Homeobox protein DLX-6 - Mus musculus (Mouse)

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Sequences

References

Cross-references

Entry information

Relevant documents

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Sequences

References

Cross-references

Entry information

Relevant documents

Molecule processing

Regions

Natural variations

Preferred order of sections

Molecule processing

Regions

Natural variations

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

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P70397 (DLX6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 89. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Protein names

Recommended name:
Homeobox protein DLX-6

Gene names

Name:

Dlx6

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Sequence length	175 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Subcellular location

Nucleus Potential.

Sequence similarities

Belongs to the distal-less homeobox family.

Contains 1 homeobox DNA-binding domain.

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	anatomical structure formation involved in morphogenesis Inferred from genetic interaction. Source: MGI embryonic limb morphogenesis Inferred from genetic interaction. Source: MGI epithelial cell differentiation Inferred from genetic interaction. Source: MGI head development Inferred from genetic interaction. Source: MGI inner ear morphogenesis Inferred from genetic interaction. Source: MGI positive regulation of epithelial cell proliferation Inferred from genetic interaction. Source: MGI
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro transcription regulatory region sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Chain

1 – 175

175

Homeobox protein DLX-6

PRO_0000049035

DNA binding

49 – 108

Homeobox

Alternative sequence

M → MMTMTTMADGLEGQDSSKSA FMEFGQQQQQQQQQQQQQQQ QQQQQQQPPPPPPPPPPQPH SQQTSPAMAGAHYPLHCLHS AAAAAAAAGSHHHHHQHHHH GSPYASSGGNSYNHRSLAAY PYM in isoform 2.

VSP_040733

Sequence		Length	Mass (Da)
Isoform 1 [UniParc]. Last modified July 10, 2007. Version 3. Checksum: 55542638D7E0CA42 Show »	FASTA	175	19,677
10 20 30 40 50 60 MSHSQHSPYL QSYHNSSAAA QTRGDDTDQQ KTTVIENGEI RFNGKGKKIR KPRTIYSSLQ 70 80 90 100 110 120 LQALNHRFQQ TQYLALPERA ELAASLGLTQ TQVKIWFQNK RSKFKKLLKQ GSNPHESDPL 130 140 150 160 170 PGSAALSPRS PALPPVWDVS ASAKGVSMPP NSYMPGYSHW YSSPHQDTMQ RPQMM « Hide
Isoform 2 [UniParc]. Checksum: 4C6B6988CC62805E Show »	FASTA	297	33,011
10 20 30 40 50 60 MMTMTTMADG LEGQDSSKSA FMEFGQQQQQ QQQQQQQQQQ QQQQQQQPPP PPPPPPPQPH 70 80 90 100 110 120 SQQTSPAMAG AHYPLHCLHS AAAAAAAAGS HHHHHQHHHH GSPYASSGGN SYNHRSLAAY 130 140 150 160 170 180 PYMSHSQHSP YLQSYHNSSA AAQTRGDDTD QQKTTVIENG EIRFNGKGKK IRKPRTIYSS 190 200 210 220 230 240 LQLQALNHRF QQTQYLALPE RAELAASLGL TQTQVKIWFQ NKRSKFKKLL KQGSNPHESD 250 260 270 280 290 PLPGSAALSP RSPALPPVWD VSASAKGVSM PPNSYMPGYS HWYSSPHQDT MQRPQMM « Hide

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression and function of Dlx genes in the osteoblast lineage." Li H., Marijanovic I., Kronenberg M.S., Erceg I., Stover M.L., Velonis D., Mina M., Heinrich J.G., Harris S.E., Upholt W.B., Kalajzic I., Lichtler A.C. Dev. Biol. 316:458-470(2008) [PubMed: 18280462] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Strain: C57BL/6. Tissue: Femur.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Tissue: Branchial arch region.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-175 (ISOFORM 1).
[4]	"Dlx genes encode DNA-binding proteins that are expressed in an overlapping and sequential pattern during basal ganglia differentiation." Liu J.K., Ghattas I., Liu S., Chen S., Rubenstein J.L.R. Dev. Dyn. 210:498-512(1997) [PubMed: 9415433] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 18-175 (ISOFORM 1). Tissue: Branchial arch region.
[5]	"The evolution of the vertebrate Dlx gene family." Stock D.W., Ellies D.L., Zhao Z., Ekker M., Ruddle F.H., Weiss K.M. Proc. Natl. Acad. Sci. U.S.A. 93:10858-10863(1996) [PubMed: 8855272] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 53-175 (ISOFORM 1). Strain: Swiss Webster. Tissue: Embryo.
+	Additional computationally mapped references.

Sequence databases
EMBL GenBank DDBJ	EF535989 mRNA. Translation: ABQ10645.1. AC122240 Genomic DNA. No translation available. BC114342 mRNA. Translation: AAI14343.1. AF022078 mRNA. Translation: AAB94583.1. U67841 mRNA. Translation: AAC52844.1.
IPI	IPI00661823. IPI00970646.
RefSeq	NP_034187.1. NM_010057.2.
UniGene	Mm.439763.
3D structure databases
ProteinModelPortal	P70397.
SMR	P70397. Positions 46-106.
ModBase	Search...
Protein-protein interaction databases
STRING	P70397.
Proteomic databases
PRIDE	P70397.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000031768; ENSMUSP00000031768; ENSMUSG00000029754. ENSMUST00000160937; ENSMUSP00000124204; ENSMUSG00000029754. ENSMUST00000171311; ENSMUSP00000128585; ENSMUSG00000029754.
GeneID	13396.
KEGG	mmu:13396.
Organism-specific databases
CTD	1750.
MGI	MGI:101927. Dlx6.
Phylogenomic databases
eggNOG	roNOG09568.
GeneTree	ENSGT00590000082824.
HOVERGEN	HBG005493.
InParanoid	P70397.
OrthoDB	EOG4QJRP4.
Gene expression databases
ArrayExpress	P70397.
Bgee	P70397.
CleanEx	MM_DLX6.
Genevestigator	P70397.
GermOnline	ENSMUSG00000029754. Mus musculus.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR020479. Homeobox_eu. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. IPR000047. HTH_motif. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
KO	K09314.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX. PR00031. HTHREPRESSR.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry name

DLX6_MOUSE

Accession

Primary (citable) accession number: P70397
Secondary accession number(s): A0AUM1, A5HKN2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	July 10, 2007
Last modified:	December 14, 2011
This is version 89 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P70397-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P70397-2)

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MMTMTTMADG...HRSLAAYPYM