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P70441

- NHRF1_MOUSE

UniProt

P70441 - NHRF1_MOUSE

Protein

Na(+)/H(+) exchange regulatory cofactor NHE-RF1

Gene

Slc9a3r1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling By similarity. May participate in HTR4 targeting to microvilli. Involved in the regulation of phosphate reabsorption in the renal proximal tubules By similarity. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa.By similarity2 Publications

    GO - Molecular functioni

    1. chloride channel regulator activity Source: UniProtKB
    2. dopamine receptor binding Source: MGI
    3. phosphatase binding Source: UniProtKB
    4. protein binding Source: UniProtKB

    GO - Biological processi

    1. actin cytoskeleton organization Source: MGI
    2. adenylate cyclase-activating dopamine receptor signaling pathway Source: MGI
    3. bile acid secretion Source: UniProtKB
    4. cAMP-mediated signaling Source: MGI
    5. cellular phosphate ion homeostasis Source: MGI
    6. cellular protein localization Source: MGI
    7. glutathione transport Source: UniProtKB
    8. microvillus assembly Source: Ensembl
    9. negative regulation of cell migration Source: MGI
    10. negative regulation of cell motility Source: UniProtKB
    11. negative regulation of cell proliferation Source: Ensembl
    12. negative regulation of ERK1 and ERK2 cascade Source: Ensembl
    13. negative regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
    14. negative regulation of platelet-derived growth factor receptor signaling pathway Source: UniProtKB
    15. negative regulation of protein kinase B signaling Source: UniProtKB
    16. negative regulation of sodium:proton antiporter activity Source: MGI
    17. negative regulation of sodium ion transport Source: MGI
    18. phospholipase C-activating dopamine receptor signaling pathway Source: MGI
    19. positive regulation of intrinsic apoptotic signaling pathway Source: Ensembl
    20. regulation of excretion Source: MGI
    21. regulation of protein kinase activity Source: UniProtKB
    22. renal absorption Source: UniProtKB
    23. renal phosphate ion absorption Source: UniProtKB
    24. renal sodium ion transport Source: MGI
    25. Wnt signaling pathway Source: UniProtKB-KW

    Keywords - Biological processi

    Wnt signaling pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Na(+)/H(+) exchange regulatory cofactor NHE-RF1
    Short name:
    NHERF-1
    Alternative name(s):
    Ezrin-radixin-moesin-binding phosphoprotein 50
    Short name:
    EBP50
    Regulatory cofactor of Na(+)/H(+) exchanger
    Sodium-hydrogen exchanger regulatory factor 1
    Solute carrier family 9 isoform A3 regulatory factor 1
    Gene namesi
    Name:Slc9a3r1
    Synonyms:Nherf, Nherf1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1349482. Slc9a3r1.

    Subcellular locationi

    Cytoplasm. Apical cell membrane. Cell projectionfilopodium By similarity. Cell projectionruffle By similarity. Cell projectionmicrovillus By similarity. Endomembrane system By similarity; Peripheral membrane protein By similarity
    Note: Colocalizes with actin in microvilli-rich apical regions of the syncytiotrophoblast. Present in lipid rafts of T-cells By similarity. Translocates from the cytoplasm to the apical cell membrane in a PODXL-dependent manner. Colocalizes with CFTR at the midpiece of sperm tail.By similarity

    GO - Cellular componenti

    1. apical part of cell Source: MGI
    2. apical plasma membrane Source: MGI
    3. brush border membrane Source: MGI
    4. centrosome Source: Ensembl
    5. cytoplasm Source: UniProtKB
    6. endomembrane system Source: UniProtKB-SubCell
    7. filopodium Source: UniProtKB-SubCell
    8. intracellular membrane-bounded organelle Source: Ensembl
    9. membrane Source: UniProtKB
    10. membrane raft Source: Ensembl
    11. microvillus Source: UniProtKB
    12. microvillus membrane Source: UniProtKB
    13. ruffle Source: UniProtKB-SubCell
    14. sperm midpiece Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 355354Na(+)/H(+) exchange regulatory cofactor NHE-RF1PRO_0000096800Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity
    Modified residuei46 – 461PhosphoserineBy similarity
    Modified residuei264 – 2641PhosphoserineBy similarity
    Modified residuei275 – 2751PhosphoserineBy similarity
    Modified residuei285 – 2851PhosphoserineBy similarity
    Modified residuei286 – 2861Phosphoserine1 Publication
    Modified residuei288 – 2881PhosphothreonineBy similarity
    Modified residuei289 – 2891Phosphoserine1 Publication
    Modified residuei297 – 2971Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP70441.
    PaxDbiP70441.
    PRIDEiP70441.

    PTM databases

    PhosphoSiteiP70441.

    Miscellaneous databases

    PMAP-CutDBP70441.

    Expressioni

    Tissue specificityi

    Expressed in spermatogenic cells.1 Publication

    Gene expression databases

    ArrayExpressiP70441.
    BgeeiP70441.
    GenevestigatoriP70441.

