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P70423

- CTR3_MOUSE

UniProt

P70423 - CTR3_MOUSE

Protein

Cationic amino acid transporter 3

Gene

Slc7a3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner.1 Publication

    GO - Molecular functioni

    1. arginine transmembrane transporter activity Source: MGI
    2. L-lysine transmembrane transporter activity Source: MGI

    GO - Biological processi

    1. arginine transport Source: MGI
    2. lysine transport Source: GOC

    Keywords - Biological processi

    Amino-acid transport, Transport

    Protein family/group databases

    TCDBi2.A.3.3.5. the amino acid-polyamine-organocation (apc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cationic amino acid transporter 3
    Short name:
    CAT-3
    Short name:
    CAT3
    Alternative name(s):
    Cationic amino acid transporter y+
    Solute carrier family 7 member 3
    Gene namesi
    Name:Slc7a3
    Synonyms:Atrc3, Cat3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:1100521. Slc7a3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 618618Cationic amino acid transporter 3PRO_0000054267Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi232 – 2321N-linked (GlcNAc...)Sequence Analysis
    Modified residuei605 – 6051PhosphothreonineBy similarity
    Modified residuei617 – 6171PhosphoserineBy similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PRIDEiP70423.

    PTM databases

    PhosphoSiteiP70423.

    Expressioni

    Tissue specificityi

    Expressed in adult brain and in a wide variety of embryonic tissues.1 Publication

    Gene expression databases

    BgeeiP70423.
    GenevestigatoriP70423.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4996965.
    STRINGi10090.ENSMUSP00000109339.

    Structurei

    3D structure databases

    ProteinModelPortaliP70423.
    SMRiP70423. Positions 32-369.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3636CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini58 – 614ExtracellularSequence Analysis
    Topological domaini83 – 10725CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini129 – 16234ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini184 – 1918CytoplasmicSequence Analysis
    Topological domaini213 – 24432ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini266 – 28520CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini307 – 33529ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini357 – 38024CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini402 – 4065ExtracellularSequence Analysis
    Topological domaini428 – 47447CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini496 – 50611ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini528 – 53912CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini561 – 5688ExtracellularSequence Analysis
    Topological domaini590 – 61829CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei37 – 5721Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei62 – 8221Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei108 – 12821Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei163 – 18321Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei192 – 21221Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei245 – 26521Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei286 – 30621Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei336 – 35621Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei381 – 40121Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei407 – 42721Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei475 – 49521Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei507 – 52721Helical; Name=12Sequence AnalysisAdd
    BLAST
    Transmembranei540 – 56021Helical; Name=13Sequence AnalysisAdd
    BLAST
    Transmembranei569 – 58921Helical; Name=14Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0531.
    GeneTreeiENSGT00700000104437.
    HOGENOMiHOG000250623.
    HOVERGENiHBG000280.
    InParanoidiB1AVE2.
    KOiK13865.
    OMAiLEYSIAV.
    OrthoDBiEOG72C501.
    PhylomeDBiP70423.
    TreeFamiTF315212.

    Family and domain databases

    InterProiIPR002293. AA/rel_permease1.
    IPR015606. CAT3.
    IPR004755. Cat_AA_permease.
    IPR029485. CAT_C.
    [Graphical view]
    PANTHERiPTHR11785. PTHR11785. 1 hit.
    PTHR11785:SF209. PTHR11785:SF209. 1 hit.
    PfamiPF13520. AA_permease_2. 1 hit.
    PF13906. AA_permease_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006060. AA_transporter. 1 hit.
    TIGRFAMsiTIGR00906. 2A0303. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P70423-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLWQALRRFG QKLVRRRVLE LGMGETRLAR CLSTLDLVAL GVGSTLGAGV    50
    YVLAGEVAKD KAGPSIVICF LVAALSSVLA GLCYAEFGAR VPGSGSAYLY 100
    SYVTVGELWA FTTGWNLILS YVIGTASVAR AWSSAFDNLI GNHISRTLKG 150
    TILLKMPHVL AEYPDFFALA LVLLLTGLLV LGASKSALVT KVFTGMNLLV 200
    LSFVIISGFI KGELRNWKLT KEDYCLTMSE SNGTCSLDSM GSGGFMPFGL 250
    EGILRGAATC FYAFVGFDCI ATTGEEAQNP QRSIPMGIVI SMFICFLAYF 300
    GVSSALTLMM PYYKLHPESP LPEAFSYVGW EPARYLVAIG SLCALSTSLL 350
    GSMFPMPRVM YSMAEDGLLF RVLAKVHSVT HIPIVATLVS GVIAAFMAFL 400
    FELTDLVDLM SIGTLLAHSL VSICVLILRY QPDQEMKSVE EEMELQEETL 450
    EAEKLTVQAL FCPVNSIPTL LSGRVVYVCS SLLAVLLTVL CLVLTWWTTP 500
    LRSGDPVWVT VVVLILGLIL AISGVIWRQP QNRTPLHFKV PAVPLLPLVS 550
    IFVNVYLMMQ MTAGTWARFG IWMLIGFAIY FGYGIQHSMK EVKNHQTLPK 600
    TRAQTIDLDL TTSCVHSI 618
    Length:618
    Mass (Da):67,460
    Last modified:February 1, 1997 - v1
    Checksum:i605AFC255A8251DC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U70859 mRNA. Translation: AAB09593.1.
    AK077593 mRNA. Translation: BAC36884.1.
    AL672308 Genomic DNA. Translation: CAM24958.1.
    BC050195 mRNA. Translation: AAH50195.1.
    CCDSiCCDS30309.1.
    RefSeqiNP_031541.1. NM_007515.2.
    XP_006527815.1. XM_006527752.1.
    XP_006527816.1. XM_006527753.1.
    XP_006527817.1. XM_006527754.1.
    UniGeneiMm.5140.

