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Protein

Cationic amino acid transporter 3

Gene

Slc7a3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner.1 Publication

GO - Molecular functioni

  • antiporter activity Source: GO_Central
  • arginine transmembrane transporter activity Source: MGI
  • basic amino acid transmembrane transporter activity Source: MGI
  • L-lysine transmembrane transporter activity Source: MGI
  • L-ornithine transmembrane transporter activity Source: GO_Central

GO - Biological processi

  • arginine transport Source: MGI
  • L-ornithine transmembrane transport Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-352230. Amino acid transport across the plasma membrane.

Protein family/group databases

TCDBi2.A.3.3.5. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Cationic amino acid transporter 3
Short name:
CAT-3
Short name:
CAT3
Alternative name(s):
Cationic amino acid transporter y+
Solute carrier family 7 member 3
Gene namesi
Name:Slc7a3
Synonyms:Atrc3, Cat3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1100521. Slc7a3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36CytoplasmicSequence analysisAdd BLAST36
Transmembranei37 – 57Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini58 – 61ExtracellularSequence analysis4
Transmembranei62 – 82Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini83 – 107CytoplasmicSequence analysisAdd BLAST25
Transmembranei108 – 128Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini129 – 162ExtracellularSequence analysisAdd BLAST34
Transmembranei163 – 183Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini184 – 191CytoplasmicSequence analysis8
Transmembranei192 – 212Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini213 – 244ExtracellularSequence analysisAdd BLAST32
Transmembranei245 – 265Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini266 – 285CytoplasmicSequence analysisAdd BLAST20
Transmembranei286 – 306Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini307 – 335ExtracellularSequence analysisAdd BLAST29
Transmembranei336 – 356Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini357 – 380CytoplasmicSequence analysisAdd BLAST24
Transmembranei381 – 401Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini402 – 406ExtracellularSequence analysis5
Transmembranei407 – 427Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini428 – 474CytoplasmicSequence analysisAdd BLAST47
Transmembranei475 – 495Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini496 – 506ExtracellularSequence analysisAdd BLAST11
Transmembranei507 – 527Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini528 – 539CytoplasmicSequence analysisAdd BLAST12
Transmembranei540 – 560Helical; Name=13Sequence analysisAdd BLAST21
Topological domaini561 – 568ExtracellularSequence analysis8
Transmembranei569 – 589Helical; Name=14Sequence analysisAdd BLAST21
Topological domaini590 – 618CytoplasmicSequence analysisAdd BLAST29

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000542671 – 618Cationic amino acid transporter 3Add BLAST618

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi232N-linked (GlcNAc...)Sequence analysis1
Modified residuei605PhosphothreonineBy similarity1
Modified residuei617PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP70423.
MaxQBiP70423.
PaxDbiP70423.
PeptideAtlasiP70423.
PRIDEiP70423.

PTM databases

iPTMnetiP70423.
PhosphoSitePlusiP70423.

Expressioni

Tissue specificityi

Expressed in adult brain and in a wide variety of embryonic tissues.1 Publication

Gene expression databases

BgeeiENSMUSG00000031297.
GenevisibleiP70423. MM.

Interactioni

Protein-protein interaction databases

MINTiMINT-4996965.
STRINGi10090.ENSMUSP00000073582.

Structurei

3D structure databases

ProteinModelPortaliP70423.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1286. Eukaryota.
COG0531. LUCA.
GeneTreeiENSGT00760000119151.
HOGENOMiHOG000250623.
HOVERGENiHBG000280.
InParanoidiP70423.
KOiK13865.
OMAiRAFKRES.
OrthoDBiEOG091G05NM.
PhylomeDBiP70423.
TreeFamiTF315212.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR015606. CAT3.
IPR004755. Cat_AA_permease.
IPR029485. CAT_C.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 3 hits.
PTHR11785:SF209. PTHR11785:SF209. 3 hits.
PfamiPF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00906. 2A0303. 1 hit.

Sequencei

Sequence statusi: Complete.

