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Protein

Neurogenin-2

Gene

Neurog2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').1 Publication

GO - Molecular functioni

  • E-box binding Source: UniProtKB
  • protein dimerization activity Source: InterPro
  • sequence-specific DNA binding Source: MGI

GO - Biological processi

  • axon guidance Source: MGI
  • cell fate commitment Source: MGI
  • cell maturation Source: MGI
  • central nervous system neuron development Source: MGI
  • forebrain development Source: MGI
  • neurogenesis Source: MGI
  • neuron differentiation Source: MGI
  • neuron migration Source: MGI
  • positive regulation of DNA binding transcription factor activity Source: UniProtKB
  • positive regulation of neuron differentiation Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Neurogenin-2
Short name:
NGN-2
Alternative name(s):
Helix-loop-helix protein mATH-4A
Short name:
mATH4A
Protein atonal homolog 4
Gene namesi
Name:Neurog2
Synonyms:Ath4a, Atoh4, Ngn2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:109619 Neurog2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001274011 – 263Neurogenin-2Add BLAST263

Proteomic databases

PaxDbiP70447
PRIDEiP70447

PTM databases

iPTMnetiP70447
PhosphoSitePlusiP70447

Expressioni

Gene expression databases

CleanExiMM_NEUROG2

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198240, 4 interactors
STRINGi10090.ENSMUSP00000029587

Structurei

3D structure databases

ProteinModelPortaliP70447
SMRiP70447
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini112 – 164bHLHPROSITE-ProRule annotationAdd BLAST53

Phylogenomic databases

eggNOGiENOG410IQ4B Eukaryota
ENOG410XZ4C LUCA
HOGENOMiHOG000063655
HOVERGENiHBG101129
InParanoidiP70447
KOiK09082

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR032655 Ngn2
PANTHERiPTHR19290:SF105 PTHR19290:SF105, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

P70447-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFVKSETLEL KEEEEVLMLL GSASPASATL TPMSSSADEE EDEELRRPGS
60 70 80 90 100
ARGQRGAEAE QGVQGSPASG AGGCRPGRLL GLMHECKRRP SRSRAVSRGA
110 120 130 140 150
KTAETVQRIK KTRRLKANNR ERNRMHNLNA ALDALREVLP TFPEDAKLTK
160 170 180 190 200
IETLRFAHNY IWALTETLRL ADHCAGAGGL QGALFTEAVL LSPGAALGAS
210 220 230 240 250
GDSPSPPSSW SCTNSPASSS NSTSPYSCTL SPASPGSDVD YWQPPPPEKH
260
RYAPHLPLAR DCI
Length:263
Mass (Da):28,216
Last modified:February 1, 1997 - v1
Checksum:i817EF8246BD8CABE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti60E → G in CAA68900 (PubMed:8948587).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76207 Genomic DNA Translation: AAC53028.1
Y07621 mRNA Translation: CAA68900.1
AF303001 Genomic DNA Translation: AAG40769.1
CCDSiCCDS17825.1
RefSeqiNP_033848.1, NM_009718.2
UniGeneiMm.42017

Genome annotation databases

GeneIDi11924
KEGGimmu:11924

Similar proteinsi

Entry informationi

Entry nameiNGN2_MOUSE
AccessioniPrimary (citable) accession number: P70447
Secondary accession number(s): P70237
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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