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Protein

Homeobox protein DLX-4

Gene

Dlx4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in determining the production of hemoglobin S. May act as a repressor.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi116 – 17560HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein DLX-4
Alternative name(s):
Homeobox protein DLX-7
Gene namesi
Name:Dlx4
Synonyms:Dlx7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:94904. Dlx4.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 240240Homeobox protein DLX-4PRO_0000049029Add
BLAST

Proteomic databases

PRIDEiP70436.

Expressioni

Tissue specificityi

Branchial arches, molar and incisor teeth and limbs.

Gene expression databases

BgeeiP70436.
CleanExiMM_DLX4.
GenevisibleiP70436. MM.

Interactioni

Protein-protein interaction databases

BioGridi199237. 2 interactions.
IntActiP70436. 1 interaction.
STRINGi10090.ENSMUSP00000021241.

Structurei

3D structure databases

ProteinModelPortaliP70436.
SMRiP70436. Positions 117-173.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the distal-less homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG240888.
GeneTreeiENSGT00800000124040.
HOGENOMiHOG000231941.
HOVERGENiHBG005493.
InParanoidiP70436.
KOiK09314.
OMAiYSGPYGH.
OrthoDBiEOG7ZKSC1.
PhylomeDBiP70436.
TreeFamiTF315720.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70436-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSLPCPLPD RGASNVVFPD LAPALSVVAA YPLGLSPGTA ASPDLSYSQS
60 70 80 90 100
YGHPRSYSHP GPATPGDSYL PRQQQLVAPS QPFHRPAEHP QELEAESEKL
110 120 130 140 150
ALSLVPSQQQ SLTRKLRKPR TIYSSLQLQH LNQRFQHTQY LALPERAQLA
160 170 180 190 200
AQLGLTQTQV KIWFQNKRSK YKKLLKQSSG EPEEDFSGRP PSLSPHSPAL
210 220 230 240
PFIWGLPKAD TLPSSGYDNS HFGAWYQHRS PDVLALPQMM
Length:240
Mass (Da):26,579
Last modified:January 24, 2006 - v2
Checksum:iECDC4D943E22364C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti132 – 1321N → D in AAC52995 (PubMed:8975708).Curated
Sequence conflicti194 – 1941S → F in BAE26247 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73329 mRNA. Translation: AAC52995.1.
AF452637 Genomic DNA. Translation: AAL99501.1.
AK145123 mRNA. Translation: BAE26247.1.
AL645850 Genomic DNA. Translation: CAI24123.1.
BC106967 mRNA. Translation: AAI06968.1.
CCDSiCCDS25273.1.
RefSeqiNP_031893.3. NM_007867.4.
UniGeneiMm.439766.

Genome annotation databases

EnsembliENSMUST00000021241; ENSMUSP00000021241; ENSMUSG00000020871.
GeneIDi13394.
KEGGimmu:13394.
UCSCiuc007kzz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73329 mRNA. Translation: AAC52995.1.
AF452637 Genomic DNA. Translation: AAL99501.1.
AK145123 mRNA. Translation: BAE26247.1.
AL645850 Genomic DNA. Translation: CAI24123.1.
BC106967 mRNA. Translation: AAI06968.1.
CCDSiCCDS25273.1.
RefSeqiNP_031893.3. NM_007867.4.
UniGeneiMm.439766.

3D structure databases

ProteinModelPortaliP70436.
SMRiP70436. Positions 117-173.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199237. 2 interactions.
IntActiP70436. 1 interaction.
STRINGi10090.ENSMUSP00000021241.

Proteomic databases

PRIDEiP70436.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021241; ENSMUSP00000021241; ENSMUSG00000020871.
GeneIDi13394.
KEGGimmu:13394.
UCSCiuc007kzz.2. mouse.

Organism-specific databases

CTDi1748.
MGIiMGI:94904. Dlx4.

Phylogenomic databases

eggNOGiNOG240888.
GeneTreeiENSGT00800000124040.
HOGENOMiHOG000231941.
HOVERGENiHBG005493.
InParanoidiP70436.
KOiK09314.
OMAiYSGPYGH.
OrthoDBiEOG7ZKSC1.
PhylomeDBiP70436.
TreeFamiTF315720.

Miscellaneous databases

NextBioi283768.
PROiP70436.
SOURCEiSearch...

Gene expression databases

BgeeiP70436.
CleanExiMM_DLX4.
GenevisibleiP70436. MM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Swiss Webster.
    Tissue: Mandible.
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Ola.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiDLX4_MOUSE
AccessioniPrimary (citable) accession number: P70436
Secondary accession number(s): Q3UM51, Q8R4I3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 24, 2006
Last modified: July 22, 2015
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.