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Protein

Cadherin-10

Gene

Cdh10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-418990. Adherens junctions interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-10
Alternative name(s):
T2-cadherin
Gene namesi
Name:Cdh10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:107436. Cdh10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 613591ExtracellularSequence analysisAdd
BLAST
Transmembranei614 – 63421HelicalSequence analysisAdd
BLAST
Topological domaini635 – 788154CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Propeptidei23 – 5432Sequence analysisPRO_0000269662Add
BLAST
Chaini55 – 788734Cadherin-10PRO_0000126646Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi256 – 2561N-linked (GlcNAc...)Sequence analysis
Glycosylationi456 – 4561N-linked (GlcNAc...)Sequence analysis
Glycosylationi534 – 5341N-linked (GlcNAc...)Sequence analysis
Modified residuei784 – 7841PhosphoserineCombined sources

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP70408.
PaxDbiP70408.
PRIDEiP70408.

PTM databases

iPTMnetiP70408.
PhosphoSiteiP70408.

Expressioni

Developmental stagei

Expressed at all stages of testicular development with highest levels found in fetal gonad.1 Publication

Gene expression databases

BgeeiP70408.
CleanExiMM_CDH10.
ExpressionAtlasiP70408. baseline and differential.
GenevisibleiP70408. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042199.

Structurei

3D structure databases

ProteinModelPortaliP70408.
SMRiP70408. Positions 56-587, 687-782.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini56 – 160105Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini161 – 269109Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini270 – 384115Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini385 – 489105Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini489 – 603115Cadherin 5PROSITE-ProRule annotationAdd
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 5 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118954.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiP70408.
KOiK06802.
OMAiLLWVCLP.
OrthoDBiEOG7GBFW7.
TreeFamiTF329887.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70408-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIYQFLRLF VLWACLPHFC CPELTFRRTP GIQQMTAESR APRSDGKILH
60 70 80 90 100
RQKRGWMWNQ FFLLEEYTGS DYQYVGKLHS DQDKGDGSLK YILSGDGAGT
110 120 130 140 150
LFIIDEKTGD IHATRRIDRE EKAFYTLRAQ AINRRTLRPV EPESEFVIKI
160 170 180 190 200
HDINDNEPTF PEEIYTASVP EMSVVGTSVV QVTATDADDP SYGNSARVIY
210 220 230 240 250
SILQGQPYFS VEPETGIIRT ALPNMNRENK EQYQVVIQAK DMGGQMGGLS
260 270 280 290 300
GTTTVNITLT DVNDNPPRFP QNTIHLRVLE SSPVGTAVGS VKATDADTGK
310 320 330 340 350
NAEVDYRIID GDGTDMFDII TEKDTQEGII TVKKPLDYEN RRLYTLKVEA
360 370 380 390 400
ENTHVDPRFY YLGPFKDTTI VKISIEDVDE PPVFSRSSYL FEVHEDIEVG
410 420 430 440 450
TIIGTVMARD PDSTSSPIRF TLDRHTDLDR IFNIHSGNGS LYTSKPLDRE
460 470 480 490 500
LSQWHNLTVI AAEINNPKET TRVSVFVRIL DVNDNAPQFA VFYDTFVCEN
510 520 530 540 550
ARPGQLIQTI SAVDKDDPLG GQKFFFSLAA VNPNFTVQDN EDNTARILTR
560 570 580 590 600
KNGFNRHEIS TYLLPVVISD NDYPIQSSTG TLTIRVCACD SQGNMQSCSA
610 620 630 640 650
EALLLPAGLS TGALIAILLC IIILLVIVVL FAALKRQRKK EPLILSKEDI
660 670 680 690 700
RDNIVSYNDE GGGEEDTQAF DIGTLRNPAA IEEKKLRRDI IPETLFIPRR
710 720 730 740 750
TPTAPDNTDV RDFINERLKE HDLDPTAPPY DSLATYAYEG NDSVAESLSS
760 770 780
LESGTTEGDQ NYDYLREWGP RFNKLAEMYG GGESDKDA
Length:788
Mass (Da):88,312
Last modified:July 27, 2011 - v3
Checksum:i4066D21DBB038AE1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti142 – 1421P → S in AAH52056 (PubMed:15489334).Curated
Sequence conflicti142 – 1421P → S in AAH62962 (PubMed:15489334).Curated
Sequence conflicti518 – 5258PLGGQKFF → VDRRSFS in AAB87708 (PubMed:8879495).Curated
Sequence conflicti549 – 5491T → A in AAB87708 (PubMed:8879495).Curated
Sequence conflicti607 – 6104AGLS → WPH in AAB87708 (PubMed:8879495).Curated
Sequence conflicti635 – 6395Missing in AAB87708 (PubMed:8879495).Curated
Sequence conflicti699 – 6991Missing in AAB87708 (PubMed:8879495).Curated
Sequence conflicti706 – 7061D → G in AAB87708 (PubMed:8879495).Curated
Sequence conflicti773 – 7731N → K in AAB87708 (PubMed:8879495).Curated
Sequence conflicti788 – 7881A → S in AAB87708 (PubMed:8879495).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK138606 mRNA. Translation: BAE23714.1.
BC052056 mRNA. Translation: AAH52056.1.
BC062962 mRNA. Translation: AAH62962.1.
U69137 mRNA. Translation: AAB87708.1.
CCDSiCCDS37047.1.
RefSeqiNP_001303687.1. NM_001316758.1.
NP_033995.1. NM_009865.3.
UniGeneiMm.117794.
Mm.446240.

