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P70539 (ACV1C_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Activin receptor type-1C

EC=2.7.11.30
Alternative name(s):
Activin receptor type IC
Short name=ACTR-IC
Activin receptor-like kinase 7
Short name=ALK-7
Gene names
Name:Acvr1c
Synonyms:Alk7
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length493 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. Ref.1 Ref.3 Ref.4 Ref.5

Catalytic activity

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactor

Magnesium or manganese.

Subunit structure

Binds the type 2 receptor protein ACVR2A.

Subcellular location

Membrane; Single-pass type I membrane protein Ref.3.

Tissue specificity

Expressed in brain, kidney, lung, liver, testis, ovary, adrenal gland, heart, prostate, gastrointestinal tract, and spleen. Distributed throughout both adult and embryonic central nervous system and pancreatic islet cells. Ref.1 Ref.2 Ref.3 Ref.4 Ref.5

Sequence similarities

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Contains 1 GS domain.

Contains 1 protein kinase domain.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentMembrane
   DomainSignal
Transmembrane
Transmembrane helix
   LigandATP-binding
Magnesium
Manganese
Metal-binding
Nucleotide-binding
   Molecular functionKinase
Receptor
Serine/threonine-protein kinase
Transferase
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processactivin receptor signaling pathway

Inferred from direct assay Ref.1. Source: GOC

apoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

cell differentiation

Inferred from direct assay Ref.5. Source: UniProtKB

cerebellum development

Inferred from expression pattern Ref.2. Source: RGD

hippocampus development

Inferred from expression pattern Ref.2. Source: RGD

midbrain development

Inferred from expression pattern Ref.2. Source: RGD

ovarian follicle development

Inferred from expression pattern PubMed 16709598. Source: RGD

protein phosphorylation

Inferred by curator Ref.1. Source: UniProtKB

regulation of apoptotic process

Inferred from direct assay Ref.5. Source: UniProtKB

response to drug

Inferred from expression pattern Ref.2. Source: RGD

response to glucose

Inferred from expression pattern PubMed 16440210. Source: RGD

response to lipid

Inferred from expression pattern PubMed 16440210. Source: RGD

response to organic cyclic compound

Inferred from expression pattern PubMed 8934566. Source: RGD

transforming growth factor beta receptor complex assembly

Inferred from direct assay Ref.2. Source: RGD

   Cellular_componentactivin receptor complex

Inferred from direct assay Ref.3. Source: UniProtKB

cell surface

Inferred from direct assay Ref.2. Source: RGD

cytoplasm

Inferred from direct assay PubMed 16440210. Source: RGD

plasma membrane

Inferred from direct assay PubMed 16440210. Source: RGD

   Molecular_functionATP binding

Inferred from direct assay PubMed 12065756. Source: HGNC

BMP receptor binding

Inferred from direct assay Ref.2. Source: RGD

SMAD binding

Inferred from direct assay PubMed 12065756. Source: HGNC

activin binding

Inferred from direct assay Ref.3. Source: MGI

activin receptor activity, type I

Inferred from direct assay Ref.1. Source: UniProtKB

growth factor binding

Inferred from sequence or structural similarity. Source: UniProt

metal ion binding

Inferred by curator Ref.1. Source: UniProtKB

protein serine/threonine kinase activity

Inferred from direct assay PubMed 12065756. Source: HGNC

transforming growth factor beta-activated receptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 493468Activin receptor type-1C
PRO_0000042630

Regions

Topological domain26 – 11388Extracellular Potential
Transmembrane114 – 13421Helical; Potential
Topological domain135 – 493359Cytoplasmic Potential
Domain165 – 19430GS
Domain195 – 485291Protein kinase
Nucleotide binding201 – 2099ATP By similarity UniProtKB Q04771

Sites

Active site3231Proton acceptor By similarity UniProtKB Q04771
Binding site2221ATP By similarity UniProtKB Q04771

Experimental info

Mutagenesis1941T → D: Constitutively activates downstream transcription factor function. Ref.1 Ref.4
Mutagenesis2221K → R: Fails to activate downstream transcription factor function. Ref.1
Sequence conflict51R → S in AAC52919. Ref.2
Sequence conflict601S → I in AAC52919. Ref.2
Sequence conflict971Q → L in AAC52919. Ref.2
Sequence conflict1831P → L in AAC52919. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P70539 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: FB2BB3C2A026BCC3

