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Reviewed, UniProtKB/Swiss-Prot P70404 (IDH3G_MOUSE)

Last modified November 25, 2008. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
    EC=1.1.1.41
Alternative name(s):
    Isocitric dehydrogenase
    NAD(+)-specific ICDH
Gene names
Name: Idh3g
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMus

Protein attributes

Sequence length393 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Catalytic activity

Isocitrate + NAD(+) = 2-oxoglutarate + CO(2) + NADH.

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity.

Enzyme regulation

Activated by increasing ADP/ATP ratios and by Ca(2+) By similarity.

Subunit structure

Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1 By similarity.

Subcellular location

Mitochondrion.

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3939Mitochondrion By similarity
Chain40 – 393354Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
PRO_0000014451

Regions

Nucleotide binding56 – 8429NAD Potential
Nucleotide binding309 – 3168ATP Potential

Sites

Metal binding2541Magnesium or manganese By similarity
Binding site1361Substrate By similarity
Binding site1671Substrate By similarity
Binding site2541Substrate By similarity
Site1741Critical for catalysis By similarity
Site2211Critical for catalysis By similarity

Amino acid modifications

Modified residue3631Phosphothreonine

Sequences

Sequence LengthMass (Da)Tools
P70404-1 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 4023560C44C1F4D3

FASTA39342,785
        10         20         30         40         50         60 
MALKVAIAAG GAAKAMLKPT LLCRPWEVLA AHVAPRRSIS SQQTIPPSAK YGGRHTVTMI 

        70         80         90        100        110        120 
PGDGIGPELM LHVKSVFRHA CVPVDFEEVH VSSNADEEDI RNAIMAIRRN RVALKGNIET 

       130        140        150        160        170        180 
NHNLPPSHKS RNNILRTSLD LYANVIHCKS LPGVVTRHKD IDILIVRENT EGEYSSLEHE 

       190        200        210        220        230        240 
SVAGVVESLK IITKAKSLRI AEYAFKLAQE SGRKKVTAVH KANIMKLGDG LFLQCCREVA 

       250        260        270        280        290        300 
AHYPQITFDS MIVDNTTMQL VSRPQQFDVM VMPNLYGNIV NNVCAGLVGG PGLVAGANYG 

       310        320        330        340        350        360 
HVYAVFETAT RNTGKSIANK NIANPTATLL ASCMMLDHLK LHSYATSIRK AVLASMDNEN 

       370        380        390 
MHTPDIGGQG TTSQAIQDII RHIRIINGRA VEA 

« Hide

References

« Hide 'large scale' references
[1]"Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse."
Brenner V., Nyakatura G., Rosenthal A., Platzer M.
Genomics 44:8-14(1997) [PubMed: 9286695] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Comparative sequence analysis of the mouse L1cam locus and the corresponding region of human Xq28."
Platzer M., Brenner V., Reichwald K., Wiehe T., Oksche A., Rosenthal A.
Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[3]Lubec G., Kang S.U.
Submitted (APR-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 102-108; 116-129; 150-190 AND 227-237, MASS SPECTROMETRY.
Strain: C57BL/6.
Tissue: Brain.
[4]"Proteomic analysis of in vivo phosphorylated synaptic proteins."
Collins M.O., Yu L., Coba M.P., Husi H., Campuzano I., Blackstock W.P., Choudhary J.S., Grant S.G.
J. Biol. Chem. 280:5972-5982(2005) [PubMed: 15572359] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-363, MASS SPECTROMETRY.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

U68564 mRNA. Translation: AAC53340.1.
AF133093 Genomic DNA. No translation available.
RefSeqNP_032349.1.
UniGeneMm.14825

3D structure databases

HSSPHSSP built from PDB template 1OSJ based on UniProtKB P00351.
ModBaseSearch...

PTM databases

PhosphoSiteP70404.

Genome annotation databases

EnsemblENSMUSG00000002010. Mus musculus. [Contig view]
GeneID15929.
KEGGmmu:15929.

Organism-specific databases

MGIMGI:1099463. Idh3g.

Phylogenomic databases

HOGENOMP70404.
HOVERGENP70404.

Gene expression databases

ArrayExpressP70404.
CleanExMM_IDH3G.
GermOnlineENSMUSG00000002010. Mus musculus.

Family and domain databases

InterProIPR004434. IsoCit_DHase_NAD_mit.
IPR001804. IsoCit_IM_DHase.
[Graphical view]
Gene3DG3DSA:3.40.718.10. IDH_IMDH. 1 hit.
PANTHERPTHR11835. IDH_IMDH_dimeric. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR00175. mito_nad_idh. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio288644.
SOURCESearch...

Entry information

Entry nameIDH3G_MOUSE
AccessionPrimary (citable) accession number: P70404
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 25, 2008
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents