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P70423

- CTR3_MOUSE

UniProt

P70423 - CTR3_MOUSE

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Protein
Cationic amino acid transporter 3
Gene
Slc7a3, Atrc3, Cat3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner.1 Publication

GO - Molecular functioni

  1. L-lysine transmembrane transporter activity Source: MGI
  2. arginine transmembrane transporter activity Source: MGI
  3. cationic amino acid transmembrane transporter activity Source: MGI

GO - Biological processi

  1. arginine transport Source: MGI
  2. lysine transport Source: GOC
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Protein family/group databases

TCDBi2.A.3.3.5. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Cationic amino acid transporter 3
Short name:
CAT-3
Short name:
CAT3
Alternative name(s):
Cationic amino acid transporter y+
Solute carrier family 7 member 3
Gene namesi
Name:Slc7a3
Synonyms:Atrc3, Cat3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1100521. Slc7a3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3636Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei37 – 5721Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini58 – 614Extracellular Reviewed prediction
Transmembranei62 – 8221Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini83 – 10725Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei108 – 12821Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini129 – 16234Extracellular Reviewed prediction
Add
BLAST
Transmembranei163 – 18321Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini184 – 1918Cytoplasmic Reviewed prediction
Transmembranei192 – 21221Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini213 – 24432Extracellular Reviewed prediction
Add
BLAST
Transmembranei245 – 26521Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini266 – 28520Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei286 – 30621Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini307 – 33529Extracellular Reviewed prediction
Add
BLAST
Transmembranei336 – 35621Helical; Name=8; Reviewed prediction
Add
BLAST
Topological domaini357 – 38024Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei381 – 40121Helical; Name=9; Reviewed prediction
Add
BLAST
Topological domaini402 – 4065Extracellular Reviewed prediction
Transmembranei407 – 42721Helical; Name=10; Reviewed prediction
Add
BLAST
Topological domaini428 – 47447Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei475 – 49521Helical; Name=11; Reviewed prediction
Add
BLAST
Topological domaini496 – 50611Extracellular Reviewed prediction
Add
BLAST
Transmembranei507 – 52721Helical; Name=12; Reviewed prediction
Add
BLAST
Topological domaini528 – 53912Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei540 – 56021Helical; Name=13; Reviewed prediction
Add
BLAST
Topological domaini561 – 5688Extracellular Reviewed prediction
Transmembranei569 – 58921Helical; Name=14; Reviewed prediction
Add
BLAST
Topological domaini590 – 61829Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 618618Cationic amino acid transporter 3
PRO_0000054267Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi232 – 2321N-linked (GlcNAc...) Reviewed prediction
Modified residuei605 – 6051Phosphothreonine By similarity
Modified residuei617 – 6171Phosphoserine By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiP70423.

PTM databases

PhosphoSiteiP70423.

Expressioni

Tissue specificityi

Expressed in adult brain and in a wide variety of embryonic tissues.1 Publication

Gene expression databases

BgeeiP70423.
GenevestigatoriP70423.

Interactioni

Protein-protein interaction databases

MINTiMINT-4996965.
STRINGi10090.ENSMUSP00000109339.

Structurei

3D structure databases

ProteinModelPortaliP70423.
SMRiP70423. Positions 32-369.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0531.
GeneTreeiENSGT00700000104437.
HOGENOMiHOG000250623.
HOVERGENiHBG000280.
InParanoidiB1AVE2.
KOiK13865.
OMAiLEYSIAV.
OrthoDBiEOG72C501.
PhylomeDBiP70423.
TreeFamiTF315212.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR015606. CAT3.
IPR004755. Cat_AA_permease.
IPR029485. CAT_C.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PTHR11785:SF209. PTHR11785:SF209. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsiTIGR00906. 2A0303. 1 hit.

Sequencei

Sequence statusi: Complete.

P70423-1 [UniParc]FASTAAdd to Basket

« Hide

MLWQALRRFG QKLVRRRVLE LGMGETRLAR CLSTLDLVAL GVGSTLGAGV    50
YVLAGEVAKD KAGPSIVICF LVAALSSVLA GLCYAEFGAR VPGSGSAYLY 100
SYVTVGELWA FTTGWNLILS YVIGTASVAR AWSSAFDNLI GNHISRTLKG 150
TILLKMPHVL AEYPDFFALA LVLLLTGLLV LGASKSALVT KVFTGMNLLV 200
LSFVIISGFI KGELRNWKLT KEDYCLTMSE SNGTCSLDSM GSGGFMPFGL 250
EGILRGAATC FYAFVGFDCI ATTGEEAQNP QRSIPMGIVI SMFICFLAYF 300
GVSSALTLMM PYYKLHPESP LPEAFSYVGW EPARYLVAIG SLCALSTSLL 350
GSMFPMPRVM YSMAEDGLLF RVLAKVHSVT HIPIVATLVS GVIAAFMAFL 400
FELTDLVDLM SIGTLLAHSL VSICVLILRY QPDQEMKSVE EEMELQEETL 450
EAEKLTVQAL FCPVNSIPTL LSGRVVYVCS SLLAVLLTVL CLVLTWWTTP 500
LRSGDPVWVT VVVLILGLIL AISGVIWRQP QNRTPLHFKV PAVPLLPLVS 550
IFVNVYLMMQ MTAGTWARFG IWMLIGFAIY FGYGIQHSMK EVKNHQTLPK 600
TRAQTIDLDL TTSCVHSI 618
Length:618
Mass (Da):67,460
Last modified:February 1, 1997 - v1
Checksum:i605AFC255A8251DC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U70859 mRNA. Translation: AAB09593.1.
AK077593 mRNA. Translation: BAC36884.1.
AL672308 Genomic DNA. Translation: CAM24958.1.
BC050195 mRNA. Translation: AAH50195.1.
CCDSiCCDS30309.1.
RefSeqiNP_031541.1. NM_007515.2.
XP_006527815.1. XM_006527752.1.
XP_006527816.1. XM_006527753.1.
XP_006527817.1. XM_006527754.1.
UniGeneiMm.5140.

Genome annotation databases

EnsembliENSMUST00000073927; ENSMUSP00000073582; ENSMUSG00000031297.
ENSMUST00000101362; ENSMUSP00000098914; ENSMUSG00000031297.
ENSMUST00000113710; ENSMUSP00000109339; ENSMUSG00000031297.
GeneIDi11989.
KEGGimmu:11989.
UCSCiuc009twt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U70859 mRNA. Translation: AAB09593.1 .
AK077593 mRNA. Translation: BAC36884.1 .
AL672308 Genomic DNA. Translation: CAM24958.1 .
BC050195 mRNA. Translation: AAH50195.1 .
CCDSi CCDS30309.1.
RefSeqi NP_031541.1. NM_007515.2.
XP_006527815.1. XM_006527752.1.
XP_006527816.1. XM_006527753.1.
XP_006527817.1. XM_006527754.1.
UniGenei Mm.5140.

3D structure databases

ProteinModelPortali P70423.
SMRi P70423. Positions 32-369.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4996965.
STRINGi 10090.ENSMUSP00000109339.

Protein family/group databases

TCDBi 2.A.3.3.5. the amino acid-polyamine-organocation (apc) family.

PTM databases

PhosphoSitei P70423.

Proteomic databases

PRIDEi P70423.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000073927 ; ENSMUSP00000073582 ; ENSMUSG00000031297 .
ENSMUST00000101362 ; ENSMUSP00000098914 ; ENSMUSG00000031297 .
ENSMUST00000113710 ; ENSMUSP00000109339 ; ENSMUSG00000031297 .
GeneIDi 11989.
KEGGi mmu:11989.
UCSCi uc009twt.1. mouse.

Organism-specific databases

CTDi 84889.
MGIi MGI:1100521. Slc7a3.

Phylogenomic databases

eggNOGi COG0531.
GeneTreei ENSGT00700000104437.
HOGENOMi HOG000250623.
HOVERGENi HBG000280.
InParanoidi B1AVE2.
KOi K13865.
OMAi LEYSIAV.
OrthoDBi EOG72C501.
PhylomeDBi P70423.
TreeFami TF315212.

Miscellaneous databases

NextBioi 280151.
PROi P70423.
SOURCEi Search...

Gene expression databases

Bgeei P70423.
Genevestigatori P70423.

Family and domain databases

InterProi IPR002293. AA/rel_permease1.
IPR015606. CAT3.
IPR004755. Cat_AA_permease.
IPR029485. CAT_C.
[Graphical view ]
PANTHERi PTHR11785. PTHR11785. 1 hit.
PTHR11785:SF209. PTHR11785:SF209. 1 hit.
Pfami PF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF006060. AA_transporter. 1 hit.
TIGRFAMsi TIGR00906. 2A0303. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A new member of the cationic amino acid transporter family is preferentially expressed in adult mouse brain."
    Ito K., Groudine M.
    J. Biol. Chem. 272:26780-26786(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Embryo.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: 129/Sv X 129/SvCp.
    Tissue: Embryonic stem cell.

Entry informationi

Entry nameiCTR3_MOUSE
AccessioniPrimary (citable) accession number: P70423
Secondary accession number(s): B1AVE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: February 1, 1997
Last modified: July 9, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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