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P70424

- ERBB2_MOUSE

UniProt

P70424 - ERBB2_MOUSE

Protein

Receptor tyrosine-protein kinase erbB-2

Gene

Erbb2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 156 (01 Oct 2014)
      Sequence version 3 (27 Sep 2005)
      Previous versions | rss
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    Functioni

    Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization By similarity.By similarity
    In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth By similarity.By similarity

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei754 – 7541ATPPROSITE-ProRule annotation
    Active sitei846 – 8461Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi727 – 7359ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein binding Source: UniProtKB
    3. receptor signaling protein tyrosine kinase activity Source: InterPro
    4. RNA polymerase I core binding Source: UniProtKB
    5. transmembrane receptor protein tyrosine kinase activity Source: BHF-UCL

    GO - Biological processi

    1. heart development Source: MGI
    2. motor neuron axon guidance Source: MGI
    3. myelination Source: MGI
    4. negative regulation of immature T cell proliferation in thymus Source: MGI
    5. nervous system development Source: MGI
    6. neuromuscular junction development Source: MGI
    7. oligodendrocyte differentiation Source: MGI
    8. peripheral nervous system development Source: MGI
    9. phosphatidylinositol 3-kinase signaling Source: Ensembl
    10. positive regulation of cell adhesion Source: Ensembl
    11. positive regulation of cell growth Source: UniProtKB
    12. positive regulation of epithelial cell proliferation Source: Ensembl
    13. positive regulation of MAP kinase activity Source: Ensembl
    14. positive regulation of protein phosphorylation Source: BHF-UCL
    15. positive regulation of Rho GTPase activity Source: BHF-UCL
    16. positive regulation of transcription from RNA polymerase III promoter Source: UniProtKB
    17. positive regulation of transcription from RNA polymerase I promoter Source: UniProtKB
    18. positive regulation of translation Source: UniProtKB
    19. protein autophosphorylation Source: Ensembl
    20. regulation of ERK1 and ERK2 cascade Source: UniProtKB
    21. regulation of microtubule-based process Source: UniProtKB
    22. transcription, DNA-templated Source: UniProtKB-KW
    23. transmembrane receptor protein tyrosine kinase signaling pathway Source: BHF-UCL
    24. wound healing Source: Ensembl

    Keywords - Molecular functioni

    Activator, Kinase, Receptor, Transferase, Tyrosine-protein kinase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_188190. PLCG1 events in ERBB2 signaling.
    REACT_188191. Signaling by ERBB2.
    REACT_188528. GRB2 events in ERBB2 signaling.
    REACT_188574. SHC1 events in ERBB2 signaling.
    REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_199058. GRB7 events in ERBB2 signaling.
    REACT_199061. Downregulation of ERBB2:ERBB3 signaling.
    REACT_215348. PI3K events in ERBB2 signaling.
    REACT_226341. PIP3 activates AKT signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Receptor tyrosine-protein kinase erbB-2 (EC:2.7.10.1)
    Alternative name(s):
    Proto-oncogene Neu
    Proto-oncogene c-ErbB-2
    p185erbB2
    CD_antigen: CD340
    Gene namesi
    Name:Erbb2
    Synonyms:Kiaa3023, Neu
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:95410. Erbb2.

