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P70536 (OXYR_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Oxytocin receptor
Short name=OT-R
Gene names
Name:Oxtr
Synonyms:Otr
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length388 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processERK1 and ERK2 cascade

Inferred from mutant phenotype PubMed 10497238. Source: RGD

digestive tract development

Inferred from expression pattern PubMed 19003903. Source: RGD

eating behavior

Inferred from mutant phenotype PubMed 15380376. Source: RGD

elevation of cytosolic calcium ion concentration

Inferred from mutant phenotype PubMed 10497238. Source: RGD

estrous cycle phase

Inferred from expression pattern PubMed 12867731. Source: RGD

female pregnancy

Inferred from expression pattern PubMed 16832906. Source: RGD

heart development

Inferred from expression pattern PubMed 15316117. Source: RGD

maternal behavior

Inferred from mutant phenotype PubMed 18513132. Source: RGD

maternal process involved in parturition

Inferred from expression pattern PubMed 18936075. Source: RGD

memory

Inferred from mutant phenotype PubMed 18304743. Source: RGD

negative regulation of gastric acid secretion

Inferred from mutant phenotype PubMed 11764003. Source: RGD

positive regulation of blood pressure

Inferred from electronic annotation. Source: Compara

positive regulation of norepinephrine secretion

Inferred from mutant phenotype PubMed 14656297. Source: RGD

positive regulation of penile erection

Inferred from mutant phenotype PubMed 18469843. Source: RGD

positive regulation of synapse assembly

Inferred from mutant phenotype PubMed 16488155. Source: RGD

positive regulation of synaptic transmission, GABAergic

Inferred from mutant phenotype PubMed 11069593. Source: RGD

positive regulation of synaptic transmission, glutamatergic

Inferred from mutant phenotype PubMed 18510735. Source: RGD

positive regulation of uterine smooth muscle contraction

Inferred from mutant phenotype PubMed 19164477. Source: RGD

response to amphetamine

Inferred from mutant phenotype PubMed 17383105. Source: RGD

response to anoxia

Inferred from mutant phenotype PubMed 18655887. Source: RGD

response to cocaine

Inferred from expression pattern PubMed 16677710. Source: RGD

response to cytokine stimulus

Inferred from expression pattern PubMed 10994633. Source: RGD

response to drug

Inferred from expression pattern PubMed 12834913PubMed 15380831. Source: RGD

response to estradiol stimulus

Inferred from expression pattern PubMed 19258489. Source: RGD

response to peptide hormone stimulus

Inferred from expression pattern PubMed 12700188PubMed 17537544. Source: RGD

response to progesterone stimulus

Inferred from expression pattern PubMed 10856882. Source: RGD

sleep

Inferred from mutant phenotype PubMed 12832103. Source: RGD

social behavior

Inferred from mutant phenotype PubMed 17383105. Source: RGD

sperm ejaculation

Inferred from mutant phenotype PubMed 18469843. Source: RGD

suckling behavior

Inferred from mutant phenotype PubMed 19106214. Source: RGD

telencephalon development

Inferred from expression pattern PubMed 11021977. Source: RGD

   Cellular_componentapical plasma membrane

Inferred from direct assay PubMed 11456414. Source: RGD

cell-cell adherens junction

Inferred from direct assay PubMed 19003903. Source: RGD

integral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

microvillus

Inferred from direct assay PubMed 11456414. Source: RGD

   Molecular_functionoxytocin receptor activity

Inferred from direct assay PubMed 15821089PubMed 19560475. Source: RGD

peptide hormone binding

Inferred from direct assay PubMed 15821089. Source: RGD

vasopressin receptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 388388Oxytocin receptor
PRO_0000070002

