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Protein

Nuclear receptor subfamily 0 group B member 1

Gene

Nr0b1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • adrenal gland development Source: HGNC
  • gonad development Source: HGNC
  • negative regulation of sequence-specific DNA binding transcription factor activity Source: RGD
  • negative regulation of transcription, DNA-templated Source: HGNC
  • negative regulation of transcription from RNA polymerase II promoter Source: RGD
  • regulation of steroid biosynthetic process Source: RGD
  • response to organic substance Source: RGD
  • response to peptide hormone Source: RGD
  • spermatogenesis Source: RGD
  • steroid biosynthetic process Source: HGNC
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Receptor, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor subfamily 0 group B member 1
Alternative name(s):
Nuclear receptor DAX-1
Gene namesi
Name:Nr0b1
Synonyms:Ahch, Dax1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi62028. Nr0b1.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity

  • Note: Shuttles between the cytoplasm and nucleus. Homodimers exits in the cytoplasm and in the nucleus (By similarity).By similarity

GO - Cellular componenti

  • cytoplasm Source: RGD
  • nucleus Source: HGNC
  • polysomal ribosome Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 472472Nuclear receptor subfamily 0 group B member 1PRO_0000053751Add
BLAST

Proteomic databases

PaxDbiP70503.
PRIDEiP70503.

PTM databases

PhosphoSiteiP70503.

Interactioni

Subunit structurei

Homodimer. Interacts with NR5A1, NR5A2, NR0B2 and with COPS2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005023.

Structurei

3D structure databases

ProteinModelPortaliP70503.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati1 – 67671Add
BLAST
Repeati68 – 135682Add
BLAST
Repeati136 – 202673Add
BLAST
Repeati203 – 255534; truncatedAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2552554 X 67 AA tandem repeatsAdd
BLAST
Regioni256 – 472217Ligand-bindingBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi13 – 175LXXLL motif 1
Motifi80 – 845LXXLL motif 2
Motifi148 – 1525LXXLL motif 3
Motifi463 – 4686AF-2 motif

Domaini

Homodimerization involved an interaction between amino and carboxy termini involving LXXLL motifs and steroid binding domain (AF-2 motif). Heterodimerizes with NR5A1 and NROB2 through its N-terminal LXXLL motifs (By similarity).By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
HOGENOMiHOG000231151.
HOVERGENiHBG005453.
InParanoidiP70503.
KOiK08562.
PhylomeDBiP70503.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
InterProiIPR033544. NR0B1.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR025900. Nuclear_receptor_repeat.
[Graphical view]
PANTHERiPTHR24081:SF1. PTHR24081:SF1. 3 hits.
PfamiPF00104. Hormone_recep. 1 hit.
PF14046. NR_Repeat. 4 hits.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
SMARTiSM00430. HOLI. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.

Sequencei

Sequence statusi: Complete.

P70503-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGEDHPWHG SILYNLLMSA KQKHGSREER EVRLGAQCWG CACGTQPVLG
60 70 80 90 100
GEGLPGGQAL SLLYRCCFCG ENHPRQGGIL YSMLTNARQP SGATEAPRAR
110 120 130 140 150
FRTPCWGCAC SNAKPLVGRX GLPAGQVPSL LYRCCFCGKK HPRQGSILYS
160 170 180 190 200
LLTNAQQTHV SREVPEAHRG GEWWQLSYCT HNVGGPEGLQ STQAMAFLYR
210 220 230 240 250
SYVCCEEQPQ QSSVASDTPV RADQTPAAPQ EQPRAPWWDT SSGVQRPIAL
260 270 280 290 300
KDPQVVCEAA SAGLLKTLRF VKYLPCFQIL PLDQQLVLVR SCWAPLLMLE
310 320 330 340 350
LAQDHLHFEM MEISEPNLMH EMLTTRRQET EGPEPADPQA TEQPQTVSAE
360 370 380 390 400
AGHVLSVAAV QAIKSFFFKC WSLNIDTKEY AYLKGTVLFN PDLPGLQCVK
410 420 430 440 450
YIESLQWRTQ QILTEHIRLM QREYQIRSAE LNSALFLLRF INTDVVTELF
460 470
FRPIIGAVSM DDMMLEMLCA KL
Length:472
Mass (Da):52,756
Last modified:February 1, 1997 - v1
Checksum:iF9E0BBA1AFF55196
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99470 mRNA. Translation: CAA67832.1.
RefSeqiNP_445769.1. NM_053317.1.
UniGeneiRn.10596.

Genome annotation databases

GeneIDi58850.
KEGGirno:58850.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99470 mRNA. Translation: CAA67832.1.
RefSeqiNP_445769.1. NM_053317.1.
UniGeneiRn.10596.

3D structure databases

ProteinModelPortaliP70503.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005023.

PTM databases

PhosphoSiteiP70503.

Proteomic databases

PaxDbiP70503.
PRIDEiP70503.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi58850.
KEGGirno:58850.

Organism-specific databases

CTDi190.
RGDi62028. Nr0b1.

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
HOGENOMiHOG000231151.
HOVERGENiHBG005453.
InParanoidiP70503.
KOiK08562.
PhylomeDBiP70503.

Miscellaneous databases

PROiP70503.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
InterProiIPR033544. NR0B1.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR025900. Nuclear_receptor_repeat.
[Graphical view]
PANTHERiPTHR24081:SF1. PTHR24081:SF1. 3 hits.
PfamiPF00104. Hormone_recep. 1 hit.
PF14046. NR_Repeat. 4 hits.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
SMARTiSM00430. HOLI. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNR0B1_RAT
AccessioniPrimary (citable) accession number: P70503
Secondary accession number(s): Q63152
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: February 1, 1997
Last modified: July 6, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.