Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Disintegrin and metalloproteinase domain-containing protein 1

Gene

Adam1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in sperm-egg fusion.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi373 – 3731Zinc; catalyticBy similarity
Active sitei374 – 3741PROSITE-ProRule annotation
Metal bindingi377 – 3771Zinc; catalyticBy similarity
Metal bindingi383 – 3831Zinc; catalyticBy similarity

GO - Molecular functioni

  • metalloendopeptidase activity Source: InterPro
  • metallopeptidase activity Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

  • male gonad development Source: RGD
  • proteolysis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BRENDAi3.4.24.B8. 5301.

Protein family/group databases

MEROPSiM12.202.

Names & Taxonomyi

Protein namesi
Recommended name:
Disintegrin and metalloproteinase domain-containing protein 1 (EC:3.4.24.-)
Short name:
ADAM 1
Alternative name(s):
Fertilin subunit alpha
Gene namesi
Name:Adam1
Synonyms:Adam1a, Ftna
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621467. Adam1a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini? – 742ExtracellularSequence analysis
Transmembranei743 – 76321HelicalSequence analysisAdd
BLAST
Topological domaini764 – 78926CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 789Disintegrin and metalloproteinase domain-containing protein 1PRO_0000029037
Signal peptidei1 – 6868Sequence analysisAdd
BLAST
Propeptidei69 – ?Sequence analysisPRO_0000029036

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi259 – 2591N-linked (GlcNAc...)Sequence analysis
Disulfide bondi348 ↔ 427By similarity
Disulfide bondi388 ↔ 411By similarity
Disulfide bondi390 ↔ 396By similarity
Glycosylationi410 – 4101N-linked (GlcNAc...)Sequence analysis
Disulfide bondi497 ↔ 517By similarity
Glycosylationi633 – 6331N-linked (GlcNAc...)Sequence analysis
Disulfide bondi670 ↔ 682Sequence analysis
Disulfide bondi676 ↔ 688Sequence analysis
Disulfide bondi690 ↔ 699Sequence analysis
Glycosylationi720 – 7201N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP70505.

PTM databases

PhosphoSiteiP70505.

Expressioni

Developmental stagei

In the testis, expressed at all stages of development.1 Publication

Interactioni

Subunit structurei

Heterodimer with ADAM2/fertilin subunit beta.

Structurei

3D structure databases

ProteinModelPortaliP70505.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini238 – 432195Peptidase M12BPROSITE-ProRule annotationAdd
BLAST
Domaini441 – 52585DisintegrinPROSITE-ProRule annotationAdd
BLAST
Domaini666 – 70035EGF-likePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi526 – 660135Cys-richAdd
BLAST

Sequence similaritiesi

Contains 1 disintegrin domain.PROSITE-ProRule annotation
Contains 1 EGF-like domain.PROSITE-ProRule annotation
Contains 1 peptidase M12B domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG006978.
InParanoidiP70505.
KOiK08607.
PhylomeDBiP70505.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProiIPR006586. ADAM_Cys-rich.
IPR018358. Disintegrin_CS.
IPR001762. Disintegrin_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]
PfamiPF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view]
PRINTSiPR00289. DISINTEGRIN.
SMARTiSM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
[Graphical view]
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70505-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVAASASRS ASTLCSPQIQ QGALKEAKVP PHIWAARHWN LGLRLVPGHA
60 70 80 90 100
SVRAGILVLL IFLPSTLCDL GSVYDSSYET VIPERLPGQG SDDPGGKVSY
110 120 130 140 150
VLLMQGQKQL LHLEVKGHYS ERNFPVYSYH HGILGQEVPL LSQACHYEGH
160 170 180 190 200
IEGVPGSFVS VSICSGLRGV LIKEETAYGI EPLLFSTDFE HILYTMAHQP
210 220 230 240 250
VVLCNVTPTD SLGDSSQRQG SSKTDELLAL SDLWSHAKYV EMFVVVNHQR
260 270 280 290 300
FQMWGSDVNT TVQAVVDIIA LANSFTRGIN TEVVLVGLEI WTEGDPIEVP
310 320 330 340 350
VDLQATLRNF NLWRQEKLMG RVRHDVAHLI VGHRPGANEG QAFLDGACSG
360 370 380 390 400
GFAAAVEAFH HEDVLLFAAL MAHELGHNLG IRHDRPGCTC GPKHLCLMHE
410 420 430 440 450
TISKTSGFSN CSSDHFLRFL HDHRGACLLD RPWHQSHKRR DAHCGNGVVE
460 470 480 490 500
ESEECDCGNA CDSHPCCEPT CTLKVGAQCS EGLCCYKCTF KKKGTLCRPA
510 520 530 540 550
EDVCDLPEYC NGITGECPAN SYMQDGTQCD RIYYCSGGLC KNPDKQCARI
560 570 580 590 600
YGYPARSAPE ECYISVNTKA NRFGNCGHPT SANLKYEACS NEDIFCGKLV
610 620 630 640 650
CTDVRYLPQV KPLHSLLQIP YGDDWCWSMD AYNVTDIPDY GDVQGGTYCA
660 670 680 690 700
PKKVCMESIC TGHATLQYDC HPQEMCHGNG VCNNFKHCHC DAGFSPPDCS
710 720 730 740 750
SGGNGGSVDS GPVGKPADRN LSLFGVGESP DSRMEDEEIN LKVVVLVVPI
760 770 780
FLIVLLCCLM LIAYLWSEVQ EAVSPGSSST TSSSESESD
Length:789
Mass (Da):86,140
Last modified:February 1, 1997 - v1
Checksum:i840A43110A4CDEE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08616 mRNA. Translation: CAA69908.1.
RefSeqiNP_064463.1. NM_020078.1.
UniGeneiRn.42919.

Genome annotation databases

GeneIDi56777.
KEGGirno:56777.
UCSCiRGD:621467. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08616 mRNA. Translation: CAA69908.1.
RefSeqiNP_064463.1. NM_020078.1.
UniGeneiRn.42919.

3D structure databases

ProteinModelPortaliP70505.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiM12.202.

PTM databases

PhosphoSiteiP70505.

Proteomic databases

PRIDEiP70505.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi56777.
KEGGirno:56777.
UCSCiRGD:621467. rat.

Organism-specific databases

CTDi8759.
RGDi621467. Adam1a.

Phylogenomic databases

HOVERGENiHBG006978.
InParanoidiP70505.
KOiK08607.
PhylomeDBiP70505.

Enzyme and pathway databases

BRENDAi3.4.24.B8. 5301.

Miscellaneous databases

PROiP70505.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProiIPR006586. ADAM_Cys-rich.
IPR018358. Disintegrin_CS.
IPR001762. Disintegrin_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]
PfamiPF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view]
PRINTSiPR00289. DISINTEGRIN.
SMARTiSM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
[Graphical view]
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and sequence analysis of rat fertilin alpha and beta - developmental expression, processing and immunolocalization."
    McLaughlin E.A., Frayne J., Barker H.L., Jury J.A., Jones R., Ford W.C.L., Hall L.
    Mol. Hum. Reprod. 3:801-809(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
    Strain: Sprague-Dawley.
    Tissue: Testis.

Entry informationi

Entry nameiADAM1_RAT
AccessioniPrimary (citable) accession number: P70505
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: February 1, 1997
Last modified: June 8, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.