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P70390

- SHOX2_MOUSE

UniProt

P70390 - SHOX2_MOUSE

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Protein

Short stature homeobox protein 2

Gene
Shox2, Og12x, Prx3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

May be a growth regulator and have a role in specifying neural systems involved in processing somatosensory information, as well as in face and body structure formation. May also have a role in heart development.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi140 – 19960HomeoboxAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding transcription factor activity Source: InterPro
  2. transcription regulatory region sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. cardiac atrium morphogenesis Source: MGI
  2. cartilage development involved in endochondral bone morphogenesis Source: MGI
  3. chondrocyte development Source: MGI
  4. chondrocyte differentiation Source: MGI
  5. embryonic digestive tract morphogenesis Source: MGI
  6. embryonic forelimb morphogenesis Source: MGI
  7. embryonic limb morphogenesis Source: MGI
  8. embryonic morphogenesis Source: MGI
  9. embryonic skeletal joint morphogenesis Source: MGI
  10. heart valve development Source: MGI
  11. muscle tissue morphogenesis Source: BHF-UCL
  12. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  13. osteoblast differentiation Source: MGI
  14. positive regulation of axonogenesis Source: BHF-UCL
  15. positive regulation of mesenchymal cell proliferation Source: MGI
  16. positive regulation of skeletal muscle fiber development Source: BHF-UCL
  17. positive regulation of smoothened signaling pathway Source: MGI
  18. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  19. regulation of branching morphogenesis of a nerve Source: BHF-UCL
  20. regulation of chondrocyte differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Short stature homeobox protein 2
Alternative name(s):
Homeobox protein Og12X
Short name:
OG-12
Paired family homeodomain protein Prx3
Gene namesi
Name:Shox2
Synonyms:Og12x, Prx3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1201673. Shox2.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 331331Short stature homeobox protein 2PRO_0000049293Add
BLAST

Proteomic databases

PaxDbiP70390.
PRIDEiP70390.

PTM databases

PhosphoSiteiP70390.

Expressioni

Tissue specificityi

Highly expressed in striated muscle followed by liver, kidney, testis, brain, heart, lung and spleen.

Developmental stagei

Expressed from E9 TO E16 day in the heart, otic region, maxillary and mandibular components of the first branchial arch, nasal processes, eyelid, midbrain, medulla oblongata, limbs, dorsal root ganglia and genital tubercle. Also expressed in non-neuronal structures around the oral cavity and in hip and shoulder regions and in mesenchyme surrounding the vertebrae.1 Publication

Gene expression databases

ArrayExpressiP70390.
BgeeiP70390.
CleanExiMM_SHOX2.
GenevestigatoriP70390.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029422.

Structurei

3D structure databases

ProteinModelPortaliP70390.
SMRiP70390. Positions 140-198.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi313 – 32614OARAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi59 – 8224Poly-GlyAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG113578.
GeneTreeiENSGT00750000117318.
HOGENOMiHOG000231518.
HOVERGENiHBG007233.
InParanoidiP70390.
KOiK09331.
OMAiEPTGCAE.
OrthoDBiEOG7J1817.
PhylomeDBiP70390.
TreeFamiTF350757.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
IPR003654. OAR_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view]
PRINTSiPR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P70390-1) [UniParc]FASTAAdd to Basket

Also known as: OG12A, PRX3A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEELTAFVSK SFDQKVKEKK EAITYREVLE SGPLRGAKEP GCVEPGRDDR    50
SSPAVRAAGG GGGAGGGGGG GGGGGGGAGG GGAGGGAGGG RSPVRELDMG 100
AAERSREPGS PRLTEVSPEL KDRKDDAKGM EDEGQTKIKQ RRSRTNFTLE 150
QLNELERLFD ETHYPDAFMR EELSQRLGLS EARVQVWFQN RRAKCRKQEN 200
QLHKGVLIGA ASQFEACRVA PYVNVGALRM PFQQDSHCNV TPLSFQVQAQ 250
LQLDSAVAHA HHHLHPHLAA HAPYMMFPAP PFGLPLATLA ADSASAASVV 300
AAAAAAKTTS KNSSIADLRL KAKKHAAALG L 331
Length:331
Mass (Da):34,905
Last modified:February 1, 1997 - v1
Checksum:iD24D297E1D73A025
GO
Isoform 2 (identifier: P70390-2) [UniParc]FASTAAdd to Basket

Also known as: OG12B, PRX3B

The sequence of this isoform differs from the canonical sequence as follows:
     235-246: Missing.

