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Protein

Na(+)/H(+) exchange regulatory cofactor NHE-RF1

Gene

Slc9a3r1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling (By similarity). May participate in HTR4 targeting to microvilli. Involved in the regulation of phosphate reabsorption in the renal proximal tubules (By similarity). Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa.By similarity2 Publications

GO - Molecular functioni

  1. beta-2 adrenergic receptor binding Source: MGI
  2. beta-catenin binding Source: MGI
  3. chloride channel regulator activity Source: UniProtKB
  4. dopamine receptor binding Source: MGI
  5. growth factor receptor binding Source: MGI
  6. PDZ domain binding Source: MGI
  7. phosphatase binding Source: UniProtKB
  8. protein self-association Source: MGI
  9. receptor binding Source: MGI

GO - Biological processi

  1. actin cytoskeleton organization Source: MGI
  2. adenylate cyclase-activating dopamine receptor signaling pathway Source: MGI
  3. auditory receptor cell stereocilium organization Source: MGI
  4. bile acid secretion Source: UniProtKB
  5. cAMP-mediated signaling Source: MGI
  6. cellular phosphate ion homeostasis Source: MGI
  7. cellular protein localization Source: MGI
  8. glutathione transport Source: UniProtKB
  9. microvillus assembly Source: MGI
  10. negative regulation of cell migration Source: MGI
  11. negative regulation of cell motility Source: UniProtKB
  12. negative regulation of cell proliferation Source: MGI
  13. negative regulation of ERK1 and ERK2 cascade Source: MGI
  14. negative regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
  15. negative regulation of platelet-derived growth factor receptor signaling pathway Source: UniProtKB
  16. negative regulation of protein kinase B signaling Source: UniProtKB
  17. negative regulation of sodium:proton antiporter activity Source: MGI
  18. negative regulation of sodium ion transport Source: MGI
  19. phospholipase C-activating dopamine receptor signaling pathway Source: MGI
  20. positive regulation of intrinsic apoptotic signaling pathway Source: MGI
  21. regulation of excretion Source: MGI
  22. regulation of protein kinase activity Source: UniProtKB
  23. renal absorption Source: UniProtKB
  24. renal phosphate ion absorption Source: UniProtKB
  25. renal sodium ion transport Source: MGI
  26. sensory perception of sound Source: MGI
  27. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Na(+)/H(+) exchange regulatory cofactor NHE-RF1
Short name:
NHERF-1
Alternative name(s):
Ezrin-radixin-moesin-binding phosphoprotein 50
Short name:
EBP50
Regulatory cofactor of Na(+)/H(+) exchanger
Sodium-hydrogen exchanger regulatory factor 1
Solute carrier family 9 isoform A3 regulatory factor 1
Gene namesi
Name:Slc9a3r1
Synonyms:Nherf, Nherf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1349482. Slc9a3r1.

Subcellular locationi

  1. Cytoplasm
  2. Apical cell membrane
  3. Cell projectionfilopodium By similarity
  4. Cell projectionruffle By similarity
  5. Cell projectionmicrovillus By similarity
  6. Endomembrane system By similarity; Peripheral membrane protein By similarity

  7. Note: Colocalizes with actin in microvilli-rich apical regions of the syncytiotrophoblast. Present in lipid rafts of T-cells (By similarity). Translocates from the cytoplasm to the apical cell membrane in a PODXL-dependent manner. Colocalizes with CFTR at the midpiece of sperm tail.By similarity

GO - Cellular componenti

  1. apical part of cell Source: MGI
  2. apical plasma membrane Source: MGI
  3. brush border membrane Source: MGI
  4. cell periphery Source: MGI
  5. centrosome Source: MGI
  6. cytoplasm Source: UniProtKB
  7. endomembrane system Source: UniProtKB-SubCell
  8. extracellular vesicular exosome Source: MGI
  9. filopodium Source: UniProtKB-SubCell
  10. intracellular membrane-bounded organelle Source: MGI
  11. membrane Source: UniProtKB
  12. membrane raft Source: Ensembl
  13. microvillus Source: UniProtKB
  14. microvillus membrane Source: UniProtKB
  15. plasma membrane Source: MGI
  16. ruffle Source: UniProtKB-SubCell
  17. sperm midpiece Source: UniProtKB
  18. stereocilium Source: MGI
  19. stereocilium bundle tip Source: MGI
  20. vesicle Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 355354Na(+)/H(+) exchange regulatory cofactor NHE-RF1PRO_0000096800Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei46 – 461PhosphoserineBy similarity
Modified residuei264 – 2641PhosphoserineBy similarity
Modified residuei275 – 2751PhosphoserineBy similarity
Modified residuei285 – 2851PhosphoserineBy similarity
Modified residuei286 – 2861Phosphoserine1 Publication
Modified residuei288 – 2881PhosphothreonineBy similarity
Modified residuei289 – 2891Phosphoserine1 Publication
Modified residuei297 – 2971Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP70441.
PaxDbiP70441.
PRIDEiP70441.

PTM databases

PhosphoSiteiP70441.

