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P70436

- DLX4_MOUSE

UniProt

P70436 - DLX4_MOUSE

Protein

Homeobox protein DLX-4

Gene

Dlx4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 2 (24 Jan 2006)
      Previous versions | rss
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    Functioni

    May play a role in determining the production of hemoglobin S. May act as a repressor.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi116 – 17560HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding transcription factor activity Source: InterPro
    2. transcription regulatory region sequence-specific DNA binding Source: InterPro

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein DLX-4
    Alternative name(s):
    Homeobox protein DLX-7
    Gene namesi
    Name:Dlx4
    Synonyms:Dlx7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:94904. Dlx4.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 240240Homeobox protein DLX-4PRO_0000049029Add
    BLAST

    Proteomic databases

    PRIDEiP70436.

    Expressioni

    Tissue specificityi

    Branchial arches, molar and incisor teeth and limbs.

    Gene expression databases

    BgeeiP70436.
    CleanExiMM_DLX4.
    GenevestigatoriP70436.

    Interactioni

    Protein-protein interaction databases

    BioGridi199237. 2 interactions.
    IntActiP70436. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP70436.
    SMRiP70436. Positions 117-173.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the distal-less homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG240888.
    GeneTreeiENSGT00720000108450.
    HOGENOMiHOG000231941.
    HOVERGENiHBG005493.
    InParanoidiP70436.
    KOiK09314.
    OMAiYSGPYGH.
    OrthoDBiEOG7ZKSC1.
    PhylomeDBiP70436.
    TreeFamiTF315720.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR000047. HTH_motif.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    PR00031. HTHREPRESSR.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P70436-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSLPCPLPD RGASNVVFPD LAPALSVVAA YPLGLSPGTA ASPDLSYSQS    50
    YGHPRSYSHP GPATPGDSYL PRQQQLVAPS QPFHRPAEHP QELEAESEKL 100
    ALSLVPSQQQ SLTRKLRKPR TIYSSLQLQH LNQRFQHTQY LALPERAQLA 150
    AQLGLTQTQV KIWFQNKRSK YKKLLKQSSG EPEEDFSGRP PSLSPHSPAL 200
    PFIWGLPKAD TLPSSGYDNS HFGAWYQHRS PDVLALPQMM 240
    Length:240
    Mass (Da):26,579
    Last modified:January 24, 2006 - v2
    Checksum:iECDC4D943E22364C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti132 – 1321N → D in AAC52995. (PubMed:8975708)Curated
    Sequence conflicti194 – 1941S → F in BAE26247. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U73329 mRNA. Translation: AAC52995.1.
    AF452637 Genomic DNA. Translation: AAL99501.1.
    AK145123 mRNA. Translation: BAE26247.1.
    AL645850 Genomic DNA. Translation: CAI24123.1.
    BC106967 mRNA. Translation: AAI06968.1.
    CCDSiCCDS25273.1.
    RefSeqiNP_031893.3. NM_007867.4.
    UniGeneiMm.439766.

    Genome annotation databases

    EnsembliENSMUST00000021241; ENSMUSP00000021241; ENSMUSG00000020871.
    GeneIDi13394.
    KEGGimmu:13394.
    UCSCiuc007kzz.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U73329 mRNA. Translation: AAC52995.1 .
    AF452637 Genomic DNA. Translation: AAL99501.1 .
    AK145123 mRNA. Translation: BAE26247.1 .
    AL645850 Genomic DNA. Translation: CAI24123.1 .
    BC106967 mRNA. Translation: AAI06968.1 .
    CCDSi CCDS25273.1.
    RefSeqi NP_031893.3. NM_007867.4.
    UniGenei Mm.439766.

    3D structure databases

    ProteinModelPortali P70436.
    SMRi P70436. Positions 117-173.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199237. 2 interactions.
    IntActi P70436. 1 interaction.

    Proteomic databases

    PRIDEi P70436.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021241 ; ENSMUSP00000021241 ; ENSMUSG00000020871 .
    GeneIDi 13394.
    KEGGi mmu:13394.
    UCSCi uc007kzz.2. mouse.

    Organism-specific databases

    CTDi 1748.
    MGIi MGI:94904. Dlx4.

    Phylogenomic databases

    eggNOGi NOG240888.
    GeneTreei ENSGT00720000108450.
    HOGENOMi HOG000231941.
    HOVERGENi HBG005493.
    InParanoidi P70436.
    KOi K09314.
    OMAi YSGPYGH.
    OrthoDBi EOG7ZKSC1.
    PhylomeDBi P70436.
    TreeFami TF315720.

    Miscellaneous databases

    NextBioi 283768.
    PROi P70436.
    SOURCEi Search...

    Gene expression databases

    Bgeei P70436.
    CleanExi MM_DLX4.
    Genevestigatori P70436.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR000047. HTH_motif.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    PR00031. HTHREPRESSR.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Swiss Webster.
      Tissue: Mandible.
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Ola.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary gland.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiDLX4_MOUSE
    AccessioniPrimary (citable) accession number: P70436
    Secondary accession number(s): Q3UM51, Q8R4I3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 115 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3