    Subcellular locationi

    Cell membrane By similarity; Single-pass type I membrane protein By similarity. Cytoplasmperinuclear region By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. apical plasma membrane Source: MGI
    2. basolateral plasma membrane Source: Ensembl
    3. cytoplasm Source: MGI
    4. cytoplasmic vesicle Source: MGI
    5. endosome membrane Source: Ensembl
    6. integral component of membrane Source: UniProtKB
    7. nucleus Source: UniProtKB-SubCell
    8. perinuclear region of cytoplasm Source: UniProtKB-SubCell
    9. plasma membrane Source: MGI
    10. receptor complex Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 12561234Receptor tyrosine-protein kinase erbB-2PRO_0000042181Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi26 ↔ 53By similarity
    Glycosylationi68 – 681N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi125 – 1251N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi163 ↔ 193By similarity
    Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi196 ↔ 205By similarity
    Disulfide bondi200 ↔ 213By similarity
    Disulfide bondi221 ↔ 228By similarity
    Disulfide bondi225 ↔ 236By similarity
    Disulfide bondi237 ↔ 245By similarity
    Disulfide bondi241 ↔ 253By similarity
    Disulfide bondi256 ↔ 265By similarity
    Glycosylationi260 – 2601N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi269 ↔ 296By similarity
    Disulfide bondi300 ↔ 312By similarity
    Disulfide bondi316 ↔ 332By similarity
    Disulfide bondi335 ↔ 339By similarity
    Disulfide bondi343 ↔ 368By similarity
    Disulfide bondi476 ↔ 505By similarity
    Disulfide bondi512 ↔ 521By similarity
    Disulfide bondi516 ↔ 529By similarity
    Glycosylationi531 – 5311N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi532 ↔ 541By similarity
    Disulfide bondi545 ↔ 561By similarity
    Disulfide bondi564 ↔ 577By similarity
    Disulfide bondi568 ↔ 585By similarity
    Glycosylationi572 – 5721N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi588 ↔ 597By similarity
    Disulfide bondi601 ↔ 624By similarity
    Disulfide bondi627 ↔ 635By similarity
    Glycosylationi630 – 6301N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi631 ↔ 643By similarity
    Modified residuei1055 – 10551PhosphoserineBy similarity
    Modified residuei1108 – 11081PhosphoserineBy similarity
    Modified residuei1140 – 11401Phosphotyrosine; by autocatalysisBy similarity
    Modified residuei1197 – 11971PhosphotyrosineSequence Analysis
    Modified residuei1249 – 12491Phosphotyrosine; by autocatalysisBy similarity

    Post-translational modificationi

    Autophosphorylated. Ligand-binding increases phosphorylation on tyrosine residues. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Signaling via SEMA4C promotes phosphorylation at Tyr-1249 By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiP70424.
    PRIDEiP70424.

    PTM databases

    PhosphoSiteiP70424.

    Expressioni

    Tissue specificityi

    Expressed predominantly in uterine epithelial cells. In the muscle, expression localizes to the synaptic sites of muscle fibers.

    Developmental stagei

    On days 1-4 of pregnancy, ERBB2 is detected primarily in epithelial cells, the day 1 uterus showing the highest accumulation. On day 5, the epithelium and the decidualizing stromal cells around the implanting blastocyst exhibit accumulation of this receptor. On days 6-8, the expression persists in the epithelium at both the implantation and interimplantation sites in addition to modest levels in the secondary decidual zone. On days 7 and 8, accumulation is also prominent in the trophoblastic giant cells.

    Gene expression databases

    ArrayExpressiP70424.
    BgeeiP70424.
    GenevestigatoriP70424.

    Interactioni

    Subunit structurei

    Homodimer. Heterodimer with EGFR, ERBB3 and ERBB4. Part of a complex with EGFR and either PIK3C2A or PIK3C2B. May interact with PIK3C2B when phosphorylated on Tyr-1197. Interacts with PRKCABP and PLXNB1. Interacts (when phosphorylated on Tyr-1249) with MEMO1. Interacts with MUC1. Interacts (when phosphorylated on Tyr-1140) with GRB7 (via SH2 domain). Interacts (when phosphorylated on Tyr-1249) with ERBB2IP. Interacts with KPNB1, RANBP2, EEA1, CRM1, CLTC, PTK6, RPA94 and ACTB By similarity. Interacts with SRC and MYOC.By similarity3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Erbb3Q615262EBI-2945468,EBI-931878
    Stat3P422274EBI-2945468,EBI-602878

    Protein-protein interaction databases

    BioGridi199496. 7 interactions.
    IntActiP70424. 4 interactions.
    MINTiMINT-138121.

    Structurei

    3D structure databases

    ProteinModelPortaliP70424.
    SMRiP70424. Positions 23-630, 678-1026.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini23 – 653631ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini675 – 1256582CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei654 – 67421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini721 – 988268Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni677 – 69014Nuclear localization signalBy similarityAdd
    BLAST
    Regioni677 – 69014Required for interaction with KPNB1 and EEA1By similarityAdd
    BLAST
    Regioni1196 – 11983Interaction with PIK3C2BBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi193 – 26977Cys-richAdd
    BLAST
    Compositional biasi1117 – 116347Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00600000084253.
    HOGENOMiHOG000230982.
    HOVERGENiHBG000490.
    InParanoidiP70424.
    KOiK05083.
    OMAiACYPLCA.
    OrthoDBiEOG7V49XM.
    PhylomeDBiP70424.
    TreeFamiTF106002.

