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Protein

Interferon beta

Gene

Ifnb1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has antiviral, antibacterial and anticancer activities.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processAntiviral defense

Enzyme and pathway databases

ReactomeiR-RNO-909733. Interferon alpha/beta signaling.
R-RNO-912694. Regulation of IFNA signaling.
R-RNO-918233. TRAF3-dependent IRF activation pathway.
R-RNO-933541. TRAF6 mediated IRF7 activation.
R-RNO-983231. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon beta
Short name:
IFN-beta
Gene namesi
Name:Ifnb1
Synonyms:Ifnb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi2865. Ifnb1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000001640422 – 184Interferon betaAdd BLAST163

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24PhosphotyrosineCombined sources1
Glycosylationi50N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi92N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi171N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

This beta interferon does not have a disulfide bond.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP70499.
PRIDEiP70499.

PTM databases

iPTMnetiP70499.
PhosphoSitePlusiP70499.

Expressioni

Gene expression databases

BgeeiENSRNOG00000006268.
GenevisibleiP70499. RN.

Interactioni

Subunit structurei

Monomer. Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008225.

Structurei

3D structure databases

ProteinModelPortaliP70499.
SMRiP70499.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0RY. Eukaryota.
ENOG41113EJ. LUCA.
GeneTreeiENSGT00760000119150.
HOGENOMiHOG000230501.
HOVERGENiHBG052086.
InParanoidiP70499.
KOiK05415.
OMAiSSTGWNE.
OrthoDBiEOG091G0V76.
PhylomeDBiP70499.
TreeFamiTF336177.

Family and domain databases

CDDicd00095. IFab. 1 hit.
InterProiView protein in InterPro
IPR009079. 4_helix_cytokine-like_core.
IPR000471. Interferon_alpha/beta/delta.
IPR015588. Interferon_beta.
PANTHERiPTHR11691. PTHR11691. 1 hit.
PTHR11691:SF43. PTHR11691:SF43. 1 hit.
PfamiView protein in Pfam
PF00143. Interferon. 1 hit.
PRINTSiPR00266. INTERFERONAB.
SMARTiView protein in SMART
SM00076. IFabd. 1 hit.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiView protein in PROSITE
PS00252. INTERFERON_A_B_D. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70499-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANRWTLHIA FLLCFSTTAL SIDYKQLQFR QSTSIRTCQK LLRQLNGRLN
60 70 80 90 100
LSYRTDFKIP MEVMHPSQME KSYTAFAIQV MLQNVFLVFR SNFSSTGWNE
110 120 130 140 150
TIVESLLDEL HQQTELLEII LKEKQEERLT WVTSTTTLGL KSYYWRVQRY
160 170 180
LKDKKYNSYA WMVVRAEVFR NFSIILRLNR NFQN
Length:184
Mass (Da):22,073
Last modified:February 1, 1997 - v1
Checksum:i1D051D29F979ADDE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87919 Genomic DNA. Translation: BAA13502.1.
PIRiJC5424.
RefSeqiNP_062000.1. NM_019127.1.
UniGeneiRn.138105.

Genome annotation databases

EnsembliENSRNOT00000008224; ENSRNOP00000008225; ENSRNOG00000006268.
GeneIDi24481.
KEGGirno:24481.
UCSCiRGD:2865. rat.

Similar proteinsi

Entry informationi

Entry nameiIFNB_RAT
AccessioniPrimary (citable) accession number: P70499
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 22, 2017
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families