P70423-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLWQALRRFG QKLVRRRVLE LGMGETRLAR CLSTLDLVAL GVGSTLGAGV
60 70 80 90 100
YVLAGEVAKD KAGPSIVICF LVAALSSVLA GLCYAEFGAR VPGSGSAYLY
110 120 130 140 150
SYVTVGELWA FTTGWNLILS YVIGTASVAR AWSSAFDNLI GNHISRTLKG
160 170 180 190 200
TILLKMPHVL AEYPDFFALA LVLLLTGLLV LGASKSALVT KVFTGMNLLV
210 220 230 240 250
LSFVIISGFI KGELRNWKLT KEDYCLTMSE SNGTCSLDSM GSGGFMPFGL
260 270 280 290 300
EGILRGAATC FYAFVGFDCI ATTGEEAQNP QRSIPMGIVI SMFICFLAYF
310 320 330 340 350
GVSSALTLMM PYYKLHPESP LPEAFSYVGW EPARYLVAIG SLCALSTSLL
360 370 380 390 400
GSMFPMPRVM YSMAEDGLLF RVLAKVHSVT HIPIVATLVS GVIAAFMAFL
410 420 430 440 450
FELTDLVDLM SIGTLLAHSL VSICVLILRY QPDQEMKSVE EEMELQEETL
460 470 480 490 500
EAEKLTVQAL FCPVNSIPTL LSGRVVYVCS SLLAVLLTVL CLVLTWWTTP
510 520 530 540 550
LRSGDPVWVT VVVLILGLIL AISGVIWRQP QNRTPLHFKV PAVPLLPLVS
560 570 580 590 600
IFVNVYLMMQ MTAGTWARFG IWMLIGFAIY FGYGIQHSMK EVKNHQTLPK
610
TRAQTIDLDL TTSCVHSI
Length:618
Mass (Da):67,460
Last modified:February 1, 1997 - v1
Checksum:i605AFC255A8251DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70859 mRNA. Translation: AAB09593.1.
AK077593 mRNA. Translation: BAC36884.1.
AL672308 Genomic DNA. Translation: CAM24958.1.
BC050195 mRNA. Translation: AAH50195.1.
CCDSiCCDS30309.1.
RefSeqiNP_001288769.1. NM_001301840.1.
NP_031541.1. NM_007515.3.
XP_006527816.1. XM_006527753.2.
XP_011245812.1. XM_011247510.1.
XP_011245813.1. XM_011247511.1.
XP_011245814.1. XM_011247512.1.
XP_011245815.1. XM_011247513.1.
XP_017173852.1. XM_017318363.1.
XP_017173853.1. XM_017318364.1.
UniGeneiMm.5140.

Genome annotation databases

EnsembliENSMUST00000073927; ENSMUSP00000073582; ENSMUSG00000031297.
ENSMUST00000101362; ENSMUSP00000098914; ENSMUSG00000031297.
ENSMUST00000113710; ENSMUSP00000109339; ENSMUSG00000031297.
GeneIDi11989.
KEGGimmu:11989.
UCSCiuc009twt.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70859 mRNA. Translation: AAB09593.1.
AK077593 mRNA. Translation: BAC36884.1.
AL672308 Genomic DNA. Translation: CAM24958.1.
BC050195 mRNA. Translation: AAH50195.1.
CCDSiCCDS30309.1.
RefSeqiNP_001288769.1. NM_001301840.1.
NP_031541.1. NM_007515.3.
XP_006527816.1. XM_006527753.2.
XP_011245812.1. XM_011247510.1.
XP_011245813.1. XM_011247511.1.
XP_011245814.1. XM_011247512.1.
XP_011245815.1. XM_011247513.1.
XP_017173852.1. XM_017318363.1.
XP_017173853.1. XM_017318364.1.
UniGeneiMm.5140.

3D structure databases

ProteinModelPortaliP70423.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4996965.
STRINGi10090.ENSMUSP00000073582.

Protein family/group databases

TCDBi2.A.3.3.5. the amino acid-polyamine-organocation (apc) family.

PTM databases

iPTMnetiP70423.
PhosphoSitePlusiP70423.

Proteomic databases

EPDiP70423.
MaxQBiP70423.
PaxDbiP70423.
PeptideAtlasiP70423.
PRIDEiP70423.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000073927; ENSMUSP00000073582; ENSMUSG00000031297.
ENSMUST00000101362; ENSMUSP00000098914; ENSMUSG00000031297.
ENSMUST00000113710; ENSMUSP00000109339; ENSMUSG00000031297.
GeneIDi11989.
KEGGimmu:11989.
UCSCiuc009twt.2. mouse.

Organism-specific databases

CTDi84889.
MGIiMGI:1100521. Slc7a3.

Phylogenomic databases

eggNOGiKOG1286. Eukaryota.
COG0531. LUCA.
GeneTreeiENSGT00760000119151.
HOGENOMiHOG000250623.
HOVERGENiHBG000280.
InParanoidiP70423.
KOiK13865.
OMAiRAFKRES.
OrthoDBiEOG091G05NM.
PhylomeDBiP70423.
TreeFamiTF315212.

Enzyme and pathway databases

ReactomeiR-MMU-352230. Amino acid transport across the plasma membrane.

Miscellaneous databases

PROiP70423.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031297.
GenevisibleiP70423. MM.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR015606. CAT3.
IPR004755. Cat_AA_permease.
IPR029485. CAT_C.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 3 hits.
PTHR11785:SF209. PTHR11785:SF209. 3 hits.
PfamiPF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00906. 2A0303. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCTR3_MOUSE
AccessioniPrimary (citable) accession number: P70423
Secondary accession number(s): B1AVE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: February 1, 1997
Last modified: November 2, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.