##gff-version 3 P70424 UniProtKB Signal peptide 1 22 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 P70424 UniProtKB Chain 23 1256 . . . ID=PRO_0000042181;Note=Receptor tyrosine-protein kinase erbB-2 P70424 UniProtKB Topological domain 23 653 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 P70424 UniProtKB Transmembrane 654 674 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P70424 UniProtKB Topological domain 675 1256 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P70424 UniProtKB Domain 721 988 . . . Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 P70424 UniProtKB Region 677 690 . . . Note=Required for interaction with KPNB1 and EEA1;Ontology_term=ECO:0000250;evidence=ECO:0000250 P70424 UniProtKB Region 1030 1180 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P70424 UniProtKB Region 1196 1198 . . . Note=Interaction with PIK3C2B;Ontology_term=ECO:0000250;evidence=ECO:0000250 P70424 UniProtKB Region 1200 1219 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P70424 UniProtKB Region 1224 1256 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P70424 UniProtKB Motif 677 690 . . . Note=Nuclear localization signal;Ontology_term=ECO:0000250;evidence=ECO:0000250 P70424 UniProtKB Compositional bias 1150 1165 . . . Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P70424 UniProtKB Compositional bias 1224 1243 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P70424 UniProtKB Active site 846 846 . . . Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10028 P70424 UniProtKB Binding site 727 735 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 P70424 UniProtKB Binding site 754 754 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 P70424 UniProtKB Modified residue 878 878 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04626 P70424 UniProtKB Modified residue 1055 1055 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04626 P70424 UniProtKB Modified residue 1079 1079 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P06494 P70424 UniProtKB Modified residue 1084 1084 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04626 P70424 UniProtKB Modified residue 1108 1108 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04626 P70424 UniProtKB Modified residue 1113 1113 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04626 P70424 UniProtKB Modified residue 1140 1140 . . . Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04626 P70424 UniProtKB Modified residue 1167 1167 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04626 P70424 UniProtKB Modified residue 1197 1197 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04626 P70424 UniProtKB Modified residue 1249 1249 . . . Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04626 P70424 UniProtKB Glycosylation 68 68 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P70424 UniProtKB Glycosylation 125 125 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P70424 UniProtKB Glycosylation 188 188 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P70424 UniProtKB Glycosylation 260 260 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P70424 UniProtKB Glycosylation 531 531 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P70424 UniProtKB Glycosylation 572 572 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P70424 UniProtKB Glycosylation 630 630 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P70424 UniProtKB Disulfide bond 26 53 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04626 P70424 UniProtKB Disulfide bond 163 193 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04626 P70424 UniProtKB Disulfide bond 196 205 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04626 P70424 UniProtKB Disulfide bond 200 213 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04626 P70424 UniProtKB Disulfide bond 221 228 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04626 P70424 UniProtKB Disulfide bond 225 236 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04626 P70424 UniProtKB Disulfide bond 237 245 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04626 P70424 UniProtKB Disulfide bond 241 253 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04626 P70424 UniProtKB Disulfide bond 256 265 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04626 P70424 UniProtKB Disulfide bond 269 296 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04626 P70424 UniProtKB Disulfide bond 300 312 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04626 P70424 UniProtKB Disulfide bond 316 332 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04626 P70424 UniProtKB Disulfide bond 335 339 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04626 P70424 UniProtKB Disulfide bond 343 368 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04626 P70424 UniProtKB Disulfide bond 476 505 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04626 P70424 UniProtKB Disulfide bond 512 521 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04626 P70424 UniProtKB Disulfide bond 516 529 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04626 P70424 UniProtKB Disulfide bond 532 541 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04626 P70424 UniProtKB Disulfide bond 545 561 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04626 P70424 UniProtKB Disulfide bond 564 577 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04626 P70424 UniProtKB Disulfide bond 568 585 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04626 P70424 UniProtKB Disulfide bond 588 597 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04626 P70424 UniProtKB Disulfide bond 601 624 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04626 P70424 UniProtKB Disulfide bond 627 635 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04626 P70424 UniProtKB Disulfide bond 631 643 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P04626