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Protein
Submitted name:

Macrophage stimulating 1 (Hepatocyte growth factor-like)

Gene

Mst1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • enzyme binding Source: RGD
  • serine-type endopeptidase activity Source: InterPro

GO - Biological processi

  • cellular response to hypoxia Source: RGD
  • spermatogenesis Source: RGD
  • sperm motility Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Serine protease homologUniRule annotation

Protein family/group databases

MEROPSiS01.975.

Names & Taxonomyi

Protein namesi
Submitted name:
Macrophage stimulating 1 (Hepatocyte growth factor-like)Imported
Submitted name:
Macrophage stimulating proteinImported
Gene namesi
Name:Mst1Imported
Synonyms:MSPImported
ORF Names:rCG_25288Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi3114. Mst1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: RGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 716698Sequence analysisPRO_5007317995Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

GO - Molecular functioni

  • enzyme binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026711.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 10593AppleInterPro annotationAdd
BLAST
Domaini109 – 18678KringleInterPro annotationAdd
BLAST
Domaini190 – 26879KringleInterPro annotationAdd
BLAST
Domaini291 – 37080KringleInterPro annotationAdd
BLAST
Domaini378 – 45780KringleInterPro annotationAdd
BLAST
Domaini489 – 714226Peptidase S1InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.SAAS annotation
Belongs to the peptidase S1 family. Plasminogen subfamily.UniRule annotation
Contains 1 peptidase S1 domain.UniRule annotation

Keywords - Domaini

KringleSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IDXR. Eukaryota.
COG5640. LUCA.
HOGENOMiHOG000112892.
HOVERGENiHBG004381.
OMAiDCRAFHY.
OrthoDBiEOG75B84T.
TreeFamiTF329901.

Family and domain databases

InterProiIPR024174. HGF-like.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR003609. Pan_app.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
[Graphical view]
PfamiPF00051. Kringle. 4 hits.
PF00024. PAN_1. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF001152. HGF_MST1. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00130. KR. 4 hits.
SM00473. PAN_AP. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF57440. SSF57440. 4 hits.
PROSITEiPS00021. KRINGLE_1. 4 hits.
PS50070. KRINGLE_2. 4 hits.
PS50948. PAN. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70521-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGWLPLLLLL AQCSRALGQR SPLNDFQLLR GTELRNLLHP VVPGPWQEDV
60 70 80 90 100
ADAEECARRC GPLLDCRAFH YNMSSHGCQL LPWTQHSLRA QLHHSSLCDL
110 120 130 140 150
FQKKDYVRTC IMDNGASYRG TVARTADGLP CQAWSRRFPN DHKYTPTPKN
160 170 180 190 200
GLEENFCRNP DGDPRGPWCY TTNRSVRFQS CGIKSCREAV CVWCNGEDYR
210 220 230 240 250
GEVDVTESGR ECQRWDLQHP HSHPFHPEKF PDKALKDNYC RNPDASERPW
260 270 280 290 300
CYTTDPNVER EFCDLPSCGP NLPPTTKGSK SQQRNKVKAS NCFRGKGEDY
310 320 330 340 350
RGTTNTTSAG VPCQRWDAQN PHQHRFVPEK YACKDLRENF CRNPDGSEAP
360 370 380 390 400
WCFTSRPGLR VAFCYQIPRC TEEVVPEGCY HGSGEQYRGS VSKTRKGVQC
410 420 430 440 450
QHWSSETPHK PQFTPTSAPH AGLEANFCRN PDGDSHGPWC YTLDPETLFD
460 470 480 490 500
YCALKRCDDD QPPSILDPPV QVQFEKCGKR VDQSNRLRVV GGHPGNSPWT
510 520 530 540 550
VSLRNRQGQH FCGGSLVKEQ WVLTARQCIW SCHDPLTGYE VWLGTINQNP
560 570 580 590 600
QPGEANLQRV SVAKTVCGPA GSQLVLLKLE RPVILNHHVA RICLPPEQYV
610 620 630 640 650
VPPGTNCEIA GWGESKGTSN STVLHVAKMK VISSQECNVK YRRRVQESEI
660 670 680 690 700
CTEGLLAPTG ACEGDYGGPL ACYTHDCWVL QGLIIPNRVC ARPRWPAIFT
710
RVSVFVDWIN KVVQLE
Length:716
Mass (Da):80,733
Last modified:February 1, 1997 - v1
Checksum:i06B7DF3EF56D921F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089796 mRNA. Translation: AAH89796.1.
X95096 mRNA. Translation: CAA64473.1.
CH473954 Genomic DNA. Translation: EDL77193.1.
PIRiJC5061.
RefSeqiNP_077328.1. NM_024352.1.
UniGeneiRn.10613.

Genome annotation databases

GeneIDi24566.
KEGGirno:24566.
UCSCiRGD:3114. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089796 mRNA. Translation: AAH89796.1.
X95096 mRNA. Translation: CAA64473.1.
CH473954 Genomic DNA. Translation: EDL77193.1.
PIRiJC5061.
RefSeqiNP_077328.1. NM_024352.1.
UniGeneiRn.10613.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026711.

Protein family/group databases

MEROPSiS01.975.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi24566.
KEGGirno:24566.
UCSCiRGD:3114. rat.

Organism-specific databases

CTDi4485.
RGDi3114. Mst1.

Phylogenomic databases

eggNOGiENOG410IDXR. Eukaryota.
COG5640. LUCA.
HOGENOMiHOG000112892.
HOVERGENiHBG004381.
OMAiDCRAFHY.
OrthoDBiEOG75B84T.
TreeFamiTF329901.

Family and domain databases

InterProiIPR024174. HGF-like.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR003609. Pan_app.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
[Graphical view]
PfamiPF00051. Kringle. 4 hits.
PF00024. PAN_1. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF001152. HGF_MST1. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00130. KR. 4 hits.
SM00473. PAN_AP. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF57440. SSF57440. 4 hits.
PROSITEiPS00021. KRINGLE_1. 4 hits.
PS50070. KRINGLE_2. 4 hits.
PS50948. PAN. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of rat macrophage-stimulating protein and its involvement in the male reproductive system."
    Ohshiro K., Iwama A., Matsuno K., Ezaki T., Sakamoto O., Hamaguchi I., Takasu N., Suda T.
    Biochem. Biophys. Res. Commun. 227:273-280(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: LiverImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: LiverImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.

Entry informationi

Entry nameiP70521_RAT
AccessioniPrimary (citable) accession number: P70521
Entry historyi
Integrated into UniProtKB/TrEMBL: February 1, 1997
Last sequence update: February 1, 1997
Last modified: June 8, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.