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Protein

RNA-binding protein 10

Gene

Rbm10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Not known. Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A).

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri135 – 16531RanBP2-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri681 – 70626C2H2-type; atypicalPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 10
Alternative name(s):
RNA-binding motif protein 10
RNA-binding protein S1-1
Gene namesi
Name:Rbm10
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi631366. Rbm10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 852852RNA-binding protein 10PRO_0000081768Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei61 – 611PhosphoserineBy similarity
Modified residuei306 – 3061N6-acetyllysineBy similarity
Modified residuei640 – 6401PhosphoserineBy similarity
Modified residuei645 – 6451PhosphoserineCombined sources
Modified residuei655 – 6551PhosphoserineCombined sources
Modified residuei658 – 6581PhosphoserineCombined sources
Modified residuei660 – 6601PhosphoserineCombined sources
Modified residuei703 – 7031PhosphoserineBy similarity
Modified residuei719 – 7191PhosphoserineCombined sources
Modified residuei767 – 7671PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP70501.
PRIDEiP70501.

PTM databases

iPTMnetiP70501.
PhosphoSiteiP70501.

Expressioni

Gene expression databases

BgeeiENSRNOG00000008472.
ExpressionAtlasiP70501. baseline.
GenevisibleiP70501. RN.

Interactioni

Subunit structurei

Associates with the spliceosome. Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011317.

Structurei

3D structure databases

ProteinModelPortaliP70501.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 13296RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini223 – 30785RRM 2PROSITE-ProRule annotationAdd
BLAST
Domaini780 – 82647G-patchPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C2H2-type zinc finger.PROSITE-ProRule annotation
Contains 1 G-patch domain.PROSITE-ProRule annotation
Contains 1 RanBP2-type zinc finger.PROSITE-ProRule annotation
Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri135 – 16531RanBP2-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri681 – 70626C2H2-type; atypicalPROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0154. Eukaryota.
ENOG410YNFQ. LUCA.
GeneTreeiENSGT00510000046476.
HOVERGENiHBG000318.
InParanoidiP70501.
KOiK13094.
PhylomeDBiP70501.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
4.10.1060.10. 1 hit.
InterProiIPR000467. G_patch_dom.
IPR012677. Nucleotide-bd_a/b_plait.
IPR033095. RBM10.
IPR000504. RRM_dom.
IPR007087. Znf_C2H2.
IPR001876. Znf_RanBP2.
[Graphical view]
PANTHERiPTHR13948:SF4. PTHR13948:SF4. 2 hits.
PfamiPF01585. G-patch. 1 hit.
PF00076. RRM_1. 1 hit.
PF00641. zf-RanBP. 1 hit.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
SM00360. RRM. 2 hits.
SM00547. ZnF_RBZ. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
SSF90209. SSF90209. 1 hit.
PROSITEiPS50174. G_PATCH. 1 hit.
PS50102. RRM. 2 hits.
PS01358. ZF_RANBP2_1. 1 hit.
PS50199. ZF_RANBP2_2. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70501-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYERRGGRG DRTGRYGATD RSQDDGGENR SRDHDYRDMD YRSYPREYGS
60 70 80 90 100
QEGKHEYDDS SEEQSAEIRG QLQSHGVQAR EVRLMRNKSS GQSRGFAFVE
110 120 130 140 150
FSHLQDATRW MEANQHSLNI LGQKVSMHYS DPKPKINEDW LCNKCGVQNF
160 170 180 190 200
KRREKCFKCG VPKSEAEQKL PLGTRLDQQA LPLGGRELSQ GLLPLPQPYQ
210 220 230 240 250
AQGVLTSQAL SQGSEPSSEN ANDTIILRNL NPHSTMDSIL GALAPYAVLS
260 270 280 290 300
SSNVRVIKDK QTQLNRGFAF IQLSTIVEAA QLLQILQALH PPLTIDGKTI
310 320 330 340 350
NVEFAKGSKR DMASNEGSRI NAASVASTAI AAAQWAISQA SQGGESTWAA
360 370 380 390 400
PEEPPVDYSY YQQDEGYGSS QGTDSLYAHG YLKNTKGPGM TGTKGDTSGA
410 420 430 440 450
GPETSLEGGT DSVSLQAFSR AQPGAAPGLY QQSAEGSSGQ GTATNSQSYT
460 470 480 490 500
IMSPAVLKSE LQSPTHPSSA LPPATSPTAP ESYSQYPVPD VSTYQYDETS
510 520 530 540 550
GYYYDPQTGL YYDPNSQYYY NAQSQQYLYW DGERRTYIPA LEQSADGHKD
560 570 580 590 600
TGASSKEGKE KKEKHKTKTA QQIAKDMERW ARSLNKQKEN FKNSFQPISA
610 620 630 640 650
LRDDERRESA TADAGYAILE KKGALAERQH TSMDLPKLAS DDRPSPPRGL
660 670 680 690 700
VAAYSGESDS EEEQERGGPE REEKLTDWQK LACLLCRRQF PSKEALIRHQ
710 720 730 740 750
QLSGLHKQNL EIHRRAHLSE NELEALEKND MEQMKYRDRA AERREKYGIP
760 770 780 790 800
EPPEPKRRKY GGISTASVDF EQPTRDGLGS DNIGSRMLQA MGWKEGSGLG
810 820 830 840 850
RKKQGIVTPI EAQTRVRGSG LGARGSSYGV TSTESYKETL HKTMVTRFNE

