921.
    UCSCi RGD:621789. rat.

    Organism-specific databases

    CTDi 130399.
    RGDi 621789. Acvr1c.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000230587.
    HOVERGENi HBG054502.
    InParanoidi P70539.
    KOi K13568.
    PhylomeDBi P70539.

    Miscellaneous databases

    NextBioi 623170.
    PROi P70539.

    Gene expression databases

    Genevestigatori P70539.

    Family and domain databases

    InterProi IPR000472. Activin_rcpt.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    IPR003605. TGF_beta_rcpt_GS.
    IPR000333. TGFB_receptor.
    [Graphical view ]
    PANTHERi PTHR23255. PTHR23255. 1 hit.
    Pfami PF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    PF08515. TGF_beta_GS. 1 hit.
    [Graphical view ]
    SMARTi SM00467. GS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS51256. GS. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a novel type I receptor serine/threonine kinase for the TGF beta superfamily from rat brain."
      Tsuchida K., Sawchenko P.E., Nishikawa S., Vale W.W.
      Mol. Cell. Neurosci. 7:467-478(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, MUTAGENESIS OF THR-194 AND LYS-222.
      Strain: Sprague-DawleyImported.
      Tissue: BrainImported.
    2. "A novel type I receptor serine-threonine kinase predominantly expressed in the adult central nervous system."
      Ryden M., Imamura T., Joernvall H., Belluardo N., Neveu I., Trupp M., Okadome T., ten Dijke P., Ibanez C.F.
      J. Biol. Chem. 271:30603-30609(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Brain1 Publication.
    3. "Activin isoforms signal through type I receptor serine/threonine kinase ALK7."
      Tsuchida K., Nakatani M., Yamakawa N., Hashimoto O., Hasegawa Y., Sugino H.
      Mol. Cell. Endocrinol. 220:59-65(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 139-159, FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INTERACTION WITH ACVR2A; ACTIVIN AB AND B.
    4. Cited for: FUNCTION, TISSUE SPECIFICITY, MUTAGENESIS OF THR-194.
    5. "The orphan receptor serine/threonine kinase ALK7 signals arrest of proliferation and morphological differentiation in a neuronal cell line."
      Joernvall H., Blokzijl A., ten Dijke P., Ibanez C.F.
      J. Biol. Chem. 276:5140-5146(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiACV1C_RAT
    AccessioniPrimary (citable) accession number: P70539
    Secondary accession number(s): P70603
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2005
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3