Reviewed, UniProtKB/Swiss-Prot P70397 (DLX6_MOUSE)

Names and origin

Protein names

Recommended name:
    Homeobox protein DLX-6

Gene names

Name:

Dlx6

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	175 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Nucleus Potential.
Sequence similarities	Belongs to the distal-less homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	anatomical structure formation involved in morphogenesis Inferred from genetic interaction. Source: MGI embryonic limb morphogenesis Inferred from genetic interaction. Source: MGI epithelial cell differentiation Inferred from genetic interaction. Source: MGI inner ear morphogenesis Inferred from genetic interaction. Source: MGI positive regulation of epithelial cell proliferation Inferred from genetic interaction. Source: MGI regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	18 – 175	158	Homeobox protein DLX-6		PRO_0000049035
Regions
	DNA binding	49 – 108	60	Homeobox

Sequences

	Sequence		Length	Mass (Da)
	P70397-1 [UniParc]. Last modified July 10, 2007. Version 3. Checksum: 55542638D7E0CA42	FASTA	175	19,677
	10 20 30 40 50 60 MSHSQHSPYL QSYHNSSAAA QTRGDDTDQQ KTTVIENGEI RFNGKGKKIR KPRTIYSSLQ 70 80 90 100 110 120 LQALNHRFQQ TQYLALPERA ELAASLGLTQ TQVKIWFQNK RSKFKKLLKQ GSNPHESDPL 130 140 150 160 170 PGSAALSPRS PALPPVWDVS ASAKGVSMPP NSYMPGYSHW YSSPHQDTMQ RPQMM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	The mouse genome sequencing consortium Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Tissue: Branchial arch region.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-175.
[3]	"Dlx genes encode DNA-binding proteins that are expressed in an overlapping and sequential pattern during basal ganglia differentiation." Liu J.K., Ghattas I., Liu S., Chen S., Rubenstein J.L.R. Dev. Dyn. 210:498-512(1997) [PubMed: 9415433] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 18-175. Tissue: Branchial arch region.
[4]	"The evolution of the vertebrate Dlx gene family." Stock D.W., Ellies D.L., Zhao Z., Ekker M., Ruddle F.H., Weiss K.M. Proc. Natl. Acad. Sci. U.S.A. 93:10858-10863(1996) [PubMed: 8855272] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 53-175. Strain: Swiss Webster. Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AC122240 Genomic DNA. No translation available. BC114342 mRNA. Translation: AAI14343.1. AF022078 mRNA. Translation: AAB94583.1. U67841 mRNA. Translation: AAC52844.1.
IPI	IPI00661823.
UniGene	Mm.439763
3D structure databases
HSSP	HSSP built from PDB template 3HDD based on UniProtKB P02836.
SMR	P70397. Positions 29-89.
ModBase	Search...
Genome annotation databases
Ensembl	ENSMUSG00000029754. Mus musculus. [Contig view]
Organism-specific databases
MGI	MGI:101927. Dlx6.
Phylogenomic databases
HOGENOM	P70397.
HOVERGEN	P70397.
Gene expression databases
ArrayExpress	P70397.
Bgee	P70397.
CleanEx	MM_DLX6.
GermOnline	ENSMUSG00000029754. Mus musculus.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR012287. Homeodomain-rel. IPR000047. HTH_lambrepressr. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00031. HTHREPRESSR.
ProDom	PD000010. Homeobox. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

DLX6_MOUSE

Accession

Primary (citable) accession number: P70397
Secondary accession number(s): A0AUM1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	July 10, 2007
Last modified:	June 16, 2009
This is version 63 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)