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Protein

Cationic amino acid transporter 3

Gene

Slc7a3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner.1 Publication

GO - Molecular functioni

  • arginine transmembrane transporter activity Source: MGI
  • basic amino acid transmembrane transporter activity Source: MGI
  • L-lysine transmembrane transporter activity Source: MGI

GO - Biological processi

  • arginine transport Source: MGI

Keywordsi

Biological processAmino-acid transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-352230 Amino acid transport across the plasma membrane

Protein family/group databases

TCDBi2.A.3.3.5 the amino acid-polyamine-organocation (apc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Cationic amino acid transporter 3
Short name:
CAT-3
Short name:
CAT3
Alternative name(s):
Cationic amino acid transporter y+
Solute carrier family 7 member 3
Gene namesi
Name:Slc7a3
Synonyms:Atrc3, Cat3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1100521 Slc7a3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36CytoplasmicSequence analysisAdd BLAST36
Transmembranei37 – 57Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini58 – 61ExtracellularSequence analysis4
Transmembranei62 – 82Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini83 – 107CytoplasmicSequence analysisAdd BLAST25
Transmembranei108 – 128Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini129 – 162ExtracellularSequence analysisAdd BLAST34
Transmembranei163 – 183Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini184 – 191CytoplasmicSequence analysis8
Transmembranei192 – 212Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini213 – 244ExtracellularSequence analysisAdd BLAST32
Transmembranei245 – 265Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini266 – 285CytoplasmicSequence analysisAdd BLAST20
Transmembranei286 – 306Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini307 – 335ExtracellularSequence analysisAdd BLAST29
Transmembranei336 – 356Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini357 – 380CytoplasmicSequence analysisAdd BLAST24
Transmembranei381 – 401Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini402 – 406ExtracellularSequence analysis5
Transmembranei407 – 427Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini428 – 474CytoplasmicSequence analysisAdd BLAST47
Transmembranei475 – 495Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini496 – 506ExtracellularSequence analysisAdd BLAST11
Transmembranei507 – 527Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini528 – 539CytoplasmicSequence analysisAdd BLAST12
Transmembranei540 – 560Helical; Name=13Sequence analysisAdd BLAST21
Topological domaini561 – 568ExtracellularSequence analysis8
Transmembranei569 – 589Helical; Name=14Sequence analysisAdd BLAST21
Topological domaini590 – 618CytoplasmicSequence analysisAdd BLAST29

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000542671 – 618Cationic amino acid transporter 3Add BLAST618

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi232N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei605PhosphothreonineBy similarity1
Modified residuei617PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP70423
MaxQBiP70423
PaxDbiP70423
PeptideAtlasiP70423
PRIDEiP70423

PTM databases

iPTMnetiP70423
PhosphoSitePlusiP70423
SwissPalmiP70423

Expressioni

Tissue specificityi

Expressed in adult brain and in a wide variety of embryonic tissues.1 Publication

Gene expression databases

BgeeiENSMUSG00000031297
GenevisibleiP70423 MM

Interactioni

Protein-protein interaction databases

BioGridi198277, 1 interactor
IntActiP70423, 1 interactor
STRINGi10090.ENSMUSP00000073582

Structurei

3D structure databases

ProteinModelPortaliP70423
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1286 Eukaryota
COG0531 LUCA
GeneTreeiENSGT00760000119151
HOGENOMiHOG000250623
HOVERGENiHBG000280
InParanoidiP70423
KOiK13865
OMAiSIIVVVQ
OrthoDBiEOG091G05NM
PhylomeDBiP70423
TreeFamiTF315212

Family and domain databases

InterProiView protein in InterPro
IPR002293 AA/rel_permease1
IPR015606 CAT3
IPR004755 Cat_AA_permease
IPR029485 CAT_C
PANTHERiPTHR43243:SF20 PTHR43243:SF20, 1 hit
PfamiView protein in Pfam
PF13520 AA_permease_2, 1 hit
PF13906 AA_permease_C, 1 hit
PIRSFiPIRSF006060 AA_transporter, 1 hit
TIGRFAMsiTIGR00906 2A0303, 1 hit

Sequencei

Sequence statusi: Complete.

P70423-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLWQALRRFG QKLVRRRVLE LGMGETRLAR CLSTLDLVAL GVGSTLGAGV
60 70 80 90 100
YVLAGEVAKD KAGPSIVICF LVAALSSVLA GLCYAEFGAR VPGSGSAYLY
110 120 130 140 150
SYVTVGELWA FTTGWNLILS YVIGTASVAR AWSSAFDNLI GNHISRTLKG
160 170 180 190 200
TILLKMPHVL AEYPDFFALA LVLLLTGLLV LGASKSALVT KVFTGMNLLV
210 220 230 240 250
LSFVIISGFI KGELRNWKLT KEDYCLTMSE SNGTCSLDSM GSGGFMPFGL
260 270 280 290 300
EGILRGAATC FYAFVGFDCI ATTGEEAQNP QRSIPMGIVI SMFICFLAYF
310 320 330 340 350
GVSSALTLMM PYYKLHPESP LPEAFSYVGW EPARYLVAIG SLCALSTSLL
360 370 380 390 400
GSMFPMPRVM YSMAEDGLLF RVLAKVHSVT HIPIVATLVS GVIAAFMAFL
410 420 430 440 450
FELTDLVDLM SIGTLLAHSL VSICVLILRY QPDQEMKSVE EEMELQEETL
460 470 480 490 500
EAEKLTVQAL FCPVNSIPTL LSGRVVYVCS SLLAVLLTVL CLVLTWWTTP
510 520 530 540 550
LRSGDPVWVT VVVLILGLIL AISGVIWRQP QNRTPLHFKV PAVPLLPLVS
560 570 580 590 600
IFVNVYLMMQ MTAGTWARFG IWMLIGFAIY FGYGIQHSMK EVKNHQTLPK
610
TRAQTIDLDL TTSCVHSI
Length:618
Mass (Da):67,460
Last modified:February 1, 1997 - v1
Checksum:i605AFC255A8251DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70859 mRNA Translation: AAB09593.1
AK077593 mRNA Translation: BAC36884.1
AL672308 Genomic DNA No translation available.
BC050195 mRNA Translation: AAH50195.1
CCDSiCCDS30309.1
RefSeqiNP_001288769.1, NM_001301840.1
NP_031541.1, NM_007515.3
XP_006527816.1, XM_006527753.2
XP_011245812.1, XM_011247510.1
XP_011245813.1, XM_011247511.1
XP_011245814.1, XM_011247512.1
XP_011245815.1, XM_011247513.1
XP_017173852.1, XM_017318363.1
XP_017173853.1, XM_017318364.1
UniGeneiMm.5140

Genome annotation databases

EnsembliENSMUST00000073927; ENSMUSP00000073582; ENSMUSG00000031297
ENSMUST00000101362; ENSMUSP00000098914; ENSMUSG00000031297
ENSMUST00000113710; ENSMUSP00000109339; ENSMUSG00000031297
GeneIDi11989
KEGGimmu:11989
UCSCiuc009twt.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCTR3_MOUSE
AccessioniPrimary (citable) accession number: P70423
Secondary accession number(s): B1AVE2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: February 1, 1997
Last modified: May 23, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health