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Protein

Short stature homeobox protein 2

Gene

Shox2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May be a growth regulator and have a role in specifying neural systems involved in processing somatosensory information, as well as in face and body structure formation. May also have a role in heart development.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi140 – 199HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • cardiac atrium morphogenesis Source: MGI
  • cartilage development involved in endochondral bone morphogenesis Source: MGI
  • chondrocyte development Source: MGI
  • chondrocyte differentiation Source: MGI
  • embryonic digestive tract morphogenesis Source: MGI
  • embryonic forelimb morphogenesis Source: MGI
  • embryonic limb morphogenesis Source: MGI
  • embryonic morphogenesis Source: MGI
  • embryonic skeletal joint morphogenesis Source: MGI
  • heart valve development Source: MGI
  • muscle tissue morphogenesis Source: BHF-UCL
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • osteoblast differentiation Source: MGI
  • positive regulation of axonogenesis Source: BHF-UCL
  • positive regulation of mesenchymal cell proliferation Source: MGI
  • positive regulation of skeletal muscle fiber development Source: BHF-UCL
  • positive regulation of smoothened signaling pathway Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of branching morphogenesis of a nerve Source: BHF-UCL
  • regulation of chondrocyte differentiation Source: MGI

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Short stature homeobox protein 2
Alternative name(s):
Homeobox protein Og12X
Short name:
OG-12
Paired family homeodomain protein Prx3
Gene namesi
Name:Shox2
Synonyms:Og12x, Prx3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1201673. Shox2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000492931 – 331Short stature homeobox protein 2Add BLAST331

Proteomic databases

PaxDbiP70390.
PeptideAtlasiP70390.
PRIDEiP70390.

PTM databases

iPTMnetiP70390.
PhosphoSitePlusiP70390.

Expressioni

Tissue specificityi

Highly expressed in striated muscle followed by liver, kidney, testis, brain, heart, lung and spleen.

Developmental stagei

Expressed from E9 TO E16 day in the heart, otic region, maxillary and mandibular components of the first branchial arch, nasal processes, eyelid, midbrain, medulla oblongata, limbs, dorsal root ganglia and genital tubercle. Also expressed in non-neuronal structures around the oral cavity and in hip and shoulder regions and in mesenchyme surrounding the vertebrae.1 Publication

Gene expression databases

BgeeiENSMUSG00000027833.
CleanExiMM_SHOX2.
ExpressionAtlasiP70390. baseline and differential.
GenevisibleiP70390. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029422.

Structurei

3D structure databases

ProteinModelPortaliP70390.
SMRiP70390.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi313 – 326OARPROSITE-ProRule annotationAdd BLAST14

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi59 – 82Poly-GlyAdd BLAST24

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
GeneTreeiENSGT00760000118958.
HOGENOMiHOG000231518.
HOVERGENiHBG007233.
InParanoidiP70390.
KOiK09331.
OMAiCTEAGRD.
OrthoDBiEOG091G0ICT.
PhylomeDBiP70390.
TreeFamiTF350757.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR000047. HTH_motif.
IPR003654. OAR_dom.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
PRINTSiPR00031. HTHREPRESSR.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P70390-1) [UniParc]FASTAAdd to basket
Also known as: OG12A, PRX3A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEELTAFVSK SFDQKVKEKK EAITYREVLE SGPLRGAKEP GCVEPGRDDR
60 70 80 90 100
SSPAVRAAGG GGGAGGGGGG GGGGGGGAGG GGAGGGAGGG RSPVRELDMG
110 120 130 140 150
AAERSREPGS PRLTEVSPEL KDRKDDAKGM EDEGQTKIKQ RRSRTNFTLE
160 170 180 190 200
QLNELERLFD ETHYPDAFMR EELSQRLGLS EARVQVWFQN RRAKCRKQEN
210 220 230 240 250
QLHKGVLIGA ASQFEACRVA PYVNVGALRM PFQQDSHCNV TPLSFQVQAQ
260 270 280 290 300
LQLDSAVAHA HHHLHPHLAA HAPYMMFPAP PFGLPLATLA ADSASAASVV
310 320 330
AAAAAAKTTS KNSSIADLRL KAKKHAAALG L
Length:331
Mass (Da):34,905
Last modified:February 1, 1997 - v1
Checksum:iD24D297E1D73A025
GO
Isoform 2 (identifier: P70390-2) [UniParc]FASTAAdd to basket
Also known as: OG12B, PRX3B

The sequence of this isoform differs from the canonical sequence as follows:
     235-246: Missing.

Show »
Length:319
Mass (Da):33,576
Checksum:i0172F8C6825A0023
GO

Sequence cautioni

The sequence AAC52831 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAC52832 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002289235 – 246Missing in isoform 2. 2 PublicationsAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66918 mRNA. Translation: AAC52833.1.
U67055 mRNA. Translation: AAC52834.1.
U65071 Genomic DNA. No translation available.
U65072 Genomic DNA. Translation: AAC52831.1. Different initiation.
U65072 Genomic DNA. Translation: AAC52832.1. Different initiation.
CCDSiCCDS17393.1. [P70390-1]
RefSeqiNP_001289286.1. NM_001302357.1. [P70390-2]
NP_001289287.1. NM_001302358.1.
NP_001289288.1. NM_001302359.1.
NP_038693.1. NM_013665.1. [P70390-1]
UniGeneiMm.39093.

Genome annotation databases

EnsembliENSMUST00000029422; ENSMUSP00000029422; ENSMUSG00000027833. [P70390-1]
GeneIDi20429.
KEGGimmu:20429.
UCSCiuc008pld.2. mouse. [P70390-2]
uc008ple.2. mouse. [P70390-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSHOX2_MOUSE
AccessioniPrimary (citable) accession number: P70390
Secondary accession number(s): P70369
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: February 1, 1997
Last modified: September 27, 2017
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families