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Protein

Mitochondrial uncoupling protein 2

Gene

Ucp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-MMU-167826. The fatty acid cycling model.
R-MMU-167827. The proton buffering model.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial uncoupling protein 2
Short name:
UCP 2
Alternative name(s):
Solute carrier family 25 member 8
UCPH
Gene namesi
Name:Ucp2
Synonyms:Slc25a8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:109354. Ucp2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10Mitochondrial matrixSequence analysis10
Transmembranei11 – 32Helical; Name=1Sequence analysisAdd BLAST22
Topological domaini33 – 77Mitochondrial intermembraneSequence analysisAdd BLAST45
Transmembranei78 – 100Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini101 – 119Mitochondrial matrixSequence analysisAdd BLAST19
Transmembranei120 – 136Helical; Name=3Sequence analysisAdd BLAST17
Topological domaini137 – 180Mitochondrial intermembraneSequence analysisAdd BLAST44
Transmembranei181 – 197Helical; Name=4Sequence analysisAdd BLAST17
Topological domaini198 – 214Mitochondrial matrixSequence analysisAdd BLAST17
Transmembranei215 – 234Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini235 – 268Mitochondrial intermembraneSequence analysisAdd BLAST34
Transmembranei269 – 291Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini292 – 309Mitochondrial matrixSequence analysisAdd BLAST18

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: UniProtKB-SubCell
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906651 – 309Mitochondrial uncoupling protein 2Add BLAST309

Proteomic databases

EPDiP70406.
PaxDbiP70406.
PRIDEiP70406.

PTM databases

PhosphoSitePlusiP70406.

Expressioni

Tissue specificityi

Highest in white adipose tissue, also detected in brown adipose tissue, heart and kidney. 4-6 times higher levels are detected in ob/ob and db/db mice.

Gene expression databases

BgeeiENSMUSG00000033685.
ExpressionAtlasiP70406. baseline and differential.
GenevisibleiP70406. MM.

Interactioni

Subunit structurei

Acts as a dimer forming a proton channel.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000120967.

Structurei

Secondary structure

1309
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi16 – 29Combined sources14
Helixi32 – 40Combined sources9
Helixi50 – 53Combined sources4
Helixi62 – 73Combined sources12
Helixi75 – 79Combined sources5
Helixi82 – 95Combined sources14
Turni96 – 98Combined sources3
Helixi99 – 107Combined sources9
Helixi116 – 133Combined sources18
Helixi136 – 146Combined sources11
Beta strandi153 – 155Combined sources3
Helixi159 – 170Combined sources12
Helixi172 – 202Combined sources31
Turni203 – 208Combined sources6
Helixi214 – 242Combined sources29
Beta strandi247 – 249Combined sources3
Helixi253 – 262Combined sources10
Helixi267 – 270Combined sources4
Helixi274 – 295Combined sources22
Helixi301 – 306Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LCKNMR-A14-309[»]
ProteinModelPortaliP70406.
SMRiP70406.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati11 – 106Solcar 1Add BLAST96
Repeati114 – 203Solcar 2Add BLAST90
Repeati212 – 297Solcar 3Add BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni276 – 298Purine nucleotide bindingBy similarityAdd BLAST23

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0753. Eukaryota.
ENOG410XRV1. LUCA.
GeneTreeiENSGT00760000119170.
HOGENOMiHOG000165140.
HOVERGENiHBG009528.
InParanoidiP70406.
KOiK15103.
OMAiLLKAHLM.
OrthoDBiEOG091G0BQ7.
PhylomeDBiP70406.
TreeFamiTF323211.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00784. MTUNCOUPLING.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70406-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGFKATDVP PTATVKFLGA GTAACIADLI TFPLDTAKVR LQIQGESQGL
60 70 80 90 100
VRTAASAQYR GVLGTILTMV RTEGPRSLYN GLVAGLQRQM SFASVRIGLY
110 120 130 140 150
DSVKQFYTKG SEHAGIGSRL LAGSTTGALA VAVAQPTDVV KVRFQAQARA
160 170 180 190 200
GGGRRYQSTV EAYKTIAREE GIRGLWKGTS PNVARNAIVN CAELVTYDLI
210 220 230 240 250
KDTLLKANLM TDDLPCHFTS AFGAGFCTTV IASPVDVVKT RYMNSALGQY
260 270 280 290 300
HSAGHCALTM LRKEGPRAFY KGFMPSFLRL GSWNVVMFVT YEQLKRALMA

AYQSREAPF
Length:309
Mass (Da):33,374
Last modified:February 1, 1997 - v1
Checksum:i329794EEA99810E5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti285V → I in BAA32532 (PubMed:9710252).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69135 mRNA. Translation: AAB17666.1.
U94593 mRNA. Translation: AAB53092.1.
AB012159 Genomic DNA. Translation: BAA32532.1.
BC012697 mRNA. Translation: AAH12697.1.
BC012967 mRNA. Translation: AAH12967.1.
CCDSiCCDS21498.1.
RefSeqiNP_035801.3. NM_011671.5.
XP_006507642.1. XM_006507579.2.
UniGeneiMm.171378.

Genome annotation databases

EnsembliENSMUST00000126534; ENSMUSP00000120967; ENSMUSG00000033685.
GeneIDi22228.
KEGGimmu:22228.
UCSCiuc009inb.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69135 mRNA. Translation: AAB17666.1.
U94593 mRNA. Translation: AAB53092.1.
AB012159 Genomic DNA. Translation: BAA32532.1.
BC012697 mRNA. Translation: AAH12697.1.
BC012967 mRNA. Translation: AAH12967.1.
CCDSiCCDS21498.1.
RefSeqiNP_035801.3. NM_011671.5.
XP_006507642.1. XM_006507579.2.
UniGeneiMm.171378.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LCKNMR-A14-309[»]
ProteinModelPortaliP70406.
SMRiP70406.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000120967.

PTM databases

PhosphoSitePlusiP70406.

Proteomic databases

EPDiP70406.
PaxDbiP70406.
PRIDEiP70406.

Protocols and materials databases

DNASUi22228.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000126534; ENSMUSP00000120967; ENSMUSG00000033685.
GeneIDi22228.
KEGGimmu:22228.
UCSCiuc009inb.3. mouse.

Organism-specific databases

CTDi7351.
MGIiMGI:109354. Ucp2.

Phylogenomic databases

eggNOGiKOG0753. Eukaryota.
ENOG410XRV1. LUCA.
GeneTreeiENSGT00760000119170.
HOGENOMiHOG000165140.
HOVERGENiHBG009528.
InParanoidiP70406.
KOiK15103.
OMAiLLKAHLM.
OrthoDBiEOG091G0BQ7.
PhylomeDBiP70406.
TreeFamiTF323211.

Enzyme and pathway databases

ReactomeiR-MMU-167826. The fatty acid cycling model.
R-MMU-167827. The proton buffering model.

Miscellaneous databases

ChiTaRSiUcp2. mouse.
PROiP70406.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033685.
ExpressionAtlasiP70406. baseline and differential.
GenevisibleiP70406. MM.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00784. MTUNCOUPLING.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUCP2_MOUSE
AccessioniPrimary (citable) accession number: P70406
Secondary accession number(s): O88285
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 30, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.