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P70424

- ERBB2_MOUSE

UniProt

P70424 - ERBB2_MOUSE

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Protein

Receptor tyrosine-protein kinase erbB-2

Gene
Erbb2, Kiaa3023, Neu
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization By similarity.1 Publication
In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth By similarity.1 Publication

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei754 – 7541ATP By similarity
Active sitei846 – 8461Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi727 – 7359ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein binding Source: UniProtKB
  3. receptor signaling protein tyrosine kinase activity Source: InterPro
  4. RNA polymerase I core binding Source: UniProtKB
  5. transmembrane receptor protein tyrosine kinase activity Source: BHF-UCL

GO - Biological processi

  1. heart development Source: MGI
  2. motor neuron axon guidance Source: MGI
  3. myelination Source: MGI
  4. negative regulation of immature T cell proliferation in thymus Source: MGI
  5. nervous system development Source: MGI
  6. neuromuscular junction development Source: MGI
  7. oligodendrocyte differentiation Source: MGI
  8. peripheral nervous system development Source: MGI
  9. phosphatidylinositol 3-kinase signaling Source: Ensembl
  10. positive regulation of cell adhesion Source: Ensembl
  11. positive regulation of cell growth Source: UniProtKB
  12. positive regulation of epithelial cell proliferation Source: Ensembl
  13. positive regulation of MAP kinase activity Source: Ensembl
  14. positive regulation of protein phosphorylation Source: BHF-UCL
  15. positive regulation of Rho GTPase activity Source: BHF-UCL
  16. positive regulation of transcription from RNA polymerase III promoter Source: UniProtKB
  17. positive regulation of transcription from RNA polymerase I promoter Source: UniProtKB
  18. positive regulation of translation Source: UniProtKB
  19. protein autophosphorylation Source: Ensembl
  20. regulation of ERK1 and ERK2 cascade Source: UniProtKB
  21. regulation of microtubule-based process Source: UniProtKB
  22. transcription, DNA-templated Source: UniProtKB-KW
  23. transmembrane receptor protein tyrosine kinase signaling pathway Source: BHF-UCL
  24. wound healing Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Activator, Kinase, Receptor, Transferase, Tyrosine-protein kinase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_188190. PLCG1 events in ERBB2 signaling.
REACT_188191. Signaling by ERBB2.
REACT_188528. GRB2 events in ERBB2 signaling.
REACT_188574. SHC1 events in ERBB2 signaling.
REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
REACT_199058. GRB7 events in ERBB2 signaling.
REACT_199061. Downregulation of ERBB2:ERBB3 signaling.
REACT_215348. PI3K events in ERBB2 signaling.
REACT_226341. PIP3 activates AKT signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor tyrosine-protein kinase erbB-2 (EC:2.7.10.1)
Alternative name(s):
Proto-oncogene Neu
Proto-oncogene c-ErbB-2
p185erbB2
CD_antigen: CD340
Gene namesi
Name:Erbb2
Synonyms:Kiaa3023, Neu
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:95410. Erbb2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 653631Extracellular Reviewed predictionAdd
BLAST
Transmembranei654 – 67421Helical; Reviewed predictionAdd
BLAST
Topological domaini675 – 1256582Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: MGI
  2. basolateral plasma membrane Source: Ensembl
  3. cytoplasm Source: MGI
  4. cytoplasmic vesicle Source: MGI
  5. endosome membrane Source: Ensembl
  6. integral component of membrane Source: UniProtKB
  7. nucleus Source: UniProtKB-SubCell
  8. perinuclear region of cytoplasm Source: UniProtKB-SubCell
  9. plasma membrane Source: MGI
  10. receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed predictionAdd
BLAST
Chaini23 – 12561234Receptor tyrosine-protein kinase erbB-2PRO_0000042181Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi26 ↔ 53 By similarity
Glycosylationi68 – 681N-linked (GlcNAc...) Reviewed prediction
Glycosylationi125 – 1251N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi163 ↔ 193 By similarity
Glycosylationi188 – 1881N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi196 ↔ 205 By similarity
Disulfide bondi200 ↔ 213 By similarity
Disulfide bondi221 ↔ 228 By similarity
Disulfide bondi225 ↔ 236 By similarity
Disulfide bondi237 ↔ 245 By similarity
Disulfide bondi241 ↔ 253 By similarity
Disulfide bondi256 ↔ 265 By similarity
Glycosylationi260 – 2601N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi269 ↔ 296 By similarity
Disulfide bondi300 ↔ 312 By similarity
Disulfide bondi316 ↔ 332 By similarity
Disulfide bondi335 ↔ 339 By similarity
Disulfide bondi343 ↔ 368 By similarity
Disulfide bondi476 ↔ 505 By similarity
Disulfide bondi512 ↔ 521 By similarity
Disulfide bondi516 ↔ 529 By similarity
Glycosylationi531 – 5311N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi532 ↔ 541 By similarity
Disulfide bondi545 ↔ 561 By similarity
Disulfide bondi564 ↔ 577 By similarity
Disulfide bondi568 ↔ 585 By similarity
Glycosylationi572 – 5721N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi588 ↔ 597 By similarity
Disulfide bondi601 ↔ 624 By similarity
Disulfide bondi627 ↔ 635 By similarity
Glycosylationi630 – 6301N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi631 ↔ 643 By similarity
Modified residuei1055 – 10551Phosphoserine By similarity
Modified residuei1108 – 11081Phosphoserine By similarity
Modified residuei1140 – 11401Phosphotyrosine; by autocatalysis By similarity
Modified residuei1197 – 11971Phosphotyrosine Reviewed prediction
Modified residuei1249 – 12491Phosphotyrosine; by autocatalysis By similarity

Post-translational modificationi

Autophosphorylated. Ligand-binding increases phosphorylation on tyrosine residues. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Signaling via SEMA4C promotes phosphorylation at Tyr-1249 By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP70424.
PRIDEiP70424.

PTM databases

PhosphoSiteiP70424.

Expressioni

Tissue specificityi

Expressed predominantly in uterine epithelial cells. In the muscle, expression localizes to the synaptic sites of muscle fibers.

Developmental stagei

On days 1-4 of pregnancy, ERBB2 is detected primarily in epithelial cells, the day 1 uterus showing the highest accumulation. On day 5, the epithelium and the decidualizing stromal cells around the implanting blastocyst exhibit accumulation of this receptor. On days 6-8, the expression persists in the epithelium at both the implantation and interimplantation sites in addition to modest levels in the secondary decidual zone. On days 7 and 8, accumulation is also prominent in the trophoblastic giant cells.

Gene expression databases

ArrayExpressiP70424.
BgeeiP70424.
GenevestigatoriP70424.

Interactioni

Subunit structurei

Homodimer. Heterodimer with EGFR, ERBB3 and ERBB4. Part of a complex with EGFR and either PIK3C2A or PIK3C2B. May interact with PIK3C2B when phosphorylated on Tyr-1197. Interacts with PRKCABP and PLXNB1. Interacts (when phosphorylated on Tyr-1249) with MEMO1. Interacts with MUC1. Interacts (when phosphorylated on Tyr-1140) with GRB7 (via SH2 domain). Interacts (when phosphorylated on Tyr-1249) with ERBB2IP. Interacts with KPNB1, RANBP2, EEA1, CRM1, CLTC, PTK6, RPA94 and ACTB By similarity. Interacts with SRC and MYOC.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Erbb3Q615262EBI-2945468,EBI-931878
Stat3P422274EBI-2945468,EBI-602878

Protein-protein interaction databases

BioGridi199496. 7 interactions.
IntActiP70424. 4 interactions.
MINTiMINT-138121.

Structurei

3D structure databases

ProteinModelPortaliP70424.
SMRiP70424. Positions 23-630, 678-1026.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini721 – 988268Protein kinaseAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni677 – 69014Nuclear localization signal By similarityAdd
BLAST
Regioni677 – 69014Required for interaction with KPNB1 and EEA1 By similarityAdd
BLAST
Regioni1196 – 11983Interaction with PIK3C2B By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi193 – 26977Cys-richAdd
BLAST
Compositional biasi1117 – 116347Pro-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00600000084253.
HOGENOMiHOG000230982.
HOVERGENiHBG000490.
InParanoidiP70424.
KOiK05083.
OMAiACYPLCA.
OrthoDBiEOG7V49XM.
PhylomeDBiP70424.
TreeFamiTF106002.