Genome annotation databases

EnsembliENSMUST00000040562; ENSMUSP00000042199; ENSMUSG00000022321.
ENSMUST00000166873; ENSMUSP00000128782; ENSMUSG00000022321.
GeneIDi320873.
KEGGimmu:320873.
UCSCiuc007vik.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK138606 mRNA. Translation: BAE23714.1.
BC052056 mRNA. Translation: AAH52056.1.
BC062962 mRNA. Translation: AAH62962.1.
U69137 mRNA. Translation: AAB87708.1.
CCDSiCCDS37047.1.
RefSeqiNP_001303687.1. NM_001316758.1.
NP_033995.1. NM_009865.3.
UniGeneiMm.117794.
Mm.446240.

3D structure databases

ProteinModelPortaliP70408.
SMRiP70408. Positions 56-587, 687-782.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042199.

PTM databases

iPTMnetiP70408.
PhosphoSiteiP70408.

Proteomic databases

MaxQBiP70408.
PaxDbiP70408.
PRIDEiP70408.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040562; ENSMUSP00000042199; ENSMUSG00000022321.
ENSMUST00000166873; ENSMUSP00000128782; ENSMUSG00000022321.
GeneIDi320873.
KEGGimmu:320873.
UCSCiuc007vik.1. mouse.

Organism-specific databases

CTDi1008.
MGIiMGI:107436. Cdh10.

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118954.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiP70408.
KOiK06802.
OMAiLLWVCLP.
OrthoDBiEOG7GBFW7.
TreeFamiTF329887.

Enzyme and pathway databases

ReactomeiR-MMU-418990. Adherens junctions interactions.

Miscellaneous databases

PROiP70408.
SOURCEiSearch...

Gene expression databases

BgeeiP70408.
CleanExiMM_CDH10.
ExpressionAtlasiP70408. baseline and differential.
GenevisibleiP70408. MM.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Spinal cord.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  3. "A comprehensive survey of the cadherins expressed in the testes of fetal, immature, and adult mice utilizing the polymerase chain reaction."
    Munro S.B., Blaschuk O.W.
    Biol. Reprod. 55:822-827(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 516-788, DEVELOPMENTAL STAGE.
    Strain: C57BL/6J.
    Tissue: Testis.
  4. "Characterization of cadherins expressed by murine thymocytes."
    Munro S.B., Duclos A.J., Jackson A.R., Baines M.G., Blaschuk O.W.
    Cell. Immunol. 169:309-312(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 732-771.
    Strain: CBA/J.
    Tissue: Thymocyte.
  5. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-784, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-784, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiCAD10_MOUSE
AccessioniPrimary (citable) accession number: P70408
Secondary accession number(s): Q3UUB3, Q80WS7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: July 27, 2011
Last modified: June 8, 2016
This is version 113 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.