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P70536

- OXYR_RAT

UniProt

P70536 - OXYR_RAT

Protein

Oxytocin receptor

Gene

Oxtr

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 2 (14 Aug 2001)
      Previous versions | rss
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    Functioni

    Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

    GO - Molecular functioni

    1. oxytocin receptor activity Source: RGD
    2. peptide hormone binding Source: RGD
    3. protein binding Source: RGD
    4. vasopressin receptor activity Source: InterPro

    GO - Biological processi

    1. digestive tract development Source: RGD
    2. eating behavior Source: RGD
    3. ERK1 and ERK2 cascade Source: RGD
    4. estrous cycle phase Source: RGD
    5. female pregnancy Source: RGD
    6. G-protein coupled receptor signaling pathway Source: RGD
    7. heart development Source: RGD
    8. maternal behavior Source: RGD
    9. maternal process involved in parturition Source: RGD
    10. memory Source: RGD
    11. negative regulation of gastric acid secretion Source: RGD
    12. positive regulation of blood pressure Source: Ensembl
    13. positive regulation of cytosolic calcium ion concentration Source: RGD
    14. positive regulation of norepinephrine secretion Source: RGD
    15. positive regulation of penile erection Source: RGD
    16. positive regulation of synapse assembly Source: RGD
    17. positive regulation of synaptic transmission, GABAergic Source: RGD
    18. positive regulation of synaptic transmission, glutamatergic Source: RGD
    19. positive regulation of uterine smooth muscle contraction Source: RGD
    20. regulation of digestive system process Source: RGD
    21. response to amphetamine Source: RGD
    22. response to anoxia Source: RGD
    23. response to cocaine Source: RGD
    24. response to cytokine Source: RGD
    25. response to drug Source: RGD
    26. response to estradiol Source: RGD
    27. response to organic cyclic compound Source: RGD
    28. response to peptide hormone Source: RGD
    29. response to progesterone Source: RGD
    30. response to steroid hormone Source: RGD
    31. sleep Source: RGD
    32. social behavior Source: RGD
    33. sperm ejaculation Source: RGD
    34. suckling behavior Source: RGD
    35. telencephalon development Source: RGD

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oxytocin receptor
    Short name:
    OT-R
    Gene namesi
    Name:Oxtr
    Synonyms:Otr
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 4

    Organism-specific databases

    RGDi3239. Oxtr.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: RGD
    2. cell-cell adherens junction Source: RGD
    3. integral component of membrane Source: UniProtKB-KW
    4. microvillus Source: RGD

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 388388Oxytocin receptorPRO_0000070002Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi8 – 81N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi26 – 261N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi112 ↔ 187PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP70536.
    PRIDEiP70536.

    PTM databases

    PhosphoSiteiP70536.

    Expressioni

    Gene expression databases

    GenevestigatoriP70536.

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliP70536.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3838ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini64 – 7411CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini98 – 11316ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini136 – 15419CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini176 – 20227ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini226 – 27449CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini294 – 30815ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini332 – 38857CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei39 – 6325Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei75 – 9723Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei114 – 13522Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei155 – 17521Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei203 – 22523Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei275 – 29319Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei309 – 33123Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi129 – 1324Poly-Leu
    Compositional biasi236 – 2427Poly-Ala

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG299951.
    GeneTreeiENSGT00660000095384.
    HOGENOMiHOG000237331.
    HOVERGENiHBG105710.
    InParanoidiP70536.
    KOiK04229.
    OMAiGPPRRNE.
    OrthoDBiEOG7Z69CP.
    PhylomeDBiP70536.
    TreeFamiTF106499.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR002062. Oxytocn_rcpt.
    IPR001817. Vasoprsn_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00665. OXYTOCINR.
    PR00896. VASOPRESSINR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P70536-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEGTPAANWS VELDLGSGVP PGEEGNRTAG PPQRNEALAR VEVAVLCLIL    50
    FLALSGNACV LLALRTTRHK HSRLFFFMKH LSIADLVVAV FQVLPQLLWD 100
    ITFRFYGPDL LCRLVKYLQV VGMFASTYLL LLMSLDRCLA ICQPLRSLRR 150
    RTDRLAVLGT WLGCLVASAP QVHIFSLREV ADGVFDCWAV FIQPWGPKAY 200
    VTWITLAVYI VPVIVLAACY GLISFKIWQN LRLKTAAAAA AAEGNDAAGG 250
    AGRAALARVS SVKLISKAKI RTVKMTFIIV LAFIVCWTPF FFVQMWSVWD 300
    VNAPKEASAF IIAMLLASLN SCCNPWIYML FTGHLFHELV QRFFCCSARY 350
    LKGSRPGETS VSKKSNSSTF VLSRRSSSQR SCSQPSSA 388
    Length:388
    Mass (Da):42,869
    Last modified:August 14, 2001 - v2
    Checksum:iFC738B254005CDD0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U15280, U15169 Genomic DNA. Translation: AAC53245.2.
    AY338194 mRNA. Translation: AAQ01564.1.
    RefSeqiNP_037003.2. NM_012871.2.
    XP_006237070.1. XM_006237008.1.
    UniGeneiRn.6841.

    Genome annotation databases

    EnsembliENSRNOT00000007724; ENSRNOP00000007724; ENSRNOG00000005806.
    GeneIDi25342.
    KEGGirno:25342.
    UCSCiRGD:3239. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U15280 , U15169 Genomic DNA. Translation: AAC53245.2 .
    AY338194 mRNA. Translation: AAQ01564.1 .
    RefSeqi NP_037003.2. NM_012871.2.
    XP_006237070.1. XM_006237008.1.
    UniGenei Rn.6841.

    3D structure databases

    ProteinModelPortali P70536.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi P70536.
    ChEMBLi CHEMBL3996.
    GuidetoPHARMACOLOGYi 369.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P70536.

    Proteomic databases

    PaxDbi P70536.
    PRIDEi P70536.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000007724 ; ENSRNOP00000007724 ; ENSRNOG00000005806 .
    GeneIDi 25342.
    KEGGi rno:25342.
    UCSCi RGD:3239. rat.

    Organism-specific databases

    CTDi 5021.
    RGDi 3239. Oxtr.

    Phylogenomic databases

    eggNOGi NOG299951.
    GeneTreei ENSGT00660000095384.
    HOGENOMi HOG000237331.
    HOVERGENi HBG105710.
    InParanoidi P70536.
    KOi K04229.
    OMAi GPPRRNE.
    OrthoDBi EOG7Z69CP.
    PhylomeDBi P70536.
    TreeFami TF106499.

    Miscellaneous databases

    NextBioi 606255.
    PROi P70536.

    Gene expression databases

    Genevestigatori P70536.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR002062. Oxytocn_rcpt.
    IPR001817. Vasoprsn_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00665. OXYTOCINR.
    PR00896. VASOPRESSINR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure, characterization, and expression of the rat oxytocin receptor gene."
      Rozen F., Russo C., Banville D., Zingg H.H.
      Proc. Natl. Acad. Sci. U.S.A. 92:200-204(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Sprague-Dawley.
      Tissue: Liver.
    2. Zingg H.H.
      Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO 84.
    3. "Rat oxytocin receptor gene nucleotide sequence."
      Terry R., Mullins D.
      Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.

    Entry informationi

    Entry nameiOXYR_RAT
    AccessioniPrimary (citable) accession number: P70536
    Secondary accession number(s): Q53ZC5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: August 14, 2001
    Last modified: October 1, 2014
    This is version 98 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3