    Family and domain databases

    Gene3Di3.80.20.20. 2 hits.
    InterProiIPR000494. EGF_rcpt_L.
    IPR006211. Furin-like_Cys-rich_dom.
    IPR006212. Furin_repeat.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR016245. Tyr_kinase_EGF/ERB/XmrK_rcpt.
    [Graphical view]
    PfamiPF00757. Furin-like. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    PF01030. Recep_L_domain. 2 hits.
    [Graphical view]
    PIRSFiPIRSF000619. TyrPK_EGF-R. 1 hit.
    PRINTSiPR00109. TYRKINASE.
    SMARTiSM00261. FU. 4 hits.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    SSF57184. SSF57184. 2 hits.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P70424-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELAAWCRWG FLLALLSPGA AGTQVCTGTD MKLRLPASPE THLDMLRHLY     50
    QGCQVVQGNL ELTYLPANAS LSFLQDIQEV QGYMLIAHNR VKHVPLQRLR 100
    IVRGTQLFED KYALAVLDNR DPLDNVTTAA PGRTPEGLRE LQLRSLTEIL 150
    KGGVLIRGNP QLCYQDMVLW KDVLRKNNQL APVDMDTNRS RACPPCAPTC 200
    KDNHCWGESP EDCQILTGTI CTSGCARCKG RLPTDCCHEQ CAAGCTGPKH 250
    SDCLACLHFN HSGICELHCP ALITYNTDTF ESMLNPEGRY TFGASCVTTC 300
    PYNYLSTEVG SCTLVCPPNN QEVTAEDGTQ RCEKCSKPCA GVCYGLGMEH 350
    LRGARAITSD NIQEFAGCKK IFGSLAFLPE SFDGNPSSGV APLKPEHLQV 400
    FETLEEITGY LYISAWPESF QDLSVFQNLR VIRGRILHDG AYSLTLQGLG 450
    IHSLGLRSLR ELGSGLALIH RNTHLCFVNT VPWDQLFRNP HQALLHSGNR 500
    PEEACGLEGL VCNSLCARGH CWGPGPTQCV NCSQFLRGQE CVEECRVWKG 550
    LPREYVRGKH CLPCHPECQP QNSSETCYGS EADQCEACAH YKDSSSCVAR 600
    CPSGVKPDLS YMPIWKYPDE EGICQPCPIN CTHSCVDLDE RGCPAEQRAS 650
    PVTFIIATVV GVLLFLIIVV VIGILIKRRR QKIRKYTMRR LLQETELVEP 700
    LTPSGAVPNQ AQMRILKETE LRKLKVLGSG AFGTVYKGIW IPDGENVKIP 750
    VAIKVLRENT SPKANKEILD EAYVMAGVGS PYVSRLLGIC LTSTVQLVTQ 800
    LMPYGCLLDH VREHRGRLGS QDLLNWCVQI AKGMSYLEEV RLVHRDLAAR 850
    NVLVKSPNHV KITDFGLARL LDIDETEYHA DGGKVPIKWM ALESILRRRF 900
    THQSDVWSYG VTVWELMTFG AKPYDGIPAR EIPDLLEKGE RLPQPPICTI 950
    DVYMIMVKCW MIDSECRPRF RELVSEFSRM ARDPQRFVVI QNEDLGPSSP 1000
    MDSTFYRSLL EDDDMGELVD AEEYLVPQQG FFSPDPALGT GSTAHRRHRS 1050
    SSARSGGGEL TLGLEPSEEE PPRSPLAPSE GAGSDVFDGD LAVGVTKGLQ 1100
    SLSPHDLSPL QRYSEDPTLP LPPETDGYVA PLACSPQPEY VNQPEVRPQS 1150
    PLTPEGPPPP IRPAGATLER PKTLSPGKNG VVKDVFAFGG AVENPEYLAP 1200
    RAGTASQPHP SPAFSPAFDN LYYWDQNSSE QGPPPSTFEG TPTAENPEYL 1250
    GLDVPV 1256
    Length:1,256
    Mass (Da):138,579
    Last modified:September 27, 2005 - v3
    Checksum:i6040978428B93A28
    GO

    Sequence cautioni

    The sequence BAC98297.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK129487 mRNA. Translation: BAC98297.1. Different initiation.
    U71126 mRNA. Translation: AAB17380.1.
    L47239 mRNA. Translation: AAA93532.1.
    CCDSiCCDS25349.1.
    RefSeqiNP_001003817.1. NM_001003817.1.
    UniGeneiMm.290822.

    Genome annotation databases

    EnsembliENSMUST00000058295; ENSMUSP00000053897; ENSMUSG00000062312.
    GeneIDi13866.
    KEGGimmu:13866.
    UCSCiuc007lgi.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK129487 mRNA. Translation: BAC98297.1 . Different initiation.
    U71126 mRNA. Translation: AAB17380.1 .
    L47239 mRNA. Translation: AAA93532.1 .
    CCDSi CCDS25349.1.
    RefSeqi NP_001003817.1. NM_001003817.1.
    UniGenei Mm.290822.

