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Protein

Activin receptor type-1C

Gene

Acvr1c

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.4 Publications

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactori

Mg2+Curated, Mn2+Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei222 – 2221ATPPROSITE-ProRule annotationBy similarity
Active sitei323 – 3231Proton acceptorPROSITE-ProRule annotationBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi201 – 2099ATPPROSITE-ProRule annotationBy similarity

GO - Molecular functioni

  • activin binding Source: MGI
  • activin receptor activity, type I Source: UniProtKB
  • ATP binding Source: HGNC
  • BMP receptor binding Source: RGD
  • growth factor binding Source: UniProtKB
  • metal ion binding Source: UniProtKB
  • protein serine/threonine kinase activity Source: HGNC
  • receptor signaling protein serine/threonine kinase activity Source: InterPro
  • SMAD binding Source: HGNC

GO - Biological processi

  • activin receptor signaling pathway Source: GOC
  • apoptotic process Source: UniProtKB-KW
  • cell differentiation Source: UniProtKB
  • cerebellum development Source: RGD
  • hippocampus development Source: RGD
  • midbrain development Source: RGD
  • ovarian follicle development Source: RGD
  • protein phosphorylation Source: UniProtKB
  • regulation of apoptotic process Source: UniProtKB
  • response to drug Source: RGD
  • response to glucose Source: RGD
  • response to lipid Source: RGD
  • response to organic cyclic compound Source: RGD
  • transforming growth factor beta receptor complex assembly Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Activin receptor type-1C (EC:2.7.11.30)
Alternative name(s):
Activin receptor type IC
Short name:
ACTR-IC
Activin receptor-like kinase 7
Short name:
ALK-7
Gene namesi
Name:Acvr1cImported
Synonyms:Alk7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621789. Acvr1c.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 11388ExtracellularSequence AnalysisAdd
BLAST
Transmembranei114 – 13421HelicalSequence AnalysisAdd
BLAST
Topological domaini135 – 493359CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • activin receptor complex Source: UniProtKB
  • cell surface Source: RGD
  • cytoplasm Source: RGD
  • plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi194 – 1941T → D: Constitutively activates downstream transcription factor function. 2 Publications
Mutagenesisi222 – 2221K → R: Fails to activate downstream transcription factor function. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 493468Activin receptor type-1CPRO_0000042630Add
BLAST

Proteomic databases

PaxDbiP70539.

Expressioni

Tissue specificityi

Expressed in brain, kidney, lung, liver, testis, ovary, adrenal gland, heart, prostate, gastrointestinal tract, and spleen. Distributed throughout both adult and embryonic central nervous system and pancreatic islet cells.5 Publications

Gene expression databases

GenevisibleiP70539. RN.

Interactioni

Subunit structurei

Binds the type 2 receptor protein ACVR2A.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000056047.