    Interactioni

    Subunit structurei

    Homodimer, and heterodimer with SLC9A3R2. Binds the N-termini of EZR, RDX and MSN. Binds the C-termini of PDGFRA, PDGFRB, ADRB2 and NOS2. Binds ARHGAP17, EPI64, GNB2L1, OPRK1, GNAQ, CTNNB1, PLCB3 and CLCN3. Forms a complex with CFTR and SLC4A7. Forms a complex with SLC4A7 and ATP6V1B1 By similarity. Binds PDZK1. Binds the C-terminus of PAG1. In resting T-cells, part of a PAG1-SLC9A3R1-MSN complex which is disrupted upon TCR activation. Directly interacts with HTR4. Interacts with MCC By similarity. Interacts with TRPC4 (via the PDZ-binding domain) By similarity. Interacts (via the PDZ 1 domain) with PODXL (via the C-terminal PDZ-binding motif DTHL); interaction is not detected in glomerular epithelium cells By similarity. Interacts (via the PDZ 1 domain) with PODXL (via the C-terminal PDZ-binding motif DTHL); the interaction take place early in the secretory pathway and is necessary for its apical membrane sorting By similarity. Interacts with SLC34A1 By similarity. Interacts with CFTR, SLC26A3 and SLC26A6.By similarity5 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CftrP263613EBI-1184085,EBI-6115317
    Slc26a3Q9WVC82EBI-1184085,EBI-6895537
    Slc26a6Q8CIW62EBI-1184085,EBI-6895517
    Slc4a10Q80ZA5-33EBI-1184085,EBI-8613086From a different organism.

    Protein-protein interaction databases

    BioGridi205077. 4 interactions.
    IntActiP70441. 12 interactions.
    MINTiMINT-144615.

    Structurei

    3D structure databases

    ProteinModelPortaliP70441.
    SMRiP70441. Positions 11-99, 145-355.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini14 – 9481PDZ 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini149 – 22981PDZ 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 PDZ (DHR) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG321335.
    HOGENOMiHOG000089940.
    HOVERGENiHBG052616.
    InParanoidiP70441.
    KOiK13365.
    OMAiVEKETHQ.
    OrthoDBiEOG7R56T6.
    PhylomeDBiP70441.
    TreeFamiTF350449.

    Family and domain databases

    Gene3Di2.30.42.10. 2 hits.
    InterProiIPR015098. EBP50_C-term.
    IPR017300. NaH_exchngr_reg_CF_NHE-RF.
    IPR001478. PDZ.
    [Graphical view]
    PfamiPF09007. EBP50_C-term. 1 hit.
    PF00595. PDZ. 2 hits.
    [Graphical view]
    PIRSFiPIRSF037866. EBP50. 1 hit.
    ProDomiPD283022. EBP50_C-term. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00228. PDZ. 2 hits.
    [Graphical view]
    SUPFAMiSSF50156. SSF50156. 2 hits.
    PROSITEiPS50106. PDZ. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P70441-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSADAAAGEP LPRLCCLEKG PNGYGFHLHG EKGKVGQFIR LVEPGSPAEK    50
    SGLLAGDRLV EVNGENVEKE THQQVVSRIR AALNAVRLLV VDPETDERLK 100
    KLGVSIREEL LRPQEKSEQA EPPAAADTHE AGDQNEAEKS HLRELRPRLC 150
    TMKKGPNGYG FNLHSDKSKP GQFIRAVDPD SPAEASGLRA QDRIVEVNGV 200
    CMEGKQHGDV VSAIKGGGDE AKLLVVDKET DEFFKKCKVI PSQEHLDGPL 250
    PEPFSNGEIQ KESSREALVE PASESPRPAL ARSASSDTSE ELNSQDSPKR 300
    QVSTEPSSTS SSSSDPILDL NISLAVAKER AHQKRSSKRA PQMDWSKKNE 350
    LFSNL 355
    Length:355
    Mass (Da):38,600
    Last modified:January 23, 2007 - v3
    Checksum:i331F6BEE31DA0A11
    GO
    Isoform 2 (identifier: P70441-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         2-317: Missing.
         318-318: L → M

    Note: No experimental confirmation available.

    Show »
    Length:39
    Mass (Da):4,560
    Checksum:i047F20869EE4EAE1
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei2 – 317316Missing in isoform 2. 1 PublicationVSP_027877Add
    BLAST
    Alternative sequencei318 – 3181L → M in isoform 2. 1 PublicationVSP_027878

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U74079 mRNA. Translation: AAB17569.1.
    AK040371 mRNA. Translation: BAC30573.2.
    BC085141 mRNA. Translation: AAH85141.1.
    CCDSiCCDS36370.1. [P70441-1]
    RefSeqiNP_036160.1. NM_012030.2. [P70441-1]
    UniGeneiMm.27842.

