Reviewed,
UniProtKB/Swiss-Prot P70397 (DLX6_MOUSE)
Last modified
June 16, 2009.
Version 63.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Homeobox protein DLX-6 | ||
| Gene names |
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| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 175 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Subcellular location | Nucleus Potential. |
| Sequence similarities | Belongs to the distal-less homeobox family. Contains 1 homeobox DNA-binding domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Nucleus |
| Domain | Homeobox |
| Ligand | DNA-binding |
| Molecular function | Developmental protein |
| Gene Ontology (GO) | |
| Biological process | anatomical structure formation involved in morphogenesis Inferred from genetic interaction. Source: MGI embryonic limb morphogenesisInferred from genetic interaction. Source: MGI epithelial cell differentiationInferred from genetic interaction. Source: MGI inner ear morphogenesisInferred from genetic interaction. Source: MGI positive regulation of epithelial cell proliferationInferred from genetic interaction. Source: MGI regulation of transcription, DNA-dependentInferred from electronic annotation. Source: InterPro |
| Cellular component | nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | The mouse genome sequencing consortium Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Tissue: Branchial arch region. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-175. |
| [3] | "Dlx genes encode DNA-binding proteins that are expressed in an overlapping and sequential pattern during basal ganglia differentiation." Liu J.K., Ghattas I., Liu S., Chen S., Rubenstein J.L.R. Dev. Dyn. 210:498-512(1997) [PubMed: 9415433] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 18-175. Tissue: Branchial arch region. |
| [4] | "The evolution of the vertebrate Dlx gene family." Stock D.W., Ellies D.L., Zhao Z., Ekker M., Ruddle F.H., Weiss K.M. Proc. Natl. Acad. Sci. U.S.A. 93:10858-10863(1996) [PubMed: 8855272] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 53-175. Strain: Swiss Webster. Tissue: Embryo. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AC122240 Genomic DNA. No translation available. BC114342 mRNA. Translation: AAI14343.1. AF022078 mRNA. Translation: AAB94583.1. U67841 mRNA. Translation: AAC52844.1. | |
| IPI | IPI00661823. |
| UniGene | Mm.439763 |
3D structure databases | |
| HSSP | HSSP built from PDB template 3HDD based on UniProtKB P02836. |
| SMR | P70397. Positions 29-89. |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSMUSG00000029754. Mus musculus. [Contig view] |
Organism-specific databases | |
| MGI | MGI:101927. Dlx6. |
Phylogenomic databases | |
| HOGENOM | P70397. |
| HOVERGEN | P70397. |
Gene expression databases | |
| ArrayExpress | P70397. |
| Bgee | P70397. |
| CleanEx | MM_DLX6. |
| GermOnline | ENSMUSG00000029754. Mus musculus. |
Family and domain databases | |
| InterPro | IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR012287. Homeodomain-rel. IPR000047. HTH_lambrepressr. [Graphical view] |
| Gene3D | G3DSA:1.10.10.60. Homeodomain-rel. 1 hit. |
| Pfam | PF00046. Homeobox. 1 hit. [Graphical view] |
| PRINTS | PR00031. HTHREPRESSR. |
| ProDom | PD000010. Homeobox. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00389. HOX. 1 hit. [Graphical view] |
| PROSITE | PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| SOURCE | Search... |
Entry information
| Entry name | DLX6_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P70397 Secondary accession number(s): A0AUM1 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


