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Protein

Neurogenin-2

Gene

Neurog2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').1 Publication

GO - Molecular functioni

  • E-box binding Source: UniProtKB
  • sequence-specific DNA binding Source: MGI

GO - Biological processi

  • axon guidance Source: MGI
  • cell fate commitment Source: MGI
  • cell maturation Source: MGI
  • central nervous system neuron development Source: MGI
  • forebrain development Source: MGI
  • neurogenesis Source: MGI
  • neuron differentiation Source: MGI
  • neuron migration Source: MGI
  • positive regulation of neuron differentiation Source: MGI
  • positive regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neurogenin-2
Short name:
NGN-2
Alternative name(s):
Helix-loop-helix protein mATH-4A
Short name:
mATH4A
Protein atonal homolog 4
Gene namesi
Name:Neurog2
Synonyms:Ath4a, Atoh4, Ngn2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:109619. Neurog2.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001274011 – 263Neurogenin-2Add BLAST263

Proteomic databases

PaxDbiP70447.
PRIDEiP70447.

PTM databases

iPTMnetiP70447.
PhosphoSitePlusiP70447.

Expressioni

Gene expression databases

CleanExiMM_NEUROG2.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.

Protein-protein interaction databases

BioGridi198240. 4 interactors.
MINTiMINT-1520816.
STRINGi10090.ENSMUSP00000029587.

Structurei

3D structure databases

ProteinModelPortaliP70447.
SMRiP70447.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini112 – 164bHLHPROSITE-ProRule annotationAdd BLAST53

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IQ4B. Eukaryota.
ENOG410XZ4C. LUCA.
HOGENOMiHOG000063655.
HOVERGENiHBG101129.
InParanoidiP70447.
KOiK09082.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR032655. Ngn2.
[Graphical view]
PANTHERiPTHR19290:SF105. PTHR19290:SF105. 1 hit.
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70447-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFVKSETLEL KEEEEVLMLL GSASPASATL TPMSSSADEE EDEELRRPGS
60 70 80 90 100
ARGQRGAEAE QGVQGSPASG AGGCRPGRLL GLMHECKRRP SRSRAVSRGA
110 120 130 140 150
KTAETVQRIK KTRRLKANNR ERNRMHNLNA ALDALREVLP TFPEDAKLTK
160 170 180 190 200
IETLRFAHNY IWALTETLRL ADHCAGAGGL QGALFTEAVL LSPGAALGAS
210 220 230 240 250
GDSPSPPSSW SCTNSPASSS NSTSPYSCTL SPASPGSDVD YWQPPPPEKH
260
RYAPHLPLAR DCI
Length:263
Mass (Da):28,216
Last modified:February 1, 1997 - v1
Checksum:i817EF8246BD8CABE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti60E → G in CAA68900 (PubMed:8948587).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76207 Genomic DNA. Translation: AAC53028.1.
Y07621 mRNA. Translation: CAA68900.1.
AF303001 Genomic DNA. Translation: AAG40769.1.
CCDSiCCDS17825.1.
RefSeqiNP_033848.1. NM_009718.2.
UniGeneiMm.42017.

Genome annotation databases

GeneIDi11924.
KEGGimmu:11924.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76207 Genomic DNA. Translation: AAC53028.1.
Y07621 mRNA. Translation: CAA68900.1.
AF303001 Genomic DNA. Translation: AAG40769.1.
CCDSiCCDS17825.1.
RefSeqiNP_033848.1. NM_009718.2.
UniGeneiMm.42017.

3D structure databases

ProteinModelPortaliP70447.
SMRiP70447.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198240. 4 interactors.
MINTiMINT-1520816.
STRINGi10090.ENSMUSP00000029587.

PTM databases

iPTMnetiP70447.
PhosphoSitePlusiP70447.

Proteomic databases

PaxDbiP70447.
PRIDEiP70447.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi11924.
KEGGimmu:11924.

Organism-specific databases

CTDi63973.
MGIiMGI:109619. Neurog2.

Phylogenomic databases

eggNOGiENOG410IQ4B. Eukaryota.
ENOG410XZ4C. LUCA.
HOGENOMiHOG000063655.
HOVERGENiHBG101129.
InParanoidiP70447.
KOiK09082.

Miscellaneous databases

PROiP70447.
SOURCEiSearch...

Gene expression databases

CleanExiMM_NEUROG2.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR032655. Ngn2.
[Graphical view]
PANTHERiPTHR19290:SF105. PTHR19290:SF105. 1 hit.
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNGN2_MOUSE
AccessioniPrimary (citable) accession number: P70447
Secondary accession number(s): P70237
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 1, 1997
Last modified: November 2, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.