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Protein

Oxytocin receptor

Gene

Oxtr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  1. oxytocin receptor activity Source: RGD
  2. peptide hormone binding Source: RGD
  3. vasopressin receptor activity Source: GO_Central

GO - Biological processi

  1. cellular response to hormone stimulus Source: GO_Central
  2. digestive tract development Source: RGD
  3. eating behavior Source: RGD
  4. ERK1 and ERK2 cascade Source: RGD
  5. female pregnancy Source: RGD
  6. G-protein coupled receptor signaling pathway Source: RGD
  7. heart development Source: RGD
  8. lactation Source: GO_Central
  9. maternal behavior Source: RGD
  10. maternal process involved in parturition Source: RGD
  11. memory Source: RGD
  12. negative regulation of gastric acid secretion Source: RGD
  13. positive regulation of blood pressure Source: Ensembl
  14. positive regulation of cytosolic calcium ion concentration Source: RGD
  15. positive regulation of norepinephrine secretion Source: RGD
  16. positive regulation of penile erection Source: RGD
  17. positive regulation of synapse assembly Source: RGD
  18. positive regulation of synaptic transmission, GABAergic Source: RGD
  19. positive regulation of synaptic transmission, glutamatergic Source: RGD
  20. positive regulation of uterine smooth muscle contraction Source: RGD
  21. positive regulation of vasoconstriction Source: GO_Central
  22. regulation of digestive system process Source: RGD
  23. regulation of systemic arterial blood pressure by vasopressin Source: GO_Central
  24. response to amphetamine Source: RGD
  25. response to anoxia Source: RGD
  26. response to cocaine Source: RGD
  27. response to cytokine Source: RGD
  28. response to drug Source: RGD
  29. response to estradiol Source: RGD
  30. response to organic cyclic compound Source: RGD
  31. response to peptide hormone Source: RGD
  32. response to progesterone Source: RGD
  33. response to steroid hormone Source: RGD
  34. sleep Source: RGD
  35. social behavior Source: RGD
  36. sperm ejaculation Source: RGD
  37. suckling behavior Source: RGD
  38. telencephalon development Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_263111. Vasopressin-like receptors.
REACT_263374. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxytocin receptor
Short name:
OT-R
Gene namesi
Name:Oxtr
Synonyms:Otr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 4

Organism-specific databases

RGDi3239. Oxtr.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3838ExtracellularSequence AnalysisAdd
BLAST
Transmembranei39 – 6325Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini64 – 7411CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei75 – 9723Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini98 – 11316ExtracellularSequence AnalysisAdd
BLAST
Transmembranei114 – 13522Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini136 – 15419CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei155 – 17521Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini176 – 20227ExtracellularSequence AnalysisAdd
BLAST
Transmembranei203 – 22523Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini226 – 27449CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei275 – 29319Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini294 – 30815ExtracellularSequence AnalysisAdd
BLAST
Transmembranei309 – 33123Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini332 – 38857CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: RGD
  2. cell-cell adherens junction Source: RGD
  3. integral component of plasma membrane Source: GO_Central
  4. microvillus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 388388Oxytocin receptorPRO_0000070002Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi8 – 81N-linked (GlcNAc...)Sequence Analysis
Glycosylationi26 – 261N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi112 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP70536.
PRIDEiP70536.

PTM databases

PhosphoSiteiP70536.

Expressioni

Gene expression databases

GenevestigatoriP70536.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliP70536.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi129 – 1324Poly-Leu
Compositional biasi236 – 2427Poly-Ala

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG299951.
GeneTreeiENSGT00760000119156.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiP70536.
KOiK04229.
OMAiGPPRRNE.
OrthoDBiEOG7Z69CP.
PhylomeDBiP70536.
TreeFamiTF106499.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002062. Oxytocn_rcpt.
IPR001817. Vasoprsn_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00665. OXYTOCINR.
PR00896. VASOPRESSINR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70536-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEGTPAANWS VELDLGSGVP PGEEGNRTAG PPQRNEALAR VEVAVLCLIL
60 70 80 90 100
FLALSGNACV LLALRTTRHK HSRLFFFMKH LSIADLVVAV FQVLPQLLWD
110 120 130 140 150
ITFRFYGPDL LCRLVKYLQV VGMFASTYLL LLMSLDRCLA ICQPLRSLRR
160 170 180 190 200
RTDRLAVLGT WLGCLVASAP QVHIFSLREV ADGVFDCWAV FIQPWGPKAY
210 220 230 240 250
VTWITLAVYI VPVIVLAACY GLISFKIWQN LRLKTAAAAA AAEGNDAAGG
260 270 280 290 300
AGRAALARVS SVKLISKAKI RTVKMTFIIV LAFIVCWTPF FFVQMWSVWD
310 320 330 340 350
VNAPKEASAF IIAMLLASLN SCCNPWIYML FTGHLFHELV QRFFCCSARY
360 370 380
LKGSRPGETS VSKKSNSSTF VLSRRSSSQR SCSQPSSA
Length:388
Mass (Da):42,869
Last modified:August 14, 2001 - v2
Checksum:iFC738B254005CDD0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15280, U15169 Genomic DNA. Translation: AAC53245.2.
AY338194 mRNA. Translation: AAQ01564.1.
RefSeqiNP_037003.2. NM_012871.2.
XP_006237070.1. XM_006237008.2.
XP_008761401.1. XM_008763179.1.
XP_008761402.1. XM_008763180.1.
XP_008761403.1. XM_008763181.1.
XP_008761404.1. XM_008763182.1.
UniGeneiRn.6841.

Genome annotation databases

EnsembliENSRNOT00000007724; ENSRNOP00000007724; ENSRNOG00000005806.
GeneIDi25342.
KEGGirno:25342.
UCSCiRGD:3239. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15280, U15169 Genomic DNA. Translation: AAC53245.2.
AY338194 mRNA. Translation: AAQ01564.1.
RefSeqiNP_037003.2. NM_012871.2.
XP_006237070.1. XM_006237008.2.
XP_008761401.1. XM_008763179.1.
XP_008761402.1. XM_008763180.1.
XP_008761403.1. XM_008763181.1.
XP_008761404.1. XM_008763182.1.
UniGeneiRn.6841.

3D structure databases

ProteinModelPortaliP70536.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiP70536.
ChEMBLiCHEMBL3996.
GuidetoPHARMACOLOGYi369.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP70536.

Proteomic databases

PaxDbiP70536.
PRIDEiP70536.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000007724; ENSRNOP00000007724; ENSRNOG00000005806.
GeneIDi25342.
KEGGirno:25342.
UCSCiRGD:3239. rat.

Organism-specific databases

CTDi5021.
RGDi3239. Oxtr.

Phylogenomic databases

eggNOGiNOG299951.
GeneTreeiENSGT00760000119156.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiP70536.
KOiK04229.
OMAiGPPRRNE.
OrthoDBiEOG7Z69CP.
PhylomeDBiP70536.
TreeFamiTF106499.

Enzyme and pathway databases

ReactomeiREACT_263111. Vasopressin-like receptors.
REACT_263374. G alpha (q) signalling events.

Miscellaneous databases

NextBioi606255.
PROiP70536.

Gene expression databases

GenevestigatoriP70536.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002062. Oxytocn_rcpt.
IPR001817. Vasoprsn_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00665. OXYTOCINR.
PR00896. VASOPRESSINR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Structure, characterization, and expression of the rat oxytocin receptor gene."
    Rozen F., Russo C., Banville D., Zingg H.H.
    Proc. Natl. Acad. Sci. U.S.A. 92:200-204(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Sprague-Dawley.
    Tissue: Liver.
  2. Zingg H.H.
    Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 84.
  3. "Rat oxytocin receptor gene nucleotide sequence."
    Terry R., Mullins D.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiOXYR_RAT
AccessioniPrimary (citable) accession number: P70536
Secondary accession number(s): Q53ZC5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: August 14, 2001
Last modified: February 4, 2015
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.