Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P70423

- CTR3_MOUSE

UniProt

P70423 - CTR3_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Cationic amino acid transporter 3

Gene

Slc7a3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner.1 Publication

GO - Molecular functioni

  1. arginine transmembrane transporter activity Source: MGI
  2. L-lysine transmembrane transporter activity Source: MGI

GO - Biological processi

  1. arginine transport Source: MGI
  2. lysine transport Source: GOC
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Protein family/group databases

TCDBi2.A.3.3.5. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Cationic amino acid transporter 3
Short name:
CAT-3
Short name:
CAT3
Alternative name(s):
Cationic amino acid transporter y+
Solute carrier family 7 member 3
Gene namesi
Name:Slc7a3
Synonyms:Atrc3, Cat3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1100521. Slc7a3.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 618618Cationic amino acid transporter 3PRO_0000054267Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi232 – 2321N-linked (GlcNAc...)Sequence Analysis
Modified residuei605 – 6051PhosphothreonineBy similarity
Modified residuei617 – 6171PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP70423.
PRIDEiP70423.

PTM databases

PhosphoSiteiP70423.

Expressioni

Tissue specificityi

Expressed in adult brain and in a wide variety of embryonic tissues.1 Publication

Gene expression databases

BgeeiP70423.
GenevestigatoriP70423.

Interactioni

Protein-protein interaction databases

MINTiMINT-4996965.
STRINGi10090.ENSMUSP00000109339.

Structurei

3D structure databases

ProteinModelPortaliP70423.
SMRiP70423. Positions 32-369.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3636CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini58 – 614ExtracellularSequence Analysis
Topological domaini83 – 10725CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini129 – 16234ExtracellularSequence AnalysisAdd
BLAST
Topological domaini184 – 1918CytoplasmicSequence Analysis
Topological domaini213 – 24432ExtracellularSequence AnalysisAdd
BLAST
Topological domaini266 – 28520CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini307 – 33529ExtracellularSequence AnalysisAdd
BLAST
Topological domaini357 – 38024CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini402 – 4065ExtracellularSequence Analysis
Topological domaini428 – 47447CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini496 – 50611ExtracellularSequence AnalysisAdd
BLAST
Topological domaini528 – 53912CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini561 – 5688ExtracellularSequence Analysis
Topological domaini590 – 61829CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei37 – 5721Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei62 – 8221Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei108 – 12821Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei163 – 18321Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei192 – 21221Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei245 – 26521Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei286 – 30621Helical; Name=7Sequence AnalysisAdd
BLAST
Transmembranei336 – 35621Helical; Name=8Sequence AnalysisAdd
BLAST
Transmembranei381 – 40121Helical; Name=9Sequence AnalysisAdd
BLAST
Transmembranei407 – 42721Helical; Name=10Sequence AnalysisAdd
BLAST
Transmembranei475 – 49521Helical; Name=11Sequence AnalysisAdd
BLAST
Transmembranei507 – 52721Helical; Name=12Sequence AnalysisAdd
BLAST
Transmembranei540 – 56021Helical; Name=13Sequence AnalysisAdd
BLAST
Transmembranei569 – 58921Helical; Name=14Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0531.
GeneTreeiENSGT00760000119151.
HOGENOMiHOG000250623.
HOVERGENiHBG000280.
InParanoidiP70423.
KOiK13865.
OMAiLEYSIAV.
OrthoDBiEOG72C501.
PhylomeDBiP70423.
TreeFamiTF315212.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR015606. CAT3.
IPR004755. Cat_AA_permease.
IPR029485. CAT_C.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PTHR11785:SF209. PTHR11785:SF209. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsiTIGR00906. 2A0303. 1 hit.

Sequencei

Sequence statusi: Complete.

