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P70407

- CADH9_MOUSE

UniProt

P70407 - CADH9_MOUSE

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Protein

Cadherin-9

Gene

Cdh9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. homophilic cell adhesion Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-9
Alternative name(s):
T1-cadherin
Gene namesi
Name:Cdh9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:107433. Cdh9.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Propeptidei22 – 5231Sequence AnalysisPRO_0000269661Add
BLAST
Chaini53 – 786734Cadherin-9PRO_0000126645Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi254 – 2541N-linked (GlcNAc...)Sequence Analysis
Glycosylationi454 – 4541N-linked (GlcNAc...)Sequence Analysis
Glycosylationi535 – 5351N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

PRIDEiP70407.

PTM databases

PhosphoSiteiP70407.

Expressioni

Developmental stagei

Not detected in fetal, newborn or 7-day-old testis. Present in 21-day-old and adult testes. Levels are 10-fold higher in adult testis than in testis of 21-day-old animals.1 Publication

Gene expression databases

BgeeiP70407.
CleanExiMM_CDH9.
ExpressionAtlasiP70407. baseline and differential.
GenevestigatoriP70407.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026432.

Structurei

3D structure databases

ProteinModelPortaliP70407.
SMRiP70407. Positions 54-588, 688-782.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 614593ExtracellularSequence AnalysisAdd
BLAST
Topological domaini636 – 786151CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei615 – 63521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini54 – 158105Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini159 – 267109Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini268 – 382115Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini383 – 487105Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini487 – 604118Cadherin 5PROSITE-ProRule annotationAdd
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 5 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG235715.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiP70407.
PhylomeDBiP70407.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70407-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRTYSCLQLV IWTCIFHMVD NSTLQGKDSS HFLRRIVNLK KDEGKMLHRA
60 70 80 90 100
KRGWMWNQFF LLEEYTGTDT QYVGKLHTDQ DKGDGNLKYI LTGDGAGNLF
110 120 130 140 150
VIDENTGDIH AAKRLDREEK SLYILRAKAI DRKTGRQVEP ESEFIIKIHD
160 170 180 190 200
INDNEPKFTK DLYTASVPEM SGVGTSVIQV TATDADDANY GNSAKVVYSI
210 220 230 240 250
LQGQPYFSVD PESGIIKTAL PDMSRENKEQ YQVVIQAKDM GGQMGGLSGT
260 270 280 290 300
TTVNITLTDV NNNPPRFPQS TYQFNSLESA PLGTHLGRIK ANDPDMGENA
310 320 330 340 350
ELEYSIAEGE GSDMFDVITD KDTQEGIITV KQNLDFEKKM LYTLRVDASN
360 370 380 390 400
THPDPRFLHL GPFKDSAMVK ISVEDVDEPP VFSKLSYLME VDEDVKEGSI
410 420 430 440 450
IGQVTAYDPD AMNNIIKYSV DRHTDMDRVF SIHSENGSIF TLKPLDRESS
460 470 480 490 500
PWHNITITAT EINNPKQSSQ IPVFIRILDI NDHAPEFATY YETFVCENAK
510 520 530 540 550
SGQLIQTISV MDKDDPPRGH KFFFEPVPEF PLNPNFTIVD NKDNTAGIVT
560 570 580 590 600
RKDGYSRNKM NTYLLPVLIF DNDYPIQSST GTLTIRVCAC DNLGNMQSCN
610 620 630 640 650
AEALMLAAGL STGALIAILL CVVILLTLIV LFAALKRQRK KEPLIISKDD
660 670 680 690 700
VRDNIVTYND EGGGEEDTQA FDIGTLRNPE AREDSKLRRD VMPETIFQIR
710 720 730 740 750
RTVPLWENID VQDFIHRRLK ENDSDPSAPP YDSLATYAYE GNDSVANSLS
760 770 780
SLESLTADCN QDYDYLSDWG PRFKKLAEMY GGNDSD
Length:786
Mass (Da):88,301
Last modified:December 12, 2006 - v2
Checksum:iD9B1CE63502F87C2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti681 – 6811A → AK in AAB87707. (PubMed:8879495)Curated
Sequence conflicti692 – 6921M → S in AAB87707. (PubMed:8879495)Curated
Sequence conflicti725 – 7273DPS → T in AAB87707. (PubMed:8879495)Curated
Sequence conflicti786 – 7861D → DLN in AAB87707. (PubMed:8879495)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC116724 Genomic DNA. No translation available.
U69136 mRNA. Translation: AAB87707.1.
UniGeneiMm.439758.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC116724 Genomic DNA. No translation available.
U69136 mRNA. Translation: AAB87707.1 .
UniGenei Mm.439758.

3D structure databases

ProteinModelPortali P70407.
SMRi P70407. Positions 54-588, 688-782.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000026432.

PTM databases

PhosphoSitei P70407.

Proteomic databases

PRIDEi P70407.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:107433. Cdh9.

Phylogenomic databases

eggNOGi NOG235715.
HOGENOMi HOG000231252.
HOVERGENi HBG005217.
InParanoidi P70407.
PhylomeDBi P70407.

Miscellaneous databases

PROi P70407.
SOURCEi Search...

Gene expression databases

Bgeei P70407.
CleanExi MM_CDH9.
ExpressionAtlasi P70407. baseline and differential.
Genevestigatori P70407.

Family and domain databases

Gene3Di 2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view ]
Pfami PF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
SMARTi SM00112. CA. 5 hits.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 5 hits.
PROSITEi PS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "A comprehensive survey of the cadherins expressed in the testes of fetal, immature, and adult mice utilizing the polymerase chain reaction."
    Munro S.B., Blaschuk O.W.
    Biol. Reprod. 55:822-827(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 679-786, DEVELOPMENTAL STAGE.
    Strain: C57BL/6.
    Tissue: Testis.
  3. "Characterization of cadherins expressed by murine thymocytes."
    Munro S.B., Duclos A.J., Jackson A.R., Baines M.G., Blaschuk O.W.
    Cell. Immunol. 169:309-312(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 733-772.
    Strain: CBA/J.
    Tissue: Thymocyte.

Entry informationi

Entry nameiCADH9_MOUSE
AccessioniPrimary (citable) accession number: P70407
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: December 12, 2006
Last modified: October 29, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3