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P70407

- CADH9_MOUSE

UniProt

P70407 - CADH9_MOUSE

Protein

Cadherin-9

Gene

Cdh9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. homophilic cell adhesion Source: InterPro

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cadherin-9
    Alternative name(s):
    T1-cadherin
    Gene namesi
    Name:Cdh9
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:107433. Cdh9.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Propeptidei22 – 5231Sequence AnalysisPRO_0000269661Add
    BLAST
    Chaini53 – 786734Cadherin-9PRO_0000126645Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi254 – 2541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi454 – 4541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi535 – 5351N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Cleavage on pair of basic residues, Glycoprotein

    Proteomic databases

    PRIDEiP70407.

    PTM databases

    PhosphoSiteiP70407.

    Expressioni

    Developmental stagei

    Not detected in fetal, newborn or 7-day-old testis. Present in 21-day-old and adult testes. Levels are 10-fold higher in adult testis than in testis of 21-day-old animals.1 Publication

    Gene expression databases

    BgeeiP70407.
    CleanExiMM_CDH9.
    GenevestigatoriP70407.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000026432.

    Structurei

    3D structure databases

    ProteinModelPortaliP70407.
    SMRiP70407. Positions 54-588, 688-782.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 614593ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini636 – 786151CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei615 – 63521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini54 – 158105Cadherin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini159 – 267109Cadherin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini268 – 382115Cadherin 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini383 – 487105Cadherin 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini487 – 604118Cadherin 5PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

    Sequence similaritiesi

    Contains 5 cadherin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG235715.
    HOGENOMiHOG000231252.
    HOVERGENiHBG005217.
    InParanoidiP70407.
    PhylomeDBiP70407.

    Family and domain databases

    Gene3Di2.60.40.60. 5 hits.
    4.10.900.10. 1 hit.
    InterProiIPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR000233. Cadherin_cytoplasmic-dom.
    IPR027397. Catenin_binding_dom.
    [Graphical view]
    PfamiPF00028. Cadherin. 5 hits.
    PF01049. Cadherin_C. 1 hit.
    [Graphical view]
    PRINTSiPR00205. CADHERIN.
    SMARTiSM00112. CA. 5 hits.
    [Graphical view]
    SUPFAMiSSF49313. SSF49313. 5 hits.
    PROSITEiPS00232. CADHERIN_1. 2 hits.
    PS50268. CADHERIN_2. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P70407-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRTYSCLQLV IWTCIFHMVD NSTLQGKDSS HFLRRIVNLK KDEGKMLHRA    50
    KRGWMWNQFF LLEEYTGTDT QYVGKLHTDQ DKGDGNLKYI LTGDGAGNLF 100
    VIDENTGDIH AAKRLDREEK SLYILRAKAI DRKTGRQVEP ESEFIIKIHD 150
    INDNEPKFTK DLYTASVPEM SGVGTSVIQV TATDADDANY GNSAKVVYSI 200
    LQGQPYFSVD PESGIIKTAL PDMSRENKEQ YQVVIQAKDM GGQMGGLSGT 250
    TTVNITLTDV NNNPPRFPQS TYQFNSLESA PLGTHLGRIK ANDPDMGENA 300
    ELEYSIAEGE GSDMFDVITD KDTQEGIITV KQNLDFEKKM LYTLRVDASN 350
    THPDPRFLHL GPFKDSAMVK ISVEDVDEPP VFSKLSYLME VDEDVKEGSI 400
    IGQVTAYDPD AMNNIIKYSV DRHTDMDRVF SIHSENGSIF TLKPLDRESS 450
    PWHNITITAT EINNPKQSSQ IPVFIRILDI NDHAPEFATY YETFVCENAK 500
    SGQLIQTISV MDKDDPPRGH KFFFEPVPEF PLNPNFTIVD NKDNTAGIVT 550
    RKDGYSRNKM NTYLLPVLIF DNDYPIQSST GTLTIRVCAC DNLGNMQSCN 600
    AEALMLAAGL STGALIAILL CVVILLTLIV LFAALKRQRK KEPLIISKDD 650
    VRDNIVTYND EGGGEEDTQA FDIGTLRNPE AREDSKLRRD VMPETIFQIR 700
    RTVPLWENID VQDFIHRRLK ENDSDPSAPP YDSLATYAYE GNDSVANSLS 750
    SLESLTADCN QDYDYLSDWG PRFKKLAEMY GGNDSD 786
    Length:786
    Mass (Da):88,301
    Last modified:December 12, 2006 - v2
    Checksum:iD9B1CE63502F87C2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti681 – 6811A → AK in AAB87707. (PubMed:8879495)Curated
    Sequence conflicti692 – 6921M → S in AAB87707. (PubMed:8879495)Curated
    Sequence conflicti725 – 7273DPS → T in AAB87707. (PubMed:8879495)Curated
    Sequence conflicti786 – 7861D → DLN in AAB87707. (PubMed:8879495)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC116724 Genomic DNA. No translation available.
    U69136 mRNA. Translation: AAB87707.1.
    UniGeneiMm.439758.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC116724 Genomic DNA. No translation available.
    U69136 mRNA. Translation: AAB87707.1 .
    UniGenei Mm.439758.

    3D structure databases

    ProteinModelPortali P70407.
    SMRi P70407. Positions 54-588, 688-782.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000026432.

    PTM databases

    PhosphoSitei P70407.

    Proteomic databases

    PRIDEi P70407.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:107433. Cdh9.

    Phylogenomic databases

    eggNOGi NOG235715.
    HOGENOMi HOG000231252.
    HOVERGENi HBG005217.
    InParanoidi P70407.
    PhylomeDBi P70407.

    Miscellaneous databases

    PROi P70407.
    SOURCEi Search...

    Gene expression databases

    Bgeei P70407.
    CleanExi MM_CDH9.
    Genevestigatori P70407.

    Family and domain databases

    Gene3Di 2.60.40.60. 5 hits.
    4.10.900.10. 1 hit.
    InterProi IPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR000233. Cadherin_cytoplasmic-dom.
    IPR027397. Catenin_binding_dom.
    [Graphical view ]
    Pfami PF00028. Cadherin. 5 hits.
    PF01049. Cadherin_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00205. CADHERIN.
    SMARTi SM00112. CA. 5 hits.
    [Graphical view ]
    SUPFAMi SSF49313. SSF49313. 5 hits.
    PROSITEi PS00232. CADHERIN_1. 2 hits.
    PS50268. CADHERIN_2. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "A comprehensive survey of the cadherins expressed in the testes of fetal, immature, and adult mice utilizing the polymerase chain reaction."
      Munro S.B., Blaschuk O.W.
      Biol. Reprod. 55:822-827(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 679-786, DEVELOPMENTAL STAGE.
      Strain: C57BL/6.
      Tissue: Testis.
    3. "Characterization of cadherins expressed by murine thymocytes."
      Munro S.B., Duclos A.J., Jackson A.R., Baines M.G., Blaschuk O.W.
      Cell. Immunol. 169:309-312(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 733-772.
      Strain: CBA/J.
      Tissue: Thymocyte.

    Entry informationi

    Entry nameiCADH9_MOUSE
    AccessioniPrimary (citable) accession number: P70407
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 25, 2002
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3