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Protein

Insulin-like growth factor-binding protein complex acid labile subunit

Gene

Igfals

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May have an important role in regulating the access of circulating IGFs to the tissues.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein complex acid labile subunit
Short name:
ALS
Gene namesi
Name:Igfals
Synonyms:Albs, Als
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:107973. Igfals.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 603580Insulin-like growth factor-binding protein complex acid labile subunitPRO_0000020696Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi64 – 641N-linked (GlcNAc...)Sequence analysis
Glycosylationi85 – 851N-linked (GlcNAc...)Sequence analysis
Glycosylationi96 – 961N-linked (GlcNAc...)Sequence analysis
Glycosylationi368 – 3681N-linked (GlcNAc...)Sequence analysis
Glycosylationi515 – 5151N-linked (GlcNAc...)Sequence analysis
Glycosylationi578 – 5781N-linked (GlcNAc...)Sequence analysis
Glycosylationi586 – 5861N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP70389.
PaxDbiP70389.
PeptideAtlasiP70389.
PRIDEiP70389.

PTM databases

PhosphoSiteiP70389.

Expressioni

Gene expression databases

BgeeiENSMUSG00000046070.

Interactioni

Subunit structurei

Forms a ternary complex of about 140 to 150 kDa with IGF-I or IGF-II and IGFBP-3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiP70389. 2 interactions.
MINTiMINT-217480.
STRINGi10090.ENSMUSP00000060169.

Structurei

3D structure databases

ProteinModelPortaliP70389.
SMRiP70389. Positions 41-589.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 7443LRRNTAdd
BLAST
Repeati75 – 9622LRR 1Add
BLAST
Repeati99 – 12022LRR 2Add
BLAST
Repeati123 – 14422LRR 3Add
BLAST
Repeati147 – 16822LRR 4Add
BLAST
Repeati171 – 19222LRR 5Add
BLAST
Repeati195 – 21622LRR 6Add
BLAST
Repeati219 – 24022LRR 7Add
BLAST
Repeati243 – 26422LRR 8Add
BLAST
Repeati267 – 28822LRR 9Add
BLAST
Repeati291 – 31222LRR 10Add
BLAST
Repeati315 – 33622LRR 11Add
BLAST
Repeati339 – 36022LRR 12Add
BLAST
Repeati363 – 38422LRR 13Add
BLAST
Repeati387 – 40822LRR 14Add
BLAST
Repeati411 – 43222LRR 15Add
BLAST
Repeati435 – 45622LRR 16Add
BLAST
Repeati459 – 48022LRR 17Add
BLAST
Repeati483 – 50422LRR 18Add
BLAST
Repeati507 – 52822LRR 19Add
BLAST
Domaini535 – 60369LRRCTAdd
BLAST

Sequence similaritiesi

Contains 19 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
HOVERGENiHBG000327.
InParanoidiP70389.
KOiK17256.
PhylomeDBiP70389.
TreeFamiTF351124.

Family and domain databases

Gene3Di3.80.10.10. 5 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF00560. LRR_1. 2 hits.
PF13855. LRR_8. 4 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 19 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70389-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRTGSPAL VVLLAFWVAL GPCYLQGTDP GASADAEGPQ CPVTCTCSYD
60 70 80 90 100
DYTDELSVFC SSRNLTQLPD GIPVSTRALW LDGNNLSSIP SAAFQNLSSL
110 120 130 140 150
DFLNLQGSWL RSLEPQALLG LQNLYHLHLE RNLLRSLAAG LFRHTPSLAS
160 170 180 190 200
LSLGNNLLGR LEEGLFRGLS HLWDLNLGWN SLVVLPDTVF QGLGNLHELV
210 220 230 240 250
LAGNKLTYLQ PALLCGLGEL RELDLSRNAL RSVKANVFIH LPRLQKLYLD
260 270 280 290 300
RNLITAVAPR AFLGMKALRW LDLSHNRVAG LLEDTFPGLL GLHVLRLAHN
310 320 330 340 350
AITSLRPRTF KDLHFLEELQ LGHNRIRQLG EKTFEGLGQL EVLTLNDNQI
360 370 380 390 400
HEVKVGAFFG LFNVAVMNLS GNCLRSLPEH VFQGLGRLHS LHLEHSCLGR
410 420 430 440 450
IRLHTFAGLS GLRRLFLRDN SISSIEEQSL AGLSELLELD LTANQLTHLP
460 470 480 490 500
RQLFQGLGQL EYLLLSNNQL TMLSEDVLGP LQRAFWLDLS HNRLETPAEG
510 520 530 540 550
LFSSLGRLRY LNLRNNSLQT FVPQPGLERL WLDANPWDCS CPLKALRDFA
560 570 580 590 600
LQNPGVVPRF VQTVCEGDDC QPVYTYNNIT CAGPANVSGL DLRDISETLF

VHC
Length:603
Mass (Da):66,960
Last modified:February 1, 1997 - v1
Checksum:i4A6223AEC7026BCC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti71 – 711G → S in BAB23677 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66900 Genomic DNA. Translation: AAB17270.1.
AK004926 mRNA. Translation: BAB23677.1.
CCDSiCCDS37497.1.
PIRiJC6128.
RefSeqiNP_032366.2. NM_008340.3.
UniGeneiMm.3135.

Genome annotation databases

GeneIDi16005.
KEGGimmu:16005.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66900 Genomic DNA. Translation: AAB17270.1.
AK004926 mRNA. Translation: BAB23677.1.
CCDSiCCDS37497.1.
PIRiJC6128.
RefSeqiNP_032366.2. NM_008340.3.
UniGeneiMm.3135.

3D structure databases

ProteinModelPortaliP70389.
SMRiP70389. Positions 41-589.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP70389. 2 interactions.
MINTiMINT-217480.
STRINGi10090.ENSMUSP00000060169.

PTM databases

PhosphoSiteiP70389.

Proteomic databases

MaxQBiP70389.
PaxDbiP70389.
PeptideAtlasiP70389.
PRIDEiP70389.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi16005.
KEGGimmu:16005.

Organism-specific databases

CTDi3483.
MGIiMGI:107973. Igfals.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
HOVERGENiHBG000327.
InParanoidiP70389.
KOiK17256.
PhylomeDBiP70389.
TreeFamiTF351124.

Miscellaneous databases

PROiP70389.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000046070.

Family and domain databases

Gene3Di3.80.10.10. 5 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF00560. LRR_1. 2 hits.
PF13855. LRR_8. 4 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 19 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiALS_MOUSE
AccessioniPrimary (citable) accession number: P70389
Secondary accession number(s): Q9DBI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: September 7, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.