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Protein

Fibroblast growth factor 10

Gene

Fgf10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiR-RNO-109704. PI3K Cascade.
R-RNO-1257604. PIP3 activates AKT signaling.
R-RNO-190370. FGFR1b ligand binding and activation.
R-RNO-190377. FGFR2b ligand binding and activation.
R-RNO-5654219. Phospholipase C-mediated cascade: FGFR1.
R-RNO-5654221. Phospholipase C-mediated cascade, FGFR2.
R-RNO-5654687. Downstream signaling of activated FGFR1.
R-RNO-5654688. SHC-mediated cascade:FGFR1.
R-RNO-5654689. PI-3K cascade:FGFR1.
R-RNO-5654693. FRS-mediated FGFR1 signaling.
R-RNO-5654695. PI-3K cascade:FGFR2.
R-RNO-5654699. SHC-mediated cascade:FGFR2.
R-RNO-5654700. FRS-mediated FGFR2 signaling.
R-RNO-5654726. Negative regulation of FGFR1 signaling.
R-RNO-5654727. Negative regulation of FGFR2 signaling.
R-RNO-5658623. FGFRL1 modulation of FGFR1 signaling.
R-RNO-5673001. RAF/MAP kinase cascade.
R-RNO-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 10
Short name:
FGF-10
Gene namesi
Name:Fgf10
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi2606. Fgf10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3636Sequence analysisAdd
BLAST
Chaini37 – 215179Fibroblast growth factor 10PRO_0000008983Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi50 – 501N-linked (GlcNAc...)Sequence analysis
Glycosylationi203 – 2031N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP70492.
PRIDEiP70492.

Expressioni

Tissue specificityi

Preferentially expressed in the lung in adults.

Gene expression databases

GenevisibleiP70492. RN.

Interactioni

Subunit structurei

Interacts with FGFR1 and FGFR2. Interacts with FGFBP1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016485.

Structurei

3D structure databases

ProteinModelPortaliP70492.
SMRiP70492. Positions 76-214.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi51 – 6919Poly-SerAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiP70492.
KOiK04358.
OMAiSSIPVTC.
OrthoDBiEOG7992S1.
PhylomeDBiP70492.
TreeFamiTF317805.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028252. FGF10.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF21. PTHR11486:SF21. 1 hit.
PfamiPF00167. FGF. 1 hit.
[Graphical view]
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70492-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWKWILTHCA SAFPHLPGCC CCFLLLFLVS SVPVTCQALG QDMVSPEATN
60 70 80 90 100
SSSSSSSSSS SSSFSSPSSA GRHVRSYNHL QGDVRWRKLF SFTKYFLKIE
110 120 130 140 150
KNGKVSGTKK ENCPYSILEI TSVEIGVVAV KAINSNYYLA MNKKGKLYGS
160 170 180 190 200
KEFNNDCKLK ERIEENGYNT YASFNWQHNG RQMYVALNGK GAPRRGQKTR
210
RKNTSAHFLP MVVHS
Length:215
Mass (Da):24,029
Last modified:February 1, 1997 - v1
Checksum:i93778EFA6FC0866A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D79215 mRNA. Translation: BAA11468.1.
RefSeqiNP_037083.1. NM_012951.1.
UniGeneiRn.44439.

Genome annotation databases

EnsembliENSRNOT00000016485; ENSRNOP00000016485; ENSRNOG00000012278.
GeneIDi25443.
KEGGirno:25443.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D79215 mRNA. Translation: BAA11468.1.
RefSeqiNP_037083.1. NM_012951.1.
UniGeneiRn.44439.

3D structure databases

ProteinModelPortaliP70492.
SMRiP70492. Positions 76-214.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016485.

Proteomic databases

PaxDbiP70492.
PRIDEiP70492.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000016485; ENSRNOP00000016485; ENSRNOG00000012278.
GeneIDi25443.
KEGGirno:25443.

Organism-specific databases

CTDi2255.
RGDi2606. Fgf10.

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiP70492.
KOiK04358.
OMAiSSIPVTC.
OrthoDBiEOG7992S1.
PhylomeDBiP70492.
TreeFamiTF317805.

Enzyme and pathway databases

ReactomeiR-RNO-109704. PI3K Cascade.
R-RNO-1257604. PIP3 activates AKT signaling.
R-RNO-190370. FGFR1b ligand binding and activation.
R-RNO-190377. FGFR2b ligand binding and activation.
R-RNO-5654219. Phospholipase C-mediated cascade: FGFR1.
R-RNO-5654221. Phospholipase C-mediated cascade, FGFR2.
R-RNO-5654687. Downstream signaling of activated FGFR1.
R-RNO-5654688. SHC-mediated cascade:FGFR1.
R-RNO-5654689. PI-3K cascade:FGFR1.
R-RNO-5654693. FRS-mediated FGFR1 signaling.
R-RNO-5654695. PI-3K cascade:FGFR2.
R-RNO-5654699. SHC-mediated cascade:FGFR2.
R-RNO-5654700. FRS-mediated FGFR2 signaling.
R-RNO-5654726. Negative regulation of FGFR1 signaling.
R-RNO-5654727. Negative regulation of FGFR2 signaling.
R-RNO-5658623. FGFRL1 modulation of FGFR1 signaling.
R-RNO-5673001. RAF/MAP kinase cascade.
R-RNO-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.

Miscellaneous databases

PROiP70492.

Gene expression databases

GenevisibleiP70492. RN.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028252. FGF10.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF21. PTHR11486:SF21. 1 hit.
PfamiPF00167. FGF. 1 hit.
[Graphical view]
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Structure and expression of the rat mRNA encoding a novel member of the fibroblast growth factor family."
    Yamasaki M., Miyake A., Tagashira S., Itoh N.
    J. Biol. Chem. 271:15918-15921(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.

Entry informationi

Entry nameiFGF10_RAT
AccessioniPrimary (citable) accession number: P70492
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: February 1, 1997
Last modified: June 8, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.