Show »
Length:319
Mass (Da):33,576
Checksum:i0172F8C6825A0023
GO

Sequence cautioni

The sequence AAC52831.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAC52832.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei235 – 24612Missing in isoform 2. VSP_002289Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U66918 mRNA. Translation: AAC52833.1.
U67055 mRNA. Translation: AAC52834.1.
U65071 Genomic DNA. No translation available.
U65072 Genomic DNA. Translation: AAC52831.1. Different initiation.
U65072 Genomic DNA. Translation: AAC52832.1. Different initiation.
CCDSiCCDS17393.1. [P70390-1]
RefSeqiNP_038693.1. NM_013665.1. [P70390-1]
XP_006501277.1. XM_006501214.1. [P70390-2]
XP_006501281.1. XM_006501218.1.
UniGeneiMm.39093.

Genome annotation databases

EnsembliENSMUST00000029422; ENSMUSP00000029422; ENSMUSG00000027833. [P70390-1]
GeneIDi20429.
KEGGimmu:20429.
UCSCiuc008pld.1. mouse. [P70390-2]
uc008ple.2. mouse. [P70390-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U66918 mRNA. Translation: AAC52833.1 .
U67055 mRNA. Translation: AAC52834.1 .
U65071 Genomic DNA. No translation available.
U65072 Genomic DNA. Translation: AAC52831.1 . Different initiation.
U65072 Genomic DNA. Translation: AAC52832.1 . Different initiation.
CCDSi CCDS17393.1. [P70390-1 ]
RefSeqi NP_038693.1. NM_013665.1. [P70390-1 ]
XP_006501277.1. XM_006501214.1. [P70390-2 ]
XP_006501281.1. XM_006501218.1.
UniGenei Mm.39093.

3D structure databases

ProteinModelPortali P70390.
SMRi P70390. Positions 140-198.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000029422.

PTM databases

PhosphoSitei P70390.

Proteomic databases

PaxDbi P70390.
PRIDEi P70390.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029422 ; ENSMUSP00000029422 ; ENSMUSG00000027833 . [P70390-1 ]
GeneIDi 20429.
KEGGi mmu:20429.
UCSCi uc008pld.1. mouse. [P70390-2 ]
uc008ple.2. mouse. [P70390-1 ]

Organism-specific databases

CTDi 6474.
MGIi MGI:1201673. Shox2.

Phylogenomic databases

eggNOGi NOG113578.
GeneTreei ENSGT00750000117318.
HOGENOMi HOG000231518.
HOVERGENi HBG007233.
InParanoidi P70390.
KOi K09331.
OMAi EPTGCAE.
OrthoDBi EOG7J1817.
PhylomeDBi P70390.
TreeFami TF350757.

Miscellaneous databases

NextBioi 298446.
PROi P70390.
SOURCEi Search...

Gene expression databases

ArrayExpressi P70390.
Bgeei P70390.
CleanExi MM_SHOX2.
Genevestigatori P70390.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
IPR003654. OAR_dom.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view ]
PRINTSi PR00031. HTHREPRESSR.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Embryo.
  2. "Cloning and characterization of four murine homeobox genes."
    Rovescalli A.C., Asoh S., Nirenberg M.W.
    Proc. Natl. Acad. Sci. U.S.A. 93:10691-10696(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 116-331 AND 235-331 (ISOFORMS 1 AND 2).
    Strain: BALB/c.
    Tissue: Embryo and Liver.
  3. "A new human homeobox gene OG12X is a member of the most conserved homeobox gene family and is expressed during heart development in mouse."
    Semina E.V., Reiter R.S., Murray J.C.
    Hum. Mol. Genet. 7:415-422(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiSHOX2_MOUSE
AccessioniPrimary (citable) accession number: P70390
Secondary accession number(s): P70369
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: February 1, 1997
Last modified: July 9, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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