Regions

Topological domain1 – 3838Extracellular Potential
Transmembrane39 – 6325Helical; Name=1; Potential
Topological domain64 – 7411Cytoplasmic Potential
Transmembrane75 – 9723Helical; Name=2; Potential
Topological domain98 – 11316Extracellular Potential
Transmembrane114 – 13522Helical; Name=3; Potential
Topological domain136 – 15419Cytoplasmic Potential
Transmembrane155 – 17521Helical; Name=4; Potential
Topological domain176 – 20227Extracellular Potential
Transmembrane203 – 22523Helical; Name=5; Potential
Topological domain226 – 27449Cytoplasmic Potential
Transmembrane275 – 29319Helical; Name=6; Potential
Topological domain294 – 30815Extracellular Potential
Transmembrane309 – 33123Helical; Name=7; Potential
Topological domain332 – 38857Cytoplasmic Potential
Compositional bias129 – 1324Poly-Leu
Compositional bias236 – 2427Poly-Ala

Amino acid modifications

Glycosylation81N-linked (GlcNAc...) Potential
Glycosylation261N-linked (GlcNAc...) Potential
Disulfide bond112 ↔ 187 By similarity

Sequences

Sequence LengthMass (Da)Tools
P70536 [UniParc].

Last modified August 14, 2001. Version 2.
Checksum: FC738B254005CDD0

FASTA38842,869
        10         20         30         40         50         60 
MEGTPAANWS VELDLGSGVP PGEEGNRTAG PPQRNEALAR VEVAVLCLIL FLALSGNACV 

        70         80         90        100        110        120 
LLALRTTRHK HSRLFFFMKH LSIADLVVAV FQVLPQLLWD ITFRFYGPDL LCRLVKYLQV 

       130        140        150        160        170        180 
VGMFASTYLL LLMSLDRCLA ICQPLRSLRR RTDRLAVLGT WLGCLVASAP QVHIFSLREV 

       190        200        210        220        230        240 
ADGVFDCWAV FIQPWGPKAY VTWITLAVYI VPVIVLAACY GLISFKIWQN LRLKTAAAAA 

       250        260        270        280        290        300 
AAEGNDAAGG AGRAALARVS SVKLISKAKI RTVKMTFIIV LAFIVCWTPF FFVQMWSVWD 

       310        320        330        340        350        360 
VNAPKEASAF IIAMLLASLN SCCNPWIYML FTGHLFHELV QRFFCCSARY LKGSRPGETS 

       370        380 
VSKKSNSSTF VLSRRSSSQR SCSQPSSA

« Hide

References

[1]"Structure, characterization, and expression of the rat oxytocin receptor gene."
Rozen F., Russo C., Banville D., Zingg H.H.
Proc. Natl. Acad. Sci. U.S.A. 92:200-204(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Sprague-Dawley.
Tissue: Liver.
[2]Zingg H.H.
Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION TO 84.
[3]"Rat oxytocin receptor gene nucleotide sequence."
Terry R., Mullins D.
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U15280, U15169 Genomic DNA. Translation: AAC53245.2.
AY338194 mRNA. Translation: AAQ01564.1.
IPIIPI00189655.
RefSeqNP_037003.2. NM_012871.2.
UniGeneRn.6841.

3D structure databases

ProteinModelPortalP70536.
ModBaseSearch...

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP70536.

Proteomic databases

PaxDbP70536.
PRIDEP70536.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000007724; ENSRNOP00000007724; ENSRNOG00000005806.
GeneID25342.
KEGGrno:25342.
UCSCRGD:3239. rat.

Organism-specific databases

CTD5021.
RGD3239. Oxtr.

Phylogenomic databases

eggNOGNOG299951.
GeneTreeENSGT00660000095384.
HOGENOMHOG000237331.
HOVERGENHBG105710.
InParanoidP70536.
KOK04229.
OMAGPPRRNE.
OrthoDBEOG4VHK6S.

Gene expression databases

GenevestigatorP70536.
GermOnlineENSRNOG00000005806. Rattus norvegicus.

Family and domain databases

InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002062. Oxytocn_rcpt.
IPR001817. Vasoprsn_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00665. OXYTOCINR.
PR00896. VASOPRESSINR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

BindingDBP70536.
ChEMBLCHEMBL3996.
NextBio606255.

Entry information

Entry nameOXYR_RAT
AccessionPrimary (citable) accession number: P70536
Secondary accession number(s): Q53ZC5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: August 14, 2001
Last modified: April 3, 2013
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents