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P70406

- UCP2_MOUSE

UniProt

P70406 - UCP2_MOUSE

Protein

Mitochondrial uncoupling protein 2

Gene

Ucp2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat By similarity.By similarity

    GO - Biological processi

    1. aging Source: Ensembl
    2. cellular response to amino acid starvation Source: Ensembl
    3. cellular response to glucose stimulus Source: Ensembl
    4. cellular response to insulin stimulus Source: Ensembl
    5. female pregnancy Source: Ensembl
    6. liver regeneration Source: Ensembl
    7. mitochondrial transport Source: Ensembl
    8. negative regulation of apoptotic process Source: Ensembl
    9. negative regulation of insulin secretion involved in cellular response to glucose stimulus Source: Ensembl
    10. positive regulation of cell death Source: Ensembl
    11. regulation of mitochondrial membrane potential Source: ParkinsonsUK-UCL
    12. response to fatty acid Source: Ensembl
    13. response to hypoxia Source: Ensembl
    14. response to superoxide Source: Ensembl

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    ReactomeiREACT_208819. The proton buffering model.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial uncoupling protein 2
    Short name:
    UCP 2
    Alternative name(s):
    Solute carrier family 25 member 8
    UCPH
    Gene namesi
    Name:Ucp2
    Synonyms:Slc25a8
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:109354. Ucp2.

    Subcellular locationi

    Mitochondrion inner membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 309309Mitochondrial uncoupling protein 2PRO_0000090665Add
    BLAST

    Proteomic databases

    PaxDbiP70406.
    PRIDEiP70406.

    PTM databases

    PhosphoSiteiP70406.

    Expressioni

    Tissue specificityi

    Highest in white adipose tissue, also detected in brown adipose tissue, heart and kidney. 4-6 times higher levels are detected in ob/ob and db/db mice.

    Gene expression databases

    ArrayExpressiP70406.
    BgeeiP70406.
    GenevestigatoriP70406.

    Interactioni

    Subunit structurei

    Acts as a dimer forming a proton channel.By similarity

    Structurei

    Secondary structure

    1
    309
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi16 – 2914
    Helixi32 – 409
    Helixi50 – 534
    Helixi62 – 7312
    Helixi75 – 795
    Helixi82 – 9514
    Turni96 – 983
    Helixi99 – 1079
    Helixi116 – 13318
    Helixi136 – 14611
    Beta strandi153 – 1553
    Helixi159 – 17012
    Helixi172 – 20231
    Turni203 – 2086
    Helixi214 – 24229
    Beta strandi247 – 2493
    Helixi253 – 26210
    Helixi267 – 2704
    Helixi274 – 29522
    Helixi301 – 3066

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2LCKNMR-A14-309[»]
    ProteinModelPortaliP70406.
    SMRiP70406. Positions 14-308.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1010Mitochondrial matrixSequence Analysis
    Topological domaini33 – 7745Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini101 – 11919Mitochondrial matrixSequence AnalysisAdd
    BLAST
    Topological domaini137 – 18044Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini198 – 21417Mitochondrial matrixSequence AnalysisAdd
    BLAST
    Topological domaini235 – 26834Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini292 – 30918Mitochondrial matrixSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3222Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei78 – 10023Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei120 – 13617Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei181 – 19717Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei215 – 23420Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei269 – 29123Helical; Name=6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati11 – 10696Solcar 1Add
    BLAST
    Repeati114 – 20390Solcar 2Add
    BLAST
    Repeati212 – 29786Solcar 3Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni276 – 29823Purine nucleotide bindingBy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 3 Solcar repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG300436.
    HOGENOMiHOG000165140.
    HOVERGENiHBG009528.
    InParanoidiP70406.
    KOiK15103.
    OMAiSPNIARN.
    OrthoDBiEOG793B7Z.
    PhylomeDBiP70406.
    TreeFamiTF323211.

    Family and domain databases

    Gene3Di1.50.40.10. 1 hit.
    InterProiIPR002030. Mit_uncoupling.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view]
    PfamiPF00153. Mito_carr. 3 hits.
    [Graphical view]
    PRINTSiPR00784. MTUNCOUPLING.
    SUPFAMiSSF103506. SSF103506. 1 hit.
    PROSITEiPS50920. SOLCAR. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P70406-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVGFKATDVP PTATVKFLGA GTAACIADLI TFPLDTAKVR LQIQGESQGL    50
    VRTAASAQYR GVLGTILTMV RTEGPRSLYN GLVAGLQRQM SFASVRIGLY 100
    DSVKQFYTKG SEHAGIGSRL LAGSTTGALA VAVAQPTDVV KVRFQAQARA 150
    GGGRRYQSTV EAYKTIAREE GIRGLWKGTS PNVARNAIVN CAELVTYDLI 200
    KDTLLKANLM TDDLPCHFTS AFGAGFCTTV IASPVDVVKT RYMNSALGQY 250
    HSAGHCALTM LRKEGPRAFY KGFMPSFLRL GSWNVVMFVT YEQLKRALMA 300
    AYQSREAPF 309
    Length:309
    Mass (Da):33,374
    Last modified:February 1, 1997 - v1
    Checksum:i329794EEA99810E5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti285 – 2851V → I in BAA32532. (PubMed:9710252)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U69135 mRNA. Translation: AAB17666.1.
    U94593 mRNA. Translation: AAB53092.1.
    AB012159 Genomic DNA. Translation: BAA32532.1.
    BC012697 mRNA. Translation: AAH12697.1.
    BC012967 mRNA. Translation: AAH12967.1.
    CCDSiCCDS21498.1.
    RefSeqiNP_035801.3. NM_011671.4.
    XP_006507642.1. XM_006507579.1.
    UniGeneiMm.171378.

    Genome annotation databases

    EnsembliENSMUST00000126534; ENSMUSP00000120967; ENSMUSG00000033685.
    GeneIDi22228.
    KEGGimmu:22228.
    UCSCiuc009inb.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U69135 mRNA. Translation: AAB17666.1 .
    U94593 mRNA. Translation: AAB53092.1 .
    AB012159 Genomic DNA. Translation: BAA32532.1 .
    BC012697 mRNA. Translation: AAH12697.1 .
    BC012967 mRNA. Translation: AAH12967.1 .
    CCDSi CCDS21498.1.
    RefSeqi NP_035801.3. NM_011671.4.
    XP_006507642.1. XM_006507579.1.
    UniGenei Mm.171378.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2LCK NMR - A 14-309 [» ]
    ProteinModelPortali P70406.
    SMRi P70406. Positions 14-308.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P70406.

    Proteomic databases

    PaxDbi P70406.
    PRIDEi P70406.

    Protocols and materials databases

    DNASUi 22228.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000126534 ; ENSMUSP00000120967 ; ENSMUSG00000033685 .
    GeneIDi 22228.
    KEGGi mmu:22228.
    UCSCi uc009inb.2. mouse.

    Organism-specific databases

    CTDi 7351.
    MGIi MGI:109354. Ucp2.

    Phylogenomic databases

    eggNOGi NOG300436.
    HOGENOMi HOG000165140.
    HOVERGENi HBG009528.
    InParanoidi P70406.
    KOi K15103.
    OMAi SPNIARN.
    OrthoDBi EOG793B7Z.
    PhylomeDBi P70406.
    TreeFami TF323211.

    Enzyme and pathway databases

    Reactomei REACT_208819. The proton buffering model.

    Miscellaneous databases

    ChiTaRSi UCP2. mouse.
    NextBioi 302263.
    PROi P70406.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P70406.
    Bgeei P70406.
    Genevestigatori P70406.

    Family and domain databases

    Gene3Di 1.50.40.10. 1 hit.
    InterProi IPR002030. Mit_uncoupling.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view ]
    Pfami PF00153. Mito_carr. 3 hits.
    [Graphical view ]
    PRINTSi PR00784. MTUNCOUPLING.
    SUPFAMi SSF103506. SSF103506. 1 hit.
    PROSITEi PS50920. SOLCAR. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Raimbault S., Bouillaud F., Ricquier D.
      Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BALB/c.
      Tissue: Muscle.
    2. "Cloning and characterization of an uncoupling protein homolog: a potential molecular mediator of human thermogenesis."
      Gimeno R.E., Dembski M., Weng X., Deng N., Shyjan A.W., Gimeno C.J., Iris F., Ellis S.J., Woolf E.A., Tartaglia L.A.
      Diabetes 46:900-906(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Spleen.
    3. "Genomic organization and promoter function of the mouse uncoupling protein 2 (UCP2) gene."
      Yamada M., Hashida T., Shibusawa N., Iwasaki T., Murakami M., Monden T., Satoh T., Mori M.
      FEBS Lett. 432:65-69(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: C57BL/6 X CBA.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Colon and Mammary gland.
    5. "Mitochondrial uncoupling protein 2 structure determined by NMR molecular fragment searching."
      Berardi M.J., Shih W.M., Harrison S.C., Chou J.J.
      Nature 476:109-113(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 14-309, SUBCELLULAR LOCATION, TOPOLOGY.

    Entry informationi

    Entry nameiUCP2_MOUSE
    AccessioniPrimary (citable) accession number: P70406
    Secondary accession number(s): O88285
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3