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Protein

CUB and zona pellucida-like domain-containing protein 1

Gene

Cuzd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

CUZD1 antiserum inhibits cell attachment and proliferation of ovarian cancer cells so may be involved in these processes (By similarity). May also play a role in the uterus during late pregnancy and/or in trypsin activation in pancreatic acinar cells.By similarity2 Publications

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • female pregnancy Source: UniProtKB
  • trypsinogen activation Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Cell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
CUB and zona pellucida-like domain-containing protein 1
Short name:
CUB and ZP domain-containing protein 1
Alternative name(s):
Integral membrane-associated protein 1
Gene namesi
Name:Cuzd1Imported
Synonyms:Itmap1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1202881. Cuzd1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 567548ExtracellularSequence analysisAdd
BLAST
Transmembranei568 – 58821HelicalSequence analysisAdd
BLAST
Topological domaini589 – 60618CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • transport vesicle membrane Source: UniProtKB-SubCell
  • zymogen granule Source: MGI
  • zymogen granule membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice display increased severity of secretagogue- and diet-induced pancreatitis which seems to be due to impaired activation of trypsin.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 606587CUB and zona pellucida-like domain-containing protein 1Sequence analysisPRO_0000233332Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi17 ↔ 58PROSITE-ProRule annotation
Glycosylationi22 – 221N-linked (GlcNAc...)Sequence analysis
Glycosylationi57 – 571N-linked (GlcNAc...)Sequence analysis
Glycosylationi67 – 671N-linked (GlcNAc...)Sequence analysis
Disulfide bondi85 ↔ 107PROSITE-ProRule annotation
Disulfide bondi154 ↔ 180PROSITE-ProRule annotation
Disulfide bondi207 ↔ 229PROSITE-ProRule annotation
Glycosylationi418 – 4181N-linked (GlcNAc...)Sequence analysis
Disulfide bondi441 ↔ 497PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP70412.
PaxDbiP70412.
PRIDEiP70412.

PTM databases

PhosphoSiteiP70412.

Expressioni

Tissue specificityi

Highly expressed in pancreatic acinar cells. Also expressed in epithelium of the uterus during late pregnancy but not detected in non-pregnant uterus or in a variety of other adult and fetal tissues.2 Publications

Developmental stagei

First detected in uterus 6 days prior to birth, increases daily to reach maximum levels 3 days before birth, abruptly decreases during the last 3 days of pregnancy and is almost undetectable by the first day after birth.1 Publication

Gene expression databases

CleanExiMM_CUZD1.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037168.

Structurei

3D structure databases

ProteinModelPortaliP70412.
SMRiP70412. Positions 57-261.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 146127CUB 1PROSITE-ProRule annotationAdd
BLAST
Domaini154 – 264111CUB 2PROSITE-ProRule annotationAdd
BLAST
Domaini275 – 518244ZPPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 CUB domains.PROSITE-ProRule annotation
Contains 1 ZP domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHBC. Eukaryota.
ENOG410XQVR. LUCA.
HOVERGENiHBG081378.
InParanoidiP70412.

Family and domain databases

Gene3Di2.60.120.290. 2 hits.
InterProiIPR000859. CUB_dom.
IPR001507. ZP_dom.
[Graphical view]
PfamiPF00431. CUB. 2 hits.
PF00100. Zona_pellucida. 1 hit.
[Graphical view]
PRINTSiPR00023. ZPELLUCIDA.
SMARTiSM00042. CUB. 2 hits.
SM00241. ZP. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 2 hits.
PROSITEiPS01180. CUB. 2 hits.
PS51034. ZP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70412-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVTGRLFIW AILAVSCGAQ LNSTEAEGKS RCTASLGGAN LGETHKALVL
60 70 80 90 100
QLSANENCTW TIERPENRSI RIIFSYIKLD PGSRCETENI KVFDGSSTSG
110 120 130 140 150
PLLGKACSRN DFVPVFESSS NSMTFQIVTG LTKFPRSVFI FYYFFSAATV
160 170 180 190 200
IPNCGGDLRA LEGSFSSPNY PKPHPELAYC VWHIQVGKGY KIQLKFTDLL
210 220 230 240 250
LEMDENCKFD FIAVYDGPST TAGLLKQLCG VEPTLESSSD AMTVVLSTDY
260 270 280 290 300
ANSYKGFSAS YTSIYIHDVN TTSLSCVSDK MRVIISKSYL PALNYNESNL
310 320 330 340 350
QLNDPTCRPN VSNVIEFSIP LHECGTVKKI EDHAISYTNR ITFIESPVSA
360 370 380 390 400
VITRQKLLQI VVTCEMEYNS TVEIMYITED DIIQNQSVLG KYNTSLALYE
410 420 430 440 450
SDSFENLVQE SPYYVDLNQT LFVQATLHTS DPSLVVFLDT CRASPTSDFA
460 470 480 490 500
SPTYDLISSG CCQDETCKVY PLFGHYGRFQ FNAFKFLKHL NSVYLKCKIL
510 520 530 540 550
ICDNNDQTSR CNQGCVPRRK RDIPSYKWKT DSVIGPIRLK RDRSASRDSG
560 570 580 590 600
LLPQIHEAEI SNQPLSRLYL FSFMVLALNV VIVAITTVKH FLNRWMDHRY

QKLQVY
Length:606
Mass (Da):68,082
Last modified:March 1, 2001 - v2
Checksum:i22C1F0A139B9E2B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69699 mRNA. Translation: AAC24898.2.
AK019038 mRNA. Translation: BAB31520.1.
UniGeneiMm.142717.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69699 mRNA. Translation: AAC24898.2.
AK019038 mRNA. Translation: BAB31520.1.
UniGeneiMm.142717.

3D structure databases

ProteinModelPortaliP70412.
SMRiP70412. Positions 57-261.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037168.

PTM databases

PhosphoSiteiP70412.

Proteomic databases

MaxQBiP70412.
PaxDbiP70412.
PRIDEiP70412.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1202881. Cuzd1.

Phylogenomic databases

eggNOGiENOG410IHBC. Eukaryota.
ENOG410XQVR. LUCA.
HOVERGENiHBG081378.
InParanoidiP70412.

Miscellaneous databases

PROiP70412.
SOURCEiSearch...

Gene expression databases

CleanExiMM_CUZD1.

Family and domain databases

Gene3Di2.60.120.290. 2 hits.
InterProiIPR000859. CUB_dom.
IPR001507. ZP_dom.
[Graphical view]
PfamiPF00431. CUB. 2 hits.
PF00100. Zona_pellucida. 1 hit.
[Graphical view]
PRINTSiPR00023. ZPELLUCIDA.
SMARTiSM00042. CUB. 2 hits.
SM00241. ZP. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 2 hits.
PROSITEiPS01180. CUB. 2 hits.
PS51034. ZP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCUZD1_MOUSE
AccessioniPrimary (citable) accession number: P70412
Secondary accession number(s): Q9CTZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.