AQ
Length:852
Mass (Da):94,388
Last modified:February 1, 1997 - v1
Checksum:iD6D2EECFEECBE189
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83948 mRNA. Translation: BAA12144.1.
RefSeqiNP_690600.1. NM_152861.4.
UniGeneiRn.8822.

Genome annotation databases

EnsembliENSRNOT00000011317; ENSRNOP00000011317; ENSRNOG00000008472.
GeneIDi64510.
KEGGirno:64510.
UCSCiRGD:631366. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83948 mRNA. Translation: BAA12144.1.
RefSeqiNP_690600.1. NM_152861.4.
UniGeneiRn.8822.

3D structure databases

ProteinModelPortaliP70501.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011317.

PTM databases

iPTMnetiP70501.
PhosphoSiteiP70501.

Proteomic databases

PaxDbiP70501.
PRIDEiP70501.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000011317; ENSRNOP00000011317; ENSRNOG00000008472.
GeneIDi64510.
KEGGirno:64510.
UCSCiRGD:631366. rat.

Organism-specific databases

CTDi8241.
RGDi631366. Rbm10.

Phylogenomic databases

eggNOGiKOG0154. Eukaryota.
ENOG410YNFQ. LUCA.
GeneTreeiENSGT00510000046476.
HOVERGENiHBG000318.
InParanoidiP70501.
KOiK13094.
PhylomeDBiP70501.

Miscellaneous databases

PROiP70501.

Gene expression databases

BgeeiENSRNOG00000008472.
ExpressionAtlasiP70501. baseline.
GenevisibleiP70501. RN.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
4.10.1060.10. 1 hit.
InterProiIPR000467. G_patch_dom.
IPR012677. Nucleotide-bd_a/b_plait.
IPR033095. RBM10.
IPR000504. RRM_dom.
IPR007087. Znf_C2H2.
IPR001876. Znf_RanBP2.
[Graphical view]
PANTHERiPTHR13948:SF4. PTHR13948:SF4. 2 hits.
PfamiPF01585. G-patch. 1 hit.
PF00076. RRM_1. 1 hit.
PF00641. zf-RanBP. 1 hit.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
SM00360. RRM. 2 hits.
SM00547. ZnF_RBZ. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
SSF90209. SSF90209. 1 hit.
PROSITEiPS50174. G_PATCH. 1 hit.
PS50102. RRM. 2 hits.
PS01358. ZF_RANBP2_1. 1 hit.
PS50199. ZF_RANBP2_2. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRBM10_RAT
AccessioniPrimary (citable) accession number: P70501
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: February 1, 1997
Last modified: September 7, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.