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Protein

Striatin

Gene

Strn

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein.

GO - Molecular functioni

  • calcium-dependent protein binding Source: RGD
  • calmodulin binding Source: RGD
  • protein complex binding Source: RGD
  • protein domain specific binding Source: RGD

GO - Biological processi

  • dendrite development Source: RGD
  • locomotory behavior Source: RGD
Complete GO annotation...

Keywords - Ligandi

Calmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Striatin
Gene namesi
Name:Strn
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3782. Strn.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • dendritic spine Source: RGD
  • membrane Source: RGD
  • neuronal cell body Source: RGD
  • postsynaptic density Source: RGD
  • postsynaptic membrane Source: RGD
  • protein complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 780780StriatinPRO_0000051234Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei137 – 1371PhosphoserineBy similarity
Modified residuei225 – 2251PhosphothreonineBy similarity
Modified residuei227 – 2271PhosphoserineBy similarity
Modified residuei229 – 2291PhosphoserineBy similarity
Modified residuei245 – 2451PhosphoserineCombined sources
Modified residuei259 – 2591PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP70483.
PRIDEiP70483.

PTM databases

iPTMnetiP70483.
PhosphoSiteiP70483.

Miscellaneous databases

PMAP-CutDBP70483.

Expressioni

Tissue specificityi

Mainly expressed in the central nervous system. Mostly confined in dendrites, not in axons, and is most abundant in dendritic spines.

Interactioni

Subunit structurei

Interacts with protein phosphatase 2A (PP2A) (Potential). Interacts with CTTNBP2; this interaction may regulate dendritic spine distribution of STRN. Activation of glutamate receptors weakens the interaction with CTTNBP2.Curated1 Publication

GO - Molecular functioni

  • calcium-dependent protein binding Source: RGD
  • calmodulin binding Source: RGD
  • protein complex binding Source: RGD
  • protein domain specific binding Source: RGD

Protein-protein interaction databases

BioGridi247832. 1 interaction.
MINTiMINT-225992.
STRINGi10116.ENSRNOP00000006527.

Structurei

3D structure databases

ProteinModelPortaliP70483.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati461 – 50040WD 1Add
BLAST
Repeati514 – 55340WD 2Add
BLAST
Repeati567 – 60640WD 3Add
BLAST
Repeati662 – 70140WD 4Add
BLAST
Repeati704 – 74340WD 5Add
BLAST
Repeati750 – 77930WD 6Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni55 – 639Caveolin-bindingSequence analysis
Regioni149 – 16618Calmodulin-bindingSequence analysisAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili53 – 12068Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the WD repeat striatin family.Curated
Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0642. Eukaryota.
ENOG410XR31. LUCA.
HOGENOMiHOG000236343.
HOVERGENiHBG007117.
InParanoidiP70483.
KOiK17608.
PhylomeDBiP70483.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR013258. Striatin_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08232. Striatin. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70483-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEQAGPGVF FSNNHPGAGG AKGLGPLAEA AAAGDGAAAA GAARAQYSLP
60 70 80 90 100
GILHFLQHEW ARFEVERAQW EVERAELQAQ IAFLQGERKG QENLKKDLVR
110 120 130 140 150
RIKMLEYALK QERAKYHKLK YGTELNQGDM KPPSYDSDEG NETEVQPQQN
160 170 180 190 200
SQFMWKQGRQ LLRQYLQEVG YTDTILDVKS KRVRALLGFS SDVTDREDDK
210 220 230 240 250
NQDSVINGTE AEVKETAMIG KSELTDSASV LDNFKFLENA AADFSDEDED
260 270 280 290 300
EDIDGREKSV IDTSTIVRKK PLPDTSEDRD TKEALKEFDF LVASEEGDNE
310 320 330 340 350
SRSAGDGTDW EKEDQCLTPE RWNVDQGVIT RLKEQYKKER KGKKGVKRPN
360 370 380 390 400
RSKLQDMLAN LRDVDELPSL QPSVGSPSRP SSSRLPEQDI SRADEVEALT
410 420 430 440 450
FPPSSGKSFI MGADEALESE LGLGELAGLT VANEADSLAY DIANNKDALR
460 470 480 490 500
KTWNPKFTLR SHFDGIRALA FHPIEPVLIT ASEDHTLKMW NLQKTAPAKK
510 520 530 540 550
STSLDVEPIY TFRAHKGPVL CVVMSSNGEQ CYSGGTDGLI QSWSTTNPNV
560 570 580 590 600
DPYDSYDPSV LRGPLLGHTD AVWGLAYSAA HQRLLSCSAD GTLRLWTTTE
610 620 630 640 650
VAPALTVFND NQELGIPASV DLVSSDPSHM VASFSKGYTS IFNMETQQRI
660 670 680 690 700
LTLESNVDST ASSSCQINRV ISHPTLPISI TAHEDRHIKF YDNNTGKLIH
710 720 730 740 750
SMVAHLEAVT SLAVDPNGLY LMSGSHDCSI RLWNLESKTC IQEFTAHRKK
760 770 780
FEESIHDVAF HPSKCYIASA GADALAKVFV
Length:780
Mass (Da):86,226
Last modified:February 1, 1997 - v1
Checksum:i67F7C22099D560F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99326 mRNA. Translation: CAA67701.1.
RefSeqiNP_062021.1. NM_019148.2.
UniGeneiRn.37469.

Genome annotation databases

GeneIDi29149.
KEGGirno:29149.
UCSCiRGD:3782. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99326 mRNA. Translation: CAA67701.1.
RefSeqiNP_062021.1. NM_019148.2.
UniGeneiRn.37469.

3D structure databases

ProteinModelPortaliP70483.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247832. 1 interaction.
MINTiMINT-225992.
STRINGi10116.ENSRNOP00000006527.

PTM databases

iPTMnetiP70483.
PhosphoSiteiP70483.

Proteomic databases

PaxDbiP70483.
PRIDEiP70483.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29149.
KEGGirno:29149.
UCSCiRGD:3782. rat.

Organism-specific databases

CTDi6801.
RGDi3782. Strn.

Phylogenomic databases

eggNOGiKOG0642. Eukaryota.
ENOG410XR31. LUCA.
HOGENOMiHOG000236343.
HOVERGENiHBG007117.
InParanoidiP70483.
KOiK17608.
PhylomeDBiP70483.

Miscellaneous databases

PMAP-CutDBP70483.
PROiP70483.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR013258. Striatin_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08232. Striatin. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel calmodulin-binding protein, belonging to the WD-repeat family, is localized in dendrites of a subset of CNS neurons."
    Castets F., Bartoli M., Barnier J.V., Baillat G., Salin P., Moqrich A., Bourgeois J.-P., Denizot F., Rougon G., Calothy G., Monneron A.
    J. Cell Biol. 134:1051-1062(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 222-243; 258-269; 451-456; 488-494 AND 764-777.
    Strain: Wistar.
    Tissue: Brain.
  2. "CTTNBP2, but not CTTNBP2NL, regulates dendritic spinogenesis and synaptic distribution of the striatin-PP2A complex."
    Chen Y.K., Chen C.Y., Hu H.T., Hsueh Y.P.
    Mol. Biol. Cell 23:4383-4392(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CTTNBP2, SUBCELLULAR LOCATION.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-245, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSTRN_RAT
AccessioniPrimary (citable) accession number: P70483
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: July 6, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.