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P70539

- ACV1C_RAT

UniProt

P70539 - ACV1C_RAT

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Protein

Activin receptor type-1C

Gene

Acvr1c

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.4 Publications

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactori

Magnesium or manganese.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei222 – 2221ATPBy similarityPROSITE-ProRule annotation
Active sitei323 – 3231Proton acceptorBy similarityPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi201 – 2099ATPBy similarityPROSITE-ProRule annotation

GO - Molecular functioni

  1. activin binding Source: MGI
  2. activin receptor activity, type I Source: UniProtKB
  3. ATP binding Source: HGNC
  4. BMP receptor binding Source: RGD
  5. growth factor binding Source: UniProt
  6. metal ion binding Source: UniProtKB
  7. protein serine/threonine kinase activity Source: HGNC
  8. receptor signaling protein serine/threonine kinase activity Source: InterPro
  9. SMAD binding Source: HGNC
  10. transforming growth factor beta-activated receptor activity Source: InterPro

GO - Biological processi

  1. activin receptor signaling pathway Source: GOC
  2. apoptotic process Source: UniProtKB-KW
  3. cell differentiation Source: UniProtKB
  4. cerebellum development Source: RGD
  5. hippocampus development Source: RGD
  6. midbrain development Source: RGD
  7. ovarian follicle development Source: RGD
  8. protein phosphorylation Source: UniProtKB
  9. regulation of apoptotic process Source: UniProtKB
  10. response to drug Source: RGD
  11. response to glucose Source: RGD
  12. response to lipid Source: RGD
  13. response to organic cyclic compound Source: RGD
  14. transforming growth factor beta receptor complex assembly Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Activin receptor type-1C (EC:2.7.11.30)
Alternative name(s):
Activin receptor type IC
Short name:
ACTR-IC
Activin receptor-like kinase 7
Short name:
ALK-7
Gene namesi
Name:Acvr1cImported
Synonyms:Alk7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi621789. Acvr1c.

Subcellular locationi

Membrane 1 Publication; Single-pass type I membrane protein 1 Publication

GO - Cellular componenti

  1. activin receptor complex Source: UniProtKB
  2. cell surface Source: RGD
  3. cytoplasm Source: RGD
  4. plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi194 – 1941T → D: Constitutively activates downstream transcription factor function. 2 Publications
Mutagenesisi222 – 2221K → R: Fails to activate downstream transcription factor function. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 493468Activin receptor type-1CPRO_0000042630Add
BLAST

Proteomic databases

PaxDbiP70539.

Expressioni

Tissue specificityi

Expressed in brain, kidney, lung, liver, testis, ovary, adrenal gland, heart, prostate, gastrointestinal tract, and spleen. Distributed throughout both adult and embryonic central nervous system and pancreatic islet cells.5 Publications

Gene expression databases

GenevestigatoriP70539.

Interactioni

Subunit structurei

Binds the type 2 receptor protein ACVR2A.

Structurei

3D structure databases

ProteinModelPortaliP70539.
SMRiP70539. Positions 161-489.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 11388ExtracellularSequence AnalysisAdd
BLAST
Topological domaini135 – 493359CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei114 – 13421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini165 – 19430GSPROSITE-ProRule annotationAdd
BLAST
Domaini195 – 485291Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 GS domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000230587.
HOVERGENiHBG054502.
InParanoidiP70539.
KOiK13568.
PhylomeDBiP70539.

Family and domain databases

InterProiIPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
SMARTiSM00467. GS. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70539-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTPARRSALS LALLLVALAS DLAAGLKCVC LLCDSSNFTC QTEGACWASV
60 70 80 90 100
MLTNGKEQVS KSCVSLPELN AQVFCHSSNN VTKTECCFTD FCNNITQHLP
110 120 130 140 150
TASPDAPRLG PTELTVVITV PVCLLSIAAM LTIWACQDRQ CTYRKTKRHN
160 170 180 190 200
VEEPLAEYSL VNAGKTLKDL IYDATASGSG SGPPLLVQRT IARTIVLQEI
210 220 230 240 250
VGKGRFGEVW HGRWCGEDVA VKIFSSRDER SWFREAEIYQ TVMLRHENIL
260 270 280 290 300
GFIAADNKDN GTWTQLWLVS EYHEQGSLYD YLNRNIVTVA GMVKLALSIA
310 320 330 340 350
SGLAHLHMEI VGTQGKPAIA HRDIKSKNIL VKKCDTCAIA DLGLAVKHDS
360 370 380 390 400
IMNTIDIPQN PKVGTKRYMA PEMLDDTMNV NIFESFKRAD IYSVGLVYWE
410 420 430 440 450
IARRCSVGGL VEEYQLPYYD MVPSDPSIEE MRKVVCDQKL RPNLPNQWQS
460 470 480 490
CEALRVMGRI MRECWYANGA ARLTALRVKK TISQLCVKED CKA
Length:493
Mass (Da):54,842
Last modified:February 1, 1997 - v1
Checksum:iFB2BB3C2A026BCC3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 51R → S in AAC52919. (PubMed:8940033)Curated
Sequence conflicti60 – 601S → I in AAC52919. (PubMed:8940033)Curated
Sequence conflicti97 – 971Q → L in AAC52919. (PubMed:8940033)Curated
Sequence conflicti183 – 1831P → L in AAC52919. (PubMed:8940033)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U35025 mRNA. Translation: AAC52803.1.
U69702 mRNA. Translation: AAC52919.1.
RefSeqiNP_620790.1. NM_139090.1.
UniGeneiRn.10580.

Genome annotation databases

GeneIDi245921.
KEGGirno:245921.
UCSCiRGD:621789. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U35025 mRNA. Translation: AAC52803.1 .
U69702 mRNA. Translation: AAC52919.1 .
RefSeqi NP_620790.1. NM_139090.1.
UniGenei Rn.10580.

3D structure databases

ProteinModelPortali P70539.
SMRi P70539. Positions 161-489.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi P70539.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 245921.
KEGGi rno:245921.
UCSCi RGD:621789. rat.

Organism-specific databases

CTDi 130399.
RGDi 621789. Acvr1c.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000230587.
HOVERGENi HBG054502.
InParanoidi P70539.
KOi K13568.
PhylomeDBi P70539.

Miscellaneous databases

NextBioi 623170.
PROi P70539.

Gene expression databases

Genevestigatori P70539.

Family and domain databases

InterProi IPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view ]
PANTHERi PTHR23255. PTHR23255. 1 hit.
Pfami PF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view ]
SMARTi SM00467. GS. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of a novel type I receptor serine/threonine kinase for the TGF beta superfamily from rat brain."
    Tsuchida K., Sawchenko P.E., Nishikawa S., Vale W.W.
    Mol. Cell. Neurosci. 7:467-478(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, MUTAGENESIS OF THR-194 AND LYS-222.
    Strain: Sprague-DawleyImported.
    Tissue: BrainImported.
  2. "A novel type I receptor serine-threonine kinase predominantly expressed in the adult central nervous system."
    Ryden M., Imamura T., Joernvall H., Belluardo N., Neveu I., Trupp M., Okadome T., ten Dijke P., Ibanez C.F.
    J. Biol. Chem. 271:30603-30609(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Brain1 Publication.
  3. "Activin isoforms signal through type I receptor serine/threonine kinase ALK7."
    Tsuchida K., Nakatani M., Yamakawa N., Hashimoto O., Hasegawa Y., Sugino H.
    Mol. Cell. Endocrinol. 220:59-65(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 139-159, FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INTERACTION WITH ACVR2A; ACTIVIN AB AND B.
  4. Cited for: FUNCTION, TISSUE SPECIFICITY, MUTAGENESIS OF THR-194.
  5. "The orphan receptor serine/threonine kinase ALK7 signals arrest of proliferation and morphological differentiation in a neuronal cell line."
    Joernvall H., Blokzijl A., ten Dijke P., Ibanez C.F.
    J. Biol. Chem. 276:5140-5146(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiACV1C_RAT
AccessioniPrimary (citable) accession number: P70539
Secondary accession number(s): P70603
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: February 1, 1997
Last modified: October 1, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3