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Protein

Disintegrin and metalloproteinase domain-containing protein 1

Gene

Adam1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in sperm-egg fusion.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi373Zinc; catalyticBy similarity1
Active sitei374PROSITE-ProRule annotation1
Metal bindingi377Zinc; catalyticBy similarity1
Metal bindingi383Zinc; catalyticBy similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • metalloendopeptidase activity Source: InterPro
  • metallopeptidase activity Source: UniProtKB

GO - Biological processi

  • binding of sperm to zona pellucida Source: RGD
  • male gonad development Source: RGD
  • proteolysis Source: UniProtKB

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDAi3.4.24.B8. 5301.

Protein family/group databases

MEROPSiM12.202.

Names & Taxonomyi

Protein namesi
Recommended name:
Disintegrin and metalloproteinase domain-containing protein 1 (EC:3.4.24.-)
Short name:
ADAM 1
Alternative name(s):
Fertilin subunit alpha
Gene namesi
Name:Adam1
Synonyms:Adam1a, Ftna
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621467. Adam1a.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini? – 742ExtracellularSequence analysis
Transmembranei743 – 763HelicalSequence analysisAdd BLAST21
Topological domaini764 – 789CytoplasmicSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000029037? – 789Disintegrin and metalloproteinase domain-containing protein 1
Signal peptidei1 – 68Sequence analysisAdd BLAST68
PropeptideiPRO_000002903669 – ?Sequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi259N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi348 ↔ 427By similarity
Disulfide bondi388 ↔ 411By similarity
Disulfide bondi390 ↔ 396By similarity
Glycosylationi410N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi497 ↔ 517By similarity
Glycosylationi633N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi670 ↔ 682Sequence analysis
Disulfide bondi676 ↔ 688Sequence analysis
Disulfide bondi690 ↔ 699Sequence analysis
Glycosylationi720N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP70505.

PTM databases

PhosphoSitePlusiP70505.

Expressioni

Developmental stagei

In the testis, expressed at all stages of development.1 Publication

Interactioni

Subunit structurei

Heterodimer with ADAM2/fertilin subunit beta.

Structurei

3D structure databases

ProteinModelPortaliP70505.
SMRiP70505.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini238 – 432Peptidase M12BPROSITE-ProRule annotationAdd BLAST195
Domaini441 – 525DisintegrinPROSITE-ProRule annotationAdd BLAST85
Domaini666 – 700EGF-likePROSITE-ProRule annotationAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi526 – 660Cys-richAdd BLAST135

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG006978.
InParanoidiP70505.
KOiK08607.
PhylomeDBiP70505.

Family and domain databases

CDDicd04269. ZnMc_adamalysin_II_like. 1 hit.
Gene3Di3.40.390.10. 2 hits.
4.10.70.10. 1 hit.
InterProiView protein in InterPro
IPR006586. ADAM_Cys-rich.
IPR018358. Disintegrin_CS.
IPR001762. Disintegrin_dom.
IPR036436. Disintegrin_dom_sf.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR024079. MetalloPept_cat_dom_sf.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
IPR034027. Reprolysin_adamalysin.
PfamiView protein in Pfam
PF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
PRINTSiPR00289. DISINTEGRIN.
SMARTiView protein in SMART
SM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiView protein in PROSITE
PS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS00142. ZINC_PROTEASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70505-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVAASASRS ASTLCSPQIQ QGALKEAKVP PHIWAARHWN LGLRLVPGHA
60 70 80 90 100
SVRAGILVLL IFLPSTLCDL GSVYDSSYET VIPERLPGQG SDDPGGKVSY
110 120 130 140 150
VLLMQGQKQL LHLEVKGHYS ERNFPVYSYH HGILGQEVPL LSQACHYEGH
160 170 180 190 200
IEGVPGSFVS VSICSGLRGV LIKEETAYGI EPLLFSTDFE HILYTMAHQP
210 220 230 240 250
VVLCNVTPTD SLGDSSQRQG SSKTDELLAL SDLWSHAKYV EMFVVVNHQR
260 270 280 290 300
FQMWGSDVNT TVQAVVDIIA LANSFTRGIN TEVVLVGLEI WTEGDPIEVP
310 320 330 340 350
VDLQATLRNF NLWRQEKLMG RVRHDVAHLI VGHRPGANEG QAFLDGACSG
360 370 380 390 400
GFAAAVEAFH HEDVLLFAAL MAHELGHNLG IRHDRPGCTC GPKHLCLMHE
410 420 430 440 450
TISKTSGFSN CSSDHFLRFL HDHRGACLLD RPWHQSHKRR DAHCGNGVVE
460 470 480 490 500
ESEECDCGNA CDSHPCCEPT CTLKVGAQCS EGLCCYKCTF KKKGTLCRPA
510 520 530 540 550
EDVCDLPEYC NGITGECPAN SYMQDGTQCD RIYYCSGGLC KNPDKQCARI
560 570 580 590 600
YGYPARSAPE ECYISVNTKA NRFGNCGHPT SANLKYEACS NEDIFCGKLV
610 620 630 640 650
CTDVRYLPQV KPLHSLLQIP YGDDWCWSMD AYNVTDIPDY GDVQGGTYCA
660 670 680 690 700
PKKVCMESIC TGHATLQYDC HPQEMCHGNG VCNNFKHCHC DAGFSPPDCS
710 720 730 740 750
SGGNGGSVDS GPVGKPADRN LSLFGVGESP DSRMEDEEIN LKVVVLVVPI
760 770 780
FLIVLLCCLM LIAYLWSEVQ EAVSPGSSST TSSSESESD
Length:789
Mass (Da):86,140
Last modified:February 1, 1997 - v1
Checksum:i840A43110A4CDEE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08616 mRNA. Translation: CAA69908.1.
RefSeqiNP_064463.1. NM_020078.1.
UniGeneiRn.42919.

Genome annotation databases

GeneIDi56777.
KEGGirno:56777.
UCSCiRGD:621467. rat.

Similar proteinsi

Entry informationi

Entry nameiADAM1_RAT
AccessioniPrimary (citable) accession number: P70505
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: February 1, 1997
Last modified: November 22, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome