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P70390

- SHOX2_MOUSE

UniProt

P70390 - SHOX2_MOUSE

Protein

Short stature homeobox protein 2

Gene

Shox2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    May be a growth regulator and have a role in specifying neural systems involved in processing somatosensory information, as well as in face and body structure formation. May also have a role in heart development.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi140 – 19960HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding transcription factor activity Source: InterPro
    2. transcription regulatory region sequence-specific DNA binding Source: InterPro

    GO - Biological processi

    1. cardiac atrium morphogenesis Source: MGI
    2. cartilage development involved in endochondral bone morphogenesis Source: MGI
    3. chondrocyte development Source: MGI
    4. chondrocyte differentiation Source: MGI
    5. embryonic digestive tract morphogenesis Source: MGI
    6. embryonic forelimb morphogenesis Source: MGI
    7. embryonic limb morphogenesis Source: MGI
    8. embryonic morphogenesis Source: MGI
    9. embryonic skeletal joint morphogenesis Source: MGI
    10. heart valve development Source: MGI
    11. muscle tissue morphogenesis Source: BHF-UCL
    12. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    13. osteoblast differentiation Source: MGI
    14. positive regulation of axonogenesis Source: BHF-UCL
    15. positive regulation of mesenchymal cell proliferation Source: MGI
    16. positive regulation of skeletal muscle fiber development Source: BHF-UCL
    17. positive regulation of smoothened signaling pathway Source: MGI
    18. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    19. regulation of branching morphogenesis of a nerve Source: BHF-UCL
    20. regulation of chondrocyte differentiation Source: MGI

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Short stature homeobox protein 2
    Alternative name(s):
    Homeobox protein Og12X
    Short name:
    OG-12
    Paired family homeodomain protein Prx3
    Gene namesi
    Name:Shox2
    Synonyms:Og12x, Prx3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1201673. Shox2.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 331331Short stature homeobox protein 2PRO_0000049293Add
    BLAST

    Proteomic databases

    PaxDbiP70390.
    PRIDEiP70390.

    PTM databases

    PhosphoSiteiP70390.

    Expressioni

    Tissue specificityi

    Highly expressed in striated muscle followed by liver, kidney, testis, brain, heart, lung and spleen.

    Developmental stagei

    Expressed from E9 TO E16 day in the heart, otic region, maxillary and mandibular components of the first branchial arch, nasal processes, eyelid, midbrain, medulla oblongata, limbs, dorsal root ganglia and genital tubercle. Also expressed in non-neuronal structures around the oral cavity and in hip and shoulder regions and in mesenchyme surrounding the vertebrae.1 Publication

    Gene expression databases

    ArrayExpressiP70390.
    BgeeiP70390.
    CleanExiMM_SHOX2.
    GenevestigatoriP70390.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000029422.

    Structurei

    3D structure databases

    ProteinModelPortaliP70390.
    SMRiP70390. Positions 140-198.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi313 – 32614OARAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi59 – 8224Poly-GlyAdd
    BLAST

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG113578.
    GeneTreeiENSGT00750000117318.
    HOGENOMiHOG000231518.
    HOVERGENiHBG007233.
    InParanoidiP70390.
    KOiK09331.
    OMAiEPTGCAE.
    OrthoDBiEOG7J1817.
    PhylomeDBiP70390.
    TreeFamiTF350757.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR000047. HTH_motif.
    IPR003654. OAR_dom.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF03826. OAR. 1 hit.
    [Graphical view]
    PRINTSiPR00031. HTHREPRESSR.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS50803. OAR. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P70390-1) [UniParc]FASTAAdd to Basket

    Also known as: OG12A, PRX3A

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEELTAFVSK SFDQKVKEKK EAITYREVLE SGPLRGAKEP GCVEPGRDDR    50
    SSPAVRAAGG GGGAGGGGGG GGGGGGGAGG GGAGGGAGGG RSPVRELDMG 100
    AAERSREPGS PRLTEVSPEL KDRKDDAKGM EDEGQTKIKQ RRSRTNFTLE 150
    QLNELERLFD ETHYPDAFMR EELSQRLGLS EARVQVWFQN RRAKCRKQEN 200
    QLHKGVLIGA ASQFEACRVA PYVNVGALRM PFQQDSHCNV TPLSFQVQAQ 250
    LQLDSAVAHA HHHLHPHLAA HAPYMMFPAP PFGLPLATLA ADSASAASVV 300
    AAAAAAKTTS KNSSIADLRL KAKKHAAALG L 331
    Length:331
    Mass (Da):34,905
    Last modified:February 1, 1997 - v1
    Checksum:iD24D297E1D73A025
    GO
    Isoform 2 (identifier: P70390-2) [UniParc]FASTAAdd to Basket

    Also known as: OG12B, PRX3B

    The sequence of this isoform differs from the canonical sequence as follows:
         235-246: Missing.

    Show »
    Length:319
    Mass (Da):33,576
    Checksum:i0172F8C6825A0023
    GO

    Sequence cautioni

    The sequence AAC52831.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAC52832.1 differs from that shown. Reason: Erroneous initiation.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei235 – 24612Missing in isoform 2. 2 PublicationsVSP_002289Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U66918 mRNA. Translation: AAC52833.1.
    U67055 mRNA. Translation: AAC52834.1.
    U65071 Genomic DNA. No translation available.
    U65072 Genomic DNA. Translation: AAC52831.1. Different initiation.
    U65072 Genomic DNA. Translation: AAC52832.1. Different initiation.
    CCDSiCCDS17393.1. [P70390-1]
    RefSeqiNP_038693.1. NM_013665.1. [P70390-1]
    XP_006501277.1. XM_006501214.1. [P70390-2]
    XP_006501281.1. XM_006501218.1.
    UniGeneiMm.39093.

    Genome annotation databases

    EnsembliENSMUST00000029422; ENSMUSP00000029422; ENSMUSG00000027833. [P70390-1]
    GeneIDi20429.
    KEGGimmu:20429.
    UCSCiuc008pld.1. mouse. [P70390-2]
    uc008ple.2. mouse. [P70390-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U66918 mRNA. Translation: AAC52833.1 .
    U67055 mRNA. Translation: AAC52834.1 .
    U65071 Genomic DNA. No translation available.
    U65072 Genomic DNA. Translation: AAC52831.1 . Different initiation.
    U65072 Genomic DNA. Translation: AAC52832.1 . Different initiation.
    CCDSi CCDS17393.1. [P70390-1 ]
    RefSeqi NP_038693.1. NM_013665.1. [P70390-1 ]
    XP_006501277.1. XM_006501214.1. [P70390-2 ]
    XP_006501281.1. XM_006501218.1.
    UniGenei Mm.39093.

    3D structure databases

    ProteinModelPortali P70390.
    SMRi P70390. Positions 140-198.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000029422.

    PTM databases

    PhosphoSitei P70390.

    Proteomic databases

    PaxDbi P70390.
    PRIDEi P70390.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000029422 ; ENSMUSP00000029422 ; ENSMUSG00000027833 . [P70390-1 ]
    GeneIDi 20429.
    KEGGi mmu:20429.
    UCSCi uc008pld.1. mouse. [P70390-2 ]
    uc008ple.2. mouse. [P70390-1 ]

    Organism-specific databases

    CTDi 6474.
    MGIi MGI:1201673. Shox2.

    Phylogenomic databases

    eggNOGi NOG113578.
    GeneTreei ENSGT00750000117318.
    HOGENOMi HOG000231518.
    HOVERGENi HBG007233.
    InParanoidi P70390.
    KOi K09331.
    OMAi EPTGCAE.
    OrthoDBi EOG7J1817.
    PhylomeDBi P70390.
    TreeFami TF350757.

    Miscellaneous databases

    NextBioi 298446.
    PROi P70390.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P70390.
    Bgeei P70390.
    CleanExi MM_SHOX2.
    Genevestigatori P70390.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR000047. HTH_motif.
    IPR003654. OAR_dom.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF03826. OAR. 1 hit.
    [Graphical view ]
    PRINTSi PR00031. HTHREPRESSR.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS50803. OAR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Tissue: Embryo.
    2. "Cloning and characterization of four murine homeobox genes."
      Rovescalli A.C., Asoh S., Nirenberg M.W.
      Proc. Natl. Acad. Sci. U.S.A. 93:10691-10696(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 116-331 AND 235-331 (ISOFORMS 1 AND 2).
      Strain: BALB/c.
      Tissue: Embryo and Liver.
    3. "A new human homeobox gene OG12X is a member of the most conserved homeobox gene family and is expressed during heart development in mouse."
      Semina E.V., Reiter R.S., Murray J.C.
      Hum. Mol. Genet. 7:415-422(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiSHOX2_MOUSE
    AccessioniPrimary (citable) accession number: P70390
    Secondary accession number(s): P70369
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3