    3D structure databases

    ProteinModelPortali P70424.
    SMRi P70424. Positions 23-630, 678-1026.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199496. 7 interactions.
    IntActi P70424. 4 interactions.
    MINTi MINT-138121.

    Chemistry

    ChEMBLi CHEMBL2311234.

    PTM databases

    PhosphoSitei P70424.

    Proteomic databases

    PaxDbi P70424.
    PRIDEi P70424.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000058295 ; ENSMUSP00000053897 ; ENSMUSG00000062312 .
    GeneIDi 13866.
    KEGGi mmu:13866.
    UCSCi uc007lgi.1. mouse.

    Organism-specific databases

    CTDi 2064.
    MGIi MGI:95410. Erbb2.
    Rougei Search...

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00600000084253.
    HOGENOMi HOG000230982.
    HOVERGENi HBG000490.
    InParanoidi P70424.
    KOi K05083.
    OMAi ACYPLCA.
    OrthoDBi EOG7V49XM.
    PhylomeDBi P70424.
    TreeFami TF106002.

    Enzyme and pathway databases

    Reactomei REACT_188190. PLCG1 events in ERBB2 signaling.
    REACT_188191. Signaling by ERBB2.
    REACT_188528. GRB2 events in ERBB2 signaling.
    REACT_188574. SHC1 events in ERBB2 signaling.
    REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_199058. GRB7 events in ERBB2 signaling.
    REACT_199061. Downregulation of ERBB2:ERBB3 signaling.
    REACT_215348. PI3K events in ERBB2 signaling.
    REACT_226341. PIP3 activates AKT signaling.

    Miscellaneous databases

    NextBioi 284764.
    PROi P70424.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P70424.
    Bgeei P70424.
    Genevestigatori P70424.

    Family and domain databases

    Gene3Di 3.80.20.20. 2 hits.
    InterProi IPR000494. EGF_rcpt_L.
    IPR006211. Furin-like_Cys-rich_dom.
    IPR006212. Furin_repeat.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR016245. Tyr_kinase_EGF/ERB/XmrK_rcpt.
    [Graphical view ]
    Pfami PF00757. Furin-like. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    PF01030. Recep_L_domain. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF000619. TyrPK_EGF-R. 1 hit.
    PRINTSi PR00109. TYRKINASE.
    SMARTi SM00261. FU. 4 hits.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    SSF57184. SSF57184. 2 hits.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
      DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryonic tail.
    2. "Differential expression of the erbB2 gene in the periimplantation mouse uterus: potential mediator of signaling by epidermal growth factor-like growth factors."
      Lim J., Dey S.K., Das S.K.
      Endocrinology 138:1328-1337(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 786-934.
      Strain: CD-1.
      Tissue: Uterus.
    3. "Synapse-associated expression of an acetylcholine receptor-inducing protein, ARIA/heregulin, and its putative receptors, ErbB2 and ErbB3, in developing mammalian muscle."
      Moscoso L.M., Chu G.C., Gautam M., Noakes P.G., Merlie J.P., Sanes J.R.
      Dev. Biol. 172:158-169(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1012-1107.
    4. "Direct and specific interaction of c-Src with Neu is involved in signaling by the epidermal growth factor receptor."
      Muthuswamy S.K., Muller W.J.
      Oncogene 11:271-279(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH SRC.
    5. "The ERBB2/HER2 receptor differentially interacts with ERBIN and PICK1 PSD-95/DLG/ZO-1 domain proteins."
      Jaulin-Bastard F., Saito H., Le Bivic A., Ollendorff V., Marchetto S., Birnbaum D., Borg J.-P.
      J. Biol. Chem. 276:15256-15263(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PRKCABP.
    6. "Myocilin mediates myelination in the peripheral nervous system through ErbB2/3 signaling."
      Kwon H.S., Johnson T.V., Joe M.K., Abu-Asab M., Zhang J., Chan C.C., Tomarev S.I.
      J. Biol. Chem. 288:26357-26371(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MYOC.

    Entry informationi

    Entry nameiERBB2_MOUSE
    AccessioniPrimary (citable) accession number: P70424
    Secondary accession number(s): Q61525, Q6ZPE0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: September 27, 2005
    Last modified: October 1, 2014
    This is version 156 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3