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P70521 (P70521_RAT) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesSubmitted name:
Macrophage stimulating 1 (Hepatocyte growth factor-like) EMBL AAH89796.1
Submitted name:
Macrophage stimulating protein EMBL CAA64473.1
Submitted name:
Protein Mst1 Ensembl ENSRNOP00000026711
Gene names
Name:Mst1 RGD 3114 EMBL EDL77193.1 Ensembl ENSRNOP00000026711
Synonyms:MSP EMBL CAA64473.1
ORF Names:rCG_25288 EMBL EDL77193.1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length716 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the peptidase S1 family. RuleBase RU000360

Contains 1 peptidase S1 domain. SAAS SAAS018056

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3131 Potential EMBL CAA64473.1
Chain32 – 716685 Potential EMBL CAA64473.1
PRO_5000146723

Sequences

Sequence LengthMass (Da)Tools
P70521 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 06B7DF3EF56D921F

FASTA71680,733
        10         20         30         40         50         60 
MGWLPLLLLL AQCSRALGQR SPLNDFQLLR GTELRNLLHP VVPGPWQEDV ADAEECARRC 

        70         80         90        100        110        120 
GPLLDCRAFH YNMSSHGCQL LPWTQHSLRA QLHHSSLCDL FQKKDYVRTC IMDNGASYRG 

       130        140        150        160        170        180 
TVARTADGLP CQAWSRRFPN DHKYTPTPKN GLEENFCRNP DGDPRGPWCY TTNRSVRFQS 

       190        200        210        220        230        240 
CGIKSCREAV CVWCNGEDYR GEVDVTESGR ECQRWDLQHP HSHPFHPEKF PDKALKDNYC 

       250        260        270        280        290        300 
RNPDASERPW CYTTDPNVER EFCDLPSCGP NLPPTTKGSK SQQRNKVKAS NCFRGKGEDY 

       310        320        330        340        350        360 
RGTTNTTSAG VPCQRWDAQN PHQHRFVPEK YACKDLRENF CRNPDGSEAP WCFTSRPGLR 

       370        380        390        400        410        420 
VAFCYQIPRC TEEVVPEGCY HGSGEQYRGS VSKTRKGVQC QHWSSETPHK PQFTPTSAPH 

       430        440        450        460        470        480 
AGLEANFCRN PDGDSHGPWC YTLDPETLFD YCALKRCDDD QPPSILDPPV QVQFEKCGKR 

       490        500        510        520        530        540 
VDQSNRLRVV GGHPGNSPWT VSLRNRQGQH FCGGSLVKEQ WVLTARQCIW SCHDPLTGYE 

       550        560        570        580        590        600 
VWLGTINQNP QPGEANLQRV SVAKTVCGPA GSQLVLLKLE RPVILNHHVA RICLPPEQYV 

       610        620        630        640        650        660 
VPPGTNCEIA GWGESKGTSN STVLHVAKMK VISSQECNVK YRRRVQESEI CTEGLLAPTG 

       670        680        690        700        710 
ACEGDYGGPL ACYTHDCWVL QGLIIPNRVC ARPRWPAIFT RVSVFVDWIN KVVQLE

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of rat macrophage-stimulating protein and its involvement in the male reproductive system."
Ohshiro K., Iwama A., Matsuno K., Ezaki T., Sakamoto O., Hamaguchi I., Takasu N., Suda T.
Biochem. Biophys. Res. Commun. 227:273-280(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Liver EMBL CAA64473.1.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver EMBL AAH89796.1.
[3]"Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
Rat Genome Sequencing Project Consortium
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. expand/collapse author list , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Brown Norway Ensembl ENSRNOP00000026711.
[4]"Gene and alternative splicing annotation with AIR."
Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., Istrail S., Li P., Sutton G.
Genome Res. 15:54-66(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: BN EMBL EDL77193.1.
[5]Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F. expand/collapse author list , Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: BN EMBL EDL77193.1.
[6]Ensembl
Submitted (FEB-2012) to UniProtKB
Cited for: IDENTIFICATION.
Strain: Brown Norway Ensembl ENSRNOP00000026711.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AABR06057042 Genomic DNA. No translation available.
BC089796 mRNA. Translation: AAH89796.1.
X95096 mRNA. Translation: CAA64473.1.
CH473954 Genomic DNA. Translation: EDL77193.1.
IPIIPI00189619.
PIRJC5061.
RefSeqNP_077328.1. NM_024352.1.
UniGeneRn.10613.

3D structure databases

HSSPHSSP built from PDB template 1KRN based on UniProtKB P00747.
SMRP70521. Positions 489-713.
ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000026711.

Protein family/group databases

MEROPSS01.975.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000026711; ENSRNOP00000026711; ENSRNOG00000019680.
GeneID24566.
KEGGrno:24566.
UCSCRGD:3114. rat.

Organism-specific databases

CTD4485.
RGD3114. Mst1.

Phylogenomic databases

eggNOGCOG5640.
GeneTreeENSGT00700000104191.
HOGENOMHOG000112892.
HOVERGENHBG004381.
InParanoidP70521.
OrthoDBEOG4H4637.

Gene expression databases

GenevestigatorP70521.

Family and domain databases

Gene3D2.40.20.10. 4 hits.
InterProIPR024174. HGF_MST1.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR003014. PAN-1_domain.
IPR003609. Pan_app.
IPR001254. Peptidase_S1.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF00051. Kringle. 4 hits.
PF00024. PAN_1. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFPIRSF001152. HGF_MST1. 1 hit.
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00130. KR. 4 hits.
SM00473. PAN_AP. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF57440. Kringle-like. 4 hits.
SSF50494. Pept_Ser_Cys. 1 hit.
PROSITEPS00021. KRINGLE_1. 4 hits.
PS50070. KRINGLE_2. 4 hits.
PS50948. PAN. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio603702.

Entry information

Entry nameP70521_RAT
AccessionPrimary (citable) accession number: P70521
Entry history
Integrated into UniProtKB/TrEMBL: February 1, 1997
Last sequence update: February 1, 1997
Last modified: April 3, 2013
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info