    Genome annotation databases

    EnsembliENSMUST00000073927; ENSMUSP00000073582; ENSMUSG00000031297.
    ENSMUST00000101362; ENSMUSP00000098914; ENSMUSG00000031297.
    ENSMUST00000113710; ENSMUSP00000109339; ENSMUSG00000031297.
    GeneIDi11989.
    KEGGimmu:11989.
    UCSCiuc009twt.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U70859 mRNA. Translation: AAB09593.1 .
    AK077593 mRNA. Translation: BAC36884.1 .
    AL672308 Genomic DNA. Translation: CAM24958.1 .
    BC050195 mRNA. Translation: AAH50195.1 .
    CCDSi CCDS30309.1.
    RefSeqi NP_031541.1. NM_007515.2.
    XP_006527815.1. XM_006527752.1.
    XP_006527816.1. XM_006527753.1.
    XP_006527817.1. XM_006527754.1.
    UniGenei Mm.5140.

    3D structure databases

    ProteinModelPortali P70423.
    SMRi P70423. Positions 32-369.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4996965.
    STRINGi 10090.ENSMUSP00000109339.

    Protein family/group databases

    TCDBi 2.A.3.3.5. the amino acid-polyamine-organocation (apc) family.

    PTM databases

    PhosphoSitei P70423.

    Proteomic databases

    PRIDEi P70423.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000073927 ; ENSMUSP00000073582 ; ENSMUSG00000031297 .
    ENSMUST00000101362 ; ENSMUSP00000098914 ; ENSMUSG00000031297 .
    ENSMUST00000113710 ; ENSMUSP00000109339 ; ENSMUSG00000031297 .
    GeneIDi 11989.
    KEGGi mmu:11989.
    UCSCi uc009twt.1. mouse.

    Organism-specific databases

    CTDi 84889.
    MGIi MGI:1100521. Slc7a3.

    Phylogenomic databases

    eggNOGi COG0531.
    GeneTreei ENSGT00700000104437.
    HOGENOMi HOG000250623.
    HOVERGENi HBG000280.
    InParanoidi B1AVE2.
    KOi K13865.
    OMAi LEYSIAV.
    OrthoDBi EOG72C501.
    PhylomeDBi P70423.
    TreeFami TF315212.

    Miscellaneous databases

    NextBioi 280151.
    PROi P70423.
    SOURCEi Search...

    Gene expression databases

    Bgeei P70423.
    Genevestigatori P70423.

    Family and domain databases

    InterProi IPR002293. AA/rel_permease1.
    IPR015606. CAT3.
    IPR004755. Cat_AA_permease.
    IPR029485. CAT_C.
    [Graphical view ]
    PANTHERi PTHR11785. PTHR11785. 1 hit.
    PTHR11785:SF209. PTHR11785:SF209. 1 hit.
    Pfami PF13520. AA_permease_2. 1 hit.
    PF13906. AA_permease_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006060. AA_transporter. 1 hit.
    TIGRFAMsi TIGR00906. 2A0303. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A new member of the cationic amino acid transporter family is preferentially expressed in adult mouse brain."
      Ito K., Groudine M.
      J. Biol. Chem. 272:26780-26786(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Tissue: Embryo.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: 129/Sv X 129/SvCp.
      Tissue: Embryonic stem cell.

    Entry informationi

    Entry nameiCTR3_MOUSE
    AccessioniPrimary (citable) accession number: P70423
    Secondary accession number(s): B1AVE2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 16, 2004
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3