##gff-version 3 P70451 UniProtKB Chain 1 823 . . . ID=PRO_0000260825;Note=Tyrosine-protein kinase Fer P70451 UniProtKB Domain 1 259 . . . Note=F-BAR;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01077 P70451 UniProtKB Domain 461 551 . . . Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191 P70451 UniProtKB Domain 564 817 . . . Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 P70451 UniProtKB Region 1 300 . . . Note=Important for interaction with membranes containing phosphoinositides;Ontology_term=ECO:0000250;evidence=ECO:0000250 P70451 UniProtKB Region 389 408 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P70451 UniProtKB Coiled coil 123 185 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 P70451 UniProtKB Coiled coil 301 381 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 P70451 UniProtKB Active site 685 685 . . . Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10028 P70451 UniProtKB Binding site 570 578 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 P70451 UniProtKB Binding site 592 592 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 P70451 UniProtKB Modified residue 402 402 . . . Note=Phosphotyrosine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:17947660,ECO:0007744|PubMed:19131326;Dbxref=PMID:17947660,PMID:19131326 P70451 UniProtKB Modified residue 434 434 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P16591 P70451 UniProtKB Modified residue 616 616 . . . Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159681;Dbxref=PMID:19159681 P70451 UniProtKB Modified residue 715 715 . . . Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10074905;Dbxref=PMID:10074905 P70451 UniProtKB Alternative sequence 1 369 . . . ID=VSP_041766;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2294399;Dbxref=PMID:2294399 P70451 UniProtKB Alternative sequence 70 127 . . . ID=VSP_021634;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 P70451 UniProtKB Alternative sequence 370 412 . . . ID=VSP_041767;Note=In isoform 4. LRCTEAKCAAQKALLEQKVQENDGKEPPPVVNYEEDARSVTSM->MDKSMECPHCEGVLEPESDPQFSKKCSIPLSPGPSSSEILRYK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2294399;Dbxref=PMID:2294399 P70451 UniProtKB Alternative sequence 444 444 . . . ID=VSP_041768;Note=In isoform 4 and isoform 5. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:16141072,ECO:0000303|PubMed:2294399;Dbxref=PMID:16141072,PMID:2294399 P70451 UniProtKB Alternative sequence 491 542 . . . ID=VSP_041769;Note=In isoform 3. GEYVLSVYSDGQRRHFIIQFVDNLYRFEGTGFSNIPQLIDHHFNTKQVITKK->ESVSIRGHRVFKHSPAYRSPLQYKASHHQEVWGGSAQPHPKG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11006284;Dbxref=PMID:11006284 P70451 UniProtKB Alternative sequence 543 823 . . . ID=VSP_041770;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11006284;Dbxref=PMID:11006284 P70451 UniProtKB Mutagenesis 135 136 . . . Note=Abolishes homooligomerization. KL->RP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10391941;Dbxref=PMID:10391941 P70451 UniProtKB Mutagenesis 322 323 . . . Note=Abolishes homooligomerization. ML->RP;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10391941;Dbxref=PMID:10391941 P70451 UniProtKB Mutagenesis 571 571 . . . Note=Abolishes kinase activity. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9742951;Dbxref=PMID:9742951 P70451 UniProtKB Mutagenesis 592 592 . . . Note=Abolishes kinase activity. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10391941;Dbxref=PMID:10391941 P70451 UniProtKB Mutagenesis 606 606 . . . Note=Abolishes interaction with PPP1CA. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16732323;Dbxref=PMID:16732323 P70451 UniProtKB Mutagenesis 616 616 . . . Note=Abolishes autophosphorylation. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159681;Dbxref=PMID:19159681 P70451 UniProtKB Mutagenesis 715 715 . . . Note=Abolishes autophosphorylation. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10074905;Dbxref=PMID:10074905 P70451 UniProtKB Mutagenesis 743 743 . . . Note=Abolishes kinase activity. D->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10391941;Dbxref=PMID:10391941 P70451 UniProtKB Sequence conflict 328 328 . . . Note=A->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 P70451 UniProtKB Sequence conflict 373 373 . . . Note=T->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 P70451 UniProtKB Sequence conflict 730 730 . . . Note=P->A;Ontology_term=ECO:0000305;evidence=ECO:0000305