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Protein

Myelin transcription factor 1-like protein

Gene

Myt1l

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function as a panneural transcription factor associated with neuronal differentiation. May play a role in the development of neurons and oligodendroglia in the CNS.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri22 – 6544CCHHC-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri496 – 53944CCHHC-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri540 – 58344CCHHC-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri895 – 93844CCHHC-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri944 – 98744CCHHC-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri997 – 104044CCHHC-type 6PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin transcription factor 1-like protein
Short name:
MyT1-L
Short name:
MyT1L
Alternative name(s):
Neural zinc finger factor 1
Short name:
NZF-1
Gene namesi
Name:Myt1l
Synonyms:Nzf1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620550. Myt1l.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11871187Myelin transcription factor 1-like proteinPRO_0000096675Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei251 – 2511PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP70475.
PRIDEiP70475.

PTM databases

iPTMnetiP70475.
PhosphoSiteiP70475.

Expressioni

Tissue specificityi

Brain, testis and pituitary gland. Expression is higher in the brain than in the testis and pituitary gland. Highest level expression seen in the developing CNS.2 Publications

Developmental stagei

Detected at E11.5 and expression is seen throughout the proliferating cortex neuroepithelium, developing medulla, and spinal cord. At E12.5 found in the nasal epithelium and at E13.5 detected in the trigeminal ganglia, dorsal root ganglia and the ganglion cell layer of the retina. At E14-E15 expressed at high levels in the brain and spinal cord and then levels subsequently decrease.2 Publications

Interactioni

Protein-protein interaction databases

BioGridi250552. 1 interaction.
STRINGi10116.ENSRNOP00000005905.

Structurei

Secondary structure

1
1187
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni515 – 5173Combined sources
Beta strandi524 – 5285Combined sources
Beta strandi534 – 5396Combined sources
Beta strandi542 – 5443Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PXENMR-A487-548[»]
DisProtiDP00049.
ProteinModelPortaliP70475.
SMRiP70475. Positions 29-60, 501-576, 895-938, 951-1043.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP70475.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1055 – 113177Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi83 – 199117Asp/Glu-richAdd
BLAST
Compositional biasi685 – 71834Ser-richAdd
BLAST

Sequence similaritiesi

Contains 6 CCHHC-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri22 – 6544CCHHC-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri496 – 53944CCHHC-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri540 – 58344CCHHC-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri895 – 93844CCHHC-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri944 – 98744CCHHC-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri997 – 104044CCHHC-type 6PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG3803. Eukaryota.
ENOG410ZPWS. LUCA.
HOGENOMiHOG000234099.
HOVERGENiHBG006433.
InParanoidiP70475.
PhylomeDBiP70475.

Family and domain databases

InterProiIPR013681. Myelin_TF.
IPR002515. Znf_C2HC.
[Graphical view]
PfamiPF08474. MYT1. 1 hit.
PF01530. zf-C2HC. 6 hits.
[Graphical view]
PROSITEiPS51802. ZF_CCHHC. 6 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P70475-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDVDAEEKRH RTRSKGVRVP VEPAIQELFS CPTPGCDGTG HVSGKYARHR
60 70 80 90 100
SVYGCPLAKK RKTQDKQPQE PAPKRKPFAV KADSSSVDEC YESDGTEDMD
110 120 130 140 150
DKEEDDDEEF SEDNDEQGDD DDEDEVDRED EEEIEEEDDE DDEDDDDGDD
160 170 180 190 200
VEEEEDDDDE EEEEEEEEEE NEDHQMSCTR IMQDPEKDDN NNDEYDNYDE
210 220 230 240 250
LVAKSLLNLG KIAEDAAYRA RTESEVNSNT SNSLEDHSSK NENLGRKSEL
260 270 280 290 300
SLDLDSDVVR ETVDSLKLLA QGHGVVLSEN ISDRSYAEGM SQQDSRNMNY
310 320 330 340 350
VMLGKPMNNG LMEKMVEESD EEVCLSSLEC LRNQCFDLAR KLSETNPQDR
360 370 380 390 400
SQPPNMSVRQ HVRQEDDFPG RTPDRSYSDM MNLMRLEEQL SPRSRTFSSC
410 420 430 440 450
AKEDGCHERD DDTTTVNSDR SEEVFDMTKG NLTLLEKAIA LETERAKAMR
460 470 480 490 500
EKMAMDAGRR DNLRSYEDQS PRQLAGEDRK SKSSDSHVKK PYYDPSRTEK
510 520 530 540 550
RESKCPTPGC DGTGHVNGLY PHHRSLSGCP HKDRVPPEIL AMHENVLKCP
560 570 580 590 600
TPGCTGRGHV NSNRNSHRSL SGCPIAAAEK LAKAQEKHQS CDVSKSNQAS
610 620 630 640 650
DRVLRPMCFV KQLEIPQYGY RNNVPTTTPR SNLAKELEKY SKTSFEYNSY
660 670 680 690 700
DNHTYGKRAI APKVQTRDIS PKGYDDAKRY CKNASPSSST TSSYAPSSSS
710 720 730 740 750
NLSCGGGSSA SSTCSKSSFD YTHDMEAAHM AATAILNLST RCREMPQNLS
760 770 780 790 800
TKPQDLCTAR NPDMEVDENG TLDLSMNKQR PRDSCCPVLT PLEPMSPQQQ
810 820 830 840 850
AVMSSRCFQL SEGDCWDLPV DYTKMKPRRV DEEDPKEITP EDLDPFQEAL
860 870 880 890 900
EERRYPGEVT IPSPKPKYPQ CKESKKDLIT LSGCPLADKS IRSMLATSSQ
910 920 930 940 950
ELKCPTPGCD GSGHITGNYA SHRSLSGCPR AKKSGIRIAQ SKEDKEDQEP
960 970 980 990 1000
IRCPVPGCDG QGHITGKYAS HRSASGCPLA AKRQKDGYLN GSQFSWKSVK
1010 1020 1030 1040 1050
TEGMSCPTPG CDGSGHVSGS FLTHRSLSGC PRATSAMKKA KLSGEQMLTI
1060 1070 1080 1090 1100
KQRASNGIEN DEEIKQLDEE IKELNESNSQ MEADMIKLRT QVTITTMESN
1110 1120 1130 1140 1150
LKTIEEENKV IEQQNESLLH ELANLSQSLI HSLANIQLPH MDPINEQNFD
1160 1170 1180
AYVTTLTEMY TNQDRYQSPE NKALLENIKQ AVRGIQV
Length:1,187
Mass (Da):132,929
Last modified:September 27, 2005 - v2
Checksum:iB31E00AE7004D112
GO
Isoform 2 (identifier: P70475-2)
Sequence is not available
Length:
Mass (Da):
Isoform 3 (identifier: P70475-3)
Sequence is not available
Length:
Mass (Da):

