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Protein

Olfactory receptor 1

Gene

Olfr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor. Activated by a lily-derived aldehyde as well as other odorants. May signal through an inositol 1,4,5-trisphosphate (IP3) second messenger system.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-RNO-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1
Alternative name(s):
Olfactory receptor 1469
Olfactory receptor HGL-SP1
Olfactory receptor OR5
Olfactory receptor-like protein I54
Gene namesi
Name:Olfr1By similarity
Synonyms:Olr1469Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1359186. Olr1469.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29ExtracellularSequence analysisAdd BLAST29
Transmembranei30 – 50Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini51 – 59CytoplasmicSequence analysis9
Transmembranei60 – 81Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini82 – 97ExtracellularSequence analysisAdd BLAST16
Transmembranei98 – 118Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini119 – 143CytoplasmicSequence analysisAdd BLAST25
Transmembranei144 – 164Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini165 – 196ExtracellularSequence analysisAdd BLAST32
Transmembranei197 – 217Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini218 – 240CytoplasmicSequence analysisAdd BLAST23
Transmembranei241 – 261Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini262 – 271ExtracellularSequence analysis10
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 314CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002338991 – 314Olfactory receptor 1Add BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 179PROSITE-ProRule annotation
Glycosylationi265N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi266N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP70526.
PRIDEiP70526.

Expressioni

Tissue specificityi

Olfactory epithelium.1 Publication

Gene expression databases

GenevisibleiP70526. RN.

Structurei

3D structure databases

ProteinModelPortaliP70526.
SMRiP70526.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00860000133705.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiP70526.
KOiK04257.
OMAiFLVAMAY.
OrthoDBiEOG091G0EOH.
PhylomeDBiP70526.
TreeFamiTF337210.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
PfamiView protein in Pfam
PF13853. 7tm_4. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P70526-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTERNQTVIS QFLLLGLPIP PEHQHVFYAL FLSMYLTTVL GNLIIIILIL
60 70 80 90 100
LDSHLHTPMY LFLSNLSFSD LCFSSVTMPK LLQNMQSQVP SIPYAGCLSQ
110 120 130 140 150
IYFFLFFGDL GNFLLVAMAY DRYVAICFPL HYMSIMSPKL CVSLVVLSWV
160 170 180 190 200
LTTFHAMLHT LLMARLSFCE DNVIPHFFCD MSALLKLACS DTRVNEVVIF
210 220 230 240 250
IVVSLFLVLP FALIIMSYVR IVSSILKVPS SQGIYKAFST CGSHLSVVSL
260 270 280 290 300
FYGTVIGLYL CPSSNNSTVK ETVMSLMYTV VTPMLNPFIY SLRNRDIKGA
310
MERIFCKRKI QLNL
Length:314
Mass (Da):35,537
Last modified:February 1, 1997 - v1
Checksum:iCFA3F5BF0BD1F896
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti181M → T in AAC64592 (PubMed:9858390).Curated1
Sequence conflicti236K → E in AAC64592 (PubMed:9858390).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07557 mRNA. Translation: CAA68842.1.
AF091571 mRNA. Translation: AAC64592.1.
M64375 mRNA. Translation: AAA41738.1.
PIRiS29707.
RefSeqiNP_997692.1. NM_212527.1.
XP_003750900.1. XM_003750852.1.
XP_008766355.1. XM_008768133.1.
UniGeneiRn.113464.
Rn.217587.

Genome annotation databases

EnsembliENSRNOT00000072702; ENSRNOP00000066076; ENSRNOG00000047958.
GeneIDi100909534.
108348032.
404976.
KEGGirno:100909534.
rno:108348032.
rno:404976.

Similar proteinsi

Entry informationi

Entry nameiOLF1_RAT
AccessioniPrimary (citable) accession number: P70526
Secondary accession number(s): Q04059, Q9QWW7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: February 1, 1997
Last modified: August 30, 2017
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families