Miscellaneous databases

PMAP-CutDBP70441.

Expressioni

Tissue specificityi

Expressed in spermatogenic cells.1 Publication

Gene expression databases

BgeeiP70441.
ExpressionAtlasiP70441. baseline and differential.
GenevestigatoriP70441.

Interactioni

Subunit structurei

Homodimer, and heterodimer with SLC9A3R2. Binds the N-termini of EZR, RDX and MSN. Binds the C-termini of PDGFRA, PDGFRB, ADRB2 and NOS2. Binds ARHGAP17, EPI64, GNB2L1, OPRK1, GNAQ, CTNNB1, PLCB3 and CLCN3. Forms a complex with CFTR and SLC4A7. Forms a complex with SLC4A7 and ATP6V1B1 (By similarity). Binds PDZK1. Binds the C-terminus of PAG1. In resting T-cells, part of a PAG1-SLC9A3R1-MSN complex which is disrupted upon TCR activation. Directly interacts with HTR4. Interacts with MCC (By similarity). Interacts with TRPC4 (via the PDZ-binding domain) (By similarity). Interacts (via the PDZ 1 domain) with PODXL (via the C-terminal PDZ-binding motif DTHL); interaction is not detected in glomerular epithelium cells (By similarity). Interacts (via the PDZ 1 domain) with PODXL (via the C-terminal PDZ-binding motif DTHL); the interaction take place early in the secretory pathway and is necessary for its apical membrane sorting (By similarity). Interacts with SLC34A1 (By similarity). Interacts with CFTR, SLC26A3 and SLC26A6.By similarity5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CftrP263613EBI-1184085,EBI-6115317
Slc26a3Q9WVC82EBI-1184085,EBI-6895537
Slc26a6Q8CIW62EBI-1184085,EBI-6895517
Slc4a10Q80ZA5-33EBI-1184085,EBI-8613086From a different organism.

Protein-protein interaction databases

BioGridi205077. 4 interactions.
IntActiP70441. 12 interactions.
MINTiMINT-144615.

Structurei

3D structure databases

ProteinModelPortaliP70441.
SMRiP70441. Positions 11-120, 145-355.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 9481PDZ 1PROSITE-ProRule annotationAdd
BLAST
Domaini149 – 22981PDZ 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 PDZ (DHR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG321335.
HOGENOMiHOG000089940.
HOVERGENiHBG052616.
InParanoidiP70441.
KOiK13365.
OMAiCTMKKGP.
OrthoDBiEOG7R56T6.
PhylomeDBiP70441.
TreeFamiTF350449.

Family and domain databases

Gene3Di2.30.42.10. 2 hits.
InterProiIPR015098. EBP50_C-term.
IPR017300. NaH_exchngr_reg_CF_NHE-RF.
IPR001478. PDZ.
[Graphical view]
PfamiPF09007. EBP50_C-term. 1 hit.
PF00595. PDZ. 2 hits.
[Graphical view]
PIRSFiPIRSF037866. EBP50. 1 hit.
ProDomiPD283022. EBP50_C-term. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00228. PDZ. 2 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 2 hits.
PROSITEiPS50106. PDZ. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P70441-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSADAAAGEP LPRLCCLEKG PNGYGFHLHG EKGKVGQFIR LVEPGSPAEK
60 70 80 90 100
SGLLAGDRLV EVNGENVEKE THQQVVSRIR AALNAVRLLV VDPETDERLK
110 120 130 140 150
KLGVSIREEL LRPQEKSEQA EPPAAADTHE AGDQNEAEKS HLRELRPRLC
160 170 180 190 200
TMKKGPNGYG FNLHSDKSKP GQFIRAVDPD SPAEASGLRA QDRIVEVNGV
210 220 230 240 250
CMEGKQHGDV VSAIKGGGDE AKLLVVDKET DEFFKKCKVI PSQEHLDGPL
260 270 280 290 300
PEPFSNGEIQ KESSREALVE PASESPRPAL ARSASSDTSE ELNSQDSPKR
310 320 330 340 350
QVSTEPSSTS SSSSDPILDL NISLAVAKER AHQKRSSKRA PQMDWSKKNE

LFSNL
Length:355
Mass (Da):38,600
Last modified:January 23, 2007 - v3
Checksum:i331F6BEE31DA0A11
GO
Isoform 2 (identifier: P70441-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-317: Missing.
     318-318: L → M

Note: No experimental confirmation available.

Show »
Length:38
Mass (Da):4,429
Checksum:i08D620869EE48A78
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 317317Missing in isoform 2. 1 PublicationVSP_027877Add
BLAST
Alternative sequencei318 – 3181L → M in isoform 2. 1 PublicationVSP_027878

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U74079 mRNA. Translation: AAB17569.1.
AK040371 mRNA. Translation: BAC30573.2.
BC085141 mRNA. Translation: AAH85141.1.
CCDSiCCDS36370.1. [P70441-1]
RefSeqiNP_036160.1. NM_012030.2. [P70441-1]
UniGeneiMm.27842.