Sequence cautioni

The sequence AAC52728 differs from that shown. Reason: Frameshift at positions 663 and 681. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti371 – 3755RTPDR → NSARG (PubMed:8980226).Curated
Sequence conflicti415 – 4151T → S in AAB40718 (PubMed:8980226).Curated
Sequence conflicti517 – 5171N → T (PubMed:8980226).Curated
Sequence conflicti517 – 5171N → T (PubMed:14744132).Curated
Sequence conflicti561 – 5611N → H in AAB40718 (PubMed:8980226).Curated
Sequence conflicti804 – 8041S → T in AAB40718 (PubMed:8980226).Curated
Sequence conflicti918 – 9181N → I in AAB40718 (PubMed:8980226).Curated
Sequence conflicti1019 – 10191G → A in AAB40718 (PubMed:8980226).Curated
Sequence conflicti1092 – 10932Missing in AAB40718 (PubMed:8980226).Curated
Sequence conflicti1098 – 10981E → D in AAB40718 (PubMed:8980226).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48809 mRNA. Translation: AAC52728.1. Frameshift.
U67081 mRNA. Translation: AAB40718.1.
PIRiT46637.
RefSeqiNP_446340.1. NM_053888.1.
UniGeneiRn.10559.

Genome annotation databases

GeneIDi116668.
KEGGirno:116668.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48809 mRNA. Translation: AAC52728.1. Frameshift.
U67081 mRNA. Translation: AAB40718.1.
PIRiT46637.
RefSeqiNP_446340.1. NM_053888.1.
UniGeneiRn.10559.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PXENMR-A487-548[»]
DisProtiDP00049.
ProteinModelPortaliP70475.
SMRiP70475. Positions 29-60, 501-576, 895-938, 951-1043.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250552. 1 interaction.
STRINGi10116.ENSRNOP00000005905.

PTM databases

iPTMnetiP70475.
PhosphoSiteiP70475.

Proteomic databases

PaxDbiP70475.
PRIDEiP70475.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi116668.
KEGGirno:116668.

Organism-specific databases

CTDi23040.
RGDi620550. Myt1l.

Phylogenomic databases

eggNOGiKOG3803. Eukaryota.
ENOG410ZPWS. LUCA.
HOGENOMiHOG000234099.
HOVERGENiHBG006433.
InParanoidiP70475.
PhylomeDBiP70475.

Miscellaneous databases

EvolutionaryTraceiP70475.
PROiP70475.

Family and domain databases

InterProiIPR013681. Myelin_TF.
IPR002515. Znf_C2HC.
[Graphical view]
PfamiPF08474. MYT1. 1 hit.
PF01530. zf-C2HC. 6 hits.
[Graphical view]
PROSITEiPS51802. ZF_CCHHC. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYT1L_RAT
AccessioniPrimary (citable) accession number: P70475
Secondary accession number(s): P70589
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: September 27, 2005
Last modified: September 7, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.