P70423 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLWQALRRFG QKLVRRRVLE LGMGETRLAR CLSTLDLVAL GVGSTLGAGV
60 70 80 90 100
YVLAGEVAKD KAGPSIVICF LVAALSSVLA GLCYAEFGAR VPGSGSAYLY
110 120 130 140 150
SYVTVGELWA FTTGWNLILS YVIGTASVAR AWSSAFDNLI GNHISRTLKG
160 170 180 190 200
TILLKMPHVL AEYPDFFALA LVLLLTGLLV LGASKSALVT KVFTGMNLLV
210 220 230 240 250
LSFVIISGFI KGELRNWKLT KEDYCLTMSE SNGTCSLDSM GSGGFMPFGL
260 270 280 290 300
EGILRGAATC FYAFVGFDCI ATTGEEAQNP QRSIPMGIVI SMFICFLAYF
310 320 330 340 350
GVSSALTLMM PYYKLHPESP LPEAFSYVGW EPARYLVAIG SLCALSTSLL
360 370 380 390 400
GSMFPMPRVM YSMAEDGLLF RVLAKVHSVT HIPIVATLVS GVIAAFMAFL
410 420 430 440 450
FELTDLVDLM SIGTLLAHSL VSICVLILRY QPDQEMKSVE EEMELQEETL
460 470 480 490 500
EAEKLTVQAL FCPVNSIPTL LSGRVVYVCS SLLAVLLTVL CLVLTWWTTP
510 520 530 540 550
LRSGDPVWVT VVVLILGLIL AISGVIWRQP QNRTPLHFKV PAVPLLPLVS
560 570 580 590 600
IFVNVYLMMQ MTAGTWARFG IWMLIGFAIY FGYGIQHSMK EVKNHQTLPK
610
TRAQTIDLDL TTSCVHSI
Length:618
Mass (Da):67,460
Last modified:February 1, 1997 - v1
Checksum:i605AFC255A8251DC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U70859 mRNA. Translation: AAB09593.1.
AK077593 mRNA. Translation: BAC36884.1.
AL672308 Genomic DNA. Translation: CAM24958.1.
BC050195 mRNA. Translation: AAH50195.1.
CCDSiCCDS30309.1.
RefSeqiNP_031541.1. NM_007515.2.
XP_006527815.1. XM_006527752.1.
XP_006527816.1. XM_006527753.1.
XP_006527817.1. XM_006527754.1.
UniGeneiMm.5140.

Genome annotation databases

EnsembliENSMUST00000073927; ENSMUSP00000073582; ENSMUSG00000031297.
ENSMUST00000101362; ENSMUSP00000098914; ENSMUSG00000031297.
ENSMUST00000113710; ENSMUSP00000109339; ENSMUSG00000031297.
GeneIDi11989.
KEGGimmu:11989.
UCSCiuc009twt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U70859 mRNA. Translation: AAB09593.1 .
AK077593 mRNA. Translation: BAC36884.1 .
AL672308 Genomic DNA. Translation: CAM24958.1 .
BC050195 mRNA. Translation: AAH50195.1 .
CCDSi CCDS30309.1.
RefSeqi NP_031541.1. NM_007515.2.
XP_006527815.1. XM_006527752.1.
XP_006527816.1. XM_006527753.1.
XP_006527817.1. XM_006527754.1.
UniGenei Mm.5140.

3D structure databases

ProteinModelPortali P70423.
SMRi P70423. Positions 32-369.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4996965.
STRINGi 10090.ENSMUSP00000109339.

Protein family/group databases

TCDBi 2.A.3.3.5. the amino acid-polyamine-organocation (apc) family.

PTM databases

PhosphoSitei P70423.

Proteomic databases

MaxQBi P70423.
PRIDEi P70423.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000073927 ; ENSMUSP00000073582 ; ENSMUSG00000031297 .
ENSMUST00000101362 ; ENSMUSP00000098914 ; ENSMUSG00000031297 .
ENSMUST00000113710 ; ENSMUSP00000109339 ; ENSMUSG00000031297 .
GeneIDi 11989.
KEGGi mmu:11989.
UCSCi uc009twt.1. mouse.

Organism-specific databases

CTDi 84889.
MGIi MGI:1100521. Slc7a3.

Phylogenomic databases

eggNOGi COG0531.
GeneTreei ENSGT00760000119151.
HOGENOMi HOG000250623.
HOVERGENi HBG000280.
InParanoidi P70423.
KOi K13865.
OMAi LEYSIAV.
OrthoDBi EOG72C501.
PhylomeDBi P70423.
TreeFami TF315212.

Miscellaneous databases

NextBioi 280151.
PROi P70423.
SOURCEi Search...

Gene expression databases

Bgeei P70423.
Genevestigatori P70423.

Family and domain databases

InterProi IPR002293. AA/rel_permease1.
IPR015606. CAT3.
IPR004755. Cat_AA_permease.
IPR029485. CAT_C.
[Graphical view ]
PANTHERi PTHR11785. PTHR11785. 1 hit.
PTHR11785:SF209. PTHR11785:SF209. 1 hit.
Pfami PF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF006060. AA_transporter. 1 hit.
TIGRFAMsi TIGR00906. 2A0303. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A new member of the cationic amino acid transporter family is preferentially expressed in adult mouse brain."
    Ito K., Groudine M.
    J. Biol. Chem. 272:26780-26786(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Embryo.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: 129/Sv X 129/SvCp.
    Tissue: Embryonic stem cell.

Entry informationi

Entry nameiCTR3_MOUSE
AccessioniPrimary (citable) accession number: P70423
Secondary accession number(s): B1AVE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: February 1, 1997
Last modified: October 29, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3