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P70397 (DLX6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein DLX-6
Gene names
Name:Dlx6
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length175 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Nucleus Potential.

Sequence similarities

Belongs to the distal-less homeobox family.

Contains 1 homeobox DNA-binding domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P70397-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P70397-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MMTMTTMADG...HRSLAAYPYM

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 175175Homeobox protein DLX-6
PRO_0000049035

Regions

DNA binding49 – 10860Homeobox

Natural variations

Alternative sequence11M → MMTMTTMADGLEGQDSSKSA FMEFGQQQQQQQQQQQQQQQ QQQQQQQPPPPPPPPPPQPH SQQTSPAMAGAHYPLHCLHS AAAAAAAAGSHHHHHQHHHH GSPYASSGGNSYNHRSLAAY PYM in isoform 2.
VSP_040733

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 10, 2007. Version 3.
Checksum: 55542638D7E0CA42

FASTA17519,677
        10         20         30         40         50         60 
MSHSQHSPYL QSYHNSSAAA QTRGDDTDQQ KTTVIENGEI RFNGKGKKIR KPRTIYSSLQ 

        70         80         90        100        110        120 
LQALNHRFQQ TQYLALPERA ELAASLGLTQ TQVKIWFQNK RSKFKKLLKQ GSNPHESDPL 

       130        140        150        160        170 
PGSAALSPRS PALPPVWDVS ASAKGVSMPP NSYMPGYSHW YSSPHQDTMQ RPQMM 

« Hide

Isoform 2 [UniParc].

Checksum: 4C6B6988CC62805E
Show »

FASTA29733,011

References

« Hide 'large scale' references
[1]"Expression and function of Dlx genes in the osteoblast lineage."
Li H., Marijanovic I., Kronenberg M.S., Erceg I., Stover M.L., Velonis D., Mina M., Heinrich J.G., Harris S.E., Upholt W.B., Kalajzic I., Lichtler A.C.
Dev. Biol. 316:458-470(2008) [PubMed: 18280462] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Strain: C57BL/6.
Tissue: Femur.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Tissue: Branchial arch region.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-175 (ISOFORM 1).
[4]"Dlx genes encode DNA-binding proteins that are expressed in an overlapping and sequential pattern during basal ganglia differentiation."
Liu J.K., Ghattas I., Liu S., Chen S., Rubenstein J.L.R.
Dev. Dyn. 210:498-512(1997) [PubMed: 9415433] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 18-175 (ISOFORM 1).
Tissue: Branchial arch region.
[5]"The evolution of the vertebrate Dlx gene family."
Stock D.W., Ellies D.L., Zhao Z., Ekker M., Ruddle F.H., Weiss K.M.
Proc. Natl. Acad. Sci. U.S.A. 93:10858-10863(1996) [PubMed: 8855272] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 53-175 (ISOFORM 1).
Strain: Swiss Webster.
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EF535989 mRNA. Translation: ABQ10645.1.
AC122240 Genomic DNA. No translation available.
BC114342 mRNA. Translation: AAI14343.1.
AF022078 mRNA. Translation: AAB94583.1.
U67841 mRNA. Translation: AAC52844.1.
IPIIPI00661823.
IPI00970646.
RefSeqNP_034187.1. NM_010057.2.
UniGeneMm.439763.

3D structure databases

ProteinModelPortalP70397.
SMRP70397. Positions 46-106.
ModBaseSearch...

Protein-protein interaction databases

STRINGP70397.

Proteomic databases

PRIDEP70397.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000031768; ENSMUSP00000031768; ENSMUSG00000029754.
ENSMUST00000160937; ENSMUSP00000124204; ENSMUSG00000029754.
ENSMUST00000171311; ENSMUSP00000128585; ENSMUSG00000029754.
GeneID13396.
KEGGmmu:13396.

Organism-specific databases

CTD1750.
MGIMGI:101927. Dlx6.

Phylogenomic databases

eggNOGroNOG09568.
GeneTreeENSGT00590000082824.
HOVERGENHBG005493.
InParanoidP70397.
OrthoDBEOG4QJRP4.

Gene expression databases

ArrayExpressP70397.
BgeeP70397.
CleanExMM_DLX6.
GenevestigatorP70397.
GermOnlineENSMUSG00000029754. Mus musculus.

Family and domain databases

InterProIPR001356. Homeobox.
IPR017970. Homeobox_CS.
IPR020479. Homeobox_eu.
IPR009057. Homeodomain-like.
IPR012287. Homeodomain-rel.
IPR000047. HTH_motif.
[Graphical view]
Gene3DG3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
KOK09314.
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. Homeodomain_like. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry nameDLX6_MOUSE
AccessionPrimary (citable) accession number: P70397
Secondary accession number(s): A0AUM1, A5HKN2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 10, 2007
Last modified: December 14, 2011
This is version 89 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families