ID   DLX4_MOUSE              Reviewed;         240 AA.
AC   P70436; Q3UM51; Q8R4I3;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 2.
DT   27-MAR-2024, entry version 175.
DE   RecName: Full=Homeobox protein DLX-4;
DE   AltName: Full=Homeobox protein DLX-7;
GN   Name=Dlx4; Synonyms=Dlx7;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Swiss Webster; TISSUE=Mandible;
RX   PubMed=8975708; DOI=10.1006/geno.1996.0634;
RA   Nakamura S., Stock D.W., Wydner K.L., Bollekens J.A., Takeshita K.,
RA   Nagai B.M., Chiba S., Kitamura T., Freeland T.M., Zhao Z., Minowada J.,
RA   Lawrence J.B., Weiss K.M., Ruddle F.H.;
RT   "Genomic analysis of a new mammalian distal-less gene: Dlx7.";
RL   Genomics 38:314-324(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=129/Ola;
RX   PubMed=11792834; DOI=10.1073/pnas.012584999;
RA   Sumiyama K., Irvine S.Q., Stock D.W., Weiss K.M., Kawasaki K., Shimizu N.,
RA   Shashikant C.S., Miller W., Ruddle F.H.;
RT   "Genomic structure and functional control of the Dlx3-7 bigene cluster.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:780-785(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Mammary gland;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   DEVELOPMENTAL STAGE.
RX   PubMed=25954033; DOI=10.1093/hmg/ddv167;
RA   Wu D., Mandal S., Choi A., Anderson A., Prochazkova M., Perry H.,
RA   Gil-Da-Silva-Lopes V.L., Lao R., Wan E., Tang P.L., Kwok P.Y., Klein O.,
RA   Zhuan B., Slavotinek A.M.;
RT   "DLX4 is associated with orofacial clefting and abnormal jaw development.";
RL   Hum. Mol. Genet. 24:4340-4352(2015).
CC   -!- FUNCTION: May play a role in determining the production of hemoglobin
CC       S. May act as a repressor. During embryonic development, plays a role
CC       in palatogenesis. {ECO:0000250|UniProtKB:Q92988}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q92988}.
CC   -!- TISSUE SPECIFICITY: Branchial arches, molar and incisor teeth and
CC       limbs.
CC   -!- DEVELOPMENTAL STAGE: Expressed in the mesenchyme of the anterior palate
CC       at 12.5 dpc, prior to the time of palate closure. Expression levels
CC       decrease at later time periods after palate closure.
CC       {ECO:0000269|PubMed:25954033}.
CC   -!- SIMILARITY: Belongs to the distal-less homeobox family. {ECO:0000305}.
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DR   EMBL; U73329; AAC52995.1; -; mRNA.
DR   EMBL; AF452637; AAL99501.1; -; Genomic_DNA.
DR   EMBL; AK145123; BAE26247.1; -; mRNA.
DR   EMBL; AL645850; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC106967; AAI06968.1; -; mRNA.
DR   CCDS; CCDS25273.1; -.
DR   RefSeq; NP_031893.3; NM_007867.4.
DR   AlphaFoldDB; P70436; -.
DR   SMR; P70436; -.
DR   BioGRID; 199237; 2.
DR   IntAct; P70436; 3.
DR   STRING; 10090.ENSMUSP00000021241; -.
DR   PaxDb; 10090-ENSMUSP00000021241; -.
DR   PeptideAtlas; P70436; -.
DR   Antibodypedia; 17993; 482 antibodies from 32 providers.
DR   DNASU; 13394; -.
DR   Ensembl; ENSMUST00000021241.8; ENSMUSP00000021241.7; ENSMUSG00000020871.9.
DR   GeneID; 13394; -.
DR   KEGG; mmu:13394; -.
DR   UCSC; uc007kzz.2; mouse.
DR   AGR; MGI:94904; -.
DR   CTD; 1748; -.
DR   MGI; MGI:94904; Dlx4.
DR   VEuPathDB; HostDB:ENSMUSG00000020871; -.
DR   eggNOG; KOG0850; Eukaryota.
DR   GeneTree; ENSGT00940000162259; -.
DR   HOGENOM; CLU_074733_2_1_1; -.
DR   InParanoid; P70436; -.
DR   OMA; LALPQMM; -.
DR   OrthoDB; 2969529at2759; -.
DR   PhylomeDB; P70436; -.
DR   TreeFam; TF315720; -.
DR   BioGRID-ORCS; 13394; 0 hits in 77 CRISPR screens.
DR   PRO; PR:P70436; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   RNAct; P70436; Protein.
DR   Bgee; ENSMUSG00000020871; Expressed in hair follicle and 39 other cell types or tissues.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; ISO:MGI.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:MGI.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISO:MGI.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:MGI.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR000047; HTH_motif.
DR   PANTHER; PTHR24327; HOMEOBOX PROTEIN; 1.
DR   PANTHER; PTHR24327:SF21; HOMEOBOX PROTEIN DLX-4; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   Genevisible; P70436; MM.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..240
FT                   /note="Homeobox protein DLX-4"
FT                   /id="PRO_0000049029"
FT   DNA_BIND        116..175
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          44..70
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          175..194
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        132
FT                   /note="N -> D (in Ref. 1; AAC52995)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        194
FT                   /note="S -> F (in Ref. 3; BAE26247)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   240 AA;  26579 MW;  ECDC4D943E22364C CRC64;
     MTSLPCPLPD RGASNVVFPD LAPALSVVAA YPLGLSPGTA ASPDLSYSQS YGHPRSYSHP
     GPATPGDSYL PRQQQLVAPS QPFHRPAEHP QELEAESEKL ALSLVPSQQQ SLTRKLRKPR
     TIYSSLQLQH LNQRFQHTQY LALPERAQLA AQLGLTQTQV KIWFQNKRSK YKKLLKQSSG
     EPEEDFSGRP PSLSPHSPAL PFIWGLPKAD TLPSSGYDNS HFGAWYQHRS PDVLALPQMM
//