Structurei

3D structure databases

ProteinModelPortaliP70539.
SMRiP70539. Positions 161-489.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini165 – 19430GSPROSITE-ProRule annotationAdd
BLAST
Domaini195 – 485291Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 GS domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000230587.
HOVERGENiHBG054502.
InParanoidiP70539.
KOiK13568.
PhylomeDBiP70539.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR000472. TFB_recept_I/II_C.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
SMARTiSM00467. GS. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70539-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPARRSALS LALLLVALAS DLAAGLKCVC LLCDSSNFTC QTEGACWASV
60 70 80 90 100
MLTNGKEQVS KSCVSLPELN AQVFCHSSNN VTKTECCFTD FCNNITQHLP
110 120 130 140 150
TASPDAPRLG PTELTVVITV PVCLLSIAAM LTIWACQDRQ CTYRKTKRHN
160 170 180 190 200
VEEPLAEYSL VNAGKTLKDL IYDATASGSG SGPPLLVQRT IARTIVLQEI
210 220 230 240 250
VGKGRFGEVW HGRWCGEDVA VKIFSSRDER SWFREAEIYQ TVMLRHENIL
260 270 280 290 300
GFIAADNKDN GTWTQLWLVS EYHEQGSLYD YLNRNIVTVA GMVKLALSIA
310 320 330 340 350
SGLAHLHMEI VGTQGKPAIA HRDIKSKNIL VKKCDTCAIA DLGLAVKHDS
360 370 380 390 400
IMNTIDIPQN PKVGTKRYMA PEMLDDTMNV NIFESFKRAD IYSVGLVYWE
410 420 430 440 450
IARRCSVGGL VEEYQLPYYD MVPSDPSIEE MRKVVCDQKL RPNLPNQWQS
460 470 480 490
CEALRVMGRI MRECWYANGA ARLTALRVKK TISQLCVKED CKA
Length:493
Mass (Da):54,842
Last modified:February 1, 1997 - v1
Checksum:iFB2BB3C2A026BCC3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 51R → S in AAC52919 (PubMed:8940033).Curated
Sequence conflicti60 – 601S → I in AAC52919 (PubMed:8940033).Curated
Sequence conflicti97 – 971Q → L in AAC52919 (PubMed:8940033).Curated
Sequence conflicti183 – 1831P → L in AAC52919 (PubMed:8940033).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35025 mRNA. Translation: AAC52803.1.
U69702 mRNA. Translation: AAC52919.1.
RefSeqiNP_620790.1. NM_139090.1.
UniGeneiRn.10580.

Genome annotation databases

GeneIDi245921.
KEGGirno:245921.
UCSCiRGD:621789. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35025 mRNA. Translation: AAC52803.1.
U69702 mRNA. Translation: AAC52919.1.
RefSeqiNP_620790.1. NM_139090.1.
UniGeneiRn.10580.

3D structure databases

ProteinModelPortaliP70539.
SMRiP70539. Positions 161-489.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000056047.

Proteomic databases

PaxDbiP70539.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi245921.
KEGGirno:245921.
UCSCiRGD:621789. rat.

Organism-specific databases

CTDi130399.
RGDi621789. Acvr1c.

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000230587.
HOVERGENiHBG054502.
InParanoidiP70539.
KOiK13568.
PhylomeDBiP70539.

Miscellaneous databases

NextBioi623170.
PROiP70539.

Gene expression databases

GenevisibleiP70539. RN.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR000472. TFB_recept_I/II_C.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
SMARTiSM00467. GS. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of a novel type I receptor serine/threonine kinase for the TGF beta superfamily from rat brain."
    Tsuchida K., Sawchenko P.E., Nishikawa S., Vale W.W.
    Mol. Cell. Neurosci. 7:467-478(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, MUTAGENESIS OF THR-194 AND LYS-222.
    Strain: Sprague-DawleyImported.
    Tissue: BrainImported.
  2. "A novel type I receptor serine-threonine kinase predominantly expressed in the adult central nervous system."
    Ryden M., Imamura T., Joernvall H., Belluardo N., Neveu I., Trupp M., Okadome T., ten Dijke P., Ibanez C.F.
    J. Biol. Chem. 271:30603-30609(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Brain1 Publication.
  3. "Activin isoforms signal through type I receptor serine/threonine kinase ALK7."
    Tsuchida K., Nakatani M., Yamakawa N., Hashimoto O., Hasegawa Y., Sugino H.
    Mol. Cell. Endocrinol. 220:59-65(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 139-159, FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INTERACTION WITH ACVR2A; ACTIVIN AB AND B.
  4. Cited for: FUNCTION, TISSUE SPECIFICITY, MUTAGENESIS OF THR-194.
  5. "The orphan receptor serine/threonine kinase ALK7 signals arrest of proliferation and morphological differentiation in a neuronal cell line."
    Joernvall H., Blokzijl A., ten Dijke P., Ibanez C.F.
    J. Biol. Chem. 276:5140-5146(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiACV1C_RAT
AccessioniPrimary (citable) accession number: P70539
Secondary accession number(s): P70603
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: February 1, 1997
Last modified: June 24, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.