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Protein

Fibroblast growth factor 10

Gene

Fgf10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor

Enzyme and pathway databases

ReactomeiR-RNO-109704 PI3K Cascade
R-RNO-1257604 PIP3 activates AKT signaling
R-RNO-190370 FGFR1b ligand binding and activation
R-RNO-190377 FGFR2b ligand binding and activation
R-RNO-5654219 Phospholipase C-mediated cascade: FGFR1
R-RNO-5654221 Phospholipase C-mediated cascade, FGFR2
R-RNO-5654687 Downstream signaling of activated FGFR1
R-RNO-5654688 SHC-mediated cascade:FGFR1
R-RNO-5654689 PI-3K cascade:FGFR1
R-RNO-5654693 FRS-mediated FGFR1 signaling
R-RNO-5654695 PI-3K cascade:FGFR2
R-RNO-5654699 SHC-mediated cascade:FGFR2
R-RNO-5654700 FRS-mediated FGFR2 signaling
R-RNO-5654706 FRS-mediated FGFR3 signaling
R-RNO-5654712 FRS-mediated FGFR4 signaling
R-RNO-5654726 Negative regulation of FGFR1 signaling
R-RNO-5654727 Negative regulation of FGFR2 signaling
R-RNO-5658623 FGFRL1 modulation of FGFR1 signaling
R-RNO-5673001 RAF/MAP kinase cascade
R-RNO-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 10
Short name:
FGF-10
Gene namesi
Name:Fgf10
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi2606 Fgf10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 36Sequence analysisAdd BLAST36
ChainiPRO_000000898337 – 215Fibroblast growth factor 10Add BLAST179

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi50N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi203N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP70492
PRIDEiP70492

Expressioni

Tissue specificityi

Preferentially expressed in the lung in adults.

Gene expression databases

BgeeiENSRNOG00000012278
GenevisibleiP70492 RN

Interactioni

Subunit structurei

Interacts with FGFR1 and FGFR2. Interacts with FGFBP1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016485

Structurei

3D structure databases

ProteinModelPortaliP70492
SMRiP70492
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi51 – 69Poly-SerAdd BLAST19

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
GeneTreeiENSGT00760000118859
HOGENOMiHOG000236341
HOVERGENiHBG007580
InParanoidiP70492
KOiK04358
OMAiSSIPVTC
OrthoDBiEOG091G0NAY
PhylomeDBiP70492
TreeFamiTF317805

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR028252 FGF10
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF21 PTHR11486:SF21, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
PRINTSiPR00263 HBGFFGF
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70492-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWKWILTHCA SAFPHLPGCC CCFLLLFLVS SVPVTCQALG QDMVSPEATN
60 70 80 90 100
SSSSSSSSSS SSSFSSPSSA GRHVRSYNHL QGDVRWRKLF SFTKYFLKIE
110 120 130 140 150
KNGKVSGTKK ENCPYSILEI TSVEIGVVAV KAINSNYYLA MNKKGKLYGS
160 170 180 190 200
KEFNNDCKLK ERIEENGYNT YASFNWQHNG RQMYVALNGK GAPRRGQKTR
210
RKNTSAHFLP MVVHS
Length:215
Mass (Da):24,029
Last modified:February 1, 1997 - v1
Checksum:i93778EFA6FC0866A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D79215 mRNA Translation: BAA11468.1
RefSeqiNP_037083.1, NM_012951.1
UniGeneiRn.44439

Genome annotation databases

EnsembliENSRNOT00000016485; ENSRNOP00000016485; ENSRNOG00000012278
GeneIDi25443
KEGGirno:25443

Similar proteinsi

Entry informationi

Entry nameiFGF10_RAT
AccessioniPrimary (citable) accession number: P70492
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health