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P70423 (CTR3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cationic amino acid transporter 3

Short name=CAT-3
Short name=CAT3
Alternative name(s):
Cationic amino acid transporter y+
Solute carrier family 7 member 3
Gene names
Name:Slc7a3
Synonyms:Atrc3, Cat3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length618 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Ref.1

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in adult brain and in a wide variety of embryonic tissues. Ref.1

Sequence similarities

Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 618618Cationic amino acid transporter 3
PRO_0000054267

Regions

Topological domain1 – 3636Cytoplasmic Potential
Transmembrane37 – 5721Helical; Name=1; Potential
Topological domain58 – 614Extracellular Potential
Transmembrane62 – 8221Helical; Name=2; Potential
Topological domain83 – 10725Cytoplasmic Potential
Transmembrane108 – 12821Helical; Name=3; Potential
Topological domain129 – 16234Extracellular Potential
Transmembrane163 – 18321Helical; Name=4; Potential
Topological domain184 – 1918Cytoplasmic Potential
Transmembrane192 – 21221Helical; Name=5; Potential
Topological domain213 – 24432Extracellular Potential
Transmembrane245 – 26521Helical; Name=6; Potential
Topological domain266 – 28520Cytoplasmic Potential
Transmembrane286 – 30621Helical; Name=7; Potential
Topological domain307 – 33529Extracellular Potential
Transmembrane336 – 35621Helical; Name=8; Potential
Topological domain357 – 38024Cytoplasmic Potential
Transmembrane381 – 40121Helical; Name=9; Potential
Topological domain402 – 4065Extracellular Potential
Transmembrane407 – 42721Helical; Name=10; Potential
Topological domain428 – 47447Cytoplasmic Potential
Transmembrane475 – 49521Helical; Name=11; Potential
Topological domain496 – 50611Extracellular Potential
Transmembrane507 – 52721Helical; Name=12; Potential
Topological domain528 – 53912Cytoplasmic Potential
Transmembrane540 – 56021Helical; Name=13; Potential
Topological domain561 – 5688Extracellular Potential
Transmembrane569 – 58921Helical; Name=14; Potential
Topological domain590 – 61829Cytoplasmic Potential

Amino acid modifications

Modified residue6051Phosphothreonine By similarity
Modified residue6171Phosphoserine By similarity
Glycosylation2321N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P70423 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 605AFC255A8251DC

FASTA61867,460
        10         20         30         40         50         60 
MLWQALRRFG QKLVRRRVLE LGMGETRLAR CLSTLDLVAL GVGSTLGAGV YVLAGEVAKD 

        70         80         90        100        110        120 
KAGPSIVICF LVAALSSVLA GLCYAEFGAR VPGSGSAYLY SYVTVGELWA FTTGWNLILS 

       130        140        150        160        170        180 
YVIGTASVAR AWSSAFDNLI GNHISRTLKG TILLKMPHVL AEYPDFFALA LVLLLTGLLV 

       190        200        210        220        230        240 
LGASKSALVT KVFTGMNLLV LSFVIISGFI KGELRNWKLT KEDYCLTMSE SNGTCSLDSM 

       250        260        270        280        290        300 
GSGGFMPFGL EGILRGAATC FYAFVGFDCI ATTGEEAQNP QRSIPMGIVI SMFICFLAYF 

       310        320        330        340        350        360 
GVSSALTLMM PYYKLHPESP LPEAFSYVGW EPARYLVAIG SLCALSTSLL GSMFPMPRVM 

       370        380        390        400        410        420 
YSMAEDGLLF RVLAKVHSVT HIPIVATLVS GVIAAFMAFL FELTDLVDLM SIGTLLAHSL 

       430        440        450        460        470        480 
VSICVLILRY QPDQEMKSVE EEMELQEETL EAEKLTVQAL FCPVNSIPTL LSGRVVYVCS 

       490        500        510        520        530        540 
SLLAVLLTVL CLVLTWWTTP LRSGDPVWVT VVVLILGLIL AISGVIWRQP QNRTPLHFKV 

       550        560        570        580        590        600 
PAVPLLPLVS IFVNVYLMMQ MTAGTWARFG IWMLIGFAIY FGYGIQHSMK EVKNHQTLPK 

       610 
TRAQTIDLDL TTSCVHSI 

« Hide

References

« Hide 'large scale' references
[1]"A new member of the cationic amino acid transporter family is preferentially expressed in adult mouse brain."
Ito K., Groudine M.
J. Biol. Chem. 272:26780-26786(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
Tissue: Embryo.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Embryo.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: 129/Sv X 129/SvCp.
Tissue: Embryonic stem cell.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U70859 mRNA. Translation: AAB09593.1.
AK077593 mRNA. Translation: BAC36884.1.
AL672308 Genomic DNA. Translation: CAM24958.1.
BC050195 mRNA. Translation: AAH50195.1.
RefSeqNP_031541.1. NM_007515.2.
XP_006527815.1. XM_006527752.1.
XP_006527816.1. XM_006527753.1.
XP_006527817.1. XM_006527754.1.
UniGeneMm.5140.

3D structure databases

ProteinModelPortalP70423.
SMRP70423. Positions 32-369.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-4996965.
STRING10090.ENSMUSP00000109339.

Protein family/group databases

TCDB2.A.3.3.5. the amino acid-polyamine-organocation (apc) family.

PTM databases

PhosphoSiteP70423.

Proteomic databases

PRIDEP70423.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000073927; ENSMUSP00000073582; ENSMUSG00000031297.
ENSMUST00000101362; ENSMUSP00000098914; ENSMUSG00000031297.
ENSMUST00000113710; ENSMUSP00000109339; ENSMUSG00000031297.
GeneID11989.
KEGGmmu:11989.
UCSCuc009twt.1. mouse.

Organism-specific databases

CTD84889.
MGIMGI:1100521. Slc7a3.

Phylogenomic databases

eggNOGCOG0531.
GeneTreeENSGT00700000104437.
HOGENOMHOG000250623.
HOVERGENHBG000280.
InParanoidB1AVE2.
KOK13865.
OMALEYSIAV.
OrthoDBEOG72C501.
PhylomeDBP70423.
TreeFamTF315212.

Gene expression databases

BgeeP70423.
GenevestigatorP70423.

Family and domain databases

InterProIPR002293. AA/rel_permease1.
IPR004755. Cat_AA_permease.
[Graphical view]
PANTHERPTHR11785. PTHR11785. 1 hit.
PfamPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsTIGR00906. 2A0303. 1 hit.
ProtoNetSearch...

Other

NextBio280151.
PROP70423.
SOURCESearch...

Entry information

Entry nameCTR3_MOUSE
AccessionPrimary (citable) accession number: P70423
Secondary accession number(s): B1AVE2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: February 1, 1997
Last modified: April 16, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot