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Protein

Interferon beta

Gene

Ifnb1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has antiviral, antibacterial and anticancer activities.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense

Enzyme and pathway databases

ReactomeiR-RNO-909733. Interferon alpha/beta signaling.
R-RNO-912694. Regulation of IFNA signaling.
R-RNO-918233. TRAF3-dependent IRF activation pathway.
R-RNO-933541. TRAF6 mediated IRF7 activation.
R-RNO-983231. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon beta
Short name:
IFN-beta
Gene namesi
Name:Ifnb1
Synonyms:Ifnb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi2865. Ifnb1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121By similarityAdd
BLAST
Chaini22 – 184163Interferon betaPRO_0000016404Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241PhosphotyrosineCombined sources
Glycosylationi50 – 501N-linked (GlcNAc...)Sequence analysis
Glycosylationi92 – 921N-linked (GlcNAc...)Sequence analysis
Glycosylationi99 – 991N-linked (GlcNAc...)Sequence analysis
Glycosylationi171 – 1711N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

This beta interferon does not have a disulfide bond.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP70499.
PRIDEiP70499.

PTM databases

iPTMnetiP70499.
PhosphoSiteiP70499.

Expressioni

Gene expression databases

GenevisibleiP70499. RN.

Interactioni

Subunit structurei

Monomer. Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008225.

Structurei

3D structure databases

ProteinModelPortaliP70499.
SMRiP70499. Positions 22-184.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0RY. Eukaryota.
ENOG41113EJ. LUCA.
GeneTreeiENSGT00760000119150.
HOGENOMiHOG000230501.
HOVERGENiHBG052086.
InParanoidiP70499.
KOiK05415.
OMAiNGRLEYC.
OrthoDBiEOG7J9VRD.
PhylomeDBiP70499.
TreeFamiTF336177.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
IPR015588. Interferon_beta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PTHR11691:SF40. PTHR11691:SF40. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70499-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANRWTLHIA FLLCFSTTAL SIDYKQLQFR QSTSIRTCQK LLRQLNGRLN
60 70 80 90 100
LSYRTDFKIP MEVMHPSQME KSYTAFAIQV MLQNVFLVFR SNFSSTGWNE
110 120 130 140 150
TIVESLLDEL HQQTELLEII LKEKQEERLT WVTSTTTLGL KSYYWRVQRY
160 170 180
LKDKKYNSYA WMVVRAEVFR NFSIILRLNR NFQN
Length:184
Mass (Da):22,073
Last modified:February 1, 1997 - v1
Checksum:i1D051D29F979ADDE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87919 Genomic DNA. Translation: BAA13502.1.
PIRiJC5424.
RefSeqiNP_062000.1. NM_019127.1.
UniGeneiRn.138105.

Genome annotation databases

EnsembliENSRNOT00000008224; ENSRNOP00000008225; ENSRNOG00000006268.
GeneIDi24481.
KEGGirno:24481.
UCSCiRGD:2865. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87919 Genomic DNA. Translation: BAA13502.1.
PIRiJC5424.
RefSeqiNP_062000.1. NM_019127.1.
UniGeneiRn.138105.

3D structure databases

ProteinModelPortaliP70499.
SMRiP70499. Positions 22-184.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008225.

PTM databases

iPTMnetiP70499.
PhosphoSiteiP70499.

Proteomic databases

PaxDbiP70499.
PRIDEiP70499.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000008224; ENSRNOP00000008225; ENSRNOG00000006268.
GeneIDi24481.
KEGGirno:24481.
UCSCiRGD:2865. rat.

Organism-specific databases

CTDi3456.
RGDi2865. Ifnb1.

Phylogenomic databases

eggNOGiENOG410J0RY. Eukaryota.
ENOG41113EJ. LUCA.
GeneTreeiENSGT00760000119150.
HOGENOMiHOG000230501.
HOVERGENiHBG052086.
InParanoidiP70499.
KOiK05415.
OMAiNGRLEYC.
OrthoDBiEOG7J9VRD.
PhylomeDBiP70499.
TreeFamiTF336177.

Enzyme and pathway databases

ReactomeiR-RNO-909733. Interferon alpha/beta signaling.
R-RNO-912694. Regulation of IFNA signaling.
R-RNO-918233. TRAF3-dependent IRF activation pathway.
R-RNO-933541. TRAF6 mediated IRF7 activation.
R-RNO-983231. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

PROiP70499.

Gene expression databases

GenevisibleiP70499. RN.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
IPR015588. Interferon_beta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PTHR11691:SF40. PTHR11691:SF40. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and expression of rat interferon beta gene and growth-inhibitory effect of its expression on rat glioma cells."
    Yokoyama S., Ohishi N., Shamoto M., Watanabe Y., Yagi K.
    Biochem. Biophys. Res. Commun. 232:698-701(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Wistar.
    Tissue: Liver.
  2. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
    Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.
    Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-24, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiIFNB_RAT
AccessioniPrimary (citable) accession number: P70499
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: July 6, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.