    Genome annotation databases

    EnsembliENSMUST00000021077; ENSMUSP00000021077; ENSMUSG00000020733. [P70441-1]
    GeneIDi26941.
    KEGGimmu:26941.
    UCSCiuc007mgp.1. mouse. [P70441-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U74079 mRNA. Translation: AAB17569.1 .
    AK040371 mRNA. Translation: BAC30573.2 .
    BC085141 mRNA. Translation: AAH85141.1 .
    CCDSi CCDS36370.1. [P70441-1 ]
    RefSeqi NP_036160.1. NM_012030.2. [P70441-1 ]
    UniGenei Mm.27842.

    3D structure databases

    ProteinModelPortali P70441.
    SMRi P70441. Positions 11-99, 145-355.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 205077. 4 interactions.
    IntActi P70441. 12 interactions.
    MINTi MINT-144615.

    PTM databases

    PhosphoSitei P70441.

    Proteomic databases

    MaxQBi P70441.
    PaxDbi P70441.
    PRIDEi P70441.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021077 ; ENSMUSP00000021077 ; ENSMUSG00000020733 . [P70441-1 ]
    GeneIDi 26941.
    KEGGi mmu:26941.
    UCSCi uc007mgp.1. mouse. [P70441-1 ]

    Organism-specific databases

    CTDi 9368.
    MGIi MGI:1349482. Slc9a3r1.

    Phylogenomic databases

    eggNOGi NOG321335.
    HOGENOMi HOG000089940.
    HOVERGENi HBG052616.
    InParanoidi P70441.
    KOi K13365.
    OMAi VEKETHQ.
    OrthoDBi EOG7R56T6.
    PhylomeDBi P70441.
    TreeFami TF350449.

    Miscellaneous databases

    NextBioi 304861.
    PMAP-CutDB P70441.
    PROi P70441.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P70441.
    Bgeei P70441.
    Genevestigatori P70441.

    Family and domain databases

    Gene3Di 2.30.42.10. 2 hits.
    InterProi IPR015098. EBP50_C-term.
    IPR017300. NaH_exchngr_reg_CF_NHE-RF.
    IPR001478. PDZ.
    [Graphical view ]
    Pfami PF09007. EBP50_C-term. 1 hit.
    PF00595. PDZ. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF037866. EBP50. 1 hit.
    ProDomi PD283022. EBP50_C-term. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00228. PDZ. 2 hits.
    [Graphical view ]
    SUPFAMi SSF50156. SSF50156. 2 hits.
    PROSITEi PS50106. PDZ. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of the cDNA and promoter sequences for the mouse sodium-hydrogen exchanger regulatory factor."
      Weinman E.J., Steplock D., Zhang X., Akhter S., Shenolikar S.
      Biochim. Biophys. Acta 1447:71-76(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Strain: C57BL/6.
      Tissue: Kidney.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6J.
      Tissue: Thymus.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6.
      Tissue: Brain.
    4. "The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange."
      Hall R.A., Premont R.T., Chow C.-W., Blitzer J.T., Pitcher J.A., Claing A., Stoffel R.H., Barak L.S., Shenolikar S., Weinman E.J., Grinstein S., Lefkowitz R.J.
      Nature 392:626-630(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH ADRB2.
    5. "Negative regulation of immune synapse formation by anchoring lipid raft to cytoskeleton through Cbp-EBP50-ERM assembly."
      Itoh K., Sakakibara M., Yamasaki S., Takeuchi A., Arase H., Miyazaki M., Nakajima N., Okada M., Saito T.
      J. Immunol. 168:541-544(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PAG1, IDENTIFICATION IN A COMPLEX WITH PAG1 AND MSN.
    6. Cited for: INTERACTION WITH PDZK1.
    7. "New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4a receptor splice variant: roles in receptor targeting."
      Joubert L., Hanson B., Barthet G., Sebben M., Claeysen S., Hong W., Marin P., Dumuis A., Bockaert J.
      J. Cell Sci. 117:5367-5379(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HTR4.
    8. "Phosphoproteome analysis of mouse liver using immobilized metal affinity purification and linear ion trap mass spectrometry."
      Jin W.-H., Dai J., Zhou H., Xia Q.-C., Zou H.-F., Zeng R.
      Rapid Commun. Mass Spectrom. 18:2169-2176(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-286.
    9. "The CD34-related molecule podocalyxin is a potent inducer of microvillus formation."
      Nielsen J.S., Graves M.L., Chelliah S., Vogl A.W., Roskelley C.D., McNagny K.M.
      PLoS ONE 2:E237-E237(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-289 AND SER-297, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    11. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
      Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
      J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    12. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
      Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.
    13. "Participation of the Cl-/HCO(3)- exchangers SLC26A3 and SLC26A6, the Cl- channel CFTR, and the regulatory factor SLC9A3R1 in mouse sperm capacitation."
      Chavez J.C., Hernandez-Gonzalez E.O., Wertheimer E., Visconti P.E., Darszon A., Trevino C.L.
      Biol. Reprod. 86:1-14(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CFTR; SLC26A3 AND SLC26A6, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiNHRF1_MOUSE
    AccessioniPrimary (citable) accession number: P70441
    Secondary accession number(s): Q8BYD8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 2, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 132 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3