Myelin transcription factor 1-like protein

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P70475 (MYT1L_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 86. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Myelin transcription factor 1-like protein
Short name=MyT1-L
Short name=MyT1L

Alternative name(s):
Neural zinc finger factor 1
Short name=NZF-1

Gene names

Name:	Myt1l
Synonyms:	Nzf1

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	1187 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May function as a panneural transcription factor associated with neuronal differentiation. May play a role in the development of neurons and oligodendrogalia in the CNS. Ref.3
Subcellular location	Nucleus Ref.3.
Tissue specificity	Brain, testis and pituitary gland. Expression is higher in the brain than in the testis and pituitary gland. Highest level expression seen in the developing CNS. Ref.1 Ref.3
Developmental stage	Detected at E11.5 and expression is seen throughout the proliferating cortex neuroepithelium, developing medulla, and spinal cord. At E12.5 found in the nasal epithelium and at E13.5 detected in the trigeminal ganglia, dorsal root ganglia and the ganglion cell layer of the retina. At E14-E15 expressed at high levels in the brain and spinal cord and then levels subsequently decrease. Ref.1 Ref.3
Sequence similarities	Contains 6 C2HC-type zinc fingers.
Sequence caution	The sequence AAC52728.1 differs from that shown. Reason: Frameshift at positions 663 and 681.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Coiled coil Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Developmental protein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW nervous system development Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	RNA polymerase II transcription coactivator activity Inferred from direct assay Ref.1. Source: RGD retinoic acid-responsive element binding Inferred from direct assay Ref.1. Source: RGD sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Select]

Isoform 1 (identifier: P70475-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P70475-2) The sequence of this isoform is not available.

Isoform 3 (identifier: P70475-3) The sequence of this isoform is not available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1187

1187

Myelin transcription factor 1-like protein

PRO_0000096675

Regions

Zinc finger

28 – 58

C2HC-type 1

Zinc finger

502 – 532

C2HC-type 2

Zinc finger

546 – 576

C2HC-type 3

Zinc finger

901 – 931

C2HC-type 4

Zinc finger

950 – 980

C2HC-type 5

Zinc finger

1003 – 1033

C2HC-type 6

Coiled coil

1055 – 1131

Potential

Compositional bias

83 – 199

117

Asp/Glu-rich

Compositional bias

685 – 718

Ser-rich

Experimental info

Sequence conflict

371 – 375

RTPDR → NSARG Ref.2

Sequence conflict

415

T → S in AAB40718. Ref.2

Sequence conflict

517

N → T Ref.2

Sequence conflict

517

N → T Ref.4

Sequence conflict

561

N → H in AAB40718. Ref.2

Sequence conflict

804

S → T in AAB40718. Ref.2

Sequence conflict

918

N → I in AAB40718. Ref.2

Sequence conflict

1019

G → A in AAB40718. Ref.2

Sequence conflict

1092 – 1093

Missing in AAB40718. Ref.2

Sequence conflict

1098

E → D in AAB40718. Ref.2

Secondary structure

1187

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

Isoform 1 [UniParc].

Last modified September 27, 2005. Version 2.
Checksum: B31E00AE7004D112
Show »

FASTA

1,187

132,929

        10         20         30         40         50         60 
MDVDAEEKRH RTRSKGVRVP VEPAIQELFS CPTPGCDGTG HVSGKYARHR SVYGCPLAKK 

        70         80         90        100        110        120 
RKTQDKQPQE PAPKRKPFAV KADSSSVDEC YESDGTEDMD DKEEDDDEEF SEDNDEQGDD 

       130        140        150        160        170        180 
DDEDEVDRED EEEIEEEDDE DDEDDDDGDD VEEEEDDDDE EEEEEEEEEE NEDHQMSCTR 

       190        200        210        220        230        240 
IMQDPEKDDN NNDEYDNYDE LVAKSLLNLG KIAEDAAYRA RTESEVNSNT SNSLEDHSSK 

       250        260        270        280        290        300 
NENLGRKSEL SLDLDSDVVR ETVDSLKLLA QGHGVVLSEN ISDRSYAEGM SQQDSRNMNY 

       310        320        330        340        350        360 
VMLGKPMNNG LMEKMVEESD EEVCLSSLEC LRNQCFDLAR KLSETNPQDR SQPPNMSVRQ 

       370        380        390        400        410        420 
HVRQEDDFPG RTPDRSYSDM MNLMRLEEQL SPRSRTFSSC AKEDGCHERD DDTTTVNSDR 

       430        440        450        460        470        480 
SEEVFDMTKG NLTLLEKAIA LETERAKAMR EKMAMDAGRR DNLRSYEDQS PRQLAGEDRK 

       490        500        510        520        530        540 
SKSSDSHVKK PYYDPSRTEK RESKCPTPGC DGTGHVNGLY PHHRSLSGCP HKDRVPPEIL 

       550        560        570        580        590        600 
AMHENVLKCP TPGCTGRGHV NSNRNSHRSL SGCPIAAAEK LAKAQEKHQS CDVSKSNQAS 

       610        620        630        640        650        660 
DRVLRPMCFV KQLEIPQYGY RNNVPTTTPR SNLAKELEKY SKTSFEYNSY DNHTYGKRAI 

       670        680        690        700        710        720 
APKVQTRDIS PKGYDDAKRY CKNASPSSST TSSYAPSSSS NLSCGGGSSA SSTCSKSSFD 

       730        740        750        760        770        780 
YTHDMEAAHM AATAILNLST RCREMPQNLS TKPQDLCTAR NPDMEVDENG TLDLSMNKQR 

       790        800        810        820        830        840 
PRDSCCPVLT PLEPMSPQQQ AVMSSRCFQL SEGDCWDLPV DYTKMKPRRV DEEDPKEITP 

       850        860        870        880        890        900 
EDLDPFQEAL EERRYPGEVT IPSPKPKYPQ CKESKKDLIT LSGCPLADKS IRSMLATSSQ 

       910        920        930        940        950        960 
ELKCPTPGCD GSGHITGNYA SHRSLSGCPR AKKSGIRIAQ SKEDKEDQEP IRCPVPGCDG 

       970        980        990       1000       1010       1020 
QGHITGKYAS HRSASGCPLA AKRQKDGYLN GSQFSWKSVK TEGMSCPTPG CDGSGHVSGS 

      1030       1040       1050       1060       1070       1080 
FLTHRSLSGC PRATSAMKKA KLSGEQMLTI KQRASNGIEN DEEIKQLDEE IKELNESNSQ 

      1090       1100       1110       1120       1130       1140 
MEADMIKLRT QVTITTMESN LKTIEEENKV IEQQNESLLH ELANLSQSLI HSLANIQLPH 

      1150       1160       1170       1180 
MDPINEQNFD AYVTTLTEMY TNQDRYQSPE NKALLENIKQ AVRGIQV

« Hide

Isoform 2 (Sequence not available).

–

Isoform 3 (Sequence not available).

–

References

[1]	"A novel family of Cys-Cys, His-Cys zinc finger transcription factors expressed in developing nervous system and pituitary gland." Jiang Y., Yu V.C., Buchholz F., O'Connell S., Rhodes S.J., Candeloro C., Xia Y.-R., Lusis A.J., Rosenfeld M.G. J. Biol. Chem. 271:10723-10730(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[2]	"X-MyT1, a Xenopus C2HC-type zinc finger protein with a regulatory function in neuronal differentiation." Bellefroid E.J., Bourguignon C., Hollemann T., Ma Q., Anderson D.J., Kintner C., Pieler T. Cell 87:1191-1202(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 371-1187.
[3]	"Myelin transcription factor 1 (Myt1) of the oligodendrocyte lineage, along with a closely related CCHC zinc finger, is expressed in developing neurons in the mammalian central nervous system." Kim J.G., Armstrong R.C., Agoston D.V., Robinsky A., Wiese C., Nagle J., Hudson L.D. J. Neurosci. Res. 50:272-290(1997) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[4]	"Solution structure of a CCHHC domain of neural zinc finger factor-1 and its implications for DNA binding." Berkovits-Cymet H.J., Amann B.T., Berg J.M. Biochemistry 43:898-903(2004) [PubMed] [Europe PMC] [Abstract] Cited for: STRUCTURE BY NMR OF 487-548.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U48809 mRNA. Translation: AAC52728.1. Frameshift.
U67081 mRNA. Translation: AAB40718.1.

IPI

IPI00208894.

PIR

T46637.

RefSeq

NP_446340.1. NM_053888.1.

UniGene

Rn.10559.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1PXE	NMR	-	A	487-548	[»]

DisProt

DP00049.

ProteinModelPortal

P70475.

SMR

P70475. Positions 29-60, 501-576, 895-938, 951-1043.

ModBase

Search...

Protein-protein interaction databases

STRING

10116.ENSRNOP00000045413.

PTM databases

PhosphoSite

P70475.

Proteomic databases

PaxDb

P70475.

PRIDE

P70475.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

116668.

KEGG

rno:116668.

Organism-specific databases

CTD

23040.

RGD

620550. Myt1l.

Phylogenomic databases

eggNOG

NOG262917.

HOGENOM

HOG000234099.

HOVERGEN

HBG006433.

InParanoid

P70475.

OrthoDB

EOG4N04D7.

Gene expression databases

ArrayExpress

P70475.

Genevestigator

P70475.

GermOnline

ENSRNOG00000004269. Rattus norvegicus.

Family and domain databases

InterPro

IPR013681. Myelin_TF.
IPR002515. Znf_C2HC.
[Graphical view]

Pfam

PF08474. MYT1. 1 hit.
PF01530. zf-C2HC. 6 hits.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P70475.

NextBio

619477.

Entry information

Entry name

MYT1L_RAT

Accession

Primary (citable) accession number: P70475
Secondary accession number(s): P70589

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2005
Last sequence update:	September 27, 2005
Last modified:	April 3, 2013
This is version 86 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Experimental info

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents