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Protein

Olfactory receptor 1

Gene

Olfr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor. Activated by a lily-derived aldehyde as well as other odorants. May signal through an inositol 1,4,5-trisphosphate (IP3) second messenger system.2 Publications

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-RNO-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1
Alternative name(s):
Olfactory receptor 1469
Olfactory receptor HGL-SP1
Olfactory receptor OR5
Olfactory receptor-like protein I54
Gene namesi
Name:Olfr1By similarity
Synonyms:Olr1469Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1359186. Olr1469.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2929ExtracellularSequence analysisAdd
BLAST
Transmembranei30 – 5021Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini51 – 599CytoplasmicSequence analysis
Transmembranei60 – 8122Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini82 – 9716ExtracellularSequence analysisAdd
BLAST
Transmembranei98 – 11821Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini119 – 14325CytoplasmicSequence analysisAdd
BLAST
Transmembranei144 – 16421Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini165 – 19632ExtracellularSequence analysisAdd
BLAST
Transmembranei197 – 21721Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini218 – 24023CytoplasmicSequence analysisAdd
BLAST
Transmembranei241 – 26121Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini262 – 27110ExtracellularSequence analysis
Transmembranei272 – 29221Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini293 – 31422CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Olfactory receptor 1PRO_0000233899Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Disulfide bondi97 ↔ 179PROSITE-ProRule annotation
Glycosylationi265 – 2651N-linked (GlcNAc...)Sequence analysis
Glycosylationi266 – 2661N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP70526.
PRIDEiP70526.

Expressioni

Tissue specificityi

Olfactory epithelium.1 Publication

Gene expression databases

GenevisibleiP70526. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067472.

Structurei

3D structure databases

ProteinModelPortaliP70526.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00810000125354.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiP70526.
KOiK04257.
OMAiFCKRKIQ.
OrthoDBiEOG7JT6WV.
PhylomeDBiP70526.
TreeFamiTF337210.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70526-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTERNQTVIS QFLLLGLPIP PEHQHVFYAL FLSMYLTTVL GNLIIIILIL
60 70 80 90 100
LDSHLHTPMY LFLSNLSFSD LCFSSVTMPK LLQNMQSQVP SIPYAGCLSQ
110 120 130 140 150
IYFFLFFGDL GNFLLVAMAY DRYVAICFPL HYMSIMSPKL CVSLVVLSWV
160 170 180 190 200
LTTFHAMLHT LLMARLSFCE DNVIPHFFCD MSALLKLACS DTRVNEVVIF
210 220 230 240 250
IVVSLFLVLP FALIIMSYVR IVSSILKVPS SQGIYKAFST CGSHLSVVSL
260 270 280 290 300
FYGTVIGLYL CPSSNNSTVK ETVMSLMYTV VTPMLNPFIY SLRNRDIKGA
310
MERIFCKRKI QLNL
Length:314
Mass (Da):35,537
Last modified:February 1, 1997 - v1
Checksum:iCFA3F5BF0BD1F896
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti181 – 1811M → T in AAC64592 (PubMed:9858390).Curated
Sequence conflicti236 – 2361K → E in AAC64592 (PubMed:9858390).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07557 mRNA. Translation: CAA68842.1.
AF091571 mRNA. Translation: AAC64592.1.
M64375 mRNA. Translation: AAA41738.1.
PIRiS29707.
RefSeqiNP_997692.1. NM_212527.1.
XP_003750900.1. XM_003750852.1.
XP_008766355.1. XM_008768133.1.
UniGeneiRn.113464.
Rn.142092.
Rn.217587.

Genome annotation databases

EnsembliENSRNOT00000072702; ENSRNOP00000066076; ENSRNOG00000047958.
GeneIDi100909534.
287484.
404976.
KEGGirno:100909534.
rno:404976.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07557 mRNA. Translation: CAA68842.1.
AF091571 mRNA. Translation: AAC64592.1.
M64375 mRNA. Translation: AAA41738.1.
PIRiS29707.
RefSeqiNP_997692.1. NM_212527.1.
XP_003750900.1. XM_003750852.1.
XP_008766355.1. XM_008768133.1.
UniGeneiRn.113464.
Rn.142092.
Rn.217587.

3D structure databases

ProteinModelPortaliP70526.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067472.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiP70526.
PRIDEiP70526.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000072702; ENSRNOP00000066076; ENSRNOG00000047958.
GeneIDi100909534.
287484.
404976.
KEGGirno:100909534.
rno:404976.

Organism-specific databases

CTDi287484.
404976.
RGDi1359186. Olr1469.

Phylogenomic databases

GeneTreeiENSGT00810000125354.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiP70526.
KOiK04257.
OMAiFCKRKIQ.
OrthoDBiEOG7JT6WV.
PhylomeDBiP70526.
TreeFamiTF337210.

Enzyme and pathway databases

ReactomeiR-RNO-381753. Olfactory Signaling Pathway.

Miscellaneous databases

PROiP70526.

Gene expression databases

GenevisibleiP70526. RN.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Olfactory epitheliumImported.
  2. "Identification of olfactory receptor mRNA sequences from the rat olfactory bulb glomerular layer."
    Singer M.S., Hughes T.E., Shepherd G.M., Greer C.A.
    NeuroReport 9:3745-3748(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 64-284.
    Strain: Sprague-Dawley1 Publication.
    Tissue: Olfactory bulb1 Publication.
  3. "A novel multigene family may encode odorant receptors: a molecular basis for odor recognition."
    Buck L., Axel R.
    Cell 65:175-187(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 193-236.
    Strain: Sprague-DawleyImported.
    Tissue: Olfactory epitheliumImported.
  4. "Rapid activation of alternative second messenger pathways in olfactory cilia from rats by different odorants."
    Boekhoff I., Tareilus E., Strotmann J., Breer H.
    EMBO J. 9:2453-2458(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiOLF1_RAT
AccessioniPrimary (citable) accession number: P70526
Secondary accession number(s): Q04059, Q9QWW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: February 1, 1997
Last modified: June 8, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.