Genome annotation databases

EnsembliENSMUST00000021077; ENSMUSP00000021077; ENSMUSG00000020733. [P70441-1]
GeneIDi26941.
KEGGimmu:26941.
UCSCiuc007mgp.1. mouse. [P70441-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U74079 mRNA. Translation: AAB17569.1.
AK040371 mRNA. Translation: BAC30573.2.
BC085141 mRNA. Translation: AAH85141.1.
CCDSiCCDS36370.1. [P70441-1]
RefSeqiNP_036160.1. NM_012030.2. [P70441-1]
UniGeneiMm.27842.

3D structure databases

ProteinModelPortaliP70441.
SMRiP70441. Positions 11-120, 145-355.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205077. 4 interactions.
IntActiP70441. 12 interactions.
MINTiMINT-144615.

PTM databases

PhosphoSiteiP70441.

Proteomic databases

MaxQBiP70441.
PaxDbiP70441.
PRIDEiP70441.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021077; ENSMUSP00000021077; ENSMUSG00000020733. [P70441-1]
GeneIDi26941.
KEGGimmu:26941.
UCSCiuc007mgp.1. mouse. [P70441-1]

Organism-specific databases

CTDi9368.
MGIiMGI:1349482. Slc9a3r1.

Phylogenomic databases

eggNOGiNOG321335.
HOGENOMiHOG000089940.
HOVERGENiHBG052616.
InParanoidiP70441.
KOiK13365.
OMAiCTMKKGP.
OrthoDBiEOG7R56T6.
PhylomeDBiP70441.
TreeFamiTF350449.

Miscellaneous databases

NextBioi304861.
PMAP-CutDBP70441.
PROiP70441.
SOURCEiSearch...

Gene expression databases

BgeeiP70441.
ExpressionAtlasiP70441. baseline and differential.
GenevestigatoriP70441.

Family and domain databases

Gene3Di2.30.42.10. 2 hits.
InterProiIPR015098. EBP50_C-term.
IPR017300. NaH_exchngr_reg_CF_NHE-RF.
IPR001478. PDZ.
[Graphical view]
PfamiPF09007. EBP50_C-term. 1 hit.
PF00595. PDZ. 2 hits.
[Graphical view]
PIRSFiPIRSF037866. EBP50. 1 hit.
ProDomiPD283022. EBP50_C-term. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00228. PDZ. 2 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 2 hits.
PROSITEiPS50106. PDZ. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of the cDNA and promoter sequences for the mouse sodium-hydrogen exchanger regulatory factor."
    Weinman E.J., Steplock D., Zhang X., Akhter S., Shenolikar S.
    Biochim. Biophys. Acta 1447:71-76(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: C57BL/6.
    Tissue: Kidney.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Thymus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6.
    Tissue: Brain.
  4. "The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange."
    Hall R.A., Premont R.T., Chow C.-W., Blitzer J.T., Pitcher J.A., Claing A., Stoffel R.H., Barak L.S., Shenolikar S., Weinman E.J., Grinstein S., Lefkowitz R.J.
    Nature 392:626-630(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ADRB2.
  5. "Negative regulation of immune synapse formation by anchoring lipid raft to cytoskeleton through Cbp-EBP50-ERM assembly."
    Itoh K., Sakakibara M., Yamasaki S., Takeuchi A., Arase H., Miyazaki M., Nakajima N., Okada M., Saito T.
    J. Immunol. 168:541-544(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PAG1, IDENTIFICATION IN A COMPLEX WITH PAG1 AND MSN.
  6. Cited for: INTERACTION WITH PDZK1.
  7. "New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4a receptor splice variant: roles in receptor targeting."
    Joubert L., Hanson B., Barthet G., Sebben M., Claeysen S., Hong W., Marin P., Dumuis A., Bockaert J.
    J. Cell Sci. 117:5367-5379(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HTR4.
  8. "Phosphoproteome analysis of mouse liver using immobilized metal affinity purification and linear ion trap mass spectrometry."
    Jin W.-H., Dai J., Zhou H., Xia Q.-C., Zou H.-F., Zeng R.
    Rapid Commun. Mass Spectrom. 18:2169-2176(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-286.
  9. "The CD34-related molecule podocalyxin is a potent inducer of microvillus formation."
    Nielsen J.S., Graves M.L., Chelliah S., Vogl A.W., Roskelley C.D., McNagny K.M.
    PLoS ONE 2:E237-E237(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-289 AND SER-297, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  11. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
    Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
    J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  12. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  13. "Participation of the Cl-/HCO(3)- exchangers SLC26A3 and SLC26A6, the Cl- channel CFTR, and the regulatory factor SLC9A3R1 in mouse sperm capacitation."
    Chavez J.C., Hernandez-Gonzalez E.O., Wertheimer E., Visconti P.E., Darszon A., Trevino C.L.
    Biol. Reprod. 86:1-14(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CFTR; SLC26A3 AND SLC26A6, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiNHRF1_MOUSE
AccessioniPrimary (citable) accession number: P70441
Secondary accession number(s): Q8BYD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: January 23, 2007
Last modified: March 4, 2015
This is version 137 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.