Activin receptor type-1C precursor - Rattus norvegicus (Rat)

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Reviewed, UniProtKB/Swiss-Prot P70539 (ACV1C_RAT)

Last modified November 25, 2008. Version 64. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Activin receptor type-1C
    EC=2.7.11.30
Alternative name(s):
    ACTR-IC
    Activin receptor-like kinase 7
      Short name=ALK-7

Gene names

Name:	Acvr1c
Synonyms:	Alk7

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

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Protein attributes

Sequence length	493 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.
Catalytic activity	ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
Cofactor	Magnesium or manganese.
Subunit structure	Binds the type 2 receptor protein ACVR2A.
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Expressed in brain, kidney, lung, liver, testis, ovary, adrenal gland, heart, prostate, gastrointestinal tract, and spleen. Distributed throughout both adult and embryonic central nervous system and pancreatic islet cells.
Sequence similarities	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 GS domain. Contains 1 protein kinase domain.

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Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Membrane
Domain	Signal Transmembrane
Ligand	ATP-binding Magnesium Manganese Metal-binding Nucleotide-binding
Molecular function	Kinase Receptor Serine/threonine-protein kinase Transferase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	cell differentiation Ref.5 Inferred from direct assay. Source: UniProtKB protein amino acid phosphorylation Ref.1 Inferred by curator. Source: UniProtKB regulation of apoptosis Ref.5 Inferred from direct assay. Source: UniProtKB
Cellular component	activin receptor complex Ref.3 Inferred from direct assay. Source: UniProtKB
Molecular function	ATP binding Ref.1 Inferred by curator. Source: UniProtKB SMAD binding Inferred from direct assay. Source: HGNC activin binding Ref.2 Ref.3 Inferred from direct assay. Source: MGI activin receptor activity, type I Ref.1 Inferred from direct assay. Source: UniProtKB magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 25

Potential

Chain

26 – 493

468

Activin receptor type-1C

PRO_0000042630

Regions

Topological domain

26 – 113

Extracellular Potential

Transmembrane

114 – 134

Potential

Topological domain

135 – 493

359

Cytoplasmic Potential

Domain

165 – 194

Domain

195 – 485

291

Protein kinase

Nucleotide binding

201 – 209

ATP By similarity

Sites

Active site

323

Proton acceptor By similarity

Binding site

222

ATP By similarity

Experimental info

Mutagenesis

194

T → D: Constitutively activates downstream transcription factor function

Mutagenesis

222

K → R: Fails to activate downstream transcription factor function

Sequence conflict

R → S in AAC52919. Ref.2

Sequence conflict

S → I in AAC52919. Ref.2

Sequence conflict

Q → L in AAC52919. Ref.2

Sequence conflict

183

P → L in AAC52919. Ref.2

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Sequences

Sequence

Length

Mass (Da)

Tools

P70539-1 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: FB2BB3C2A026BCC3
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FASTA

493

54,842

        10         20         30         40         50         60 
MTPARRSALS LALLLVALAS DLAAGLKCVC LLCDSSNFTC QTEGACWASV MLTNGKEQVS 

        70         80         90        100        110        120 
KSCVSLPELN AQVFCHSSNN VTKTECCFTD FCNNITQHLP TASPDAPRLG PTELTVVITV 

       130        140        150        160        170        180 
PVCLLSIAAM LTIWACQDRQ CTYRKTKRHN VEEPLAEYSL VNAGKTLKDL IYDATASGSG 

       190        200        210        220        230        240 
SGPPLLVQRT IARTIVLQEI VGKGRFGEVW HGRWCGEDVA VKIFSSRDER SWFREAEIYQ 

       250        260        270        280        290        300 
TVMLRHENIL GFIAADNKDN GTWTQLWLVS EYHEQGSLYD YLNRNIVTVA GMVKLALSIA 

       310        320        330        340        350        360 
SGLAHLHMEI VGTQGKPAIA HRDIKSKNIL VKKCDTCAIA DLGLAVKHDS IMNTIDIPQN 