FASTA49354,842
        10         20         30         40         50         60 
MTPARRSALS LALLLVALAS DLAAGLKCVC LLCDSSNFTC QTEGACWASV MLTNGKEQVS 

        70         80         90        100        110        120 
KSCVSLPELN AQVFCHSSNN VTKTECCFTD FCNNITQHLP TASPDAPRLG PTELTVVITV 

       130        140        150        160        170        180 
PVCLLSIAAM LTIWACQDRQ CTYRKTKRHN VEEPLAEYSL VNAGKTLKDL IYDATASGSG 

       190        200        210        220        230        240 
SGPPLLVQRT IARTIVLQEI VGKGRFGEVW HGRWCGEDVA VKIFSSRDER SWFREAEIYQ 

       250        260        270        280        290        300 
TVMLRHENIL GFIAADNKDN GTWTQLWLVS EYHEQGSLYD YLNRNIVTVA GMVKLALSIA 

       310        320        330        340        350        360 
SGLAHLHMEI VGTQGKPAIA HRDIKSKNIL VKKCDTCAIA DLGLAVKHDS IMNTIDIPQN 

       370        380        390        400        410        420 
PKVGTKRYMA PEMLDDTMNV NIFESFKRAD IYSVGLVYWE IARRCSVGGL VEEYQLPYYD 

       430        440        450        460        470        480 
MVPSDPSIEE MRKVVCDQKL RPNLPNQWQS CEALRVMGRI MRECWYANGA ARLTALRVKK 

       490 
TISQLCVKED CKA 

« Hide

References

[1]"Molecular cloning of a novel type I receptor serine/threonine kinase for the TGF beta superfamily from rat brain."
Tsuchida K., Sawchenko P.E., Nishikawa S., Vale W.W.
Mol. Cell. Neurosci. 7:467-478(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, MUTAGENESIS OF THR-194 AND LYS-222.
Strain: Sprague-Dawley.
Tissue: Brain.
[2]"A novel type I receptor serine-threonine kinase predominantly expressed in the adult central nervous system."
Ryden M., Imamura T., Joernvall H., Belluardo N., Neveu I., Trupp M., Okadome T., ten Dijke P., Ibanez C.F.
J. Biol. Chem. 271:30603-30609(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Brain.
[3]"Activin isoforms signal through type I receptor serine/threonine kinase ALK7."
Tsuchida K., Nakatani M., Yamakawa N., Hashimoto O., Hasegawa Y., Sugino H.
Mol. Cell. Endocrinol. 220:59-65(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 139-159, FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INTERACTION WITH ACVR2A; ACTIVIN AB AND B.
[4]"The MH1 domains of smad2 and smad3 are involved in the regulation of the ALK7 signals."
Watanabe R., Yamada Y., Ihara Y., Someya Y., Kubota A., Kagimoto S., Kuroe A., Iwakura T., Shen Z.-P., Inada A., Adachi T., Ban N., Miyawaki K., Sunaga Y., Tsuda K., Seino Y.
Biochem. Biophys. Res. Commun. 254:707-712(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY, MUTAGENESIS OF THR-194.
[5]"The orphan receptor serine/threonine kinase ALK7 signals arrest of proliferation and morphological differentiation in a neuronal cell line."
Joernvall H., Blokzijl A., ten Dijke P., Ibanez C.F.
J. Biol. Chem. 276:5140-5146(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U35025 mRNA. Translation: AAC52803.1.
U69702 mRNA. Translation: AAC52919.1.
RefSeqNP_620790.1. NM_139090.1.
UniGeneRn.10580.

3D structure databases

ProteinModelPortalP70539.
SMRP70539. Positions 161-489.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbP70539.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID245921.
KEGGrno:245921.
UCSCRGD:621789. rat.

Organism-specific databases

CTD130399.
RGD621789. Acvr1c.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000230587.
HOVERGENHBG054502.
InParanoidP70539.
KOK13568.
PhylomeDBP70539.

Gene expression databases

GenevestigatorP70539.

Family and domain databases

InterProIPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERPTHR23255. PTHR23255. 1 hit.
PfamPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
SMARTSM00467. GS. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio623170.
PROP70539.

Entry information

Entry nameACV1C_RAT
AccessionPrimary (citable) accession number: P70539
Secondary accession number(s): P70603
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: February 1, 1997
Last modified: June 11, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families