Family and domain databases

Gene3Di3.80.20.20. 2 hits.
InterProiIPR000494. EGF_rcpt_L.
IPR006211. Furin-like_Cys-rich_dom.
IPR006212. Furin_repeat.
IPR009030. Growth_fac_rcpt_N_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016245. Tyr_kinase_EGF/ERB/XmrK_rcpt.
[Graphical view]
PfamiPF00757. Furin-like. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF01030. Recep_L_domain. 2 hits.
[Graphical view]
PIRSFiPIRSF000619. TyrPK_EGF-R. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00261. FU. 4 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70424-1 [UniParc]FASTAAdd to Basket

« Hide

MELAAWCRWG FLLALLSPGA AGTQVCTGTD MKLRLPASPE THLDMLRHLY     50
QGCQVVQGNL ELTYLPANAS LSFLQDIQEV QGYMLIAHNR VKHVPLQRLR 100
IVRGTQLFED KYALAVLDNR DPLDNVTTAA PGRTPEGLRE LQLRSLTEIL 150
KGGVLIRGNP QLCYQDMVLW KDVLRKNNQL APVDMDTNRS RACPPCAPTC 200
KDNHCWGESP EDCQILTGTI CTSGCARCKG RLPTDCCHEQ CAAGCTGPKH 250
SDCLACLHFN HSGICELHCP ALITYNTDTF ESMLNPEGRY TFGASCVTTC 300
PYNYLSTEVG SCTLVCPPNN QEVTAEDGTQ RCEKCSKPCA GVCYGLGMEH 350
LRGARAITSD NIQEFAGCKK IFGSLAFLPE SFDGNPSSGV APLKPEHLQV 400
FETLEEITGY LYISAWPESF QDLSVFQNLR VIRGRILHDG AYSLTLQGLG 450
IHSLGLRSLR ELGSGLALIH RNTHLCFVNT VPWDQLFRNP HQALLHSGNR 500
PEEACGLEGL VCNSLCARGH CWGPGPTQCV NCSQFLRGQE CVEECRVWKG 550
LPREYVRGKH CLPCHPECQP QNSSETCYGS EADQCEACAH YKDSSSCVAR 600
CPSGVKPDLS YMPIWKYPDE EGICQPCPIN CTHSCVDLDE RGCPAEQRAS 650
PVTFIIATVV GVLLFLIIVV VIGILIKRRR QKIRKYTMRR LLQETELVEP 700
LTPSGAVPNQ AQMRILKETE LRKLKVLGSG AFGTVYKGIW IPDGENVKIP 750
VAIKVLRENT SPKANKEILD EAYVMAGVGS PYVSRLLGIC LTSTVQLVTQ 800
LMPYGCLLDH VREHRGRLGS QDLLNWCVQI AKGMSYLEEV RLVHRDLAAR 850
NVLVKSPNHV KITDFGLARL LDIDETEYHA DGGKVPIKWM ALESILRRRF 900
THQSDVWSYG VTVWELMTFG AKPYDGIPAR EIPDLLEKGE RLPQPPICTI 950
DVYMIMVKCW MIDSECRPRF RELVSEFSRM ARDPQRFVVI QNEDLGPSSP 1000
MDSTFYRSLL EDDDMGELVD AEEYLVPQQG FFSPDPALGT GSTAHRRHRS 1050
SSARSGGGEL TLGLEPSEEE PPRSPLAPSE GAGSDVFDGD LAVGVTKGLQ 1100
SLSPHDLSPL QRYSEDPTLP LPPETDGYVA PLACSPQPEY VNQPEVRPQS 1150
PLTPEGPPPP IRPAGATLER PKTLSPGKNG VVKDVFAFGG AVENPEYLAP 1200
RAGTASQPHP SPAFSPAFDN LYYWDQNSSE QGPPPSTFEG TPTAENPEYL 1250
GLDVPV 1256
Length:1,256
Mass (Da):138,579
Last modified:September 27, 2005 - v3
Checksum:i6040978428B93A28
GO

Sequence cautioni

The sequence BAC98297.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK129487 mRNA. Translation: BAC98297.1. Different initiation.
U71126 mRNA. Translation: AAB17380.1.
L47239 mRNA. Translation: AAA93532.1.
CCDSiCCDS25349.1.
RefSeqiNP_001003817.1. NM_001003817.1.
UniGeneiMm.290822.

Genome annotation databases

EnsembliENSMUST00000058295; ENSMUSP00000053897; ENSMUSG00000062312.
GeneIDi13866.
KEGGimmu:13866.
UCSCiuc007lgi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK129487 mRNA. Translation: BAC98297.1 . Different initiation.
U71126 mRNA. Translation: AAB17380.1 .
L47239 mRNA. Translation: AAA93532.1 .
CCDSi CCDS25349.1.
RefSeqi NP_001003817.1. NM_001003817.1.
UniGenei Mm.290822.