       370        380        390        400        410        420 
PKVGTKRYMA PEMLDDTMNV NIFESFKRAD IYSVGLVYWE IARRCSVGGL VEEYQLPYYD 

       430        440        450        460        470        480 
MVPSDPSIEE MRKVVCDQKL RPNLPNQWQS CEALRVMGRI MRECWYANGA ARLTALRVKK 

       490 
TISQLCVKED CKA

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References

[1]	"Molecular cloning of a novel type I receptor serine/threonine kinase for the TGF beta superfamily from rat brain." Tsuchida K., Sawchenko P.E., Nishikawa S., Vale W.W. Mol. Cell. Neurosci. 7:467-478(1996) [PubMed: 8875430] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, MUTAGENESIS OF THR-194 AND LYS-222. Strain: Sprague-Dawley. Tissue: Brain.
[2]	"A novel type I receptor serine-threonine kinase predominantly expressed in the adult central nervous system." Ryden M., Imamura T., Joernvall H., Belluardo N., Neveu I., Trupp M., Okadome T., ten Dijke P., Ibanez C.F. J. Biol. Chem. 271:30603-30609(1996) [PubMed: 8940033] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Brain.
[3]	"Activin isoforms signal through type I receptor serine/threonine kinase ALK7." Tsuchida K., Nakatani M., Yamakawa N., Hashimoto O., Hasegawa Y., Sugino H. Mol. Cell. Endocrinol. 220:59-65(2004) [PubMed: 15196700] [Abstract] Cited for: PROTEIN SEQUENCE OF 139-159, FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INTERACTION WITH ACVR2A; ACTIVIN AB AND B.
[4]	"The MH1 domains of smad2 and smad3 are involved in the regulation of the ALK7 signals." Watanabe R., Yamada Y., Ihara Y., Someya Y., Kubota A., Kagimoto S., Kuroe A., Iwakura T., Shen Z.-P., Inada A., Adachi T., Ban N., Miyawaki K., Sunaga Y., Tsuda K., Seino Y. Biochem. Biophys. Res. Commun. 254:707-712(1999) [PubMed: 9920806] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY, MUTAGENESIS OF THR-194.
[5]	"The orphan receptor serine/threonine kinase ALK7 signals arrest of proliferation and morphological differentiation in a neuronal cell line." Joernvall H., Blokzijl A., ten Dijke P., Ibanez C.F. J. Biol. Chem. 276:5140-5146(2001) [PubMed: 11084022] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY.

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Cross-references

Sequence databases
	U35025 mRNA. Translation: AAC52803.1. U69702 mRNA. Translation: AAC52919.1.
RefSeq	NP_620790.1.
UniGene	Rn.10580
3D structure databases
HSSP	HSSP built from PDB template 1IAS based on UniProtKB P36897.
SMR	P70539. Positions 161-489.
ModBase	Search...
Genome annotation databases
Ensembl	ENSRNOG00000004828. Rattus norvegicus. [Contig view]
GeneID	245921.
KEGG	rno:245921.
Organism-specific databases
RGD	621789. Acvr1c.
Phylogenomic databases
HOVERGEN	P70539.
Gene expression databases
ArrayExpress	P70539.
GermOnline	ENSRNOG00000004828. Rattus norvegicus.
Family and domain databases
InterPro	IPR000472. Activin_rcpt. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_bd_CS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR003605. TGF_beta_rcpt_GS. [Graphical view]
Pfam	PF01064. Activin_recp. 1 hit. PF00069. Pkinase. 1 hit. PF08515. TGF_beta_GS. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00467. GS. 1 hit. [Graphical view]
PROSITE	PS51256. GS. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	623170.

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Entry information

Entry name

ACV1C_RAT

Accession

Primary (citable) accession number: P70539
Secondary accession number(s): P70603

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 25, 2005
Last sequence update:	February 1, 1997
Last modified:	November 25, 2008
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Keywords

Gene Ontology (GO)

Sequence annotation (Features)

Molecule processing

Regions

Sites

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents