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Protein

Myosin-binding protein H

Gene

Mybph

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to myosin; probably involved in interaction with thick myofilaments in the A-band.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-binding protein H
Short name:
MyBP-H
Alternative name(s):
H-protein
Gene namesi
Name:Mybph
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1858196. Mybph.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Thick filament

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 483483Myosin-binding protein HPRO_0000072699Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21PhosphothreonineBy similarity
Modified residuei6 – 61PhosphothreonineBy similarity
Modified residuei26 – 261PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP70402.
PaxDbiP70402.
PRIDEiP70402.

2D gel databases

SWISS-2DPAGEP70402.

PTM databases

iPTMnetiP70402.
PhosphoSiteiP70402.

Expressioni

Tissue specificityi

Skeletal muscle.

Gene expression databases

BgeeiP70402.
CleanExiMM_MYBPH.
GenevisibleiP70402. MM.

Interactioni

Protein-protein interaction databases

BioGridi207275. 1 interaction.
STRINGi10090.ENSMUSP00000042195.

Structurei

3D structure databases

ProteinModelPortaliP70402.
SMRiP70402. Positions 78-369, 387-470.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini79 – 17496Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini178 – 26689Ig-like C2-type 1Add
BLAST
Domaini275 – 37096Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini388 – 47285Ig-like C2-type 2Add
BLAST

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. MyBP family.Curated
Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiENOG410IF9Q. Eukaryota.
ENOG410YAE6. LUCA.
GeneTreeiENSGT00840000129685.
HOGENOMiHOG000290713.
HOVERGENiHBG056788.
InParanoidiP70402.
OMAiKMNIQGD.
OrthoDBiEOG7VDXP6.
TreeFamiTF334735.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
PS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70402-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGKATSEAS VSTPEETAPE PAKVPTTEPS GEVAASESTG QEQAPEPQKP
60 70 80 90 100
QAQDPAAPAA SAMPAATKPE PPSEDVPSAP LRLTLEDVSH SSLTVSWEPP
110 120 130 140 150
EKLGKLGLQG YVLEFCREGA SEWVPVNPRP VMVTQQTVRN LALGDKFFLR
160 170 180 190 200
VTAVSSAGAG PPAVLDQPVH IQEITEAPKI RVPRHLRQTY IRQVGESVNL
210 220 230 240 250
QIPFQGKPKP QVSWTHNGHA LDNQRVNVRS GDQDSILFIR SAQRADSGRY
260 270 280 290 300
ELTVHLEGLE AKASIDILVI EKPGPPSSIK LLDVWGCNAA LEWTPPQDTG
310 320 330 340 350
NTELLGYTVQ KADKRTGQWF TVLERYHPTT CTISDLIIGN SYSFRVFSEN
360 370 380 390 400
LCGLSDLATT TKELAHIHKA DITAKPREFI ERDFSEAPSF TQPLADHTST
410 420 430 440 450
PGYSTQLFCS VRASPKPKII WMKNKMDIQG DPKYRAVSEQ GVCTLEIRKP
460 470 480
SPFDSGVYTC KAINVLGEAS VDCRLEVKAS ATH
Length:483
Mass (Da):52,641
Last modified:July 27, 2011 - v2
Checksum:iC8E8653EBEC6F169
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti249 – 2491R → C in AAB08426 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U68267 mRNA. Translation: AAB08426.1.
AC137104 Genomic DNA. No translation available.
CCDSiCCDS35713.1.
RefSeqiNP_058029.2. NM_016749.2.
XP_006529817.1. XM_006529754.1.
UniGeneiMm.379067.

Genome annotation databases

EnsembliENSMUST00000038445; ENSMUSP00000042195; ENSMUSG00000042451.
ENSMUST00000191577; ENSMUSP00000141104; ENSMUSG00000042451.
GeneIDi53311.
KEGGimmu:53311.
UCSCiuc007crh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U68267 mRNA. Translation: AAB08426.1.
AC137104 Genomic DNA. No translation available.
CCDSiCCDS35713.1.
RefSeqiNP_058029.2. NM_016749.2.
XP_006529817.1. XM_006529754.1.
UniGeneiMm.379067.

3D structure databases

ProteinModelPortaliP70402.
SMRiP70402. Positions 78-369, 387-470.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207275. 1 interaction.
STRINGi10090.ENSMUSP00000042195.

PTM databases

iPTMnetiP70402.
PhosphoSiteiP70402.

2D gel databases

SWISS-2DPAGEP70402.

Proteomic databases

MaxQBiP70402.
PaxDbiP70402.
PRIDEiP70402.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038445; ENSMUSP00000042195; ENSMUSG00000042451.
ENSMUST00000191577; ENSMUSP00000141104; ENSMUSG00000042451.
GeneIDi53311.
KEGGimmu:53311.
UCSCiuc007crh.1. mouse.

Organism-specific databases

CTDi4608.
MGIiMGI:1858196. Mybph.

Phylogenomic databases

eggNOGiENOG410IF9Q. Eukaryota.
ENOG410YAE6. LUCA.
GeneTreeiENSGT00840000129685.
HOGENOMiHOG000290713.
HOVERGENiHBG056788.
InParanoidiP70402.
OMAiKMNIQGD.
OrthoDBiEOG7VDXP6.
TreeFamiTF334735.

Miscellaneous databases

ChiTaRSiMybph. mouse.
PROiP70402.
SOURCEiSearch...

Gene expression databases

BgeeiP70402.
CleanExiMM_MYBPH.
GenevisibleiP70402. MM.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
PS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Ramos C.H.I., Fischman D.A., Reinach F.C.
    Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiMYBPH_MOUSE
AccessioniPrimary (citable) accession number: P70402
Secondary accession number(s): E9QKH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 27, 2011
Last modified: June 8, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.