P70407 (CADH9_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cadherin-9

Alternative name(s):
T1-cadherin

Gene names

Name:

Cdh9

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	786 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Subcellular location	Cell membrane; Single-pass type I membrane protein Potential.
Developmental stage	Not detected in fetal, newborn or 7-day-old testis. Present in 21-day-old and adult testes. Levels are 10-fold higher in adult testis than in testis of 21-day-old animals. Ref.2
Domain	Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain By similarity.
Sequence similarities	Contains 5 cadherin domains.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell membrane Membrane
Domain	Repeat Signal Transmembrane Transmembrane helix
Ligand	Calcium Metal-binding
PTM	Cleavage on pair of basic residues Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	homophilic cell adhesion Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Propeptide	22 – 52	31	Potential		PRO_0000269661
	Chain	53 – 786	734	Cadherin-9		PRO_0000126645
Regions
	Topological domain	22 – 614	593	Extracellular Potential
	Transmembrane	615 – 635	21	Helical; Potential
	Topological domain	636 – 786	151	Cytoplasmic Potential
	Domain	54 – 158	105	Cadherin 1
	Domain	159 – 267	109	Cadherin 2
	Domain	268 – 382	115	Cadherin 3
	Domain	383 – 487	105	Cadherin 4
	Domain	487 – 604	118	Cadherin 5
Amino acid modifications
	Glycosylation	21	1	N-linked (GlcNAc...) Potential
	Glycosylation	254	1	N-linked (GlcNAc...) Potential
	Glycosylation	454	1	N-linked (GlcNAc...) Potential
	Glycosylation	535	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	681	1	A → AK in AAB87707. Ref.2
	Sequence conflict	692	1	M → S in AAB87707. Ref.2
	Sequence conflict	725 – 727	3	DPS → T in AAB87707. Ref.2
	Sequence conflict	786	1	D → DLN in AAB87707. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P70407 [UniParc]. Last modified December 12, 2006. Version 2. Checksum: D9B1CE63502F87C2	FASTA	786	88,301
	10 20 30 40 50 60 MRTYSCLQLV IWTCIFHMVD NSTLQGKDSS HFLRRIVNLK KDEGKMLHRA KRGWMWNQFF 70 80 90 100 110 120 LLEEYTGTDT QYVGKLHTDQ DKGDGNLKYI LTGDGAGNLF VIDENTGDIH AAKRLDREEK 130 140 150 160 170 180 SLYILRAKAI DRKTGRQVEP ESEFIIKIHD INDNEPKFTK DLYTASVPEM SGVGTSVIQV 190 200 210 220 230 240 TATDADDANY GNSAKVVYSI LQGQPYFSVD PESGIIKTAL PDMSRENKEQ YQVVIQAKDM 250 260 270 280 290 300 GGQMGGLSGT TTVNITLTDV NNNPPRFPQS TYQFNSLESA PLGTHLGRIK ANDPDMGENA 310 320 330 340 350 360 ELEYSIAEGE GSDMFDVITD KDTQEGIITV KQNLDFEKKM LYTLRVDASN THPDPRFLHL 370 380 390 400 410 420 GPFKDSAMVK ISVEDVDEPP VFSKLSYLME VDEDVKEGSI IGQVTAYDPD AMNNIIKYSV 430 440 450 460 470 480 DRHTDMDRVF SIHSENGSIF TLKPLDRESS PWHNITITAT EINNPKQSSQ IPVFIRILDI 490 500 510 520 530 540 NDHAPEFATY YETFVCENAK SGQLIQTISV MDKDDPPRGH KFFFEPVPEF PLNPNFTIVD 550 560 570 580 590 600 NKDNTAGIVT RKDGYSRNKM NTYLLPVLIF DNDYPIQSST GTLTIRVCAC DNLGNMQSCN 610 620 630 640 650 660 AEALMLAAGL STGALIAILL CVVILLTLIV LFAALKRQRK KEPLIISKDD VRDNIVTYND 670 680 690 700 710 720 EGGGEEDTQA FDIGTLRNPE AREDSKLRRD VMPETIFQIR RTVPLWENID VQDFIHRRLK 730 740 750 760 770 780 ENDSDPSAPP YDSLATYAYE GNDSVANSLS SLESLTADCN QDYDYLSDWG PRFKKLAEMY GGNDSD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[2]	"A comprehensive survey of the cadherins expressed in the testes of fetal, immature, and adult mice utilizing the polymerase chain reaction." Munro S.B., Blaschuk O.W. Biol. Reprod. 55:822-827(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 679-786, DEVELOPMENTAL STAGE. Strain: C57BL/6. Tissue: Testis.
[3]	"Characterization of cadherins expressed by murine thymocytes." Munro S.B., Duclos A.J., Jackson A.R., Baines M.G., Blaschuk O.W. Cell. Immunol. 169:309-312(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 733-772. Strain: CBA/J. Tissue: Thymocyte.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC116724 Genomic DNA. No translation available. U69136 mRNA. Translation: AAB87707.1.
IPI	IPI00109177.
UniGene	Mm.439758.
3D structure databases
ProteinModelPortal	P70407.
SMR	P70407. Positions 54-588, 688-782.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000026432.
PTM databases
PhosphoSite	P70407.
Proteomic databases
PRIDE	P70407.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	uc011zro.1. mouse.
Organism-specific databases
MGI	MGI:107433. Cdh9.
Phylogenomic databases
eggNOG	NOG235715.
HOGENOM	HOG000231252.
HOVERGEN	HBG005217.
InParanoid	P70407.
OrthoDB	EOG4CZBF8.
Gene expression databases
ArrayExpress	P70407.
Bgee	P70407.
CleanEx	MM_CDH9.
Genevestigator	P70407.
GermOnline	ENSMUSG00000025370. Mus musculus.
Family and domain databases
Gene3D	2.60.40.60. 5 hits.
InterPro	IPR002126. Cadherin. IPR015919. Cadherin-like. IPR020894. Cadherin_CS. IPR000233. Cadherin_cytoplasmic-dom. [Graphical view]
Pfam	PF00028. Cadherin. 5 hits. PF01049. Cadherin_C. 1 hit. [Graphical view]
PRINTS	PR00205. CADHERIN.
SMART	SM00112. CA. 5 hits. [Graphical view]
SUPFAM	SSF49313. Cadherin. 5 hits.
PROSITE	PS00232. CADHERIN_1. 2 hits. PS50268. CADHERIN_2. 5 hits. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

CADH9_MOUSE

Accession

Primary (citable) accession number: P70407

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 25, 2002
Last sequence update:	December 12, 2006
Last modified:	May 1, 2013
This is version 94 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program