3D structure databases

ProteinModelPortali P70424.
SMRi P70424. Positions 23-630, 678-1026.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 199496. 7 interactions.
IntActi P70424. 4 interactions.
MINTi MINT-138121.

Chemistry

ChEMBLi CHEMBL2311234.

PTM databases

PhosphoSitei P70424.

Proteomic databases

PaxDbi P70424.
PRIDEi P70424.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000058295 ; ENSMUSP00000053897 ; ENSMUSG00000062312 .
GeneIDi 13866.
KEGGi mmu:13866.
UCSCi uc007lgi.1. mouse.

Organism-specific databases

CTDi 2064.
MGIi MGI:95410. Erbb2.
Rougei Search...

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00600000084253.
HOGENOMi HOG000230982.
HOVERGENi HBG000490.
InParanoidi P70424.
KOi K05083.
OMAi ACYPLCA.
OrthoDBi EOG7V49XM.
PhylomeDBi P70424.
TreeFami TF106002.

Enzyme and pathway databases

Reactomei REACT_188190. PLCG1 events in ERBB2 signaling.
REACT_188191. Signaling by ERBB2.
REACT_188528. GRB2 events in ERBB2 signaling.
REACT_188574. SHC1 events in ERBB2 signaling.
REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
REACT_199058. GRB7 events in ERBB2 signaling.
REACT_199061. Downregulation of ERBB2:ERBB3 signaling.
REACT_215348. PI3K events in ERBB2 signaling.
REACT_226341. PIP3 activates AKT signaling.

Miscellaneous databases

NextBioi 284764.
PROi P70424.
SOURCEi Search...

Gene expression databases

ArrayExpressi P70424.
Bgeei P70424.
Genevestigatori P70424.

Family and domain databases

Gene3Di 3.80.20.20. 2 hits.
InterProi IPR000494. EGF_rcpt_L.
IPR006211. Furin-like_Cys-rich_dom.
IPR006212. Furin_repeat.
IPR009030. Growth_fac_rcpt_N_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016245. Tyr_kinase_EGF/ERB/XmrK_rcpt.
[Graphical view ]
Pfami PF00757. Furin-like. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF01030. Recep_L_domain. 2 hits.
[Graphical view ]
PIRSFi PIRSF000619. TyrPK_EGF-R. 1 hit.
PRINTSi PR00109. TYRKINASE.
SMARTi SM00261. FU. 4 hits.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryonic tail.
  2. "Differential expression of the erbB2 gene in the periimplantation mouse uterus: potential mediator of signaling by epidermal growth factor-like growth factors."
    Lim J., Dey S.K., Das S.K.
    Endocrinology 138:1328-1337(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 786-934.
    Strain: CD-1.
    Tissue: Uterus.
  3. "Synapse-associated expression of an acetylcholine receptor-inducing protein, ARIA/heregulin, and its putative receptors, ErbB2 and ErbB3, in developing mammalian muscle."
    Moscoso L.M., Chu G.C., Gautam M., Noakes P.G., Merlie J.P., Sanes J.R.
    Dev. Biol. 172:158-169(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1012-1107.
  4. "Direct and specific interaction of c-Src with Neu is involved in signaling by the epidermal growth factor receptor."
    Muthuswamy S.K., Muller W.J.
    Oncogene 11:271-279(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH SRC.
  5. "The ERBB2/HER2 receptor differentially interacts with ERBIN and PICK1 PSD-95/DLG/ZO-1 domain proteins."
    Jaulin-Bastard F., Saito H., Le Bivic A., Ollendorff V., Marchetto S., Birnbaum D., Borg J.-P.
    J. Biol. Chem. 276:15256-15263(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PRKCABP.
  6. "Myocilin mediates myelination in the peripheral nervous system through ErbB2/3 signaling."
    Kwon H.S., Johnson T.V., Joe M.K., Abu-Asab M., Zhang J., Chan C.C., Tomarev S.I.
    J. Biol. Chem. 288:26357-26371(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MYOC.

Entry informationi

Entry nameiERBB2_MOUSE
AccessioniPrimary (citable) accession number: P70424
Secondary accession number(s): Q61525, Q6ZPE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: September 27, 2005
Last modified: September 3, 2014
This is version 155 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi