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Protein
Submitted name:

Macrophage stimulating 1 (Hepatocyte growth factor-like)

Gene

Mst1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • enzyme binding Source: RGD
  • serine-type endopeptidase activity Source: InterPro

GO - Biological processi

  • cellular response to hypoxia Source: RGD
  • flagellated sperm motility Source: RGD
  • spermatogenesis Source: RGD

Keywordsi

Molecular functionSerine protease homologUniRule annotation

Protein family/group databases

MEROPSiS01.975.

Names & Taxonomyi

Protein namesi
Submitted name:
Macrophage stimulating 1 (Hepatocyte growth factor-like)Imported
Submitted name:
Macrophage stimulating proteinImported
Gene namesi
Name:Mst1Imported
Synonyms:MSPImported
ORF Names:rCG_25288Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi3114. Mst1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: RGD

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_501013316519 – 716Sequence analysisAdd BLAST698

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi191 ↔ 268PROSITE-ProRule annotation
Disulfide bondi212 ↔ 251PROSITE-ProRule annotation
Disulfide bondi240 ↔ 263PROSITE-ProRule annotation
Disulfide bondi313 ↔ 352PROSITE-ProRule annotation
Disulfide bondi341 ↔ 364PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000019680.

Interactioni

GO - Molecular functioni

  • enzyme binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026711.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 105AppleInterPro annotationAdd BLAST93
Domaini109 – 186KringleInterPro annotationAdd BLAST78
Domaini190 – 268KringleInterPro annotationAdd BLAST79
Domaini291 – 370KringleInterPro annotationAdd BLAST80
Domaini378 – 457KringleInterPro annotationAdd BLAST80
Domaini489 – 714Peptidase S1InterPro annotationAdd BLAST226

Sequence similaritiesi

Belongs to the peptidase S1 family. Plasminogen subfamily.UniRule annotation

Keywords - Domaini

KringlePROSITE-ProRule annotationSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IDXR. Eukaryota.
COG5640. LUCA.
HOGENOMiHOG000112892.
HOVERGENiHBG004381.
OrthoDBiEOG091G0AH5.
TreeFamiTF329901.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiView protein in InterPro
IPR024174. HGF-like.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR003609. Pan_app.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
PfamiView protein in Pfam
PF00051. Kringle. 4 hits.
PF00024. PAN_1. 1 hit.
PF00089. Trypsin. 1 hit.
PIRSFiPIRSF001152. HGF_MST1. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiView protein in SMART
SM00130. KR. 4 hits.
SM00473. PAN_AP. 1 hit.
SM00020. Tryp_SPc. 1 hit.
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF57440. SSF57440. 4 hits.
PROSITEiView protein in PROSITE
PS00021. KRINGLE_1. 3 hits.
PS50070. KRINGLE_2. 4 hits.
PS50948. PAN. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.

Sequencei

Sequence statusi: Complete.

P70521-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGWLPLLLLL AQCSRALGQR SPLNDFQLLR GTELRNLLHP VVPGPWQEDV
60 70 80 90 100
ADAEECARRC GPLLDCRAFH YNMSSHGCQL LPWTQHSLRA QLHHSSLCDL
110 120 130 140 150
FQKKDYVRTC IMDNGASYRG TVARTADGLP CQAWSRRFPN DHKYTPTPKN
160 170 180 190 200
GLEENFCRNP DGDPRGPWCY TTNRSVRFQS CGIKSCREAV CVWCNGEDYR
210 220 230 240 250
GEVDVTESGR ECQRWDLQHP HSHPFHPEKF PDKALKDNYC RNPDASERPW
260 270 280 290 300
CYTTDPNVER EFCDLPSCGP NLPPTTKGSK SQQRNKVKAS NCFRGKGEDY
310 320 330 340 350
RGTTNTTSAG VPCQRWDAQN PHQHRFVPEK YACKDLRENF CRNPDGSEAP
360 370 380 390 400
WCFTSRPGLR VAFCYQIPRC TEEVVPEGCY HGSGEQYRGS VSKTRKGVQC
410 420 430 440 450
QHWSSETPHK PQFTPTSAPH AGLEANFCRN PDGDSHGPWC YTLDPETLFD
460 470 480 490 500
YCALKRCDDD QPPSILDPPV QVQFEKCGKR VDQSNRLRVV GGHPGNSPWT
510 520 530 540 550
VSLRNRQGQH FCGGSLVKEQ WVLTARQCIW SCHDPLTGYE VWLGTINQNP
560 570 580 590 600
QPGEANLQRV SVAKTVCGPA GSQLVLLKLE RPVILNHHVA RICLPPEQYV
610 620 630 640 650
VPPGTNCEIA GWGESKGTSN STVLHVAKMK VISSQECNVK YRRRVQESEI
660 670 680 690 700
CTEGLLAPTG ACEGDYGGPL ACYTHDCWVL QGLIIPNRVC ARPRWPAIFT
710
RVSVFVDWIN KVVQLE
Length:716
Mass (Da):80,733
Last modified:February 1, 1997 - v1
Checksum:i06B7DF3EF56D921F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089796 mRNA. Translation: AAH89796.1.
X95096 mRNA. Translation: CAA64473.1.
CH473954 Genomic DNA. Translation: EDL77193.1.
PIRiJC5061.
RefSeqiNP_077328.1. NM_024352.1.
UniGeneiRn.10613.

Genome annotation databases

GeneIDi24566.
KEGGirno:24566.
UCSCiRGD:3114. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089796 mRNA. Translation: AAH89796.1.
X95096 mRNA. Translation: CAA64473.1.
CH473954 Genomic DNA. Translation: EDL77193.1.
PIRiJC5061.
RefSeqiNP_077328.1. NM_024352.1.
UniGeneiRn.10613.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026711.

Protein family/group databases

MEROPSiS01.975.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi24566.
KEGGirno:24566.
UCSCiRGD:3114. rat.

Organism-specific databases

CTDi4485.
RGDi3114. Mst1.

Phylogenomic databases

eggNOGiENOG410IDXR. Eukaryota.
COG5640. LUCA.
HOGENOMiHOG000112892.
HOVERGENiHBG004381.
OrthoDBiEOG091G0AH5.
TreeFamiTF329901.

Gene expression databases

BgeeiENSRNOG00000019680.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiView protein in InterPro
IPR024174. HGF-like.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR003609. Pan_app.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
PfamiView protein in Pfam
PF00051. Kringle. 4 hits.
PF00024. PAN_1. 1 hit.
PF00089. Trypsin. 1 hit.
PIRSFiPIRSF001152. HGF_MST1. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiView protein in SMART
SM00130. KR. 4 hits.
SM00473. PAN_AP. 1 hit.
SM00020. Tryp_SPc. 1 hit.
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF57440. SSF57440. 4 hits.
PROSITEiView protein in PROSITE
PS00021. KRINGLE_1. 3 hits.
PS50070. KRINGLE_2. 4 hits.
PS50948. PAN. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiP70521_RAT
AccessioniPrimary (citable) accession number: P70521
Entry historyiIntegrated into UniProtKB/TrEMBL: February 1, 1997
Last sequence update: February 1, 1997
Last modified: May 10, 2017
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.