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Protein

Protein CASP

Gene

Cux1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in intra-Golgi retrograde transport.By similarity

GO - Molecular functioni

  • chromatin binding Source: MGI
  • DNA binding Source: MGI
  • sequence-specific DNA binding Source: MGI
  • transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding Source: MGI

GO - Biological processi

  • inner ear auditory receptor cell differentiation Source: MGI
  • intra-Golgi vesicle-mediated transport Source: InterPro
  • kidney development Source: MGI
  • lung development Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: MGI

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CASP
Gene namesi
Name:Cux1
Synonyms:Cutl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:88568 Cux1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 619CytoplasmicSequence analysisAdd BLAST619
Transmembranei620 – 640Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini641 – 678LumenalSequence analysisAdd BLAST38

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000717911 – 678Protein CASPAdd BLAST678

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei586PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

EPDiP70403
MaxQBiP70403
PaxDbiP70403
PeptideAtlasiP70403
PRIDEiP70403

PTM databases

iPTMnetiP70403

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

CleanExiMM_CUX1

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with GOLGA5 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000004097

Structurei

3D structure databases

SMRiP70403
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili16 – 40Sequence analysisAdd BLAST25
Coiled coili67 – 374Sequence analysisAdd BLAST308
Coiled coili427 – 454Sequence analysisAdd BLAST28
Coiled coili502 – 556Sequence analysisAdd BLAST55

Sequence similaritiesi

Belongs to the CASP family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0963 Eukaryota
KOG2252 Eukaryota
ENOG410XPRP LUCA
HOVERGENiHBG053415

Family and domain databases

InterProiView protein in InterPro
IPR012955 CASP_C
PfamiView protein in Pfam
PF08172 CASP_C, 1 hit

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P70403-1) [UniParc]FASTAAdd to basket
Also known as: CASP

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAANVGSMSQ YWKRFDLQQL QRELDAAATV LANRQDESEQ SRKRLIEQSR
60 70 80 90 100
EFKKNTPEDL RKQVAPLLKS FQGEIDALSK RSKEAEAAFL TVYKRLIDVP
110 120 130 140 150
DPVPALDVGQ QLEIKVQRLH DIETENQKLR ETLEEYNKEF AEVKNQEVTI
160 170 180 190 200
KALKEKIREY EQTLKSQAET IALEKEQKLQ NDFAEKERKL QETQMSTTSK
210 220 230 240 250
LEEAEHKLQT LQTALEKTRT ELFDLKTKYD EETTAKADEI EMIMTDLERA
260 270 280 290 300
NQRAEVAQRE AETLREQLSS ANHSLQLASQ IQKAPDVEQA IEVLTRSSLE
310 320 330 340 350
VELAAKEREI AQLVEDVQRL QASLTKLREN SASQISQLEQ QLNAKNSTLK
360 370 380 390 400
QLEEKLKGQA DYEEVKKELN TLKSMEFAPS EGAGTQDSTK PLEVLLLEKN
410 420 430 440 450
RSLQSENATL RISNSDLSGR CAELQIHLTE ATAKAVEQKE LIARLEQDLS
460 470 480 490 500
TIQSIQRPDA EGASEQGLEK IPEPIKEATA LFYGPSMSSS GTLPEGQVDS
510 520 530 540 550
LLSIISSQRE RFRTRNQELE AESRMAQHTI QALQSELDSL RADNIKLFEK
560 570 580 590 600
IKFLQSYPGR GIGSDDTELR YSSQYEERLD PFSSFSKRER QRKYLGLSPW
610 620 630 640 650
DKATLGMGRL ILSNKTARTI GFFYTLFLHC LVFLVLYKLA WSESVERDCA
660 670
ATCAKKFADH LHKFHESDNG AAAGDLWQ
Length:678
Mass (Da):77,269
Last modified:January 10, 2006 - v2
Checksum:iC04905EE48CC2D37
GO
Isoform 5 (identifier: P53564-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P53564.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,515
Mass (Da):165,596
GO
Isoform 2 (identifier: P53564-2) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P53564.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,413
Mass (Da):154,697
GO
Isoform 3 (identifier: P53564-3) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P53564.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: No experimental confirmation available.
Length:1,504
Mass (Da):164,487
GO
Isoform 4 (identifier: P53564-4) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P53564.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,332
Mass (Da):144,361
GO
Isoform 6 (identifier: P53564-5) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P53564.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:460
Mass (Da):49,021
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9S → F in AAH14289 (PubMed:15489334).Curated1
Sequence conflicti27A → T in AAH14289 (PubMed:15489334).Curated1
Sequence conflicti27A → T in AAH54370 (PubMed:15489334).Curated1
Sequence conflicti288 – 289Missing in AAB08430 (PubMed:9332351).Curated2
Sequence conflicti288 – 289Missing in AAH54370 (PubMed:15489334).Curated2
Sequence conflicti616T → M in AAH54370 (PubMed:15489334).Curated1
Sequence conflicti621G → S in AAH54370 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U68542 mRNA Translation: AAB08430.1
BC014289 mRNA Translation: AAH14289.1
BC054370 mRNA Translation: AAH54370.1
CCDSiCCDS71685.1 [P70403-1]
UniGeneiMm.320317
Mm.436792

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCASP_MOUSE
AccessioniPrimary (citable) accession number: P70403
Secondary accession number(s): Q7TQJ4, Q91WN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 10, 2006
Last modified: March 28, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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